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Article: Could Balint have done more for Ferenczi?

Mészáros, Judit

2003 Volume 63, Issue 3, Page(s) 239–255

Abstract: After Ferenczi's death of pernicious anemia in 1933 at the age of 59, Michael Balint became ... Balint, who later became the literary executor of Ferenczi, was devoted enough in countering the charges ... Balint and Jones is cited, as are reports of Ferenczi's contemporaries; Balint's efforts are placed ...

Abstract	After Ferenczi's death of pernicious anemia in 1933 at the age of 59, Michael Balint became the greatest advocate of his late analyst, teacher, colleague, and friend. He was faced with widespread avoidance, a conspiracy of silence against Ferenczi in the psychoanalytic movement. Ernest Jones, in particular, an analysand of Ferenczi and fellow member of the Secret Committee founded by Freud before World War I, seriously attacked Ferenczi. In the third volume of the Freud biography, Jones alleged that in the last years of his life Ferenczi suffered mental deterioration caused by the pernicious anemia, and that this mental decline was the real cause of Ferenczi's technical experimentations, thereby belittling the importance of Ferenczi's independent work in the last phase of his life. This article answers whether Michael Balint, who later became the literary executor of Ferenczi, was devoted enough in countering the charges that lead to a fifty-year silence on Ferenczi's eminent place in psychoanalysis. Correspondence between Balint and Jones is cited, as are reports of Ferenczi's contemporaries; Balint's efforts are placed within the context of the psychoanalytic rivalries after Freud's death.
MeSH term(s)	History, 20th Century ; Psychoanalysis/history ; Psychoanalytic Theory ; Psychoanalytic Therapy/methods ; United Kingdom
Language	English
Publishing date	2003-09
Publishing country	England
Document type	Biography ; Historical Article ; Journal Article
ZDB-ID	219399-1
ISSN	1573-6741 ; 0002-9548
ISSN (online)	1573-6741
ISSN	0002-9548
DOI	10.1023/a:1025493004332
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Article ; Online: Application of Magnetic Adaptive Testing for Nondestructive Investigation of 2507 Duplex Stainless Steel.

Vértesy, Gábor / Mészáros, István / Bögre, Bálint

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 7

Abstract: Duplex stainless steels are two-phase alloys, which contain ferritic and austenitic phases in their microstructure. Their duplex structure provides exceptional resistance to pitting and chloride stress corrosion cracking, and their strength is about ... ...

Abstract	Duplex stainless steels are two-phase alloys, which contain ferritic and austenitic phases in their microstructure. Their duplex structure provides exceptional resistance to pitting and chloride stress corrosion cracking, and their strength is about twice that of austenitic stainless steels. Due to their good properties, they are widely used in chemical and petrochemical industries as a base material in pressure vessels, pipelines and containers. Duplex stainless steel samples were nondestructively investigated by measuring sets of magnetic minor hysteresis loops using the method called magnetic adaptive testing (MAT). Several series of heat-treated and cold-rolled 2507 duplex stainless steels were measured, and the magnetic parameters were compared with the results of the DC magnetometry of the samples. It was found that the changes in the material properties that were generated by heat treatment and mechanical deformation could easily be followed by magnetic measurements. In contrast to DC magnetic measurements, good correlation was found with the magnetic parameters determined by MAT method and Vickers hardness. Based on our experiments, MAT seems to be a powerful tool for the nondestructive characterization of duplex stainless steels.
Language	English
Publishing date	2023-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23073702
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Article ; Online: Computational resources for identifying and describing proteins driving liquid-liquid phase separation.

Pancsa, Rita / Vranken, Wim / Mészáros, Bálint

Briefings in bioinformatics

2021 Volume 22, Issue 5

Abstract: One of the most intriguing fields emerging in current molecular biology is the study of membraneless organelles formed via liquid-liquid phase separation (LLPS). These organelles perform crucial functions in cell regulation and signalling, and recent ... ...

