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  1. Article ; Online: Lung aeration, ventilation, and perfusion imaging.

    Ball, Lorenzo / Scaramuzzo, Gaetano / Herrmann, Jacob / Cereda, Maurizio

    Current opinion in critical care

    2023  Volume 28, Issue 3, Page(s) 302–307

    Abstract: Purpose of review: Lung imaging is a cornerstone of the management of patients admitted to the intensive care unit (ICU), providing anatomical and functional information on the respiratory system function. The aim of this review is to provide an ... ...

    Abstract Purpose of review: Lung imaging is a cornerstone of the management of patients admitted to the intensive care unit (ICU), providing anatomical and functional information on the respiratory system function. The aim of this review is to provide an overview of mechanisms and applications of conventional and emerging lung imaging techniques in critically ill patients.
    Recent findings: Chest radiographs provide information on lung structure and have several limitations in the ICU setting; however, scoring systems can be used to stratify patient severity and predict clinical outcomes. Computed tomography (CT) is the gold standard for assessment of lung aeration but requires moving the patients to the CT facility. Dual-energy CT has been recently applied to simultaneous study of lung aeration and perfusion in patients with respiratory failure. Lung ultrasound has an established role in the routine bedside assessment of ICU patients, but has poor spatial resolution and largely relies on the analysis of artifacts. Electrical impedance tomography is an emerging technique capable of depicting ventilation and perfusion at the bedside and at the regional level.
    Summary: Clinicians should be confident with the technical aspects, indications, and limitations of each lung imaging technique to improve patient care.
    MeSH term(s) Humans ; Lung/diagnostic imaging ; Perfusion Imaging ; Respiration ; Respiration, Artificial ; Tomography, X-Ray Computed
    Language English
    Publishing date 2023-07-01
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000000942
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  2. Article ; Online: Mechanical Models of Collagen Networks for Understanding Changes in the Failure Properties of Aging Skin.

    Witt, Nathan J / Woessner, Alan E / Herrmann, Jacob / Quinn, Kyle P / Sander, Edward A

    Journal of biomechanical engineering

    2024  Volume 146, Issue 7

    Abstract: Skin undergoes mechanical alterations due to changes in the composition and structure of the collagenous dermis with aging. Previous studies have conflicting findings, with both increased and decreased stiffness reported for aging skin. The underlying ... ...

    Abstract Skin undergoes mechanical alterations due to changes in the composition and structure of the collagenous dermis with aging. Previous studies have conflicting findings, with both increased and decreased stiffness reported for aging skin. The underlying structure-function relationships that drive age-related changes are complex and difficult to study individually. One potential contributor to these variations is the accumulation of nonenzymatic crosslinks within collagen fibers, which affect dermal collagen remodeling and mechanical properties. Specifically, these crosslinks make individual fibers stiffer in their plastic loading region and lead to increased fragmentation of the collagenous network. To better understand the influence of these changes, we investigated the impact of nonenzymatic crosslink changes on the dermal microstructure using discrete fiber networks representative of the dermal microstructure. Our findings suggest that stiffening the plastic region of collagen's mechanical response has minimal effects on network-level stiffness and failure stresses. Conversely, simulating fragmentation through a loss of connectivity substantially reduces network stiffness and failure stress, while increasing stretch ratios at failure.
    MeSH term(s) Skin Aging ; Stress, Mechanical ; Extracellular Matrix ; Collagen ; Skin
    Chemical Substances Collagen (9007-34-5)
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 243094-0
    ISSN 1528-8951 ; 0148-0731
    ISSN (online) 1528-8951
    ISSN 0148-0731
    DOI 10.1115/1.4064406
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  3. Article ; Online: Automated Oxygen Delivery and Conservation: Promises and Pitfalls.

    Kaczka, David W / Herrmann, Jacob

    Respiratory care

    2020  Volume 65, Issue 10, Page(s) 1627–1629

    MeSH term(s) Humans ; Oxygen ; Respiratory Physiological Phenomena
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2020-09-23
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 603252-7
    ISSN 1943-3654 ; 0098-9142 ; 0020-1324
    ISSN (online) 1943-3654
    ISSN 0098-9142 ; 0020-1324
    DOI 10.4187/respcare.08480
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  4. Article ; Online: An agent-based model of tissue maintenance and self-repair.

