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Article ; Online: Sharing a single ventilator ("In vitro").

Rodríguez-Villar, Sancho

Medicina intensiva

2020 Volume 44, Issue 8, Page(s) 514–516

Keywords	covid19
Language	English
Publishing date	2020-05-11
Publishing country	Spain
Document type	Case Reports ; Letter
ISSN	2173-5727
ISSN (online)	2173-5727
DOI	10.1016/j.medin.2020.04.021
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Sharing a single ventilator (“in vitro”)

Rodríguez-Villar, Sancho

Med Intensiva

Keywords	covid19
Publisher	PMC
Document type	Article ; Online
DOI	10.1016/j.medin.2020.04.021
Database	COVID19

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Article ; Online: Anabolic-androgenic steroids abuse-induced seizures: A case report in a young male bodybuilder.

Rodriguez-Villar, Sancho / Hallal-Peche, Fadi / Kearney, Tara / Stavropoulos, Ioannis / Theochari, Evangelia / Valentin, Antonio

Seizure

2022 Volume 96, Page(s) 22–24

Abstract: None. ...

Abstract	None.
MeSH term(s)	Anabolic Agents/adverse effects ; Humans ; Male ; Seizures/chemically induced ; Steroids
Chemical Substances	Anabolic Agents ; Steroids
Language	English
Publishing date	2022-01-15
Publishing country	England
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1137610-7
ISSN	1532-2688 ; 1059-1311
ISSN (online)	1532-2688
ISSN	1059-1311
DOI	10.1016/j.seizure.2022.01.010
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Zs.A 3573: Show issues

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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: A case of periorbital necrotizing fasciitis rapidly progressing to severe multiorgan failure.

Eiben, Paola / Rodriguez-Villar, Sancho

Journal of surgical case reports

2018 Volume 2018, Issue 4, Page(s) rjy083

Abstract: Periorbital necrotizing fasciitis (PNF) is a severe suppurative infection of the subcutaneous tissue and underlying fascia of the periorbital region. Typically, the course of PNF is milder and has a better prognosis than that of necrotizing fasciitis in ... ...

Abstract	Periorbital necrotizing fasciitis (PNF) is a severe suppurative infection of the subcutaneous tissue and underlying fascia of the periorbital region. Typically, the course of PNF is milder and has a better prognosis than that of necrotizing fasciitis in other parts of the body. As such, this disease is thought to be associated with a significantly smaller risk of morbidity and mortality. Nevertheless, it is a rare and devastating condition that can lead to disfigurement, blindness and death. Early recognition is critical to improved patient outcomes. Here, we describe a case of PNF in a 60-year-old male that rapidly progressed to widespread systemic involvement and severe multiorgan failure requiring ventilatory, cardiovascular and renal support. Treatment included broad-spectrum antibiotics, intravenous immunoglobulin and surgical debridement. This case highlights the life-threatening nature of PNF, as demonstrated by rapid progression to multiorgan dysfunction and the need of an urgent surgical intervention.
Language	English
Publishing date	2018-04-30
Publishing country	England
Document type	Case Reports
ISSN	2042-8812
ISSN	2042-8812
DOI	10.1093/jscr/rjy083
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Correction to: Management of industrial high-pressure fluid injection injuries (IHPFII): the Water Jetting Association (WJA) experience with water driven injuries.

Rodríguez-Villar, Sancho / Kennedy, Robert Charles / Dall'Antonia, Martino / Menichetti, Carlos Pilasi

European journal of trauma and emergency surgery : official publication of the European Trauma Society

2019 Volume 45, Issue 3, Page(s) 571–572

Abstract: The original article can be found online. ...

Abstract	The original article can be found online.
Language	English
Publishing date	2019-04-26
Publishing country	Germany
Document type	Journal Article ; Published Erratum
ZDB-ID	2275480-5
ISSN	1863-9941 ; 1863-9933
ISSN (online)	1863-9941
ISSN	1863-9933
DOI	10.1007/s00068-019-01124-2
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Zs.A 1221: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 607: Show issues

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Article ; Online: New-onset refractory status epilepticus responsive to VNS: A case report.

