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  1. Article ; Online: Light People: Professor Lan Fu.

    Wang, Hui / Yu, Cun

    Light, science & applications

    2023  Volume 12, Issue 1, Page(s) 294

    Abstract: ... Prof. Lan Fu from the Australian National University (ANU).As an outstanding student of Prof ... about Professor Lan Fu's unique charisma as an academic and her fascinating life philosophy. ...

    Abstract Editorial: III-V semiconductors are compound semiconductor materials formed by combining group-III and group-V elements. With properties such as direct bandgap, high electron mobility, good homogeneity of large-size crystals and good lattice matching, they are widely used in micro- and opto-electronics, integrated circuits, laser communications, etc., and promise great potentials. Our Light People is someone who has long been engaged in the research of III-V semiconductor materials, structures and devices. She is Prof. Lan Fu from the Australian National University (ANU).As an outstanding student of Prof. Chennupati Jagadish, President of the Australian Academy of Sciences, Prof. Fu is not only a leading researcher in her field, but also a scientist with an independent spirit. She is currently the Head of the Department of Electronic Materials Engineering, Research School of Physics, The Australian National University, where she leads a team in the research of III-V semiconductors.A sincere and humble person, Prof. Fu focuses on nurturing professional attitude, critical thinking and problem solving skills in her students. In addition, she is actively involved in various professional activities, which allows her to integrate research and practice. She believes that integrity, passion, curiosity and perseverance are the key characters of a good scientific researcher and encourages her students to avoid being arrogant or rush but concentrate on good rigorous work.For this issue of Light People, we will learn about Professor Lan Fu's unique charisma as an academic and her fascinating life philosophy.
    Language English
    Publishing date 2023-12-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2662628-7
    ISSN 2047-7538 ; 2047-7538
    ISSN (online) 2047-7538
    ISSN 2047-7538
    DOI 10.1038/s41377-023-01325-w
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  2. Article ; Online: Six-year transition of physio-cognitive decline syndrome: Results from I-Lan Longitudinal Aging Study.

    Lee, Wei-Ju / Peng, Li-Ning / Lin, Ming-Hsien / Loh, Ching-Hui / Chung, Chih-Ping / Wang, Pei-Ning / Chen, Liang-Kung

    Archives of gerontology and geriatrics

    2022  Volume 102, Page(s) 104743

    Abstract: ... evaluate the potential of its reversibility.: Methods: 963 participants from the I-Lan Longitudinal ...

    Abstract Objectives: To explore associations between PCDS, incident dementia and mortality risk and evaluate the potential of its reversibility.
    Methods: 963 participants from the I-Lan Longitudinal Aging Study were followed up for 6 years for analysis. A subsample of 513 participants was invited to participate 3 years earlier. The 1.5 standard deviation lower age- and education-matched norms of neuropsychiatric assessments determined cognitive impairment. Weakness and slowness were defined by the Asian Working Group for Sarcopenia 2019. PCDS was defined as cognitive impairment plus mobility impairment, i.e., weakness and/or slowness.
    Results: The prevalence of PCDS was 19.0% among 1709 participants aged 63.5 ± 9.0 years (from 50 to 90 years) and increased with age (14.7% in people aged 50-64 years, 19.5% in people aged 65-74 years, 36.7% in people aged 75-84 years and 45.5% in people aged ≥ 85 years, p for trend <0.001). 13.6% and 8.3% of participants had improved PCDS conditions in 513 participants at 3-year and in 963 participants at 6-year assessments. Of 118 participants with PCDS at baseline,36 (30.5%) returned to non-PCDS in 6 years. Being female and having good nutrition were potential associated factors. During the mean follow-up period of 5.9 ± 0.9 years, 182 deaths occurred in the 10,065 person-years. PCDS could predict the 6-year risk of mortality (HR 1.56, 95% CI 1.02-2.39, p = 0.012) and 6-year incident dementia (OR 3.42, 95% CI: 1.41-8.29, p = 0.007).
    Conclusions: PCDS significantly predict 6-year mortality and 6-year incident dementia. Reversibility of PCDS made it as an optimal target for intervention and prevention.
    MeSH term(s) Aging ; Cognitive Dysfunction/epidemiology ; Dementia ; Female ; Frailty ; Humans ; Longitudinal Studies ; Male ; Syndrome
    Language English
    Publishing date 2022-06-03
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603162-6
    ISSN 1872-6976 ; 0167-4943
    ISSN (online) 1872-6976
    ISSN 0167-4943
    DOI 10.1016/j.archger.2022.104743
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1729: Show issues Location:
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  3. Article: [Gridded Emission Inventories of Major Criteria Air Pollutants and Source Contributions in Lan-Bai Metropolitan Area, Northwest China].

