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  1. Article: A case report of urinary tract infection from

    Puca, Edmond / Koci, Markelian / Puca, Entela / Como, Najada

    New microbes and new infections

    2023  Volume 53, Page(s) 101133

    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2750179-6
    ISSN 2052-2975
    ISSN 2052-2975
    DOI 10.1016/j.nmni.2023.101133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: What could drive the re-emergence of infectious diseases in a post-Covid19 era?

    Shapo, Leidon / Puca, Edmond

    Travel medicine and infectious disease

    2023  Volume 52, Page(s) 102546

    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Communicable Diseases
    Language English
    Publishing date 2023-01-28
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2023.102546
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6236: Show issues Location:
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  3. Article ; Online: Premature Ovarian Failure Related to SARS-CoV-2 Infection.

    Puca, Entela / Puca, Edmond

    Journal of medical cases

    2022  Volume 13, Issue 4, Page(s) 155–158

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is known to have a wide spectrum of effects on the respiratory, cardiac, neurological, hematopoietic, gastrointestinal, ocular and urological systems, but there is very little ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is known to have a wide spectrum of effects on the respiratory, cardiac, neurological, hematopoietic, gastrointestinal, ocular and urological systems, but there is very little information on its effects on the human ovary. Our aims are to describe a unique case that developed amenorrhea during and after SARS-CoV-2 infection and to push researchers to do more researches to understand the effects of SARS-CoV-2 infection on the ovaries. A 27-year-old female patient presented with amenorrhea. She had fever on the second day of the menstrual cycle, and her cycle had been interrupted on the same day. The patient had a sub-febrile temperature, myalgia, fatigue, sweating, loss of appetite, and mild sleep disorder. Based on clinical, laboratory, and reverse transcription polymerase chain reaction (RT-PCR) data of a nasopharyngeal swab sample, she had a positive result for SARS-CoV-2 infection. Till now there are limited publications on the effect of SARS-CoV-2 infection on the ovaries. In particular, the potential adverse effects of SARS-CoV-2 infection on fertility are unclear. Coronavirus disease 2019 (COVID-19) patients need to be followed up for a long time, and clinicians need to pay attention to menstrual disturbances, especially in young female patients. More evidence, through both epidemiologic and clinical studies, as well as long-term follow-up studies, is needed to understand the impact of this infection on the human ovary, especially in reproductive-aged women.
    Language English
    Publishing date 2022-03-25
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 2586383-6
    ISSN 1923-4163 ; 1923-4163
    ISSN (online) 1923-4163
    ISSN 1923-4163
    DOI 10.14740/jmc3791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: For how long can monkeypox reach the Balkan region?

    Puca, Edmond / Shapo, Laidon

    Travel medicine and infectious disease

    2022  Volume 49, Page(s) 102382

    MeSH term(s) Balkan Peninsula ; Humans ; Mpox (monkeypox)/diagnosis ; Mpox (monkeypox)/epidemiology
    Language English
    Publishing date 2022-06-11
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2022.102382
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6236: Show issues Location:
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  5. Article ; Online: Authors' response comments on "Diagnosis of monkeypox virus - An overview".

    Altindis, Mustafa / Puca, Edmond / Shapo, Laidon

    Travel medicine and infectious disease

    2022  Volume 51, Page(s) 102512

    Language English
    Publishing date 2022-11-30
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2022.102512
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6236: Show issues Location:
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  6. Article ; Online: Multiple cerebral septic emboli sourcing from a ventricular assist device: a case report.

    Roçi, Ermir / Puca, Edmond / Sula, Fatmir / Dodaj, Stela / Vyshka, Gentian

    AME case reports

    2023  Volume 7, Page(s) 38

    Abstract: Background: Patients carrying portable cardiac devices are at high risk of serious infections, such as endocarditis and sepsis. The event of a neurological complication should be taken into account, despite the fact that this group of patients is as a ... ...

    Abstract Background: Patients carrying portable cardiac devices are at high risk of serious infections, such as endocarditis and sepsis. The event of a neurological complication should be taken into account, despite the fact that this group of patients is as a rule, strictly anticoagulated and monitored duly.
    Case description: We present the case of a patient of middle age with heart failure awaiting for organ transplantation, and meanwhile having a ventricular assist device (VAD) implanted. The suspicion of an infection was raised following a purulent drainage from the external lead of the device, as well as the clinical picture of malaise, fever and sweating. A right hemiparesis complicated the condition and the brain computerized tomography (CT) scan demonstrated the presence of several hemorrhagic lesions. The suspicion of septic emboli was proven following the result of hemoculture yielding
    Conclusions: The patient was treated with antibiotics, anti-seizure drugs and with supportive therapy, with good recovery of the clinical picture. He was transferred to a cardiac surgery facility for a revision, or eventually for a replacement of the VAD. There is clearly a need for an increased awareness of probable neurological events among patients holding external heart devices. Available guidelines for their follow-up and monitoring should be strictly respected, in order to avoid complications, and eventually install a prompt and adequate treatment.
    Language English
    Publishing date 2023-09-05
    Publishing country China
    Document type Case Reports
    ISSN 2523-1995
    ISSN (online) 2523-1995
    DOI 10.21037/acr-23-50
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Diagnosis of monkeypox virus - An overview.