Abstract	One of the most intriguing fields emerging in current molecular biology is the study of membraneless organelles formed via liquid-liquid phase separation (LLPS). These organelles perform crucial functions in cell regulation and signalling, and recent years have also brought about the understanding of the molecular mechanism of their formation. The LLPS field is continuously developing and optimizing dedicated in vitro and in vivo methods to identify and characterize these non-stoichiometric molecular condensates and the proteins able to drive or contribute to LLPS. Building on these observations, several computational tools and resources have emerged in parallel to serve as platforms for the collection, annotation and prediction of membraneless organelle-linked proteins. In this survey, we showcase recent advancements in LLPS bioinformatics, focusing on (i) available databases and ontologies that are necessary to describe the studied phenomena and the experimental results in an unambiguous way and (ii) prediction methods to assess the potential LLPS involvement of proteins. Through hands-on application of these resources on example proteins and representative datasets, we give a practical guide to show how they can be used in conjunction to provide in silico information on LLPS.
MeSH term(s)	Databases, Factual ; Models, Chemical ; Organelles/chemistry ; Proteins/chemistry ; Proteins/isolation & purification
Chemical Substances	Proteins
Language	English
Publishing date	2021-01-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2068142-2
ISSN	1477-4054 ; 1467-5463
ISSN (online)	1477-4054
ISSN	1467-5463
DOI	10.1093/bib/bbaa408
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Article: Complex Study of Eutectoidal Phase Transformation of 2507-Type Super-Duplex Stainless Steel.

Mészáros, István / Bögre, Bálint

Materials (Basel, Switzerland)

2019 Volume 12, Issue 13

Abstract: The aim of this work was to study expansively the process of the eutectoidal phase transformation of 2507-type super-duplex stainless steel. Three sample sets were prepared. The first sample set was made to investigate the effect of the previous cold ... ...

Abstract	The aim of this work was to study expansively the process of the eutectoidal phase transformation of 2507-type super-duplex stainless steel. Three sample sets were prepared. The first sample set was made to investigate the effect of the previous cold rolling and heat treatment for the eutectoidal phase transformation. Samples were cold rolled at seven different rolling reductions which was followed by heat treatment at five different temperatures. The second sample set was prepared to determine the activation energy of the eutectoidal decomposition process using the Arrhenius equation. Samples were cold rolled at seven different rolling reductions and were heat treated at the same temperature during eight different terms. A third sample set was made to study how another plastic-forming technology, beside the cold rolling, can influence the eutectoidal decomposition. Samples were elongated by single axis tensile stress and were heat treated at the same temperature. The results of the first and the third sample sets were compared. The rest δ-ferrite contents were calculated using the results of AC and DC magnetometer measurements. DC magnetometer was used as a feritscope device in this work. Light microscope and electron back scattering diffraction (EBSD) images demonstrated the process of the eutectoidal decomposition. The thermoelectric power and the hardness of the samples were measured. The results of the thermoelectric power measurement were compared with the results of the δ-ferrite content measurement. The accurate value of the coercive field was determined by a Foerster-type DC coercimeter device.
Language	English
Publishing date	2019-07-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma12132205
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Article ; Online: Towards Unraveling the Histone Code by Fragment Blind Docking.

Bálint, Mónika / Horváth, István / Mészáros, Nikolett / Hetényi, Csaba

International journal of molecular sciences

2019 Volume 20, Issue 2

Abstract: Histones serve as protein spools for winding the DNA in the nucleosome. High variability of their post-translational modifications result in a unique code system often responsible for the pathomechanisms of epigenetics-based diseases. Decoding is ... ...

Abstract	Histones serve as protein spools for winding the DNA in the nucleosome. High variability of their post-translational modifications result in a unique code system often responsible for the pathomechanisms of epigenetics-based diseases. Decoding is performed by reader proteins via complex formation with the N-terminal peptide tails of histones. Determination of structures of histone-reader complexes would be a key to unravel the histone code and the design of new drugs. However, the large number of possible histone complex variations imposes a true challenge for experimental structure determination techniques. Calculation of such complexes is difficult due to considerable size and flexibility of peptides and the shallow binding surfaces of the readers. Moreover, location of the binding sites is often unknown, which requires a blind docking search over the entire surface of the target protein. To accelerate the work in this field, a new approach is presented for prediction of the structure of histone H3 peptide tails docked to their targets. Using a fragmenting protocol and a systematic blind docking method, a collection of well-positioned fragments of the H3 peptide is produced. After linking the fragments, reconstitution of anchoring regions of the target-bound H3 peptide conformations was possible. As a first attempt of combination of blind and fragment docking approaches, our new method is named fragment blind docking (FBD).
MeSH term(s)	Algorithms ; Amino Acid Sequence ; DNA/chemistry ; DNA/metabolism ; Histone Code ; Histones/chemistry ; Histones/metabolism ; Ligands ; Methylation ; Models, Molecular ; Molecular Structure ; Peptides ; Protein Binding ; Protein Conformation ; Structure-Activity Relationship
Chemical Substances	Histones ; Ligands ; Peptides ; DNA (9007-49-2)
Language	English
Publishing date	2019-01-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms20020422
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Article ; Online: Soils in distress

