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Article ; Online: Does transcription-associated DNA damage limit lifespan?

Callegari, A John

2016 Volume 41, Page(s) 1–7

Abstract: Small mammals undergo an aging process similar to that of larger mammals, but aging occurs at a dramatically faster rate. This phenomenon is often assumed to be the result of damage caused by reactive oxygen species generated in mitochondria. An ... ...

Abstract	Small mammals undergo an aging process similar to that of larger mammals, but aging occurs at a dramatically faster rate. This phenomenon is often assumed to be the result of damage caused by reactive oxygen species generated in mitochondria. An alternative explanation for the phenomenon is suggested here. The rate of RNA synthesis is dramatically elevated in small mammals and correlates quantitatively with the rate of aging among different mammalian species. The rate of RNA synthesis is reduced by caloric restriction and inhibition of TOR pathway signaling, two perturbations that increase lifespan in multiple metazoan species. From bacteria to man, the transcription of a gene has been found to increase the rate at which it is damaged, and a number of lines of evidence suggest that DNA damage is sufficient to induce multiple symptoms associated with normal aging. Thus, the correlations frequently found between the rate of RNA synthesis and the rate of aging could potentially reflect an important role for transcription-associated DNA damage in the aging process.
MeSH term(s)	Aging/genetics ; Animals ; Caloric Restriction ; DNA Damage/genetics ; Humans ; Longevity/genetics ; Mutation ; Transcription, Genetic
Language	English
Publishing date	2016-05
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	2071608-4
ISSN	1568-7856 ; 1568-7864
ISSN (online)	1568-7856
ISSN	1568-7864
DOI	10.1016/j.dnarep.2016.03.001
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Article: Multimodal machine learning models identify chemotherapy drugs with prospective clinical efficacy in dogs with relapsed B-cell lymphoma.

Callegari, A John / Tsang, Josephine / Park, Stanley / Swartzfager, Deanna / Kapoor, Sheena / Choy, Kevin / Lim, Sungwon

Frontiers in oncology

2024 Volume 14, Page(s) 1304144

Abstract: Dogs with B-cell lymphoma typically respond well to first-line CHOP-based chemotherapy, but there is no standard of care for relapsed patients. To help veterinary oncologists select effective drugs for dogs with lymphoid malignancies such as B-cell ... ...

Abstract	Dogs with B-cell lymphoma typically respond well to first-line CHOP-based chemotherapy, but there is no standard of care for relapsed patients. To help veterinary oncologists select effective drugs for dogs with lymphoid malignancies such as B-cell lymphoma, we have developed multimodal machine learning models that integrate data from multiple tumor profiling modalities and predict the likelihood of a positive clinical response for 10 commonly used chemotherapy drugs. Here we report on clinical outcomes that occurred after oncologists received a prediction report generated by our models. Remarkably, we found that dogs that received drugs predicted to be effective by the models experienced better clinical outcomes by every metric we analyzed (overall response rate, complete response rate, duration of complete response, patient survival times) relative to other dogs in the study and relative to historical controls.
Language	English
Publishing date	2024-02-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1304144
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Article ; Online: Dynamics of DNA replication in a eukaryotic cell.

Kelly, Thomas / Callegari, A John

Proceedings of the National Academy of Sciences of the United States of America

2019 Volume 116, Issue 11, Page(s) 4973–4982

Abstract: Each genomic locus in a eukaryotic cell has a distinct average time of replication during S phase that depends on the spatial and temporal pattern of replication initiation events. Replication timing can affect genomic integrity because late replication ... ...

