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Article ; Online: Factors Influencing Sustainable Development Literacy among Engineering Undergraduates in China: Based on the College Impact Model.

Qi, Shuyu / Huang, Danning / Ma, Qiutong / Zhou, Mi

International journal of environmental research and public health

2023 Volume 20, Issue 2

Abstract: Achieving carbon neutrality is a major strategy to combat climate change and achieve sustainable development. Training engineering undergraduates with sustainable development literacy is an important way to achieve this goal in the field of higher ... ...

Abstract	Achieving carbon neutrality is a major strategy to combat climate change and achieve sustainable development. Training engineering undergraduates with sustainable development literacy is an important way to achieve this goal in the field of higher education. Based on the college impact model, this research surveyed 1070 engineering undergraduates in Chinese universities to explore the influence of institutional support on undergraduates' sustainable development literacy, and the empirical analysis was conducted using Structural Equation Modeling. The results showed that institutional support positively and significantly influenced the sustainability development literacy of engineering undergraduates, and student engagement had a mediating role in the relationship between institutional support and sustainability development literacy. Relevant recommendations for cultivating engineering undergraduates with high-level sustainability development literacy are proposed here.
MeSH term(s)	Humans ; Literacy ; Sustainable Development ; Universities ; Students ; China
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20021249
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Article: Unravelling the roles of Autophagy in OSCC: A renewed perspective from mechanisms to potential applications.

Gou, Qiutong / Zheng, Ling-Li / Huang, Haixia

Frontiers in pharmacology

2022 Volume 13, Page(s) 994643

Abstract: Oral squamous cell carcinoma (OSCC) is associated with a low survival rate and a high disability rate, making it a serious health burden, particularly in Southeast Asian countries. Therefore, improvements in the diagnosis, treatment, and prognosis ... ...

Abstract	Oral squamous cell carcinoma (OSCC) is associated with a low survival rate and a high disability rate, making it a serious health burden, particularly in Southeast Asian countries. Therefore, improvements in the diagnosis, treatment, and prognosis prediction of OSCC are highly warranted. Autophagy has a significant impact on cancer development. Studies on autophagy in various human cancers have made outstanding contributions; however, the relationship between autophagy and OSCC remains to be explored. This review highlights the roles of autophagy in OSCC and discusses the relationship between autophagy and Epithelial-mesenchymal transition. Considering the lack of OSCC biomarkers, we focus on the studies involving OSCC-related bioinformatics analysis and molecular targets. Based on some classical targets, we summarize several key autophagy-related biomarkers with a considerable potential for clinical application, which may become the hotspot of OSCC research. In conclusion, we elaborate on the interrelationship between autophagy and OSCC and highlight the shortcomings of current studies to provide insights into the potential clinical strategies.
Language	English
Publishing date	2022-10-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.994643
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Article ; Online: A protocol to isolate bone marrow innate lymphoid cells for alymphoid mouse reconstitution.

Jacquelot, Nicolas / Huang, Qiutong / Belz, Gabrielle T / Seillet, Cyril

STAR protocols

2022 Volume 3, Issue 3, Page(s) 101534

Abstract: Innate lymphoid cells (ILCs) and adaptive T cells remain a challenge to study because of a significant overlap in their transcriptomic profiles. Here, we describe the adoptive transfer of ILC progenitors into mice genetically deficient in innate and ... ...

Abstract	Innate lymphoid cells (ILCs) and adaptive T cells remain a challenge to study because of a significant overlap in their transcriptomic profiles. Here, we describe the adoptive transfer of ILC progenitors into mice genetically deficient in innate and adaptive immune cells to allow detailed study of the development and function of ILCs and gene regulation in an in vivo setting. For complete details on the use and execution of this protocol, please refer to Jacquelot et al. (2021) and Seillet et al. (2016).
MeSH term(s)	Animals ; Bone Marrow ; Immunity, Innate ; Lymphocytes ; Lymphoid Progenitor Cells ; Mice ; T-Lymphocytes
Language	English
Publishing date	2022-07-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2666-1667
ISSN (online)	2666-1667
DOI	10.1016/j.xpro.2022.101534
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Article: Targeting Potential of Innate Lymphoid Cells in Melanoma and Other Cancers.

Seo, Hobin / Verma, Amisha / Kinzel, Megan / Huang, Qiutong / Mahoney, Douglas J / Jacquelot, Nicolas

Pharmaceutics

2023 Volume 15, Issue 7

Abstract: Reinvigorating the killing function of tumor-infiltrating immune cells through the targeting of regulatory molecules expressed on lymphocytes has markedly improved the prognosis of cancer patients, particularly in melanoma. While initially thought to ... ...

