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Article ; Online: Tribute to David Loye

Raymond Bradley

Interdisciplinary Journal of Partnership Studies, Vol 9, Iss

2022 Volume 2

Abstract: A tribute briefly describing Raymond Bradley’s gratitude to David Loye for his friendship, support ... neuropsychologist Karl Pribram, and extended over four decades before David’s passing. ...

Abstract	A tribute briefly describing Raymond Bradley’s gratitude to David Loye for his friendship, support, and mentorship. Their relationship began through a mutual acquaintance, the world-renowned neuropsychologist Karl Pribram, and extended over four decades before David’s passing.
Keywords	David Loye ; Karl Pribram ; Raymond Bradley ; Neuropsychology ; Holographic Principles ; Ethnology. Social and cultural anthropology ; GN301-674 ; Organizational behaviour ; change and effectiveness. Corporate culture ; HD58.7-58.95
Language	English
Publishing date	2022-10-01T00:00:00Z
Publisher	University of Minnesota Libraries Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Reintervention after valve-sparing aortic root replacement: A comprehensive analysis of 781 David V procedures.

Singh, Sameer K / Levine, Dov / Patel, Parth / Norton, Elizabeth / Wang, Chunhui / Kurlansky, Paul / Childress, Patra / Chung, Megan / Olakunle, Oreoluwa / George, Isaac / Leshnower, Bradley / Chen, Edward P / Takayama, Hiroo

The Journal of thoracic and cardiovascular surgery

2023 Volume 167, Issue 4, Page(s) 1229–1238.e7

Abstract: ... from 2005 to 2020 undergoing David V VSRR for aortic aneurysm (91%) or dissection (9%) were included. Median ...

Abstract	Objective: Studies of reintervention after valve-sparing aortic root replacement (VSRR) are limited by sample size and failure to evaluate all types of reinterventions, including distal aorta and transcatheter interventions. In this report, reintervention after VSRR using a large patient cohort was comprehensively analyzed. Methods: In a series involving 2 academic aortic centers, 781 consecutive patients from 2005 to 2020 undergoing David V VSRR for aortic aneurysm (91%) or dissection (9%) were included. Median age was 50 years, and 23% had a bicuspid aortic valve (AV). Median follow-up was 7.0 years. Open or transcatheter reintervention on the AV, proximal, or distal thoracic aorta was identified. Cumulative incidence was calculated, and subdistribution hazard models identified factors associated with reintervention. Time-dependent incidence of reintervention was plotted using risk-hazard functions. Results: Sixty-eight reinterventions (57 open, 11 transcatheter) were performed. Reinterventions were divided by indication into degenerative AV (n = 26, including 1 transcatheter aortic valve replacement), endocarditis (n = 11), proximal aorta (n = 8), and distal aorta (n = 23, including 10 thoracic endovascular aortic repairs). Risk of reintervention for endocarditis peaked 1 to 3 years after VSRR, whereas other indications had stable, low rates of occurrence throughout the follow-up period. The cumulative incidence of reintervention was 12.5% whereas the cumulative incidence of AV reintervention was 7.0% at 10 years and was associated with residual postoperative aortic insufficiency. In-hospital mortality after reintervention was 3%. Conclusions: Reintervention rates after VSRR are relatively low in long-term follow-up and can be performed with acceptable operative risk. The majority of reinterventions are performed for indications other than AV degeneration, with the timing of reintervention varying by the specific clinical indication.
MeSH term(s)	Humans ; Middle Aged ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Retrospective Studies ; Aorta/surgery ; Aortic Aneurysm/surgery ; Heart Valve Prosthesis Implantation/methods ; Endocarditis/surgery ; Treatment Outcome
Language	English
Publishing date	2023-05-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	3104-5
ISSN	1097-685X ; 0022-5223
ISSN (online)	1097-685X
ISSN	0022-5223
DOI	10.1016/j.jtcvs.2023.04.013
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Article ; Online: A Tribute to David J. Lim, MD: Researcher, Mentor, Organizer, and Friend.

Welling, D Bradley

The Annals of otology, rhinology, and laryngology

2019 Volume 128, Issue 6_suppl, Page(s) 6S–7S

Language	English
Publishing date	2019-05-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	120642-4
ISSN	1943-572X ; 0003-4894
ISSN (online)	1943-572X
ISSN	0003-4894
DOI	10.1177/0003489419834953
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Article: David Casarett's Stoned: A Doctor's Case for Medical Marijuana.