    Wang, Wen-Peng / Wang, Zhan-Xiang / Li, Ji-Xiang / Gao, Hong / Huang, Tao / Mao, Xiao-Xuan / Ma, Jian-Min

    Huan jing ke xue= Huanjing kexue

    2021  Volume 42, Issue 3, Page(s) 1315–1327

    Abstract: Lan-Bai Metropolitan Area in Gansu province is an important heavy-industry base with the highest ... criteria air pollutants in the Lan-Bai Metropolitan Area based on emission data and statistical yearbooks ... The results showed that the total annual emissions of seven major criteria air pollutants in the Lan-Bai ...

    Abstract Lan-Bai Metropolitan Area in Gansu province is an important heavy-industry base with the highest level of total air pollutant emissions in Northwest China. It is significant to study the high-resolution pollutant emission inventory to forecast regional air quality and to simulate pollutant emission reduction, as well as provide early warnings and forecasts, and to control air pollution. Taking Lanzhou and Baiyin as the main research areas, this study established the gridded emission inventories of seven major criteria air pollutants in the Lan-Bai Metropolitan Area based on emission data and statistical yearbooks of 2015-2016. The spatial pollution characteristics and emission source contributions were also studied. The results showed that the total annual emissions of seven major criteria air pollutants in the Lan-Bai Metropolitan Area were as followings:NO
    Language Chinese
    Publishing date 2021-03-20
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 0250-3301
    ISSN 0250-3301
    DOI 10.13227/j.hjkx.202007131
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  4. Article ; Online: Theoretical insights on the oxygen-reduction reaction mechanism of LaN

    Sun, Xiaoxu / Li, Kai / Yin, Cong / Wang, Ying / Tang, Hao / Wu, Zhijian

    Journal of molecular modeling

    2017  Volume 24, Issue 1, Page(s) 14

    Abstract: ... reduction reaction (ORR) process, and ORR mechanism on LaN ...

    Abstract We studied the structural stability, adsorption behavior of the key intermediates in the oxygen-reduction reaction (ORR) process, and ORR mechanism on LaN
    Language English
    Publishing date 2017-12-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1284729-x
    ISSN 0948-5023 ; 1610-2940
    ISSN (online) 0948-5023
    ISSN 1610-2940
    DOI 10.1007/s00894-017-3550-2
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  5. Article ; Online: Anti-microtubule activity of the traditional Chinese medicine herb Northern Ban Lan (Isatis tinctoria) leads to glucobrassicin.

    Guan, Pingyin / Zhou, Jianning / Girel, Sergey / Zhu, Xin / Schwab, Marian / Zhang, Kunxi / Wang-Müller, Qiyan / Bigler, Laurent / Nick, Peter

    Journal of integrative plant biology

    2021  Volume 63, Issue 12, Page(s) 2058–2074

    Abstract: ... based healing. The herb Northern Ban Lan (Isatis tinctoria) is famous for its antiviral and ...

    Abstract Traditional Chinese medicine (TCM) belongs to the most elaborate and extensive systems of plant-based healing. The herb Northern Ban Lan (Isatis tinctoria) is famous for its antiviral and anti-inflammatory activity. Although numerous components isolated from I. tinctoria have been characterized so far, their modes of action have remained unclear. Here, we show that extracts from I. tinctoria exert anti-microtubular activity. Using time-lapse microscopy in living tobacco BY-2 (Nicotiana tabacum L. cv Bright Yellow 2) cells expressing green fluorescent protein-tubulin, we use activity-guided fractionation to screen out the biologically active compounds of I. tinctoria. Among 54 fractions obtained from either leaves or roots of I. tinctoria by methanol (MeOH/H
    MeSH term(s) Glucosinolates ; HeLa Cells ; Humans ; Indoles ; Isatis/chemistry ; Medicine, Chinese Traditional ; Microtubules
    Chemical Substances Glucosinolates ; Indoles ; glucobrassicin (EA6EH0IU89)
    Language English
    Publishing date 2021-11-10
    Publishing country China (Republic : 1949- )
    Document type Journal Article
    ZDB-ID 2130095-1
    ISSN 1744-7909 ; 1672-9072
    ISSN (online) 1744-7909
    ISSN 1672-9072
    DOI 10.1111/jipb.13177
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  6. Article ; Online: Functional mapping of tillering QTLs using the Wang-Lan-Ding model and a SSSL population.

