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Article ; Online: Cost-effectiveness of ocrelizumab for treatment of Iranian patients with relapsing multiple sclerosis.

Ayati, Nayyereh / Taheri, Saeed / Sahraian, Mohammad Ali / Nikfar, Shekoufeh

Current journal of neurology

2023 Volume 20, Issue 3, Page(s) 154–161

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-11-27
Publishing country	Iran
Document type	Journal Article
ISSN	2717-011X
ISSN (online)	2717-011X
DOI	10.18502/cjn.v20i3.7691
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Cladribine tablets are a cost-effective strategy in high-disease activity relapsing multiple sclerosis patients in Iran.

Ayati, Nayyereh / Fleifel, Lora / Sharifi, Shahdak / Sahraian, Mohammad Ali / Nikfar, Shekoufeh

Current journal of neurology

2023 Volume 20, Issue 3, Page(s) 146–153

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-11-27
Publishing country	Iran
Document type	Journal Article
ISSN	2717-011X
ISSN (online)	2717-011X
DOI	10.18502/cjn.v20i3.7690
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Article ; Online: Short and long term impacts of COVID-19 on the pharmaceutical sector.

Ayati, Nayyereh / Saiyarsarai, Parisa / Nikfar, Shekoufeh

Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences

2020 Volume 28, Issue 2, Page(s) 799–805

Abstract: Background: The novel coronavirus disease 2019 (COVID-19) was characterized as a global pandemic by the WHO on March 11th, 2020. This pandemic had major effects on the health market, the pharmaceutical sector, and was associated with considerable ... ...

Abstract	Background: The novel coronavirus disease 2019 (COVID-19) was characterized as a global pandemic by the WHO on March 11th, 2020. This pandemic had major effects on the health market, the pharmaceutical sector, and was associated with considerable impacts; which may appear in short and long-term time-horizon and need identification and appropriate planning to reduce their socio-economic burden. Objectives: Current short communication study assessed pharmaceutical market crisis during the COVID-19 era; discussing short- and long-term impacts of the pandemic on the pharmaceutical sector. Results: Short-term impacts of COVID-19 pandemic includes demand changes, regulation revisions, research and development process changes and the shift towards tele-communication and tele-medicine. In addition, industry growth slow-down, approval delays, moving towards self-sufficiency in pharm-production supply chain and trend changes in consumption of health-market products along with ethical dilemma could be anticipated as long-term impacts of COVID-19 pandemic on pharmaceutical sector in both global and local levels. Conclusion: The pandemic of COVID-19 poses considerable crisis on the health markets, including the pharmaceutical sector; and identification of these effects, may guide policy-makers towards more evidence-informed planning to overcome accompanying challenges. Graphical abstract .
MeSH term(s)	COVID-19/economics ; Drug Industry/economics ; Drug Industry/trends ; Humans ; Pharmaceutical Preparations/economics ; Pharmaceutical Preparations/supply & distribution ; Policy Making ; Research/economics ; Research/trends ; Telemedicine/trends ; Time Factors
Chemical Substances	Pharmaceutical Preparations
Keywords	covid19
Language	English
Publishing date	2020-07-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2129183-4
ISSN	2008-2231 ; 1560-8115
ISSN (online)	2008-2231
ISSN	1560-8115
DOI	10.1007/s40199-020-00358-5
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Article: Pharmacogenomics Implementation and Hurdles to Overcome; In the Context of a Developing Country.

Ayati, Nayyereh / Afzali, Monireh / Hasanzad, Mandana / Kebriaeezadeh, Abbas / Rajabzadeh, Ali / Nikfar, Shekoufeh

Iranian journal of pharmaceutical research : IJPR

2022 Volume 20, Issue 4, Page(s) 92–106

Abstract: Having multiple dimensions, uncertainties and several stakeholders, the costly pharmacogenomics (PGx) is associated with dynamic implementation complexities. Identification of these challenges is critical to harness its full potential, especially in ... ...