Abstract	Each genomic locus in a eukaryotic cell has a distinct average time of replication during S phase that depends on the spatial and temporal pattern of replication initiation events. Replication timing can affect genomic integrity because late replication is associated with an increased mutation rate. For most eukaryotes, the features of the genome that specify the location and timing of initiation events are unknown. To investigate these features for the fission yeast,
MeSH term(s)	AT Rich Sequence ; Chromosomes, Fungal/genetics ; Computer Simulation ; DNA Replication ; DNA Replication Timing ; DNA-Directed RNA Polymerases/metabolism ; Eukaryotic Cells/cytology ; Eukaryotic Cells/metabolism ; Genome, Fungal ; Models, Biological ; Origin Recognition Complex/genetics ; Probability ; Schizosaccharomyces/cytology ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/metabolism ; Transcription, Genetic
Chemical Substances	Origin Recognition Complex ; Schizosaccharomyces pombe Proteins ; DNA-Directed RNA Polymerases (EC 2.7.7.6)
Language	English
Publishing date	2019-02-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.1818680116
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Article ; Online: Coordination of DNA damage tolerance mechanisms with cell cycle progression in fission yeast.

Callegari, A John / Kelly, Thomas J

Cell cycle (Georgetown, Tex.)

2015 Volume 15, Issue 2, Page(s) 261–273

Abstract: DNA damage tolerance (DDT) mechanisms allow cells to synthesize a new DNA strand when the template is damaged. Many mutations resulting from DNA damage in eukaryotes are generated during DDT when cells use the mutagenic translesion polymerases, Rev1 and ... ...

Abstract	DNA damage tolerance (DDT) mechanisms allow cells to synthesize a new DNA strand when the template is damaged. Many mutations resulting from DNA damage in eukaryotes are generated during DDT when cells use the mutagenic translesion polymerases, Rev1 and Polζ, rather than mechanisms with higher fidelity. The coordination among DDT mechanisms is not well understood. We used live-cell imaging to study the function of DDT mechanisms throughout the cell cycle of the fission yeast Schizosaccharomyces pombe. We report that checkpoint-dependent mitotic delay provides a cellular mechanism to ensure the completion of high fidelity DDT, largely by homology-directed repair (HDR). DDT by mutagenic polymerases is suppressed during the checkpoint delay by a mechanism dependent on Rad51 recombinase. When cells pass the G2/M checkpoint and can no longer delay mitosis, they completely lose the capacity for HDR and simultaneously exhibit a requirement for Rev1 and Polζ. Thus, DDT is coordinated with the checkpoint response so that the activity of mutagenic polymerases is confined to a vulnerable period of the cell cycle when checkpoint delay and HDR are not possible.
MeSH term(s)	DNA Damage ; DNA Repair ; DNA Replication ; DNA, Fungal/genetics ; DNA, Fungal/metabolism ; DNA-Directed DNA Polymerase/genetics ; DNA-Directed DNA Polymerase/metabolism ; G2 Phase Cell Cycle Checkpoints/genetics ; Gene Expression Regulation, Fungal ; Mitosis ; Nucleotidyltransferases/genetics ; Nucleotidyltransferases/metabolism ; Rad51 Recombinase/genetics ; Rad51 Recombinase/metabolism ; Schizosaccharomyces/genetics ; Schizosaccharomyces/metabolism ; Schizosaccharomyces pombe Proteins/genetics ; Schizosaccharomyces pombe Proteins/metabolism ; Signal Transduction ; Time-Lapse Imaging
Chemical Substances	DNA, Fungal ; RHP51 protein, S pombe ; Schizosaccharomyces pombe Proteins ; DNA polymerase zeta (EC 2.7.7.-) ; Nucleotidyltransferases (EC 2.7.7.-) ; Rad51 Recombinase (EC 2.7.7.-) ; DNA-Directed DNA Polymerase (EC 2.7.7.7)
Language	English
Publishing date	2015-12-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.1080/15384101.2015.1121353
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Article ; Online: Contributions of side effects to contraceptive discontinuation and method switch among Kenyan women: a prospective cohort study.

Rothschild, C W / Richardson, B A / Guthrie, B L / Kithao, P / Omurwa, T / Mukabi, J / Callegari, L S / Lokken, E L / John-Stewart, G / Unger, J A / Kinuthia, J / Drake, A L

BJOG : an international journal of obstetrics and gynaecology

2022 Volume 129, Issue 6, Page(s) 926–937

Abstract: Objective: To determine the contribution of specific contraceptive side effects to method switch and modern-method discontinuation among Kenyan women.: Design: A prospective cohort study.: Setting: Five counties in Western Kenya.: Participants: ...