Alger, Bradley E

Cerebrum : the Dana forum on brain science

2016 Volume 2016

Abstract: With legal cannabis sales at $5.4 billion in 2015 and expected to rise by another billion this year in the United States, legalization and marijuana's impact on health is a hot topic of national debate. Casarett, a physician at the University of ... ...

Abstract	With legal cannabis sales at $5.4 billion in 2015 and expected to rise by another billion this year in the United States, legalization and marijuana's impact on health is a hot topic of national debate. Casarett, a physician at the University of Pennsylvania, immerses himself in the culture, science, and smoke of medical marijuana in order to sort out the truth behind the buzz. Our reviewer, who has authored more than 120 research papers and reviews on the regulation of synaptic inhibition and endocannabinoids, tell us what the author got right, but also overlooked on his journey to learn more about a complex and controversial subject.
Language	English
Publishing date	2016-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2251230-5
ISSN	1524-6205
ISSN	1524-6205
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Book ; Online: David Petraeus

Gericke, Bradley T

a biography

(Greenwood biographies)

2011

Abstract: ... David Petraeus, today's most prominent military leader ...

Institution	United States / Army ebrary, Inc
Author's details	Bradley T. Gericke
Series title	Greenwood biographies
Abstract	This in-depth and forthright biography examines the personal and professional life of General David Petraeus, today's most prominent military leader
Keywords	Generals ; Iraq War, 2003-
Language	English
Size	Online-Ressource (xxiii, 203 p)
Publisher	Greenwood
Publishing place	Santa Barbara, Calif
Document type	Book ; Online
Note	Includes bibliographical references and index
ISBN	1282932780 ; 128293354X ; 9780313383779 ; 9781282933545 ; 9781282932784 ; 0313383774
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: Durability and safety of David V valve-sparing root replacement in acute type A aortic dissection.

Rosenblum, Joshua M / Leshnower, Bradley G / Moon, Rena C / Lasanajak, Yi / Binongo, Jose / McPherson, LaRonica / Chen, Edward P

The Journal of thoracic and cardiovascular surgery

2018 Volume 157, Issue 1, Page(s) 14–23.e1

Abstract: ... We examine the long-term safety and durability of the David V VSRR compared with ROOT in TAAD repair ... In highly-selected patients, the David V VSRR provides a safe repair of acute TAAD with concomitant root ...

Abstract	Background: Valve-sparing root replacement (VSRR) is an attractive option in type A aortic dissection (TAAD) repair for a young patient with normal cusp anatomy, but conventional root replacement using a composite valved-conduit (ROOT) remains the gold standard in this emergent clinical setting. We examine the long-term safety and durability of the David V VSRR compared with ROOT in TAAD repair. Methods: From March 2004 to April 2017, 136 patients underwent repair of acute TAAD using either ROOT (n = 77; 56.6%) or VSRR (n = 59; 43.4%). Annual echocardiograms were performed for follow-up in VSRR patients. Univariable regression, Kaplan-Meier, and competing risk analyses were performed. Results: Preoperative characteristics were similar between groups, except that VSRR patients were younger (mean age 43.5 ± 11.4 years VSRR vs 50.4 ± 3.0 years ROOT; P = .001). Both groups had similar rates of preoperative malperfusion or shock (29.3% VSRR vs 37.0% ROOT; P = .35) and ≥3+ aortic insufficiency (63% VSRR vs 76.8% ROOT). Thirty-day mortality in the VSRR group was 2/59 (3.4%) and 11/77 in the ROOT group (14.3%; P < .001). All-cause survival at 9 years was 92% (VSRR) and 59% (ROOT; P = .002). The incidence of aortic reintervention was similar between groups (20%-23% at 5 years; P = .81). At 9 years of follow-up, 5/52 (9.6%) VSRR patients had ≥2+ aortic insufficiency, and 1 patient required valve reintervention. Conclusions: In highly-selected patients, the David V VSRR provides a safe repair of acute TAAD with concomitant root pathology and valve insufficiency. In our center, the incidence of valve-related reintervention at long-term follow-up is low after emergent repair.
MeSH term(s)	Adult ; Aneurysm, Dissecting/surgery ; Aortic Aneurysm/surgery ; Aortic Valve/surgery ; Aortic Valve Insufficiency/surgery ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/methods ; Echocardiography ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2018-10-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	3104-5
ISSN	1097-685X ; 0022-5223
ISSN (online)	1097-685X
ISSN	0022-5223
DOI	10.1016/j.jtcvs.2018.10.059
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Article ; Online: Risk Factors for Late Aortic Valve Dysfunction After the David V Valve-Sparing Root Replacement.

