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  1. Article ; Online: Asthma deaths in children in the UK the last straw!

    Levy, Mark L / Fleming, Louise / Bush, Andrew

    The British journal of general practice : the journal of the Royal College of General Practitioners

    2024  

    Language English
    Publishing date 2024-04-29
    Publishing country England
    Document type Editorial
    ZDB-ID 1043148-2
    ISSN 1478-5242 ; 0035-8797 ; 0960-1643
    ISSN (online) 1478-5242
    ISSN 0035-8797 ; 0960-1643
    DOI 10.3399/bjgp24X738201
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 576: Show issues Location:
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    Zs.MO 100: Show issues

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  2. Article ; Online: EDITORIAL COMMENT.

    Levy, Brittany E / Harris, Andrew M

    Urology

    2022  Volume 169, Page(s) 265

    Language English
    Publishing date 2022-11-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2022.06.044
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    Zs.A 1142: Show issues Location:
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    Zs.MO 275: Show issues

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  3. Article ; Online: Surgical Specialty Consultation for Pediatric Facial Laceration Repair: An American and Canadian Survey.

    Miller, Andrew F / Levy, Jason A / Lyons, Todd W

    Pediatric emergency care

    2024  

    Abstract: Objective: We sought to describe patterns of and indications for surgical specialty consultation for facial laceration repair in pediatric emergency departments (PEDs).: Methods: We performed a multicenter survey of PED leadership throughout the ... ...

    Abstract Objective: We sought to describe patterns of and indications for surgical specialty consultation for facial laceration repair in pediatric emergency departments (PEDs).
    Methods: We performed a multicenter survey of PED leadership throughout the United States and Canada evaluating the practice patterns of surgical specialty consultation for patients presenting for facial lacerations requiring repair. We measured demographics of PEDs, factors influencing the decision to obtain a surgical specialty consultation, and the presence and components of consultation guidelines. Factors related to consultation were ranked on a Likert scale from 1 to 5 (1 = Not at all important, 5 = Extremely important). We evaluated relationships between reported rates of surgical specialty consultation and PED region, annual PED volume, and reported factors associated with PED consultation.
    Results: Survey responses were received from 67/124 (54%) queried PEDs. The median self-reported rate of surgical specialty consultation for facial lacerations was 10% and ranged from 1% to 70%, with resident physicians performing the repair 71% of the time a subspecialist was consulted. There was regional variability in specialty consultation, with the highest and lowest rate in the Midwest and Canada, respectively (P = 0.03). The top 4 influential factors prompting consultation with the highest percentage of responses of "Extremely Important" or "Very Important" were: discretion of the physician caring for the patient (95%), parental preference (39%), limited PED resources (32%), and patient requires sedation (32%). Surgical specialty consult guidelines were used in only 6% of PEDs with consensus that depth necessitating more than 2-layer repair or involvement of critical structures should prompt consultation.
    Conclusions: Surgical specialty usage in the management of patients who present with facial lacerations to PEDs has significant variation related to patient, provider, and department-level factors that influence the decision to consult. Lack of consult guidelines represent a potential opportunity to standardize care delivery to this common presentation.
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632588-9
    ISSN 1535-1815 ; 0749-5161
    ISSN (online) 1535-1815
    ISSN 0749-5161
    DOI 10.1097/PEC.0000000000003133
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    Zs.A 2083: Show issues Location:
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  4. Article ; Online: Novel therapeutic directions in Cushing's syndrome.

    Levy, Andrew

    Expert review of endocrinology & metabolism

    2019  Volume 1, Issue 2, Page(s) 199–207

    Abstract: Cushing's disease is the most common cause of endogenous hypercortisolemia. It is a rare disease of unknown etiology that is prone to relapse and damaging to quality of life, even in remission. A significant proportion of patients are not cured by ... ...

    Abstract Cushing's disease is the most common cause of endogenous hypercortisolemia. It is a rare disease of unknown etiology that is prone to relapse and damaging to quality of life, even in remission. A significant proportion of patients are not cured by primary surgical treatment, and adjuvant radiotherapy has become an increasingly unattractive proposition for clinicians who wish to spare their patients hypopituitarism and other potential complications. The few effective pharmacological options that are available currently tend to have dose-limiting side effects and new alternatives that are safer and more effective than the adrenal cortical enzyme inhibitors and adrenolytic drugs would be most welcome. This article discusses preliminary efficacy data for several potential new groups of drugs.
    Language English
    Publishing date 2019-02-12
    Publishing country England
    Document type Journal Article
    ISSN 1744-8417
    ISSN (online) 1744-8417
    DOI 10.1586/17446651.1.2.199
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  5. Article ; Online: Molecular Insights into IQSEC2 Disease.