    Bates, Jason H T / Herrmann, Jacob / Casey, Dylan T / Suki, Béla

    American journal of physiology. Cell physiology

    2023  Volume 324, Issue 4, Page(s) C941–C950

    Abstract: We hypothesized that a system that possesses the capacity for ongoing maintenance of its tissues will necessarily also have the capacity to self-heal following a perturbation. We used an agent-based model of tissue maintenance to investigate this idea, ... ...

    Abstract We hypothesized that a system that possesses the capacity for ongoing maintenance of its tissues will necessarily also have the capacity to self-heal following a perturbation. We used an agent-based model of tissue maintenance to investigate this idea, and in particular to determine the extent to which the current state of the tissue must influence cell behavior in order for tissue maintenance and self-healing to be stable. We show that a mean level of tissue density is robustly maintained when catabolic agents digest tissue at a rate proportional to local tissue density, but that the spatial heterogeneity of the tissue at homeostasis increases with the rate at which tissue is digested. The rate of self-healing is also increased by increasing either the amount of tissue removed or deposited at each time step by catabolic or anabolic agents, respectively, and by increasing the density of both agent types on the tissue. We also found that tissue maintenance and self-healing are stable with an alternate rule in which cells move preferentially to tissue regions of low density. The most basic form of self-healing can thus be achieved with cells that follow very simple rules of behavior, provided these rules are based in some way on the current state of the local tissue. Straightforward mechanisms can accelerate the rate of self-healing, as might be beneficial to the organism.
    MeSH term(s) Homeostasis ; Models, Biological
    Language English
    Publishing date 2023-03-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00531.2022
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  5. Article ; Online: Correction to: A comparison of endotracheal tube compensation technique for the measurement of respiratory mechanical impedance at low frequencies.

    Cruz, Andrea F / Herrmann, Jacob / Carvalho, Carlos R R / Kaczka, David W

    Journal of clinical monitoring and computing

    2022  Volume 36, Issue 4, Page(s) 1237

    Language English
    Publishing date 2022-01-18
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 1418733-4
    ISSN 1573-2614 ; 1387-1307 ; 0748-1977
    ISSN (online) 1573-2614
    ISSN 1387-1307 ; 0748-1977
    DOI 10.1007/s10877-022-00809-1
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  6. Article ; Online: Virtual Biopsy: Just an AI Software or a Medical Procedure?

    Murray, Jacob M / Wiegand, Bodo / Hadaschik, Boris / Herrmann, Ken / Kleesiek, Jens

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2022  Volume 63, Issue 4, Page(s) 511–513

    MeSH term(s) Artificial Intelligence ; Biopsy ; Software
    Language English
    Publishing date 2022-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.121.263749
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  7. Article ; Online: Biochemical and structural insight into the chemical resistance and cofactor specificity of the formate dehydrogenase from Starkeya novella.

    Partipilo, Michele / Whittaker, Jacob J / Pontillo, Nicola / Coenradij, Jelmer / Herrmann, Andreas / Guskov, Albert / Slotboom, Dirk Jan

    The FEBS journal

    2023  Volume 290, Issue 17, Page(s) 4238–4255

    Abstract: Formate dehydrogenases (Fdhs) mediate the oxidation of formate to carbon dioxide and concomitant reduction of nicotinamide adenine dinucleotide ( ... ...

    Abstract Formate dehydrogenases (Fdhs) mediate the oxidation of formate to carbon dioxide and concomitant reduction of nicotinamide adenine dinucleotide (NAD
    MeSH term(s) NAD/metabolism ; Formate Dehydrogenases/genetics ; NADP/metabolism ; Formates/metabolism ; Sulfhydryl Compounds
    Chemical Substances NAD (0U46U6E8UK) ; Formate Dehydrogenases (EC 1.17.1.9) ; NADP (53-59-8) ; Formates ; Sulfhydryl Compounds
    Language English
    Publishing date 2023-06-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2173655-8
    ISSN 1742-4658 ; 1742-464X
    ISSN (online) 1742-4658
    ISSN 1742-464X
    DOI 10.1111/febs.16871
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  8. Article ; Online: Native adiponectin plays a role in the adipocyte-mediated conversion of fibroblasts to myofibroblasts.

    El-Hattab, Mariam Y / Sinclair, Noah / Liszewski, Jesse N / Schrodt, Michael V / Herrmann, Jacob / Klingelhutz, Aloysius J / Sander, Edward A / Ankrum, James A

    Journal of the Royal Society, Interface

    2023  Volume 20, Issue 202, Page(s) 20230004

    Abstract: Adipocytes regulate tissues through production of adipokines that can act both locally and systemically. Adipocytes also have been found to play a critical role in regulating the healing process. To better understand this role, we developed a three- ... ...