Esaki, Jiro / Leshnower, Bradley G / Binongo, Jose N / Lasanajak, Yi / McPherson, LaRonica / Guyton, Robert A / Chen, Edward P

The Annals of thoracic surgery

2017 Volume 104, Issue 5, Page(s) 1479–1487

Abstract: ... AS) after David V VSRR.: Methods: A retrospective review from 2005 to 2015 at a US academic center ...

Abstract	Background: Valve-sparing root replacement (VSRR) is an established therapy for aortic root pathology. However, late aortic valve dysfunction requiring reoperation remains a primary concern of this procedure. This study examines risk factors for late aortic insufficiency (AI) and aortic stenosis (AS) after David V VSRR. Methods: A retrospective review from 2005 to 2015 at a US academic center identified 282 patients who underwent VSRR. Cox proportional hazards regression analysis was used to identify risk factors for late AI and AS after VSRR. Results: The mean age was 46.4 years. Sixty-four patients (22.7%) had bicuspid valves, and 41 patients (14.5%) had Marfan syndrome. The incidence of reoperations was 27 (9.6%), and 42 cases (14.9%) presented with acute type A dissection. Operative mortality was 8 (2.8%). Seven-year survival was 90.9%. Seven-year cumulative incidence of reoperation, greater than 2+ AI and greater than moderate AS were 3.1%, 2.2%, and 0.8%, respectively. Multivariable analysis showed aortic root size 55 mm or larger (hazard ratio 3.44, 95% confidence interval: 1.27 to 9.29, p = 0.01) to be a risk factor for late AI whereas bicuspid valve (hazard ratio 16.07, 95% confidence interval: 3.12 to 82.68, p = 0.001) and cusp repair were found to be risk factors (hazard ratio 5.91, 95% confidence interval: 1.17 to 29.86, p = 0.03) for late AS. Conclusions: Valve-sparing root replacement can be performed with low operative risk and good overall long-term survival even in complex clinical settings. Durable valve function can be expected; however, aortic root size 55 cm or more, bicuspid valve anatomy, and cusp repair represent independent risk factors for late aortic valve dysfunction after these procedures.
MeSH term(s)	Adult ; Analysis of Variance ; Aortic Valve/abnormalities ; Aortic Valve/surgery ; Aortic Valve Insufficiency/diagnosis ; Aortic Valve Insufficiency/mortality ; Aortic Valve Insufficiency/surgery ; Aortic Valve Stenosis/diagnostic imaging ; Aortic Valve Stenosis/mortality ; Aortic Valve Stenosis/surgery ; Bicuspid Aortic Valve Disease ; Cardiac Valve Annuloplasty/methods ; Cohort Studies ; Female ; Heart Valve Diseases/surgery ; Heart Valve Prosthesis Implantation/adverse effects ; Heart Valve Prosthesis Implantation/methods ; Hospital Mortality ; Humans ; Kaplan-Meier Estimate ; Male ; Marfan Syndrome/mortality ; Marfan Syndrome/surgery ; Middle Aged ; Multivariate Analysis ; Organ Sparing Treatments/methods ; Postoperative Complications/physiopathology ; Postoperative Complications/surgery ; Prognosis ; Proportional Hazards Models ; Reoperation/methods ; Reoperation/mortality ; Retrospective Studies ; Risk Assessment ; Severity of Illness Index ; Survival Analysis ; Treatment Outcome
Language	English
Publishing date	2017-06-29
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2017.04.005
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Article ; Online: Clinical Outcomes of the David V Valve-Sparing Root Replacement Compared With Bioprosthetic Valve-Conduits for Aortic Root Aneurysms.

Esaki, Jiro / Leshnower, Bradley G / Binongo, Jose N / Lasanajak, Yi / McPherson, LaRonica / Halkos, Michael E / Guyton, Robert A / Chen, Edward P

The Annals of thoracic surgery

2017 Volume 103, Issue 6, Page(s) 1824–1832

Abstract: Background: Valve-sparing root replacement (VSRR) is an established therapy for aortic root pathology. Limited insight exists when the results of VSRR are compared with those of conventional root replacement with use of a bioprosthetic composite conduit ...