Rodriguez-Villar, Sancho / Ahmed, Mohamed Ahmed / Haddad, Saif / Mantoan, Laura / Singh, Neeraj / Mahdi-Roger, Mohamed / Stavropoulos, Ioannis / Selway, Richard / Valentin, Antonio

Epileptic disorders : international epilepsy journal with videotape

2023 Volume 25, Issue 4, Page(s) 571–574

MeSH term(s)	Humans ; Status Epilepticus/diagnosis ; Status Epilepticus/therapy ; Vagus Nerve Stimulation
Language	English
Publishing date	2023-06-14
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2086797-9
ISSN	1950-6945 ; 1294-9361
ISSN (online)	1950-6945
ISSN	1294-9361
DOI	10.1002/epd2.20064
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5740: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 252: Show issues
Zs.MN 11: Show issues

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Article ; Online: Management of industrial high-pressure fluid injection injuries (IHPFII): the Water Jetting Association (WJA) experience with water driven injuries.

Rodríguez-Villar, Sancho / Kennedy, Robert Charles / Dall'Antonia, Martino / Menichetti, Carlos Pilasi

European journal of trauma and emergency surgery : official publication of the European Trauma Society

2019 Volume 45, Issue 3, Page(s) 507–515

Abstract: Background: Industrial high-pressure fluid injection injuries (IHPFII) are largely occupational in nature, where these injuries are most often sustained by male manual workers. Such traumatic injuries are largely sustained with water, grease, paint, ... ...

Abstract	Background: Industrial high-pressure fluid injection injuries (IHPFII) are largely occupational in nature, where these injuries are most often sustained by male manual workers. Such traumatic injuries are largely sustained with water, grease, paint, gasoline or paint thinner. IHPFII are extremely serious injuries with life and limb-threatening potential carrying the risk of life-long disability. Methods: We reviewed the Water Jetting Association© adverse incident database of advisory alerts detailing cases from around the world that have been brought to the association's attention and the English-language literature on high-pressure hydrostatic injuries from 1937 to 2018. Results: Accidents involving high-pressure water jets in the industry are uncommon. The clinical impact in all of the cases reviewed and the effects of water jet impacts range from instant fatalities at scene to loss of limb function and amputation. The majority of observed fatalities are due to major hemorrhage (exsanguination) secondary to the direct dissection of great vessels or high-energy blunt soft tissue injury and traumatic brain injury. Conclusions: As with any other trauma, IHPWJI commonly result in amputation or death. Nonetheless, a lack of comprehension of the potential severity of injuries and range of infective complications appears to be largely due to the apparent benignity of the initial presentation of the wound. This in turn leads to delays (both avoidable and unavoidable) in the transfer to appropriate medical facilities and definitive care. There is an identifiable need for education (including for health care providers across multiple levels), training and the availability of personal trauma kits for the timely and effective management of IHPWJI from the initial jet impact on the scene, as well as a need for an established referral system.
MeSH term(s)	Acute Kidney Injury/etiology ; Acute Kidney Injury/therapy ; Amputation ; Brain Injuries, Traumatic/etiology ; Brain Injuries, Traumatic/mortality ; Brain Injuries, Traumatic/therapy ; Compartment Syndromes/etiology ; Compartment Syndromes/therapy ; Edema/etiology ; Exsanguination/etiology ; Exsanguination/mortality ; Exsanguination/therapy ; Humans ; Hydrostatic Pressure/adverse effects ; Occupational Injuries/etiology ; Occupational Injuries/mortality ; Occupational Injuries/therapy ; Rhabdomyolysis/etiology ; Rhabdomyolysis/therapy ; Soft Tissue Injuries/etiology ; Soft Tissue Injuries/therapy ; Subcutaneous Emphysema/diagnostic imaging ; Subcutaneous Emphysema/etiology ; Wound Infection/etiology ; Wound Infection/therapy
Language	English
Publishing date	2019-03-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2275480-5
ISSN	1863-9941 ; 1863-9933
ISSN (online)	1863-9941
ISSN	1863-9933
DOI	10.1007/s00068-019-01106-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1221: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 607: Show issues

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Article ; Online: Antithrombin III deficiency-induced coagulopathy in the context of COVID-19: a case series.