Abstract	Objective: To determine the contribution of specific contraceptive side effects to method switch and modern-method discontinuation among Kenyan women. Design: A prospective cohort study. Setting: Five counties in Western Kenya. Participants: Women aged ≥18 years old and emancipated female minors ≥14 years old using modern, reversible contraception were recruited while attending 10 public health facilities. Methods: Patient-reported adverse effect symptoms, method switch and discontinuation were reported through weekly text message-based surveys for 24 weeks. Main outcome measurements: Prevalence, hazards ratio (HR). Results: Among 825 women, 44% were using implants, 43% injectables, 7% an intrauterine device and 6% oral contraceptive pills at enrolment. Most (61%) women were continuing a method used in the previous month. During the 24-week follow up, incidence of contraceptive switch was 61.3 per 100 person-years (95% confidence interval [CI] 52.4-71.8) and incidence of discontinuation was 38.5 per 100 person-years (95% CI 31.6-47.0). On average, one-quarter (prevalence [Pr] 0.24, 95% CI 0.22-0.26) of participants reported side effects or method problems weekly, with sexual side effects the most prevalent symptom (Pr 0.15, 95% CI 0.13-0.16). Lack of expected bleeding was associated with higher risk of method switch (adjusted hazard ratio [aHR] 2.36, 95% CI 1.22-4.57). Risk of all-modern method discontinuation was higher among women experiencing irregular bleeding (aHR 2.39, 95% CI 1.20-4.77), weight changes (aHR 2.72, 95% CI 1.47-4.68) and sexual side effects (aHR 2.42, 95% CI 1.40-4.20). Conclusions: Addressing irregular bleeding, weight changes and sexual side effects through development of new products that minimise these specific side effects and anticipatory counseling may reduce method-related discontinuation. Tweetable abstract: Bleeding, weight changes, sexual problems associated with discontinuation of #contraception, but many continue despite side effects.
MeSH term(s)	Adolescent ; Adult ; Contraception/adverse effects ; Contraception/methods ; Contraception Behavior ; Contraceptives, Oral, Combined ; Female ; Humans ; Kenya/epidemiology ; Male ; Prospective Studies
Chemical Substances	Contraceptives, Oral, Combined
Language	English
Publishing date	2022-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2000931-8
ISSN	1471-0528 ; 0306-5456 ; 1470-0328
ISSN (online)	1471-0528
ISSN	0306-5456 ; 1470-0328
DOI	10.1111/1471-0528.17032
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Article ; Online: Early Pregnancy Loss Management in the Emergency Department vs Outpatient Setting.

Benson, Lyndsey S / Holt, Sarah K / Gore, John L / Callegari, Lisa S / Chipman, Anne K / Kessler, Larry / Dalton, Vanessa K

JAMA network open

2023 Volume 6, Issue 3, Page(s) e232639

Abstract: Importance: Early pregnancy loss (EPL), or miscarriage, is the most common complication of early pregnancy, and many patients experiencing EPL present to the emergency department (ED). Little is known about how patients who present to the ED with EPL ... ...