Abstract	Background: Valve-sparing root replacement (VSRR) is an established therapy for aortic root pathology. Limited insight exists when the results of VSRR are compared with those of conventional root replacement with use of a bioprosthetic composite conduit (BIO). This study compares the operative and midterm results of VSRR and BIO. Methods: A retrospective review from 2002 to 2015 at a United States academic center identified 282 patients who underwent VSRR and 425 patients who underwent BIO. Propensity-score matching was performed based on 20 preoperative characteristics, and 123 matched pairs were identified. Results: The mean age (VSRR 53.5 ± 11.1, BIO 53.0 ± 13.0; p = 0.74) and left ventricular ejection fraction (VSRR 54.5 ± 9.2%, BIO 54.4 ± 9.4%; p = 0.99) were equivalent in both groups. The incidence of bicuspid valves (VSRR 26.0%, BIO 27.6%; p = 0.77), Marfan syndrome (VSRR 6.5%, BIO 4.9%; p = 0.58), type A dissection (VSRR 13.0%, BIO 13.0%; p = 0.99), reoperation (VSRR 15.4%, BIO 20.3%; p = 0.32) and arch replacement (VSRR 60.2%, BIO 63.4%; p = 0.60) were similar between the groups. Operative mortality was 5.7% in VSRR and 0.8% in BIO (p = 0.07). There were no significant differences in postoperative renal failure (VSRR 0.8%, BIO 0.0%; p = 0.99) or stroke (VSRR 3.3%, BIO 0.8%; p = 0.37) between the groups. The 7-year survival (VSSR 82.4%, BIO 83.0%; p = 0.53), 7-year freedom from reoperation (VSRR 97.4%, BIO 95.8%; p = 0.48), and 7-year freedom from greater than moderate aortic insufficiency (AI) (VSRR 98.1%, BIO 100.0%; p = 0.47) were similar between groups. Conclusions: VSRR and BIO result in equivalent operative mortality and morbidity with similar midterm survival and valve durability. VSRR is an effective alternative to BIO for aortic root pathologic conditions; however, careful patient selection is paramount.
MeSH term(s)	Adult ; Aged ; Aorta/surgery ; Aortic Aneurysm/surgery ; Aortic Valve/surgery ; Bioprosthesis ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/adverse effects ; Blood Vessel Prosthesis Implantation/methods ; Endocarditis/etiology ; Female ; Heart Valve Prosthesis Implantation/methods ; Humans ; Kaplan-Meier Estimate ; Length of Stay ; Male ; Middle Aged ; Postoperative Complications ; Propensity Score ; Retrospective Studies
Language	English
Publishing date	2017-06
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2016.09.055
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Article ; Online: Expanding the indications for the David V aortic root replacement: early results.

Leshnower, Bradley G / Guyton, Robert A / Myung, Richard J / Puskas, John D / Kilgo, Patrick D / McPherson, Laronica / Chen, Edward P

The Journal of thoracic and cardiovascular surgery

2012 Volume 143, Issue 4, Page(s) 879–884

Abstract: Objective: To examine the early results of the David V valve-sparing aortic root replacement ... From 2005 to 2011, 150 David V valve-sparing aortic root replacements were performed within Emory Healthcare ... A total of 78 patients (expanded group) had undergone the David V in expanded, difficult clinical settings ...

