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  1. Article ; Online: Long-term ambient ozone, omega-3 fatty acid, genetic susceptibility, and risk of mental disorders among middle-aged and older adults in UK biobank.

    Jin, Jianbo / Xu, Zhihu / Beevers, Sean D / Huang, Jing / Kelly, Frank / Li, Guoxing

    Environmental research

    2023  Volume 243, Page(s) 117825

    Abstract: Background: Evidence linking ozone to depression and anxiety disorders remains sparse and results are heterogeneous. It remains unknown whether omega-3 fatty acid, or genetic susceptibility of mental disorders modify the impacts of ozone. The aim is to ... ...

    Abstract Background: Evidence linking ozone to depression and anxiety disorders remains sparse and results are heterogeneous. It remains unknown whether omega-3 fatty acid, or genetic susceptibility of mental disorders modify the impacts of ozone. The aim is to assess the associations of ambient ozone with depression and anxiety, and further explore the potential modification effects of omega-3 fatty acid and genetic susceptibility.
    Methods: In total of 257,534 participants were enrolled from 2006 to 2010 and followed up to 2016. Depression and anxiety were assessed using mental health questionnaires, primary care records and hospital admission records. The annual average concentrations of ozone were calculated and linked to individuals by home address. Dietary intake and plasma concentration were selected to reflect levels of omega-3 fatty acid. Polygenetic risk scores were selected to reflect genetic susceptibility. We examined the associations of ozone and incident mental disorders, and potential modification of omega-3 fatty acid and genetic susceptibility.
    Results: Incidences of depression (N = 6957) and anxiety (N = 6944) was associated with increase of ozone. Higher levels of omega-3 fatty acid might attenuate the ozone related depression risk. However, the modification effects of genetic susceptibility were not found.
    Conclusions: Long-term exposure to ambient ozone increase the risk of mental disorders among the middle aged and older adults, and omega-3 fatty acid could reduce the adverse effects of ozone on mental health. Higher intake of omega-3 fatty acid is a potential strategy to prevent the risks caused by ozone on public mental health.
    MeSH term(s) Middle Aged ; Humans ; Aged ; Fatty Acids, Omega-3 ; Ozone/toxicity ; UK Biobank ; Biological Specimen Banks ; Mental Disorders/chemically induced ; Mental Disorders/epidemiology ; Genetic Predisposition to Disease
    Chemical Substances Fatty Acids, Omega-3 ; Ozone (66H7ZZK23N)
    Language English
    Publishing date 2023-12-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2023.117825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Sir William Osler and the nature of essential hypertension.

    Beevers, D G

    Journal of human hypertension

    2013  Volume 28, Issue 1, Page(s) 15–17

    MeSH term(s) Blood Pressure Determination/history ; England ; Essential Hypertension ; History, 20th Century ; Humans ; Hypertension/history ; Publishing/history ; Textbooks as Topic/history
    Language English
    Publishing date 2013-05-23
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 639472-3
    ISSN 1476-5527 ; 0950-9240
    ISSN (online) 1476-5527
    ISSN 0950-9240
    DOI 10.1038/jhh.2013.40
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: CaseReport: Aldosterone-secreting adrenal carcinoma complicating longstanding hypertension.

    Shantsila, A / Lip, G Y H / Beevers, D G

    Journal of human hypertension

    2019  Volume 34, Issue 5, Page(s) 411–412

    MeSH term(s) Adrenal Cortex Neoplasms ; Adrenal Gland Neoplasms/complications ; Adrenal Glands ; Aldosterone ; Carcinoma ; Humans ; Hyperaldosteronism/complications ; Hyperaldosteronism/diagnosis ; Hypertension/etiology
    Chemical Substances Aldosterone (4964P6T9RB)
    Language English
    Publishing date 2019-05-14
    Publishing country England
    Document type Letter
    ZDB-ID 639472-3
    ISSN 1476-5527 ; 0950-9240
    ISSN (online) 1476-5527
    ISSN 0950-9240
    DOI 10.1038/s41371-019-0209-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Problems in the detection and management of hypertension.

    Beevers, D G

    Proceedings of the Royal Society of Medicine

    2010  Volume 70, Issue Suppl 5, Page(s) 17–18

    Language English
    Publishing date 2010-10-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 209243-8
    ISSN 0035-9157
    ISSN 0035-9157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Reading for Pleasure: Contemporary novels on the bus.

    Beevers, D G

    British medical journal (Clinical research ed.)

    2010  Volume 282, Issue 6264, Page(s) 639–640

    Language English
    Publishing date 2010-08-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 80088-0
    ISSN 0267-0623 ; 0959-8138 ; 0959-8146 ; 0007-1447
    ISSN 0267-0623 ; 0959-8138 ; 0959-8146 ; 0007-1447
    DOI 10.1136/bmj.282.6264.639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Antihypertensive treatment in people of very old age with frailty: time for a paradigm shift?