Abstract	Importance: Early pregnancy loss (EPL), or miscarriage, is the most common complication of early pregnancy, and many patients experiencing EPL present to the emergency department (ED). Little is known about how patients who present to the ED with EPL differ from those who present to outpatient clinics and how their management and outcomes differ. Objective: To compare the management and outcomes of patients with EPL who present to the ED vs outpatient clinics. Design, setting, and participants: This retrospective cohort study used the IBM MarketScan Research Database, a national insurance claims database. Participants were pregnant people aged 15 to 49 years in the US who presented to either an ED or outpatient clinic for initial diagnosis of EPL from October 2015 through December 2019. Data analysis was performed from May 2021 to March 2022. Exposures: The primary exposure was location of service (ED vs outpatient clinic). Other exposures of interest included demographic characteristics, current pregnancy history, and comorbidities. Main outcomes and measures: The primary outcome was EPL management type (surgical, medication, or expectant management). Complications, including blood transfusion and hospitalization, and characteristics associated with location of service were also evaluated. Bivariable analyses and multivariable logistic regression were used for data analysis. Results: A total of 117 749 patients with EPL diagnoses were identified, with a mean (SD) age of 31.8 (6.1) years. Of these patients, 20 826 (17.7%) initially presented to the ED, and 96 923 (82.3%) presented to outpatient clinics. Compared with the outpatient setting, patients in the ED were less likely to receive surgical (2925 patients [14.0%] vs 23 588 patients [24.3%]) or medication (1116 patients [5.4%] vs 10 878 patients [11.2%]) management. In the adjusted analysis, characteristics associated with decreased odds of active (surgical or medication) vs expectant management included ED (vs outpatient) presentation (adjusted odds ratio [aOR], 0.46; 95% CI, 0.44-0.47), urban location (aOR, 0.87; 95% CI, 0.82-0.91), and being a dependent on an insurance policy (vs primary policy holder) (aOR, 0.71; 95% CI, 0.67-0.74); whereas older age (aOR per 1-year increase 1.01; 95% CI, 1.01-1.01), established prenatal care (aOR, 2.35; 95% CI, 2.29-2.42), and medical comorbidities (aOR, 1.05; 95% CI, 1.02-1.09) were associated with increased odds of receiving active management. Patients in the ED were more likely than those in outpatient clinics to need a blood transfusion (287 patients [1.4%] vs 202 patients [0.2%]) or hospitalization (463 patients [2.2%] vs 472 patients [0.5%]), but complications were low regardless of location of service. Conclusions and relevance: In this cohort study of privately insured patients with EPL, differences in management between the ED vs outpatient setting may reflect barriers to accessing comprehensive EPL management options. More research is needed to understand these significant differences in management approaches by practice setting, and to what extent EPL management reflects patient preferences in both outpatient and ED settings.
MeSH term(s)	Female ; Pregnancy ; Humans ; Cohort Studies ; Outpatients ; Retrospective Studies ; Abortion, Spontaneous/epidemiology ; Emergency Service, Hospital
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.2639
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Article: Bone Measures by Dual-Energy X-Ray Absorptiometry and Peripheral Quantitative Computed Tomography in Young Women With Type 1 Diabetes Mellitus.

Jiang, Hongyuan / Robinson, Dale L / Nankervis, Alison / Garland, Suzanne M / Callegari, Emma T / Price, Sarah / Lee, Peter V S / Wark, John D

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry

2020 Volume 24, Issue 2, Page(s) 259–267

Abstract: Understanding bone fragility in young adult females with type 1 diabetes mellitus (T1DM) is of great clinical importance since the high fracture risk in this population remains unexplained. This study aimed to investigate bone health in young adult T1DM ... ...

Abstract	Understanding bone fragility in young adult females with type 1 diabetes mellitus (T1DM) is of great clinical importance since the high fracture risk in this population remains unexplained. This study aimed to investigate bone health in young adult T1DM females by comparing relevant variables determined by dual-energy X-ray absorptiometry (DXA), peripheral quantitative computed tomography (pQCT) at the tibia and pQCT-based finite element analysis (pQCT-FEA) between T1DM subjects (n = 21) and age-, height- and weight-matched controls (n = 63). Tibial trabecular density (lower by 7.1%; 228.8 ± 33.6 vs 246.4 ± 31.8 mg/cm
MeSH term(s)	Absorptiometry, Photon ; Bone Density ; Bone and Bones ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/diagnostic imaging ; Female ; Humans ; Tomography, X-Ray Computed ; Young Adult
Language	English
Publishing date	2020-05-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2040951-5
ISSN	1094-6950
ISSN	1094-6950
DOI	10.1016/j.jocd.2020.05.009
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Article ; Online: Bone turnover marker determinants in young women: results from the Safe-D study.