Gardner, Andrew J / Kirkin, Daniel J / Rodriguez-Villar, Sancho / Leoz Abellanas, Gonzalo / Tee, Alice / Valentin, Antonio

British journal of haematology

2021 Volume 194, Issue 6, Page(s) 1007–1009

MeSH term(s)	Aged ; Antithrombin III Deficiency/blood ; Antithrombin III Deficiency/etiology ; COVID-19/blood ; COVID-19/complications ; Humans ; Male ; Middle Aged ; SARS-CoV-2/metabolism
Language	English
Publishing date	2021-05-30
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.17575
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Uh III Zs.182: Show issues

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Article ; Online: Methodology for the analysis and comparison of protocols for glycaemic control in intensive care.

Fernández-Méndez, Rocío / Rodríguez-Villar, Sancho / Méndez, Pablo F / Windle, Richard / Adams, Gary George

Journal of evaluation in clinical practice

2018 Volume 25, Issue 2, Page(s) 251–259

Abstract: Rationale, aims, and objectives: The practice of glycaemic control of critically ill patients admitted to intensive care units (ICUs) is guided by clinical management protocols, designed locally by the ICUs. These protocols differ significantly in their ...

Abstract	Rationale, aims, and objectives: The practice of glycaemic control of critically ill patients admitted to intensive care units (ICUs) is guided by clinical management protocols, designed locally by the ICUs. These protocols differ significantly in their aims and methods. The aim of this study was to develop a standardized methodology for the systematic and objective analysis and comparison of protocols for glycaemic control implemented in any ICU. Method: The protocols for glycaemic control implemented in seven ICUs of a UK-based ICU network were analysed using techniques of inductive content analysis, through an open coding process and the framework method. This involved the identification and classification of protocol instructions for glycaemic control, as well as of the processes and decisions pertaining to each of these instructions. These were used to develop a framework for the structured and systematic description and comparison of the protocols' contents, and to develop a technique for the protocols' graphic visualization. Results: The following elements were identified or developed: (1) 35 quantifiable variables and 11 non-quantifiable subjects that could be present in an ICU protocol for glycaemic control, to be used as a framework for the description and comparison of contents; (2) a technique for condensing a protocol into a single, comprehensive flowchart; (3) using these flowcharts, a method for assessing the complexity and comprehensiveness of the protocols. Conclusions: The methodology developed in this study will allow for any future work analysing the contents of glycaemic control protocols to be carried out in a structured and standardized way. This may be done either as a standalone study, or as the essential first step in any investigation on the impact of new protocols. In turn, the methodology will facilitate the performance of regional, national, and international comparisons, demonstrating the usefulness of this study at a global scale.
MeSH term(s)	Blood Glucose/analysis ; Clinical Protocols ; Critical Illness ; Glycemic Index ; Humans ; Hyperglycemia/prevention & control ; Intensive Care Units ; Medical Audit ; United Kingdom
Chemical Substances	Blood Glucose
Language	English
Publishing date	2018-10-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1327355-3
ISSN	1365-2753 ; 1356-1294
ISSN (online)	1365-2753
ISSN	1356-1294
DOI	10.1111/jep.13047
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4464: Show issues

Location:
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Article ; Online: Automatic real-time analysis and interpretation of arterial blood gas sample for Point-of-care testing: Clinical validation.

Rodríguez-Villar, Sancho / Poza-Hernández, Paloma / Freigang, Sascha / Zubizarreta-Ormazabal, Idoia / Paz-Martín, Daniel / Holl, Etienne / Pérez-Pardo, Osvaldo Ceferino / Tovar-Doncel, María Sherezade / Wissa, Sonja Maria / Cimadevilla-Calvo, Bonifacio / Tejón-Pérez, Guillermo / Moreno-Fernández, Ismael / Escario-Méndez, Alejandro / Arévalo-Serrano, Juan / Valentín, Antonio / Do-Vale, Bruno Manuel / Fletcher, Helen Marie / Lorenzo-Fernández, Jesús Medardo

PloS one

2021 Volume 16, Issue 3, Page(s) e0248264

Abstract: Background: Point-of-care arterial blood gas (ABG) is a blood measurement test and a useful diagnostic tool that assists with treatment and therefore improves clinical outcomes. However, numerically reported test results make rapid interpretation ... ...