    Shantsila, Eduard / Lip, Gregory Y H / Shantsila, Alena / Kurpas, Donata / Beevers, Gareth / Gill, Paramjit S / Williams, Nefyn H

    Journal of hypertension

    2023  Volume 41, Issue 10, Page(s) 1502–1510

    Abstract: The optimal management of hypertension in individuals aged 80 years or older with frailty remains uncertain due to multiple gaps in evidence. Complex health issues, polypharmacy, and limited physiological reserve make responding to antihypertensive ... ...

    Abstract The optimal management of hypertension in individuals aged 80 years or older with frailty remains uncertain due to multiple gaps in evidence. Complex health issues, polypharmacy, and limited physiological reserve make responding to antihypertensive treatments unpredictable. Patients in this age group may have limited life expectancy, so their quality of life should be prioritized when making treatment decisions. Further research is needed to identify which patients would benefit from more relaxed blood pressure targets and which antihypertensive medications are preferable or should be avoided. A paradigm shift is required in attitudes towards treatment, placing equal emphasis on deprescribing and prescribing when optimizing care. This review discusses the current evidence on managing hypertension in individuals aged 80 years or older with frailty, but further research is essential to address the gaps in knowledge and improve the care of this population.
    MeSH term(s) Humans ; Antihypertensive Agents/therapeutic use ; Frailty ; Deprescriptions ; Quality of Life ; Hypertension/drug therapy ; Hypertension/chemically induced ; Polypharmacy
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2023-07-05
    Publishing country Netherlands
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 605532-1
    ISSN 1473-5598 ; 0263-6352 ; 0952-1178
    ISSN (online) 1473-5598
    ISSN 0263-6352 ; 0952-1178
    DOI 10.1097/HJH.0000000000003495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Positive imagery training increases positive self-referent cognition in depression.

    Dainer-Best, Justin / Shumake, Jason D / Beevers, Christopher G

    Behaviour research and therapy

    2018  Volume 111, Page(s) 72–83

    Abstract: ... to different positive cues (e.g., an achievement) every other day for two weeks. The NTC provided neutral cues ...

    Abstract Depressed adults often show a bias towards negative self-referent processing at the expense of positive self-referent processing. The current study assessed whether a mental imagery intervention (Positive Self Reference Training-PSRT) delivered via the Internet could improve self-referent processing and depressive symptomatology among adults with moderate or greater depression symptoms. Participants were recruited via online methods and randomly assigned to one of two computerized interventions: active PSRT (n=44) or control training (NTC; n=43). The PSRT involved visualizing the self in response to different positive cues (e.g., an achievement) every other day for two weeks. The NTC provided neutral cues about objects. Self-referential processing of positive and negative adjectives and depression symptoms were measured at baseline, one week, and two weeks after initiating training. Over those two weeks, PSRT participants showed a greater increase in positive self-referent processing than did NTC participants. Negative self-referent processing and symptoms of depression declined comparably in both groups. Similarly, for both groups, increase in positive and decrease in negative self-referent processing was associated with a greater reduction in depression. These results indicate that mental imagery has the potential to improve self-referential processing, especially for positive stimuli, which may, in turn, help reduce depressive symptomatology.
    MeSH term(s) Adolescent ; Adult ; Depression/psychology ; Depression/therapy ; Female ; Humans ; Imagery, Psychotherapy/statistics & numerical data ; Internet ; Male ; Middle Aged ; Self Concept ; Therapy, Computer-Assisted/methods ; Treatment Outcome ; Young Adult
    Language English
    Publishing date 2018-10-06
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 211997-3
    ISSN 1873-622X ; 0005-7967
    ISSN (online) 1873-622X
    ISSN 0005-7967
    DOI 10.1016/j.brat.2018.09.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The superior longitudinal fasciculus and its functional triple-network mechanisms in brooding.

    Pisner, D A / Shumake, J / Beevers, C G / Schnyer, D M

    NeuroImage. Clinical

    2019  Volume 24, Page(s) 101935

    Abstract: Brooding, which refers to a repetitive focus on one's distress, is associated with functional connectivity within Default-Mode, Salience, and Executive-Control networks (DMN; SN; ECN), comprising the so-called "triple-network" of attention. Individual ... ...