Abstract	Reinvigorating the killing function of tumor-infiltrating immune cells through the targeting of regulatory molecules expressed on lymphocytes has markedly improved the prognosis of cancer patients, particularly in melanoma. While initially thought to solely strengthen adaptive T lymphocyte anti-tumor activity, recent investigations suggest that other immune cell subsets, particularly tissue-resident innate lymphoid cells (ILCs), may benefit from immunotherapy treatment. Here, we describe the recent findings showing immune checkpoint expression on tissue-resident and tumor-infiltrating ILCs and how their effector function is modulated by checkpoint blockade-based therapies in cancer. We discuss the therapeutic potential of ILCs beyond the classical PD-1 and CTLA-4 regulatory molecules, exploring other possibilities to manipulate ILC effector function to further impede tumor growth and quench disease progression.
Language	English
Publishing date	2023-07-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15072001
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Article ; Online: Parallel worlds of the adaptive and innate immune cell networks.

Huang, Qiutong / Belz, Gabrielle T

Current opinion in immunology

2019 Volume 58, Page(s) 53–59

Abstract: Adaptive and innate immune cells have typically been functionally and temporally segregated even though they share a number of salient features. Over the past decade, significant advances have been made in understanding the composition and diversity of ... ...

Abstract	Adaptive and innate immune cells have typically been functionally and temporally segregated even though they share a number of salient features. Over the past decade, significant advances have been made in understanding the composition and diversity of both innate and adaptive cell populations. This has shed light on how cells from two distinct pathways are so highly complementary. Innate lymphoid cells (ILCs) are pivotally positioned in tissues to form a stable population akin to tissue-resident T cells that protects the body. Nevertheless, the pathway by which different lymphocytes enter tissues, terminally differentiate and are replenished to maintain populations remains incompletely understood. Recent evidence challenges our assumptions about the sedentary lifestyles of so called 'tissue-resident cells' and pushes us to consider their roles in orchestrating protection of the immune system beyond the classical models.
MeSH term(s)	Adaptive Immunity/immunology ; Animals ; Cell Differentiation/immunology ; Cell Lineage/immunology ; Cell Movement/immunology ; Humans ; Immunity, Innate/immunology ; Lymphocytes/cytology ; Lymphocytes/immunology ; Lymphoid Tissue/cytology ; Lymphoid Tissue/immunology ; T-Lymphocytes/cytology ; T-Lymphocytes/immunology
Language	English
Publishing date	2019-05-21
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1035767-1
ISSN	1879-0372 ; 0952-7915
ISSN (online)	1879-0372
ISSN	0952-7915
DOI	10.1016/j.coi.2019.04.008
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Zs.A 2773: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Bach2: An Instrument of Heterogeneity for Long-Term Protection.

Huang, Qiutong / Belz, Gabrielle T

Immunity

2018 Volume 48, Issue 4, Page(s) 618–620

Abstract: Generation of functionally diverse effector and memory killer T cells is essential for immediate and long-term protective immunity. Herndler-Brandstetter et al. (2018) report that Bach2 promotes functional plasticity of effector T cells and the ... ...

Abstract	Generation of functionally diverse effector and memory killer T cells is essential for immediate and long-term protective immunity. Herndler-Brandstetter et al. (2018) report that Bach2 promotes functional plasticity of effector T cells and the transition into the long-term memory compartment by regulating the expression of the inhibitory receptor KLRG1.
MeSH term(s)	Memory ; T-Lymphocytes, Cytotoxic
Language	English
Publishing date	2018-04-18
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/j.immuni.2018.03.033
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Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

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Article ; Online: PD-1 regulates ILC3-driven intestinal immunity and homeostasis.

Jacquelot, Nicolas / Xiong, Le / Cao, Wang H J / Huang, Qiutong / Yu, Huiyang / Sayad, Azin / Anttila, Casey J A / Baldwin, Tracey M / Hickey, Peter F / Amann-Zalcenstein, Daniela / Ohashi, Pamela S / Nutt, Stephen L / Belz, Gabrielle T / Seillet, Cyril

Mucosal immunology

2024

Abstract: Interleukin-(IL) 22 production by intestinal group 3 innate lymphoid cells (ILC3) is critical to maintain gut homeostasis. However, IL-22 needs to be tightly controlled; reduced IL-22 expression is associated with intestinal epithelial barrier defect ... ...