    Luan, Xin / Xiong, Liang / Xu, Haiming / Zhu, Haitao / Bu, Suhong / Meng, Lijun / Liu, Guifu / Wang, Shaokui

    Molecular genetics and genomics : MGG

    2021  Volume 296, Issue 6, Page(s) 1279–1286

    Abstract: ... agronomic traits in plants. Based on the Wang-Lan-Ding model, we ever applied a DH population to carry out ... mapping was again conducted on tiller number using the Wang-Lan-Ding model and a single segment ...

    Abstract Understanding dynamic changes in the genetic architecture of quantitative traits is crucial in developmental genetics. Functional mapping is an appropriate method that passes a mathematical equation to describe a biological developmental process with the genetic mapping framework. Appropriate genetic model and applicable mapping population are indispensable condition for functional mapping of important agronomic traits in plants. Based on the Wang-Lan-Ding model, we ever applied a DH population to carry out functional mapping QTLs underlying growth trajectory on tiller number. However, inconsistent genetic background among the DH lines might disturb the mapping results. With the advent of innovative research materials, single segment substitution lines, allows us to do more precise genetic analyses. Thus functional mapping was again conducted on tiller number using the Wang-Lan-Ding model and a single segment substitution line population with the genetic background of Huajingxian 74 so as to explore QTL dynamic mechanism to regulate developmental traits. We detected that all five single segment substitution lines harbored tillering QTLs with additives and/or dominances to influence the four functional parameters, the optimum tillering time (t
    MeSH term(s) Chromosome Mapping/methods ; Chromosomes, Plant/genetics ; Epistasis, Genetic/genetics ; Models, Theoretical ; Oryza/classification ; Oryza/genetics ; Phenotype ; Plant Breeding/methods ; Quantitative Trait Loci/genetics
    Language English
    Publishing date 2021-09-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2044817-X
    ISSN 1617-4623 ; 1617-4615
    ISSN (online) 1617-4623
    ISSN 1617-4615
    DOI 10.1007/s00438-021-01819-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article: Functional mapping of tillering QTLs using the Wang–Lan–Ding model and a SSSL population

    Luan, Xin / Xiong, Liang / Xu, Haiming / Zhu, Haitao / Bu, Suhong / Meng, Lijun / Liu, Guifu / Wang, Shaokui

    Molecular genetics and genomics. 2021 Nov., v. 296, no. 6

    2021  

    Abstract: ... agronomic traits in plants. Based on the Wang–Lan–Ding model, we ever applied a DH population to carry out ... mapping was again conducted on tiller number using the Wang–Lan–Ding model and a single segment ... the tillering decreased rate (c), which were estimated from the Wang–Lan–Ding model and with some biological ...