    Abstract Brooding, which refers to a repetitive focus on one's distress, is associated with functional connectivity within Default-Mode, Salience, and Executive-Control networks (DMN; SN; ECN), comprising the so-called "triple-network" of attention. Individual differences in brain structure that might perseverate dysfunctional connectivity of brain networks associated with brooding are less clear, however. Using diffusion and functional Magnetic Resonance Imaging, we explored multimodal relationships between brooding severity, white-matter microstructure, and resting-state functional connectivity in depressed adults (N = 32-44), and then examined whether findings directly replicated in a demographically-similar, independent sample (N = 36-45). Among the fully-replicated results, three core findings emerged. First, brooding severity is associated with functional integration and segregation of the triple-network, particularly with a Precuneal subnetwork of the DMN. Second, microstructural asymmetry of the Superior Longitudinal Fasciculus (SLF) provides a robust structural connectivity basis for brooding and may account for over 20% of its severity (Discovery: adj. R
    MeSH term(s) Adolescent ; Adult ; Attention/physiology ; Brain/diagnostic imaging ; Brain/physiology ; Depressive Disorder, Major/diagnostic imaging ; Depressive Disorder, Major/physiopathology ; Depressive Disorder, Major/psychology ; Executive Function/physiology ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Nerve Net/diagnostic imaging ; Nerve Net/physiology ; White Matter/diagnostic imaging ; White Matter/physiology ; Young Adult
    Language English
    Publishing date 2019-07-19
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2701571-3
    ISSN 2213-1582 ; 2213-1582
    ISSN (online) 2213-1582
    ISSN 2213-1582
    DOI 10.1016/j.nicl.2019.101935
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Conversational assessment using artificial intelligence is as clinically useful as depression scales and preferred by users.

    Weisenburger, Rachel L / Mullarkey, Michael C / Labrada, Jocelyn / Labrousse, Daniel / Yang, Michelle Y / MacPherson, Allison Huff / Hsu, Kean J / Ugail, Hassan / Shumake, Jason / Beevers, Christopher G

    Journal of affective disorders

    2024  Volume 351, Page(s) 489–498

    Abstract: Background: Depression is prevalent, chronic, and burdensome. Due to limited screening access, depression often remains undiagnosed. Artificial intelligence (AI) models based on spoken responses to interview questions may offer an effective, efficient ... ...

    Abstract Background: Depression is prevalent, chronic, and burdensome. Due to limited screening access, depression often remains undiagnosed. Artificial intelligence (AI) models based on spoken responses to interview questions may offer an effective, efficient alternative to other screening methods.
    Objective: The primary aim was to use a demographically diverse sample to validate an AI model, previously trained on human-administered interviews, on novel bot-administered interviews, and to check for algorithmic biases related to age, sex, race, and ethnicity.
    Methods: Using the Aiberry app, adults recruited via social media (N = 393) completed a brief bot-administered interview and a depression self-report form. An AI model was used to predict form scores based on interview responses alone. For all meaningful discrepancies between model inference and form score, clinicians performed a masked review to determine which one they preferred.
    Results: There was strong concurrent validity between the model predictions and raw self-report scores (r = 0.73, MAE = 3.3). 90 % of AI predictions either agreed with self-report or with clinical expert opinion when AI contradicted self-report. There was no differential model performance across age, sex, race, or ethnicity.
    Limitations: Limitations include access restrictions (English-speaking ability and access to smartphone or computer with broadband internet) and potential self-selection of participants more favorably predisposed toward AI technology.
    Conclusion: The Aiberry model made accurate predictions of depression severity based on remotely collected spoken responses to a bot-administered interview. This study shows promising results for the use of AI as a mental health screening tool on par with self-report measures.
    MeSH term(s) Adult ; Humans ; Artificial Intelligence ; Depression/diagnosis ; Communication ; Ethnicity ; Internet
    Language English
    Publishing date 2024-01-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2024.01.212
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Self-referential schemas and attentional bias predict severity and naturalistic course of depression symptoms.

    Disner, Seth G / Shumake, Jason D / Beevers, Christopher G

    Cognition & emotion

    2016  Volume 31, Issue 4, Page(s) 632–644

    Abstract: Attentional bias and self-referential schemas have been observed in numerous cross-sectional studies of depressed adults and are theorised to maintain negative mood. However, few longitudinal studies have examined whether maladaptive cognition predicts ... ...

    Abstract Attentional bias and self-referential schemas have been observed in numerous cross-sectional studies of depressed adults and are theorised to maintain negative mood. However, few longitudinal studies have examined whether maladaptive cognition predicts the course of depressive symptoms. Fifty-seven adults with elevated depression symptoms were assessed for negative attentional bias using a dot-probe task with eye-tracking and self-referential schemas using a self-referent encoding task. Participants subsequently completed five weekly depression symptom assessments. Participants with more negative self-referential schemas had higher baseline depression symptoms (r = .55). However, participants who spent more time attending to negative words showed greater symptom worsening over time (r = .42). The findings for negative self-referential schemas replicate past research, while the findings for negative attention bias represent the first evidence showing that attentional biases predict naturalistic symptom course. This work suggests that negative attention biases maintain depression symptoms and represent an important treatment target for neurocognitive therapeutics.
    MeSH term(s) Adolescent ; Attentional Bias ; Cross-Sectional Studies ; Depression/diagnosis ; Depression/psychology ; Female ; Humans ; Male ; Prognosis ; Self Concept ; Young Adult
    Language English
    Publishing date 2016-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 639123-0
    ISSN 1464-0600 ; 0269-9931
    ISSN (online) 1464-0600
    ISSN 0269-9931
    DOI 10.1080/02699931.2016.1146123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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