Abstract	Interleukin-(IL) 22 production by intestinal group 3 innate lymphoid cells (ILC3) is critical to maintain gut homeostasis. However, IL-22 needs to be tightly controlled; reduced IL-22 expression is associated with intestinal epithelial barrier defect while its overexpression promotes tumor development. Here, using a single-cell ribonucleic acid sequencing approach, we identified a core set of genes associated with increased IL-22 production by ILC3. Among these genes, programmed cell death 1 (PD-1), extensively studied in the context of cancer and chronic infection, was constitutively expressed on a subset of ILC3. These cells, found in the crypt of the small intestine and colon, displayed superior capacity to produce IL-22. PD-1 expression on ILC3 was dependent on the microbiota and was induced during inflammation in response to IL-23 but, conversely, was reduced in the presence of Notch ligand. PD-1
Language	English
Publishing date	2024-03-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2411370-0
ISSN	1935-3456 ; 1933-0219
ISSN (online)	1935-3456
ISSN	1933-0219
DOI	10.1016/j.mucimm.2024.03.002
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Zs.A 6796: Show issues

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Article ; Online: 2D bimetallic Ni/Fe MOF nanosheet composites as a peroxidase-like nanozyme for colorimetric assay of multiple targets.

Li, Qiutong / Wang, Qian / Li, Ying / Zhang, Xiaodan / Huang, Yuming

Analytical methods : advancing methods and applications

2021 Volume 13, Issue 17, Page(s) 2066–2074

Abstract: In this contribution, 2D Ni/Fe MOF nanosheets were synthesized by a simple two-step ultrasound strategy at room temperature, i.e. the 2D Ni-MOF with a lamellar structure was first synthesized by the top-down ultrasonic assisted stripping route, followed ... ...

Abstract	In this contribution, 2D Ni/Fe MOF nanosheets were synthesized by a simple two-step ultrasound strategy at room temperature, i.e. the 2D Ni-MOF with a lamellar structure was first synthesized by the top-down ultrasonic assisted stripping route, followed by introducing Fe3+ ions as a metal node and terephthalic acid as an organic ligand to form 2D Ni/Fe MOF nanosheets that exhibited weak oxidase-like and strong peroxidase-like properties. Relative to that of the single metal Ni-MOF and Fe-MOF, the peroxidase-mimicking capability of the 2D Ni/Fe MOF nanosheets increased by over 14-fold and 3-fold, respectively. Reactive oxygen trials indicated that the 2D Ni/Fe MOF nanosheets can efficiently catalyze the decomposition of H2O2 to generate the ˙OH and O2˙- radicals, which can oxidize TMB to oxTMB from colorless to blue. The kinetic trial demonstrated the high affinity of the 2D Ni/Fe MOF nanosheet to H2O2 with a Km of 0.037 mM, which was 100 times lower than that of HRP. These impressive characteristics are likely related to the good dispersion of the in situ formed Fe MOF in the 2D Ni-MOF nanosheet structure with coordinatively unsaturated metal sites. This allows the 2D Ni/Fe MOF nanosheets to expose more active metal sites and to enhance the intrinsic catalytic activity of each site due to the synergistic interaction between the two metals. Interestingly, glutathione can obviously restrict the peroxidase-like activity of the 2D Ni/Fe MOF nanosheet, while the inhibited TMB oxidation can be restored upon further introducing Hg2+ ions due to the high and specific affinity of Hg2+ to thiol groups in glutathione. Based on the above facts, the 2D Ni/Fe MOF nanozyme was used to construct a nanoplatform to determine multiple targets, i.e. H2O2, glutathione and Hg2+. The 2D Ni/Fe MOF nanozyme-based colorimetric assay exhibits a linear response to H2O2, glutathione and Hg2+ ions over the 0.01-100 μM, 0.02-100 μM, and 100 nM to 200 μM ranges, respectively. The limits of detection (3σ) for the determination of H2O2, glutathione and Hg2+ are 10 nM, 10 nM, and 100 nM, respectively. This method was used to determinate the content of Hg2+ ions in real water samples.
MeSH term(s)	Colorimetry ; Hydrogen Peroxide ; Metal-Organic Frameworks ; Oxidoreductases ; Peroxidase ; Peroxidases
Chemical Substances	Metal-Organic Frameworks ; Hydrogen Peroxide (BBX060AN9V) ; Oxidoreductases (EC 1.-) ; Peroxidases (EC 1.11.1.-) ; Peroxidase (EC 1.11.1.7)
Language	English
Publishing date	2021-04-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2515210-5
ISSN	1759-9679 ; 1759-9660
ISSN (online)	1759-9679
ISSN	1759-9660
DOI	10.1039/d1ay00281c
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Article: Rational Design of N-Doped Carbon Nanocage-Equipped Co-Nₓ Active Sites for Oxidase Mimicking and Sensing Applications