    Abstract Adipocytes regulate tissues through production of adipokines that can act both locally and systemically. Adipocytes also have been found to play a critical role in regulating the healing process. To better understand this role, we developed a three-dimensional human adipocyte spheroid system that has an adipokine profile similar to
    MeSH term(s) Humans ; Myofibroblasts/metabolism ; Transforming Growth Factor beta1/pharmacology ; Transforming Growth Factor beta1/metabolism ; Adiponectin/metabolism ; Signal Transduction/physiology ; Fibroblasts/metabolism ; Adipocytes/metabolism ; Lipids ; Actins/metabolism ; Cell Differentiation ; Cells, Cultured
    Chemical Substances Transforming Growth Factor beta1 ; Adiponectin ; Lipids ; Actins
    Language English
    Publishing date 2023-05-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2156283-0
    ISSN 1742-5662 ; 1742-5689
    ISSN (online) 1742-5662
    ISSN 1742-5689
    DOI 10.1098/rsif.2023.0004
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  9. Article ; Online: Effects of Lung Injury and Abdominal Insufflation on Respiratory Mechanics and Lung Volume During Time-Controlled Adaptive Ventilation.

    Ramcharran, Harry / Wetmore, Greg / Cooper, Scott / Herrmann, Jacob / Cruz, Andrea F / Kaczka, David W / Satalin, Joshua / Blair, Sarah / Andrews, Penny L / Habashi, Nader M / Nieman, Gary F / Kollisch-Singule, Michaela

    Respiratory care

    2024  

    Abstract: Background: Lung volume measurements are important for monitoring functional aeration and recruitment, and may help guide adjustments in ventilator settings. The expiratory phase of APRV may provide physiologic information about lung volume based on the ...

    Abstract Background: Lung volume measurements are important for monitoring functional aeration and recruitment, and may help guide adjustments in ventilator settings. The expiratory phase of APRV may provide physiologic information about lung volume based on the expiratory flow-time slope, angle, and time to approach a no-flow state (T
    Methods: Eight pigs (35.2±1.0kg) were mechanically ventilated using an Engström Carescape R860 on the APRV mode. All settings were held constant except the expiratory duration (T
    Results: Lung elastance increased with Tween-induced lung injury from 29.3±7.3cmH
    Conclusions: Changes in ELV over time, and the T
    Language English
    Publishing date 2024-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603252-7
    ISSN 1943-3654 ; 0098-9142 ; 0020-1324
    ISSN (online) 1943-3654
    ISSN 0098-9142 ; 0020-1324
    DOI 10.4187/respcare.11745
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  10. Article: An Analytic Model of Tissue Self-Healing and Its Network Implementation: Application to Fibrosis and Aging.

    Suki, Béla / Herrmann, Jacob / Bates, Jason H T

    Frontiers in physiology

    2020  Volume 11, Page(s) 583024

    Abstract: Here we present a model capable of self-healing and explore its ability to resolve pathological alterations in biological tissue. We derive a simple analytic model consisting of an agent representing a cell that exhibits anabolic or catabolic activity, ... ...

    Abstract Here we present a model capable of self-healing and explore its ability to resolve pathological alterations in biological tissue. We derive a simple analytic model consisting of an agent representing a cell that exhibits anabolic or catabolic activity, and which interacts with its tissue substrate according to tissue stiffness. When perturbed, this system returns toward a stable fixed point, a process corresponding to self-healing. We implemented this agent-substrate mechanism numerically on a hexagonal elastic network representing biological tissue. Agents, representing fibroblasts, were placed on the network and allowed to migrate around while they remodeled the network elements according to their activity which was determined by the stiffnesses of network elements that each agent encountered during its random walk. Initial injury to the network was simulated by increasing the stiffness of a single central network element above baseline. This system also exhibits a fixed point represented by the uniform baseline state. During the approach to the fixed point, interactions between the agents and the network create a transient spatially extended halo of stiffer network elements around the site of initial injury, which aids in overall injury repair. Non-equilibrium constraints generated by persistent injury prohibit the network to return to baseline and results in progressive stiffening, mimicking the development of fibrosis. Additionally, reducing anabolic or catabolic rates delay self-healing, reminiscent of aging. Our model thus embodies what may be the simplest set of attributes required of a spatiotemporal self-healing system, and so may help understand altered self-healing in chronic fibrotic diseases and aging.
    Language English
    Publishing date 2020-10-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2020.583024
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