Abstract	Background: Point-of-care arterial blood gas (ABG) is a blood measurement test and a useful diagnostic tool that assists with treatment and therefore improves clinical outcomes. However, numerically reported test results make rapid interpretation difficult or open to interpretation. The arterial blood gas algorithm (ABG-a) is a new digital diagnostics solution that can provide clinicians with real-time interpretation of preliminary data on safety features, oxygenation, acid-base disturbances and renal profile. The main aim of this study was to clinically validate the algorithm against senior experienced clinicians, for acid-base interpretation, in a clinical context. Methods: We conducted a prospective international multicentre observational cross-sectional study. 346 sample sets and 64 inpatients eligible for ABG met strict sampling criteria. Agreement was evaluated using Cohen's kappa index, diagnostic accuracy was evaluated with sensitivity, specificity, efficiency or global accuracy and positive predictive values (PPV) and negative predictive values (NPV) for the prevalence in the study population. Results: The concordance rates between the interpretations of the clinicians and the ABG-a for acid-base disorders were an observed global agreement of 84,3% with a Cohen's kappa coefficient 0.81; 95% CI 0.77 to 0.86; p < 0.001. For detecting accuracy normal acid-base status the algorithm has a sensitivity of 90.0% (95% CI 79.9 to 95.3), a specificity 97.2% (95% CI 94.5 to 98.6) and a global accuracy of 95.9% (95% CI 93.3 to 97.6). For the four simple acid-base disorders, respiratory alkalosis: sensitivity of 91.2 (77.0 to 97.0), a specificity 100.0 (98.8 to 100.0) and global accuracy of 99.1 (97.5 to 99.7); respiratory acidosis: sensitivity of 61.1 (38.6 to 79.7), a specificity of 100.0 (98.8 to 100.0) and global accuracy of 98.0 (95.9 to 99.0); metabolic acidosis: sensitivity of 75.8 (59.0 to 87.2), a specificity of 99.7 (98.2 to 99.9) and a global accuracy of 97.4 (95.1 to 98.6); metabolic alkalosis sensitivity of 72.2 (56.0 to 84.2), a specificity of 95.5 (92.5 to 97.3) and a global accuracy of 93.0 (88.8 to 95.3); the four complex acid-base disorders, respiratory and metabolic alkalosis, respiratory and metabolic acidosis, respiratory alkalosis and metabolic acidosis, respiratory acidosis and metabolic alkalosis, the sensitivity, specificity and global accuracy was also high. For normal acid-base status the algorithm has PPV 87.1 (95% CI 76.6 to 93.3) %, and NPV 97.9 (95% CI 95.4 to 99.0) for a prevalence of 17.4 (95% CI 13.8 to 21.8). For the four-simple acid-base disorders and the four complex acid-base disorders the PPV and NPV were also statistically significant. Conclusions: The ABG-a showed very high agreement and diagnostic accuracy with experienced senior clinicians in the acid-base disorders in a clinical context. The method also provides refinement and deep complex analysis at the point-of-care that a clinician could have at the bedside on a day-to-day basis. The ABG-a method could also have the potential to reduce human errors by checking for imminent life-threatening situations, analysing the internal consistency of the results, the oxygenation and renal status of the patient.
MeSH term(s)	Acid-Base Equilibrium/physiology ; Acid-Base Imbalance/diagnosis ; Acidosis/blood ; Adolescent ; Adult ; Aged ; Algorithms ; Alkalosis/blood ; Alkalosis, Respiratory/diagnosis ; Arterial Pressure/physiology ; Blood Gas Analysis/methods ; Child ; Child, Preschool ; Cross-Sectional Studies ; Female ; Humans ; Hydrogen-Ion Concentration ; Male ; Middle Aged ; Models, Theoretical ; Point-of-Care Testing/trends ; Predictive Value of Tests ; Prevalence ; Prospective Studies ; Reproducibility of Results ; Sensitivity and Specificity
Language	English
Publishing date	2021-03-10
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0248264
Database	MEDical Literature Analysis and Retrieval System OnLINE

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