    Levy, Nina S / Borisov, Veronika / Lache, Orit / Levy, Andrew P

    International journal of molecular sciences

    2023  Volume 24, Issue 5

    Abstract: Recent insights into IQSEC2 disease are summarized in this review as follows: (1) Exome sequencing of IQSEC2 patient DNA has led to the identification of numerous missense mutations that delineate at least six and possibly seven essential functional ... ...

    Abstract Recent insights into IQSEC2 disease are summarized in this review as follows: (1) Exome sequencing of IQSEC2 patient DNA has led to the identification of numerous missense mutations that delineate at least six and possibly seven essential functional domains present in the IQSEC2 gene. (2) Experiments using IQSEC2 transgenic and knockout (KO) mouse models have recapitulated the presence of autistic-like behavior and epileptic seizures in affected animals; however, seizure severity and etiology appear to vary considerably between models. (3) Studies in IQSEC2 KO mice reveal that IQSEC2 is involved in inhibitory as well as stimulatory neurotransmission. The overall picture appears to be that mutated or absent IQSEC2 arrests neuronal development, resulting in immature neuronal networks. Subsequent maturation is aberrant, leading to increased inhibition and reduced neuronal transmission. (4) The levels of Arf6-GTP remain constitutively high in IQSEC2 knockout mice despite the absence of IQSEC2 protein, indicating impaired regulation of the Arf6 guanine nucleotide exchange cycle. (5) A new therapy that has been shown to reduce the seizure burden for the IQSEC2 A350V mutation is heat treatment. Induction of the heat shock response may be responsible for this therapeutic effect.
    MeSH term(s) Animals ; Mice ; Autistic Disorder/genetics ; Epilepsy/genetics ; Guanine Nucleotide Exchange Factors/genetics ; Mice, Knockout ; Mutation ; Nerve Tissue Proteins/metabolism ; Seizures/genetics ; Humans
    Chemical Substances Guanine Nucleotide Exchange Factors ; IQSEC2 protein, mouse ; Nerve Tissue Proteins ; IQSEC2 protein, human
    Language English
    Publishing date 2023-03-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24054984
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  6. Article ; Online: Hamilton's rule in economic decision-making.

    Levy, Moshe / Lo, Andrew W

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 16, Page(s) e2108590119

    Abstract: Hamilton’s rule [W. D. Hamilton, Am. Nat. 97, 354–356 (1963); W. D. Hamilton, J. Theor. Biol. 7, 17–52 (1964)] quantifies the central evolutionary ideas of inclusive fitness and kin selection into a simple algebraic relationship. Evidence consistent with ...

    Abstract Hamilton’s rule [W. D. Hamilton, Am. Nat. 97, 354–356 (1963); W. D. Hamilton, J. Theor. Biol. 7, 17–52 (1964)] quantifies the central evolutionary ideas of inclusive fitness and kin selection into a simple algebraic relationship. Evidence consistent with Hamilton’s rule is found in many animal species. A drawback of investigating Hamilton’s rule in these species is that one can estimate whether a given behavior is consistent with the rule, but a direct examination of the exact cutoff for altruistic behavior predicted by Hamilton is almost impossible. However, to the degree that economic resources confer survival benefits in modern society, Hamilton’s rule may be applicable to economic decision-making, in which case techniques from experimental economics offer a way to determine this cutoff. We employ these techniques to examine whether Hamilton’s rule holds in human decision-making, by measuring the dependence between an experimental subject’s maximal willingness to pay for a gift of $50 to be given to someone else and the genetic relatedness of the subject to the gift’s recipient. We find good agreement with the predictions of Hamilton’s rule. Moreover, regression analysis of the willingness to pay versus genetic relatedness, the number of years living in the same residence, age, and sex shows that almost all the variation is explained by genetic relatedness. Similar but weaker results are obtained from hypothetical questions regarding the maximal risk to her own life that the subject is willing to take in order to save the recipient’s life.
    MeSH term(s) Altruism ; Biological Evolution ; Decision Making ; Economics, Behavioral ; Humans ; Selection, Genetic
    Language English
    Publishing date 2022-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2108590119
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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  7. Book: The man who got lost in duty free