    Altindis, Mustafa / Puca, Edmond / Shapo, Laidon

    Travel medicine and infectious disease

    2022  Volume 50, Page(s) 102459

    Abstract: Monkeypox is an emerging zoonotic disease caused by monkeypox virus which is a DNA virus. The virus is transmitted to humans as a result of close contact with infected animals, infected humans or contaminated inanimate objects. The disease has a ... ...

    Abstract Monkeypox is an emerging zoonotic disease caused by monkeypox virus which is a DNA virus. The virus is transmitted to humans as a result of close contact with infected animals, infected humans or contaminated inanimate objects. The disease has a incubation period usually 7-14 days and it causes fever, headache, fatigue, myalgia, widespread body aches, swelling in lymph nodes and skin lesions. It may be difficult to distinguish monkeypox on the basis of clinical presentation alone, especially for cases with an atypical appearance, because of the various conditions that cause skin rashes. Testing should be offered to anyone who falls under the suspected case definition for monkeypox infection. Suitable samples are surface lesion and/or skin materials such as exudates swabs and crusts. Laboratory confirmation of specimens from suspected case is done using nucleic acid amplification testing, such as real-time or conventional polymerase chain reaction. Confirmation of MPXV infection should consider clinical and epidemiological information. Positive detection using an OPXV PCR assay followed by confirmation of MPXV via PCR and/or sequencing, or positive detection using MPXV PCR assay in suspected cases indicates confirmation of MPXV infection. Genetic sequence data (GSD) provide information on the origin and epidemic and characteristics of cases. There is a need to develop a more global and effective laboratory network for this emerging zoonosis, as well as to strengthen laboratory capacity, and international specimens referral capacities.
    MeSH term(s) Animals ; Humans ; Monkeypox virus/genetics ; Mpox (monkeypox)/diagnosis ; Mpox (monkeypox)/epidemiology ; Mpox (monkeypox)/pathology ; Polymerase Chain Reaction ; Nucleic Acid Amplification Techniques
    Language English
    Publishing date 2022-09-13
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2022.102459
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6236: Show issues Location:
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  8. Article ; Online: Evaluation of neutrophil-to-lymphocyte ratio and immune response in patients vaccinated with Pfizer-Biontech vaccine.

    Mediu, Ridvana / Rama, Ariol / Puca, Edmond

    Journal of infection in developing countries

    2022  Volume 16, Issue 5, Page(s) 745–751

    Abstract: Introduction: Research on SARS-CoV-2 virus has focused on aspects such as treatment, virology, epidemiology and vaccine development. The efficacy of vaccines against SARS-CoV-2 is important for controlling the pandemic. This study assessed how the ... ...

    Abstract Introduction: Research on SARS-CoV-2 virus has focused on aspects such as treatment, virology, epidemiology and vaccine development. The efficacy of vaccines against SARS-CoV-2 is important for controlling the pandemic. This study assessed how the immune response is affected by age and gender, and its role in causing inflammation as measured by neutrophil-to-lymphocyte ratio (NLR) in vaccinated patients versus non-vaccinated COVID-19 negative patients.
    Methodology: A case-control study was done involving 187 randomly selected patients who had undergone laboratory examinations to evaluate the SARS-CoV-2 IgG antibody titer and hematological parameters at 21 to 31 days after the second dose of vaccination. Patients were divided into case and control groups according to their vaccination status.
    Results: The average age among the cases was 51 ± 13 years whereas the average age among the control group was 47 ± 15 years. In cases where the response to immunization was measured by SARS-CoV-2 IgG antibody, results had a median of 7.7 U/mL characterized by a large variation (p < 0.0001). There was no significant difference based on age (p = 0.451) and gender (p = 0.622) in SARS-CoV-2 IgG antibody titers in patients vaccinated with two doses of Pfizer-BioNTech COVID-19 vaccine. In addition, there was no significant difference in NLR ratio between cases and controls (p = 0.117).
    Conclusions: Our data showed that there is no inflammation at 21 to 31 days post vaccination with Pfizer-BioNTech COVID-19 vaccine, regardless of age and gender, based on the hematological parameters.
    MeSH term(s) Adult ; Antibodies, Viral ; BNT162 Vaccine ; COVID-19/prevention & control ; COVID-19 Vaccines ; Case-Control Studies ; Humans ; Immunity ; Immunoglobulin G ; Lymphocytes ; Middle Aged ; Neutrophils ; SARS-CoV-2 ; Vaccines, Inactivated ; Viral Vaccines
    Chemical Substances Antibodies, Viral ; COVID-19 Vaccines ; Immunoglobulin G ; Vaccines, Inactivated ; Viral Vaccines ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2022-05-30
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2394024-4
    ISSN 1972-2680 ; 2036-6590
    ISSN (online) 1972-2680
    ISSN 2036-6590
    DOI 10.3855/jidc.16310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Severe hypocalcaemia in a COVID-19 female patient.