Callegari, Emma T / Garland, Suzanne M / Gorelik, Alexandra / Chiang, Cherie Y / Wark, John D

Annals of clinical biochemistry

2017 Volume 55, Issue 3, Page(s) 328–340

Abstract: Background Bone turnover markers (BTMs) may provide insight into bone health in young women, but have been little studied in this demographic. We aimed to explore the association between body composition, hormonal contraception, bone mineral density and ... ...

Abstract	Background Bone turnover markers (BTMs) may provide insight into bone health in young women, but have been little studied in this demographic. We aimed to explore the association between body composition, hormonal contraception, bone mineral density and biochemical parameters and BTMs in young women. Methods Participants were community-dwelling females aged 16-25 years, living in Victoria, Australia. Carboxy-terminal cross-linking telopeptide of type 1 collagen (CTX) and total procollagen type 1 N-propeptide (P1NP) were analysed on the Roche Elecsys automated analyzer. A total of 305 were evaluated, after excluding participants with medical conditions or medications (except hormonal contraceptives), which may affect bone metabolism. Results Median (Q1, Q3) BTM values were 540 (410, 690) ng/L for CTX and 61.7 (46.2, 83.7) µg/L for P1NP. Serum CTX and P1NP were inversely associated with chronological age ( P < 0.001), transferrin ( P < 0.020) and serum dehydroepiandrosterone sulphate concentration ( P < 0.001). BTM values were up to 22% lower in combined oral contraceptive (COC) pill users ( P < 0.001). Serum CTX was inversely associated with per cent body fat ( P = 0.009) and tibial cortical volumetric bone mineral density (vBMD; P = 0.003). Serum P1NP concentrations were 23 µg/L higher in participants who reported using an osteopath in the previous year ( P = 0.007). Conclusions These data suggest that BTMs are influenced by age, COC use, body composition, iron status and hormonal profiles. Higher CTX values were associated with lower tibial cortical vBMD. Examining BTMs in relation to interventions aimed at improving bone health in young women is warranted.
MeSH term(s)	Absorptiometry, Photon ; Adolescent ; Adult ; Anthropometry ; Biomarkers/blood ; Bone Density ; Bone Remodeling ; Collagen Type I/blood ; Cross-Sectional Studies ; Female ; Gonadal Steroid Hormones/metabolism ; Humans ; Iron/metabolism ; Life Style ; Multivariate Analysis ; Peptides/blood ; Victoria ; Young Adult
Chemical Substances	Biomarkers ; Collagen Type I ; Gonadal Steroid Hormones ; Peptides ; collagen type I trimeric cross-linked peptide ; Iron (E1UOL152H7)
Language	English
Publishing date	2017-12-21
Publishing country	England
Document type	Journal Article
ZDB-ID	390309-6
ISSN	1758-1001 ; 0004-5632
ISSN (online)	1758-1001
ISSN	0004-5632
DOI	10.1177/0004563217719734
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Article ; Online: Predictors and correlates of serum 25-hydroxyvitamin D concentrations in young women: results from the Safe-D study.

Callegari, Emma T / Garland, Suzanne M / Gorelik, Alexandra / Reavley, Nicola J / Wark, John D

The British journal of nutrition

2017 Volume 118, Issue 4, Page(s) 263–272

Abstract: Vitamin D deficiency is a global public health concern. Studies of serum 25-hydroxyvitamin D (25(OH)D) determinants in young women are limited and few include objective covariates. Our aims were to define the prevalence of vitamin D deficiency and ... ...