Abstract	Having multiple dimensions, uncertainties and several stakeholders, the costly pharmacogenomics (PGx) is associated with dynamic implementation complexities. Identification of these challenges is critical to harness its full potential, especially in developing countries with fragile healthcare systems and scarce resources. This is the first study aimed to identify most salient challenges related to PGx implementation, with respect to the experiences of early-adopters and local experts' prospects, in the context of a developing country in the Middle East. To perform a comprehensive reconnaissance on PGx adoption challenges a scoping literature review was conducted based on national drug policy components: efficacy/safety, access, affordability and rational use of medicine (RUM). Strategic option development and analysis workshop method with cognitive mapping as the technique was used to evaluate challenges in the context of Iran. The cognitive maps were face-validated and analyzed via Decision Explorer XML. The findings indicated a complex network of issues relative to PGx adoption, categorized in national drug policy indicators. In the rational use of medicine category, ethics, education, bench -to- bedside strategies, guidelines, compliance, and health system issues were found. Clinical trial issues, test's utility, and biomarker validation were identified in the efficacy group. Affordability included pricing, reimbursement, and value assessment issues. Finally, access category included regulation, availability, and stakeholder management challenges. The current study identified the most significant challenges ahead of clinical implementation of PGx in a developing country. This could be the basis of a policy-note development in future work, which may consolidate vital communication among stakeholders and accelerate the efficient implementation in developing new-comer countries.
Language	English
Publishing date	2022-02-10
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2578271-X
ISSN	1735-0328 ; 1726-6890
ISSN	1735-0328 ; 1726-6890
DOI	10.22037/ijpr.2021.114899.15091
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Article: Cost-Effectiveness Comparison between Ticagrelor and Clopidogrel in Acute Coronary Syndrome in Iran.

Hashemi-Meshkini, Amir / Tajik, Amirmohammad / Ayati, Nayyereh / Nikfar, Shekoufeh / Koochak, Reza / Yaghoubifard, Saeed / Abbasi, Azam / Varmaghani, Mehdi

The journal of Tehran Heart Center

2023 Volume 18, Issue 2, Page(s) 94–101

Abstract: Background: The present study aimed to determine the cost-effectiveness of ticagrelor compared with clopidogrel in Iranian patients with acute coronary syndrome (ACS).: Methods: A 1-year decision tree model combined with a 20-year Markov transition ... ...

Abstract	Background: The present study aimed to determine the cost-effectiveness of ticagrelor compared with clopidogrel in Iranian patients with acute coronary syndrome (ACS). Methods: A 1-year decision tree model combined with a 20-year Markov transition model was used to simulate the long-term cost and effectiveness of both ticagrelor and clopidogrel in Iran based on an Iranian payer's perspective. Clinical efficacy data were extracted from the PLATO trial and other published studies. Costs were estimated based on local prices in public sectors. Deterministic and probabilistic sensitivity analyses were used to test the robustness of base-case results over the uncertainties of model inputs. All calculations, analyses, and modeling were done in TreeAge 2011 and Microsoft Excel 2013. Results: Compared with clopidogrel, the treatment of Iranian ACS patients with ticagrelor for 20 years resulted in an additional cost of US$ 2.39 in a hypothetical cohort of 1000 patients. However, ticagrelor led to 7.2 quality-adjusted life-years (QALYs) gained per 1000 hypothetical patients. Accordingly, the estimated incremental cost-effectiveness ratio for this analysis was US$ 332.032 per 1 QALY gained. Conclusion: Ticagrelor was a cost-effective antiplatelet medicine compared with clopidogrel in Iranian patients with ACS. This could help Iran's policymakers to allocate resources more efficiently to ACS.
Language	English
Publishing date	2023-07-06
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2476998-8
ISSN	2008-2371 ; 1735-5370 ; 1735-8620
ISSN (online)	2008-2371
ISSN	1735-5370 ; 1735-8620
DOI	10.18502/jthc.v18i2.13318
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Article ; Online: Short and long term impacts of COVID-19 on the pharmaceutical sector

Ayati, Nayyereh / Saiyarsarai, Parisa / Nikfar, Shekoufeh

DARU Journal of Pharmaceutical Sciences ; ISSN 2008-2231

2020

Keywords	covid19
Language	English
Publisher	Springer Science and Business Media LLC
Publishing country	us
Document type	Article ; Online
DOI	10.1007/s40199-020-00358-5
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Short and long term impacts of COVID-19 on the pharmaceutical sector

Ayati, Nayyereh / Saiyarsarai, Parisa / Nikfar, Shekoufeh

Abstract: BACKGROUND: The novel coronavirus disease 2019 (COVID-19) was characterized as a global pandemic by the WHO on March 11th, 2020. This pandemic had major effects on the health market, the pharmaceutical sector, and was associated with considerable impacts; ...