    Puca, Edmond / Puca, Entela / Pipero, Pellumb / Kraja, Holta / Como, Najada

    Endocrinology, diabetes & metabolism case reports

    2021  Volume 2021

    Abstract: Summary: Comorbidities are a risk factor for patients with COVID-19 and the mechanisms of disease remain unclear. The aim of this paper is to present a case report of an COVID-19 patient with severe hypocalcaemia. This is a report of an 81-year-old ... ...

    Abstract Summary: Comorbidities are a risk factor for patients with COVID-19 and the mechanisms of disease remain unclear. The aim of this paper is to present a case report of an COVID-19 patient with severe hypocalcaemia. This is a report of an 81-year-old female, suffered from myalgia and fatigue for more than 3-4 weeks. Fever and cough appear 2 days before she presented to the emergency room. On physical examination, she was febrile with a temperature of 38.8°C, accompanied by cough, sore throat, headache, fatigue, and muscle ache. Her past medical history was remarkable with no chronic disease. She had lymphopenia. Laboratory test revealed moderate liver dysfunction, hypoalbuminemia, and severe hypocalcaemia (serum corrected calcium level: 5.7 mg/dL). Parathyroid hormone (PTH) was 107.9 pg/mL (range: 15-65) and 25(OH)2D levels was 4.5 ng/mL (range: 25-80). Chest CT scan detected peripheral ground-glass opacity. Throat swab for coronavirus by RT-PCR assay tested positive for the virus. She was treated with lopinavir/ritonavir, third generation cephalosporin, anticoagulant, daily high-dose calcium acetate, vitamin D3, fresh frozen plasma and oxygen therapy. She was discharged after two negative throat swab tests for coronavirus by conventional RT-PCR.
    Learning points: Comorbidities are a risk factor for patients with COVID-19. Laboratory findings are unspecific in COVID-19 patients; laboratory abnormalities include lymphopenia, elevated of LDH, CPK and the inflammatory markers, such as C reactive protein, ferritinemia and the erythrocyte sedimentation rate. In addition to inflammatory markers, in COVID-19 patients it is crucial to check the level of vitamin D and calcium. There may be a correlation between vitamin D deficiency and the severity of COVID-19 disease.
    Language English
    Publishing date 2021-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2785530-2
    ISSN 2052-0573
    ISSN 2052-0573
    DOI 10.1530/EDM-20-0097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Albanian university students' knowledge, attitudes, and practices regarding COVID-19 infection and vaccine: A cross-sectional study.

    Merkuri, Lumturi / Puca, Edmond / Kamberi, Fatjona / Alimehmeti, Ilir / Qorri, Erda / Borshi, Xhejni

    Journal of infection in developing countries

    2023  Volume 17, Issue 1, Page(s) 10–17

    Abstract: Introduction: COVID-19 pandemic remains a public health concern worldwide. Given that, students represent a subgroup of the population with an impact on the pandemic.: Aim: The aim of this study is to evaluate the knowledge, attitudes, and practices ... ...

    Abstract Introduction: COVID-19 pandemic remains a public health concern worldwide. Given that, students represent a subgroup of the population with an impact on the pandemic.
    Aim: The aim of this study is to evaluate the knowledge, attitudes, and practices of Albanian students about COVID-19, and to provide a database to plan and implement preventive evidence-based interventions.
    Methodology: An online survey was conducted among Albanian university students during April-May 2022, to collect information on their knowledge, attitudes, and practices related to COVID-19, through a structured questionnaire.
    Results: A total of 906 students, 72.8% females, were included in it. 93.4% of participants knew the ways of transmission of COVID-19; 92.5% had information about preventive measures, but only 30% knew about quarantine and 37.0% knew vaccination as a preventive measure. Regarding attitudes, 54.8% of participants believed that COVID-19 infection is very dangerous. 46.5% have a negative attitude toward covid vaccines. Almost all respondents (93.7%) apply regular hand washing as a preventive measure; 82.8% cover their mouth when coughing or sneezing; but only 28.2% always use a mask indoors.
    Conclusions: Albanian university students had good knowledge, positive attitudes, and appropriate preventive practices against COVID-19, but the study found that some limitations in terms of information and misconceptions still exist. Raising awareness and providing adequate information, education, and more effective communication programs will have a positive impact on increasing knowledge, improving attitudes, and supporting the required student behavior change.
    MeSH term(s) Female ; Humans ; Male ; COVID-19/prevention & control ; COVID-19/epidemiology ; Cross-Sectional Studies ; Pandemics/prevention & control ; Health Knowledge, Attitudes, Practice ; Universities ; Students ; Surveys and Questionnaires ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2023-01-31
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2394024-4
    ISSN 1972-2680 ; 2036-6590
    ISSN (online) 1972-2680
    ISSN 2036-6590
    DOI 10.3855/jidc.17587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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