Abstract	Vitamin D deficiency is a global public health concern. Studies of serum 25-hydroxyvitamin D (25(OH)D) determinants in young women are limited and few include objective covariates. Our aims were to define the prevalence of vitamin D deficiency and examine serum 25(OH)D correlates in an exploratory study of women aged 16-25 years. We studied 348 healthy females living in Victoria, Australia, recruited through Facebook. Data collected included serum 25(OH)D assayed by liquid chromatography-tandem MS, relevant serum biochemistry, soft tissue composition by dual-energy X-ray absorptiometry, skin melanin density, Fitzpatrick skin type, sun exposure using UV dosimeters and lifestyle factors. Mean serum 25(OH)D was 68 (sd 27) nmol/l and 26 % were vitamin D deficient (25(OH)D 2 h in the sun in summer daily, holidaying in the most recent summer period, serum Fe levels, height and multivitamin use were positively associated with 25(OH)D. Fat mass and a blood draw in any season except summer was inversely associated with 25(OH)D. Vitamin D deficiency is common in young women. Factors such as hormonal contraception, sun exposure and sun-related attitudes, as well as dietary supplement use are essential to consider when assessing vitamin D status. Further investigation into methods to safely optimise vitamin D status and to improve understanding of the impact of vitamin D status on long-term health outcomes is required.
MeSH term(s)	Adipose Tissue ; Adolescent ; Adult ; Body Height ; Contraceptives, Oral, Hormonal ; Dietary Supplements ; Female ; Humans ; Iron/blood ; Life Style ; Prevalence ; Seasons ; Sunlight ; Victoria/epidemiology ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/epidemiology ; Vitamin D Deficiency/etiology ; Vitamins/administration & dosage ; Vitamins/blood ; Young Adult
Chemical Substances	Contraceptives, Oral, Hormonal ; Vitamins ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H) ; Iron (E1UOL152H7)
Language	English
Publishing date	2017-08
Publishing country	England
Document type	Journal Article
ZDB-ID	280396-3
ISSN	1475-2662 ; 0007-1145
ISSN (online)	1475-2662
ISSN	0007-1145
DOI	10.1017/S0007114517002021
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Article ; Online: Serum 25-hydroxyvitamin D and mental health in young Australian women: Results from the Safe-D study.

Callegari, Emma T / Reavley, Nicola / Gorelik, Alexandra / Garland, Suzanne M / Wark, John D

Journal of affective disorders

2017 Volume 224, Page(s) 48–55

Abstract: Background: While there is evidence linking vitamin D status with mood, this association and its clinical significance remain uncertain. Moreover, few studies have focused on young, community-dwelling females. The Safe-D study examined the association ... ...

Abstract	Background: While there is evidence linking vitamin D status with mood, this association and its clinical significance remain uncertain. Moreover, few studies have focused on young, community-dwelling females. The Safe-D study examined the association between serum 25-hydroxyvitamin D (25OHD) levels and mental health in young women. Methods: Participants completed an online questionnaire, wore a UV dosimeter to measure personal sun exposure and underwent a comprehensive health assessment. Serum 25OHD was measured by liquid chromatography-tandem mass spectrometry in 353 healthy women aged 16-25 years, living in Victoria, Australia. Mental health measures included: Patient Health Questionnaire (PHQ-9), 7-item Generalized Anxiety Disorder Scale (GAD-7), Kessler psychological distress scale (K10) and 12-item short-form health survey (SF-12), plus any self-reported mental disorder diagnoses or medication use. Results: The prevalence of self-reported mental disorder was 26% and of vitamin D deficiency 27%. The median (Q1, Q3) scores for the PHQ-9, GAD-7, K10 and SF-12 MCS were 6 (3, 9), 5 (2, 8), 19 (15, 25) and 43 (34, 49), respectively. Serum 25OHD levels were not associated with mental health scores. Vitamin D status was not associated with a reported diagnosis of depression or anxiety. Limitations: There was a low prevalence of severe vitamin D deficiency and mental health symptoms, which may reduce study power. Conclusion: Our findings do not support an association between serum 25OHD levels and mental health status in young women. Longitudinal studies and randomized clinical trials investigating vitamin D and mood in young women are needed to confirm and extend these results.
MeSH term(s)	Adolescent ; Adult ; Anxiety/blood ; Biomarkers/blood ; Cross-Sectional Studies ; Depression/blood ; Female ; Health Surveys ; Humans ; Mental Health/statistics & numerical data ; Prevalence ; Self Report ; Victoria ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamins/blood ; Young Adult
Chemical Substances	Biomarkers ; Vitamins ; Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2017--15
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2016.10.002
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