Wang, Qian / Li, Qiutong / Lu, Yuwan / Zhang, Xiaodan / Huang, Yuming

ACS sustainable chemistry & engineering. 2021 May 26, v. 9, no. 22

2021

Abstract: Rational design of high-performance nanozyme is of great significance for sensing applications. Here, N-doped carbon nanocages containing Co-Nₓ active sites (CoNₓ-NC) were fabricated by simple acid etching of Co@NC, which is the product of Co–Co Prussian ...

Abstract	Rational design of high-performance nanozyme is of great significance for sensing applications. Here, N-doped carbon nanocages containing Co-Nₓ active sites (CoNₓ-NC) were fabricated by simple acid etching of Co@NC, which is the product of Co–Co Prussian blue analogues carbonized in an N₂ atmosphere. Both optimized Co@NC-650 and CoNₓ-NC-650 exhibit catalase- and oxidase-like properties. They rapidly decompose H₂O₂ into O₂ and oxidize colorless 3,3′,5,5′-tetramethylbenzidine (TMB) into a blue product. This enables them with no peroxidase-like activity. The oxidase-like activity of CoNₓ-NC-650 is 3.9 times that of unetched Co@NC-650. The acid treatment dissolves Co nanoparticles generated during carbonization, forming extra mesoporous structures and increasing the exposure of more Co-Nₓ active species. The Michaelis–Menten constant for CoNₓ-NC-650 with a TMB substrate is 0.186 mM, which is 3.2 times lower than that of oxidase-mimicking CeO₂ nanoparticles, suggesting a higher affinity to TMB. Given its excellent oxidase-like activity, the CoNₓ-NC-650 was used to sensitively and selectively determine acetylcholinesterase (AChE) activity based on thiocholine inhibition of the TMB color reaction. Thiocholine is produced via hydrolysis of acetylthiocholine catalyzed by AChE. The colorimetric biosensor has a linear response to AChE over 0.6–800 mU L–¹ concentration range and a detection limit (3σ) of 0.2 mU L–¹. The assay was successfully applied to determine AChE activity in biological samples.
Keywords	acetylcholinesterase ; acid treatment ; biosensors ; carbon ; carbonization ; color ; colorimetry ; detection limit ; enzyme kinetics ; green chemistry ; hydrolysis ; porous media
Language	English
Dates of publication	2021-0526
Size	p. 7668-7677.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ISSN	2168-0485
DOI	10.1021/acssuschemeng.1c02635
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Giant Polymer Vesicles with a Latticelike Membrane.

Zhang, Xinyue / Huang, Qiutong / Wang, Fangyingkai / Sun, Hui / Xiao, Jiangang / Cornel, Erik Jan / Zhu, Yunqing / Du, Jianzhong

ACS macro letters

2021 Volume 10, Issue 8, Page(s) 1015–1022

Abstract: Hierarchical self-assembly offers great possibilities to mimic biological systems with finely arranged complex structures. Herein, we demonstrate the preparation and formation mechanism of an unusual giant polymer vesicle with a latticelike membrane ( ... ...

Abstract	Hierarchical self-assembly offers great possibilities to mimic biological systems with finely arranged complex structures. Herein, we demonstrate the preparation and formation mechanism of an unusual giant polymer vesicle with a latticelike membrane (GVLM). This GVLM is formed by fusion-induced particle assembly (FIPA) of small vesicles that are self-assembled from poly(ethylene oxide)-
MeSH term(s)	Hydrophobic and Hydrophilic Interactions ; Microscopy, Electron, Transmission ; Nanostructures ; Polyethylene Glycols/chemistry ; Polymers/chemistry
Chemical Substances	Polymers ; Polyethylene Glycols (3WJQ0SDW1A)
Language	English
Publishing date	2021-07-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2161-1653
ISSN (online)	2161-1653
DOI	10.1021/acsmacrolett.1c00254
Database	MEDical Literature Analysis and Retrieval System OnLINE

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