Abstract	BACKGROUND: The novel coronavirus disease 2019 (COVID-19) was characterized as a global pandemic by the WHO on March 11th, 2020. This pandemic had major effects on the health market, the pharmaceutical sector, and was associated with considerable impacts; which may appear in short and long-term time-horizon and need identification and appropriate planning to reduce their socio-economic burden. OBJECTIVES: Current short communication study assessed pharmaceutical market crisis during the COVID-19 era; discussing short- and long-term impacts of the pandemic on the pharmaceutical sector. RESULTS: Short-term impacts of COVID-19 pandemic includes demand changes, regulation revisions, research and development process changes and the shift towards tele-communication and tele-medicine. In addition, industry growth slow-down, approval delays, moving towards self-sufficiency in pharm-production supply chain and trend changes in consumption of health-market products along with ethical dilemma could be anticipated as long-term impacts of COVID-19 pandemic on pharmaceutical sector in both global and local levels. CONCLUSION: The pandemic of COVID-19 poses considerable crisis on the health markets, including the pharmaceutical sector; and identification of these effects, may guide policy-makers towards more evidence-informed planning to overcome accompanying challenges. Graphical abstract .
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #621499
Database	COVID19

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Article: Comparison of Treatment Response Achieved by Tablet Splitting Versus Whole Tablet Administration of Levothyroxine in Patients with Thyroid Cancer.

Ashrafpour, Ramin / Ayati, Narjess / Sadeghi, Ramin / Zare Namdar, Samira / Ayati, Nayyereh / Ghahremani, Somayyeh / Zakavi, Seyed Rasoul

Asia Oceania journal of nuclear medicine & biology

2018 Volume 6, Issue 2, Page(s) 108–112

Abstract: Objectives: TSH suppression by Levothyroxine consumption is a mainstay of thyroid cancer treatment. Tablet-splitting is a worldwide approach in dose adjustment in patients. However, it is highly recommended to evaluate the validity of tablet splitting ... ...

Abstract	Objectives: TSH suppression by Levothyroxine consumption is a mainstay of thyroid cancer treatment. Tablet-splitting is a worldwide approach in dose adjustment in patients. However, it is highly recommended to evaluate the validity of tablet splitting for each distinctive drug by clinical trials before routinely using tablet halves in clinical practice. In this study we compared the effect of 150 µg dose of Levothyroxine by use of a100 and a 50 µg tablets or one and half 100 µg tablets in Differentiated thyroid cancer (DTC) patients. Methods: One hundred DTC patients treated with one and half 100 µg Levothyroxine tablets were randomly divided into two groups. The first group continued taking medication as before and the second group received the same daily dose by taking one 100 and one 50 microgram Levothyroxine tablets. The mean changes in TSH and T3 levels and patients weight were compared between the groups. Results: 91 patients completed the study. Levothyroxine consumption pattern, age, gender distribution, weight and TSH levels were comparable between groups at the beginning of the study. The mean change of body weights, serum levels of T3 and TSH showed no significant difference between groups in different time points during the study (P>0.05). Conclusion: This study showed similar efficacy of tablet splitting and two tablets administration for Levothyroxine; however, patients preferred two tablets at the end of the study. It can be concluded that tablet splitting can be used as an alternative way when the 50 µg tablet is not available.
Language	English
Publishing date	2018-05-28
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2724313-8
ISSN	2322-5726 ; 2322-5718
ISSN (online)	2322-5726
ISSN	2322-5718
DOI	10.22038/aojnmb.2018.26793.1187
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Article ; Online: Evaluation of serum Asymmetric Dimethyl Arginine concentrations in coronary artery disease patients without traditional cardiovascular risk factors.

Ghayour-Mobarhan, Majid / Ayati, Nayyereh / Sahebkar, Amirhossein / Moohebati, Mohsen / Ayati, Narjes / Elyasi, Sepideh / Mohammadpour, Amir Houshang

Acta bio-medica : Atenei Parmensis

2018 Volume 89, Issue 2, Page(s) 203–208

Abstract: Background: Previous studies have shown that Asymmetric Dimethyl Arginine (ADMA) is increased significantly during coronary artery diseases (CAD). However it is not clear either this increase is due to cardiovascular disease (CVD) risk factors or ADMA ... ...