    Levy, Andrew

    (Video casebook: medicine ; 2)

    1999  

    Author's details Andrew Levy
    Series title Video casebook: medicine ; 2
    Video casebook ; medicine
    Video casebook ; medicine
    Collection Video casebook ; medicine
    Video casebook ; medicine
    Keywords Diagnostic Techniques and Procedures / case report ; Diagnostic Techniques and Procedures / problems and exercises
    Language English
    Size IX, 158 S. : Ill.
    Publisher Blackwell Science
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    Note Systemvoraussetzungen: Windows 95/98/NT, 486 DX2 Processor, 16 Mb RAM, 10 MB free hard disk space, 16 Bit colour screen driver, 4 speed CD-ROM Drive, Sound Card; Macintosh, 68030 processor, 16 Mb RAM, System 7.1, Double speed CD-ROM drive
    Accompanying material 1 CD-ROM (12 cm)
    HBZ-ID HT011105527
    ISBN 0-632-05382-8 ; 978-0-632-05382-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1999 A 6156 order for loan Magazin
    1999 MO 130 <<[Begleitmaterial]>> order for loan Magazin

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  8. Book: The toy boy and the burgundy car

    Levy, Andrew

    (Video casebook: medicine ; 1)

    1999  

    Author's details Andrew Levy
    Series title Video casebook: medicine ; 1
    Video casebook ; medicine
    Video casebook ; medicine
    Collection Video casebook ; medicine
    Video casebook ; medicine
    Keywords Diagnostic Techniques and Procedures / case report ; Diagnostic Techniques and Procedures / problems and exercises
    Language English
    Size IX, 160 S. : Ill.
    Publisher Blackwell Science
    Publishing place London u.a.
    Publishing country Great Britain
    Document type Book
    Note Systemvoraussetzungen: Windows 95/98/NT, 486 DX2 Processor, 16 Mb RAM, 10 MB free hard disk space, 16 Bit colour screen driver, 4 speed CD-ROM Drive, Sound Card; Macintosh, 68030 processor, 16 Mb RAM, System 7.x, Double speed CD-ROM drive
    Accompanying material 1 CD-ROM (12 cm)
    HBZ-ID HT011105407
    ISBN 0-632-05122-1 ; 978-0-632-05122-9
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1999 A 6155 order for loan Magazin
    1999 MO 129 <<[Begleitmaterial]>> order for loan Magazin

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  9. Article: Regular (up to 10 puffs 4-hourly) inhaled salbutamol should be prescribed at discharge after an asthma attack: myth or maxim?

    Warraich, Sara / Bush, Andrew / Levy, Mark L / Fleming, Louise

    Breathe (Sheffield, England)

    2023  Volume 19, Issue 3, Page(s) 230054

    Abstract: Over the past 20 years, the concept of asthma weaning plans on discharge after an attack has crept into common practice, although the precise origin of these plans is unclear. High use of short-acting ... ...

    Abstract Over the past 20 years, the concept of asthma weaning plans on discharge after an attack has crept into common practice, although the precise origin of these plans is unclear. High use of short-acting β
    Language English
    Publishing date 2023-10-10
    Publishing country England
    Document type Journal Article ; Review ; Comment
    ZDB-ID 2562899-9
    ISSN 2073-4735 ; 1810-6838
    ISSN (online) 2073-4735
    ISSN 1810-6838
    DOI 10.1183/20734735.0054-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: PD(AI): the role of artificial intelligence in the management of patent ductus arteriosus.

    Sharma, Puneet / Beam, Kristyn / Levy, Philip / Beam, Andrew L

    Journal of perinatology : official journal of the California Perinatal Association

    2023  Volume 43, Issue 2, Page(s) 257–258

    MeSH term(s) Infant, Newborn ; Humans ; Ductus Arteriosus, Patent/diagnostic imaging ; Ductus Arteriosus, Patent/therapy ; Artificial Intelligence ; Infant, Premature ; Indomethacin ; Persistent Fetal Circulation Syndrome
    Chemical Substances Indomethacin (XXE1CET956)
    Language English
    Publishing date 2023-01-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 645021-0
    ISSN 1476-5543 ; 0743-8346
    ISSN (online) 1476-5543
    ISSN 0743-8346
    DOI 10.1038/s41372-023-01606-7
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