    Abstract Understanding dynamic changes in the genetic architecture of quantitative traits is crucial in developmental genetics. Functional mapping is an appropriate method that passes a mathematical equation to describe a biological developmental process with the genetic mapping framework. Appropriate genetic model and applicable mapping population are indispensable condition for functional mapping of important agronomic traits in plants. Based on the Wang–Lan–Ding model, we ever applied a DH population to carry out functional mapping QTLs underlying growth trajectory on tiller number. However, inconsistent genetic background among the DH lines might disturb the mapping results. With the advent of innovative research materials, single segment substitution lines, allows us to do more precise genetic analyses. Thus functional mapping was again conducted on tiller number using the Wang–Lan–Ding model and a single segment substitution line population with the genetic background of Huajingxian 74 so as to explore QTL dynamic mechanism to regulate developmental traits. We detected that all five single segment substitution lines harbored tillering QTLs with additives and/or dominances to influence the four functional parameters, the optimum tillering time (t₀), the maximum tiller number (K), the tillering increased rate (r) and the tillering decreased rate (c), which were estimated from the Wang–Lan–Ding model and with some biological meaning. They mainly brought the inflexion point (t₀) delay, the peak increase (K) and the degradation (c) acceleration, while the growth (r) slow down. Moreover, epistatic interactions among these QTLs were confirmed to be prevalent. A total of 39 significant epistatic effects were detected to associate with the four parameters, occupying 34.8% of 112 pairs of epistatic interactions investigated. Contrary to the QTL effects, these epistatic effects largely decreased t₀, K and c, while increased r. Our results indicated that the five QTL effects and their epistatic effects significantly changed the shape and trajectory of tiller number via influence of the four functional parameters. Rational use of these QTLs is expected to improve tillering number of rice by molecular design breeding.
    Keywords epistasis ; equations ; genetic background ; genetic models ; genomics ; rice ; substitution lines ; tillering
    Language English
    Dates of publication 2021-11
    Size p. 1279-1286.
    Publishing place Springer Berlin Heidelberg
    Document type Article
    ISSN 1617-4615
    DOI 10.1007/s00438-021-01819-5
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  8. Article: Anti‐microtubule activity of the traditional Chinese medicine herb Northern Ban Lan (Isatis tinctoria) leads to glucobrassicin

    Guan, Pingyin / Zhou, Jianning / Girel, Sergey / Zhu, Xin / Schwab, Marian / Zhang, Kunxi / Wang‐Müller, Qiyan / Bigler, Laurent / Nick, Peter

    Journal of integrative plant biology. 2021 Dec., v. 63, no. 12

    2021  

    Abstract: ... based healing. The herb Northern Ban Lan (Isatis tinctoria) is famous for its antiviral and anti ... the antiviral activity of Northern Ban Lan is discussed in the context of microtubules being hijacked ...

    Abstract Traditional Chinese medicine (TCM) belongs to the most elaborate and extensive systems of plant‐based healing. The herb Northern Ban Lan (Isatis tinctoria) is famous for its antiviral and anti‐inflammatory activity. Although numerous components isolated from I. tinctoria have been characterized so far, their modes of action have remained unclear. Here, we show that extracts from I. tinctoria exert anti‐microtubular activity. Using time‐lapse microscopy in living tobacco BY‐2 (Nicotiana tabacum L. cv Bright Yellow 2) cells expressing green fluorescent protein‐tubulin, we use activity‐guided fractionation to screen out the biologically active compounds of I. tinctoria. Among 54 fractions obtained from either leaves or roots of I. tinctoria by methanol (MeOH/H₂O 8:2), or ethyl acetate extraction, one specific methanolic root fraction was selected, because it efficiently and rapidly eliminated microtubules. By combination of further purification with ultra‐high‐performance liquid chromatography and high‐resolution tandem mass spectrometry most of the bioactivity could be assigned to the glucosinolate compound glucobrassicin. Glucobrassicin can also affect microtubules and induce apoptosis in HeLa cells. In the light of these findings, the antiviral activity of Northern Ban Lan is discussed in the context of microtubules being hijacked by many viral pathogens for cell‐to‐cell spread.
    Keywords Isatis tinctoria ; Nicotiana tabacum ; Oriental traditional medicine ; anti-inflammatory activity ; antiviral properties ; apoptosis ; ethyl acetate ; fluorescence ; fractionation ; glucobrassicin ; medicinal plants ; methanol ; microscopy ; microtubules ; tandem mass spectrometry ; tobacco ; ultra-performance liquid chromatography
    Language English
    Dates of publication 2021-12
    Size p. 2058-2074.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 2130095-1
    ISSN 1744-7909 ; 1672-9072
    ISSN (online) 1744-7909
    ISSN 1672-9072
    DOI 10.1111/jipb.13177
    Database NAL-Catalogue (AGRICOLA)

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  9. Article ; Online: Elucidation of the mechanism of reflowering in tree peony (Paeonia suffruticosa) 'Zi Luo Lan' by defoliation and gibberellic acid application.

    Xue, Jingqi / Li, Tingting / Wang, Shunli / Xue, Yuqian / Hu, Fengrong / Zhang, Xiuxin

    Plant physiology and biochemistry : PPB

    2018  Volume 132, Page(s) 571–578

    Abstract: In this study, the reflowering mechanism of tree peony (Paeonia suffruticosa 'Zi Luo Lan') after ...