Abstract	Objective: To examine the early results of the David V valve-sparing aortic root replacement procedure in expanded, higher risk clinical scenarios with appropriately selected patients. Methods: From 2005 to 2011, 150 David V valve-sparing aortic root replacements were performed within Emory Healthcare. A total of 78 patients (expanded group) had undergone the David V in expanded, difficult clinical settings such as emergent type A dissection (n = 29), grade 3+ or greater aortic insufficiency (AI) (n = 53), or reoperative cardiac surgery (n = 14). These patients were evaluated and compared with a group of 72 patients (traditional group) with less than grade 3+ AI who underwent a David V in a traditional, elective setting. The mean follow-up was 19 months (range, 1-72), and the follow-up data were 88% complete. Results: There were 3 operative deaths (2.2%), all occurring in the expanded group. The overall patient survival at 6 years was 95%. Three patients required aortic valve replacement: two for severe AI and one for fungal endocarditis. Both groups had concomitant cusp repairs performed in conjunction with the David V (traditional, n = 10; and expanded, n = 16; P = .27). At follow-up, freedom from moderate AI was 93%, and the freedom from aortic valve replacement was 98%. No significant difference was observed in the freedom from moderate AI between the expanded and traditional groups (91% vs 95%, respectively; P = .16). Conclusions: In selected patients possessing appropriate aortic cusp anatomy, the David V can be safely and effectively performed for the expanded indications of aortic dissection, severe AI, and reoperative cardiac surgery with low operative risk. Valve function has remained excellent in the short term, providing evidence of durability and a low rate of valve-related complications.
MeSH term(s)	Adult ; Aortic Diseases/diagnostic imaging ; Aortic Diseases/mortality ; Aortic Diseases/surgery ; Aortic Valve/diagnostic imaging ; Aortic Valve/surgery ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/adverse effects ; Blood Vessel Prosthesis Implantation/instrumentation ; Blood Vessel Prosthesis Implantation/methods ; Blood Vessel Prosthesis Implantation/mortality ; Cardiac Surgical Procedures/adverse effects ; Cardiac Surgical Procedures/mortality ; Chi-Square Distribution ; Female ; Georgia ; Heart Valve Prosthesis Implantation ; Hospital Mortality ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Patient Selection ; Reoperation ; Replantation/adverse effects ; Replantation/mortality ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Time Factors ; Treatment Outcome ; Ultrasonography
Language	English
Publishing date	2012-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	3104-5
ISSN	1097-685X ; 0022-5223
ISSN (online)	1097-685X
ISSN	0022-5223
DOI	10.1016/j.jtcvs.2012.01.048
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Article ; Online: Severity of Preoperative Aortic Regurgitation Does Not Impact Valve Durability of Aortic Valve Repair Following the David V Valve Sparing Aortic Root Replacement.

Keeling, W Brent / Leshnower, Bradley G / Binongo, Jose / Lasanajak, Yi / McPherson, LaRonica / Chen, Edward P

The Annals of thoracic surgery

2017 Volume 103, Issue 3, Page(s) 756–763

Abstract: Background: The David V valve-sparing aortic root replacement (VSRR) is an established and durable ...

Abstract	Background: The David V valve-sparing aortic root replacement (VSRR) is an established and durable method of root reconstruction for varying pathologies. However, the impact of the severity of preoperative aortic regurgitation (AR) on long-term durability remains unclear. The purpose of this research was to investigate the impact of the degree of preoperative AR on midterm durability following VSRR. Methods: A retrospective review of the adult cardiac surgical database at a single academic center was undertaken from 2005 to 2015 for 223 adult patients who underwent VSRR. Patients were followed annually with echocardiograms, and a prospectively maintained database kept track of patient data. Follow-up was 97.7% complete, and the median echocardiographic follow-up was 25.5 months (range, 1 to 123 months). Patients with preoperative AR less than or equal to 2 were compared with patients with AR greater than 2 to determine the impact of preoperative AR upon valve repair durability. Results: There were 223 patients who underwent VSRR during the study period, including 114 (51.1%) who required concomitant cusp repair. The operative mortality was 5 (2.2%). Ninety-seven patients (43.5%) had preoperative AR greater than 2. A total of 213 patients (95.5%) were available for long-term follow-up; of these patients, 7 (3.3%) had AR greater than 2. Fifty-two patients had a bicuspid aortic valve (22 AR ≤2 and 30 AR >2; p = 0.02). Patients with preoperative AR greater than 2 experienced greater reverse left ventricular remodeling and increases in left ventricular ejection fraction than did patients with preoperative AR less than or equal to 2 (p < 0.01). The midterm freedom from AR greater than 2 was similar for both preoperative AR groups (p = 0.57). The 8-year freedom from AR greater than 2 was 89.1% (95% confidence interval, 55.3% to 97.8%) for patients with preoperative AR less than or equal to 2 and 92.7% (95% confidence interval, 78.8% to 97.6%) for preoperative AR greater than 2. Five patients (2.4%) required aortic valve replacement during the follow-up period (3 preoperative AR ≤2, 2 preoperative AR >2). Conclusions: VSRR remains an effective and durable treatment for severe AR and preserved leaflet architecture. The severity of preoperative AR does not appear to impact midterm freedom from moderate to severe AR. VSRR results in significant left ventricular remodeling in patients with preoperative AR greater than 2.
MeSH term(s)	Aged ; Aortic Valve Insufficiency/surgery ; Female ; Heart Valve Prosthesis Implantation ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Severity of Illness Index ; Time Factors ; Treatment Outcome ; Ventricular Remodeling
Language	English
Publishing date	2017-03
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	211007-6
ISSN	1552-6259 ; 0003-4975
ISSN (online)	1552-6259
ISSN	0003-4975
DOI	10.1016/j.athoracsur.2016.07.004
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