Abstract	Background: Previous studies have shown that Asymmetric Dimethyl Arginine (ADMA) is increased significantly during coronary artery diseases (CAD). However it is not clear either this increase is due to cardiovascular disease (CVD) risk factors or ADMA is increased independently in CAD. The aim of this study is to evaluate ADMA's plasma level as an independent biomarker in CADs. Patients and methods: In current study a total of 165 subjects with no traditional CVD's RFs, who fulfilled the inclusion and exclusion criteria, were recruited; 55 CAD+ patients which had more than 50% stenosis (CAD+); 55 CAD- patients which had less than 50% stenosis in their coronary arteries (CAD-), based on their angiography record and 55 healthy individuals as controls. CAD+ patients were divided into three groups: single (SVD), double (2VD), and triple vessel (3VD) disease. Plasma level of soluble ADMA was measured with an enzyme-linked immono sorbent assay (ELISA) kit. Results: No significant difference between ADMA's plasma levels was found between CAD+, CAD- and healthy groups. In addition ADMA's plasma levels was not significantly different between CAD+'s subgroups. Conclusions: The result of this study indicates no significant relation between ADMA's plasma levels and either presence or severity of coronary artery stenosis. Therefore, it is presumed that ADMA may not be an independent biomarker for CADs.
MeSH term(s)	Arginine/analogs & derivatives ; Arginine/blood ; Biomarkers/blood ; Case-Control Studies ; Coronary Artery Disease/blood ; Coronary Stenosis/blood ; Female ; Humans ; Male ; Middle Aged
Chemical Substances	Biomarkers ; N,N-dimethylarginine (63CV1GEK3Y) ; Arginine (94ZLA3W45F)
Language	English
Publishing date	2018-06-07
Publishing country	Italy
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2114240-3
ISSN	2531-6745 ; 0392-4203
ISSN (online)	2531-6745
ISSN	0392-4203
DOI	10.23750/abm.v89i2.5335
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Article ; Online: Comparison of Treatment Response Achieved by Tablet Splitting Versus Whole Tablet Administration of Levothyroxine in Patients with Thyroid Cancer

Ramin Ashrafpour / Narjess Ayati / Ramin Sadeghi / Samira Zare Namdar / Nayyereh Ayati / Somaye Ghahremani / Seyed Rasoul Zakavi

Asia Oceania Journal of Nuclear Medicine and Biology, Vol 6, Iss 2, Pp 108-

2018 Volume 112

Abstract: Objective(s): TSH suppression by Levothyroxine consumption is a mainstayof thyroid cancer treatment. Tablet-splitting is a worldwide approach in doseadjustment in patients. However, it is highly recommended to evaluate the validityof tablet splitting for ...

Abstract	Objective(s): TSH suppression by Levothyroxine consumption is a mainstayof thyroid cancer treatment. Tablet-splitting is a worldwide approach in doseadjustment in patients. However, it is highly recommended to evaluate the validityof tablet splitting for each distinctive drug by clinical trials before routinely usingtablet halves in clinical practice. In this study we compared the effect of 150 μg doseof Levothyroxine by use of a100 and a 50 μg tablets or one and half 100 μg tablets inDifferentiated thyroid cancer (DTC) patients.Methods: One hundred DTC patients treated with one and half 100 μg Levothyroxinetablets were randomly divided into two groups. The first group continued takingmedication as before and the second group received the same daily dose by taking one100 and one 50 microgram Levothyroxine tablets. The mean changes in TSH and T3levels and patients weight were compared between the groups.Results: 91 patients completed the study. Levothyroxine consumption pattern, age,gender distribution, weight and TSH levels were comparable between groups at thebeginning of the study. The mean change of body weights, serum levels of T3 and TSHshowed no significant difference between groups in different time points during thestudy (P>0.05).Conclusion: This study showed similar efficacy of tablet splitting and two tabletsadministration for Levothyroxine; however, patients preferred two tablets at the endof the study. It can be concluded that tablet splitting can be used as an alternative waywhen the 50 μg tablet is not available.
Keywords	Tablet splitting ; Differentiated thyroid cancer ; TSH ; Levothyroxine ; suppressive therapy ; Medical physics. Medical radiology. Nuclear medicine ; R895-920 ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2018-06-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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