    Abstract In this study, the reflowering mechanism of tree peony (Paeonia suffruticosa 'Zi Luo Lan') after defoliation and gibberellic acid (GA) application (autumn-flowering treatment) was investigated by monitoring the morphological changes, measuring the endogenous GA
    MeSH term(s) Abscisic Acid/metabolism ; Flowers/anatomy & histology ; Flowers/genetics ; Flowers/physiology ; Flowers/ultrastructure ; Gene Expression Regulation, Plant/drug effects ; Genes, Plant ; Gibberellins/pharmacology ; Paeonia/anatomy & histology ; Paeonia/genetics ; Paeonia/growth & development ; Paeonia/physiology ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Seasons ; Starch/metabolism ; Temperature ; Time Factors
    Chemical Substances Gibberellins ; Plant Proteins ; Abscisic Acid (72S9A8J5GW) ; Starch (9005-25-8) ; gibberellic acid (BU0A7MWB6L)
    Language English
    Publishing date 2018-10-10
    Publishing country France
    Document type Journal Article
    ZDB-ID 742978-2
    ISSN 1873-2690 ; 0981-9428
    ISSN (online) 1873-2690
    ISSN 0981-9428
    DOI 10.1016/j.plaphy.2018.10.004
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    In stock of ZB MED Bonn / Germany

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  10. Article ; Online: FNIH-defined Sarcopenia Predicts Adverse Outcomes Among Community-Dwelling Older People in Taiwan: Results From I-Lan Longitudinal Aging Study.

    Tang, Ting-Ching / Hwang, An-Chun / Liu, Li-Kuo / Lee, Wei-Ju / Chen, Liang-Yu / Wu, Yi-Hui / Huang, Chung-Yu / Hung, Cheng-Hao / Wang, Chih-Jen / Lin, Ming-Hsien / Peng, Li-Ning / Chen, Liang-Kung

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2017  Volume 73, Issue 6, Page(s) 828–834

    Abstract: ... of the I-Lan Longitudinal Aging Study were obtained for analysis. Overall, 1,839 community-dwelling people aged ...

    Abstract Background: To evaluate the predictive validity of sarcopenia defined by the Foundation for the National Institutes of Health (FNIH) Sarcopenia Project among Asian older adults.
    Methods: Data of the I-Lan Longitudinal Aging Study were obtained for analysis. Overall, 1,839 community-dwelling people aged 50 years and older, capable of completing a 6-m walk, with life expectancy of more than 6 months, and not institutionalized at time of data collection were enrolled for study. Data for subjects aged 65 years and older were obtained for study. The outcome measures were all-cause mortality and a composite adverse outcome which includes hospitalizations, emergency department visits, institutionalization, and falls.
    Results: Data of 728 eligible elderly participants (73.4 ± 5.4 years; 52.9% males) were analyzed. The prevalence of FNIH-diagnosed sarcopenia was 9.5%: 11.9% males; 6.7% females. Participants having FNIH-defined sarcopenia were considerably older, frailer, more obese, with poorer physical performance than nonsarcopenic subjects (All p < .001); during mean follow-up of 32.9 ± 8.8 months, they also had 3.8 times higher risk of dying, independent of age, sex, multimorbidity, cognitive function, and nutritional status (hazard ratio = 3.8; 95% confidence interval = 1.26-11.45; p = .018). Moreover, sarcopenia defined by grip strength-BMI ratio (WeakBMI) showed stronger association with composite adverse outcomes than traditional handgrip strength (hazard ratio = 1.99; 95% confidence interval = 1.01-3.93; p = .047 vs hazard ratio = 1.80; 95% confidence interval = 0.89-3.62; p = .102 in fully-adjusted model).
    Conclusion: Among community-dwelling older people in Taiwan, participants with FNIH-defined sarcopenia had a significantly greater risk of all-cause mortality and composite falls, emergency department visits, institutionalization, and hospitalization.
    MeSH term(s) Aged ; Female ; Geriatric Assessment ; Humans ; Independent Living ; Longitudinal Studies ; Male ; Predictive Value of Tests ; Sarcopenia/epidemiology ; Taiwan/epidemiology
    Language English
    Publishing date 2017-10-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glx148
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