Attila Bodor / Gábor Feigl / Bálint Kolossa / Enikő Mészáros / Krisztián Laczi / Etelka Kovács / Katalin Perei / Gábor Rákhely

Ecotoxicology and Environmental Safety, Vol 269, Iss , Pp 115807- (2024)

The impacts and ecological risks of (micro)plastic pollution in the terrestrial environment

1481

Abstract: Plastics have revolutionised human industries, thanks to their versatility and durability. However, their extensive use, coupled with inadequate waste disposal, has resulted in plastic becoming ubiquitous in every environmental compartment, posing ... ...

Abstract	Plastics have revolutionised human industries, thanks to their versatility and durability. However, their extensive use, coupled with inadequate waste disposal, has resulted in plastic becoming ubiquitous in every environmental compartment, posing potential risks to the economy, human health and the environment. Additionally, under natural conditions, plastic waste breaks down into microplastics (MPs<5 mm). The increasing quantity of MPs exerts a significant burden on the soil environment, particularly in agroecosystems, presenting a new stressor for soil-dwelling organisms. In this review, we delve into the effects of MP pollution on soil ecosystems, with a specific attention to (a) MP transport to soils, (b) potential changes of MPs under environmental conditions, (c) and their interaction with the physical, chemical and biological components of the soil. We aim to shed light on the alterations in the distribution, activity, physiology and growth of soil flora, fauna and microorganisms in response to MPs, offering an ecotoxicological perspective for environmental risk assessment of plastics. The effects of MPs are strongly influenced by their intrinsic traits, including polymer type, shape, size and abundance. By exploring the multifaceted interactions between MPs and the soil environment, we provide critical insights into the consequences of plastic contamination. Despite the growing body of research, there remain substantial knowledge gaps regarding the long-term impact of MPs on the soil. Our work underscores the importance of continued research efforts and the adoption of standardised approaches to address plastic pollution and ensure a sustainable future for our planet.
Keywords	Microplastic ; Soil physicochemical properties ; Ecotoxicity ; Microbial activity ; Microbial functions ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Mutations of Intrinsically Disordered Protein Regions Can Drive Cancer but Lack Therapeutic Strategies.

Mészáros, Bálint / Hajdu-Soltész, Borbála / Zeke, András / Dosztányi, Zsuzsanna

Biomolecules

2021 Volume 11, Issue 3

Abstract: Many proteins contain intrinsically disordered regions (IDRs) which carry out important functions without relying on a single well-defined conformation. IDRs are increasingly recognized as critical elements of regulatory networks and have been also ... ...

Abstract	Many proteins contain intrinsically disordered regions (IDRs) which carry out important functions without relying on a single well-defined conformation. IDRs are increasingly recognized as critical elements of regulatory networks and have been also associated with cancer. However, it is unknown whether mutations targeting IDRs represent a distinct class of driver events associated with specific molecular and system-level properties, cancer types and treatment options. Here, we used an integrative computational approach to explore the direct role of intrinsically disordered protein regions driving cancer. We showed that around 20% of cancer drivers are primarily targeted through a disordered region. These IDRs can function in multiple ways which are distinct from the functional mechanisms of ordered drivers. Disordered drivers play a central role in context-dependent interaction networks and are enriched in specific biological processes such as transcription, gene expression regulation and protein degradation. Furthermore, their modulation represents an alternative mechanism for the emergence of all known cancer hallmarks. Importantly, in certain cancer patients, mutations of disordered drivers represent key driving events. However, treatment options for such patients are currently severely limited. The presented study highlights a largely overlooked class of cancer drivers associated with specific cancer types that need novel therapeutic options.
MeSH term(s)	Evolution, Molecular ; Humans ; Intrinsically Disordered Proteins/chemistry ; Intrinsically Disordered Proteins/genetics ; Intrinsically Disordered Proteins/metabolism ; Mutation ; Neoplasms/genetics ; Neoplasms/metabolism ; Protein Binding/genetics ; Protein Binding/physiology ; Protein Conformation
Chemical Substances	Intrinsically Disordered Proteins
Language	English
Publishing date	2021-03-04
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom11030381
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Article ; Online: PSINDB: the postsynaptic protein-protein interaction database.

Kalman, Zsofia E / Dudola, Dániel / Mészáros, Bálint / Gáspári, Zoltán / Dobson, Laszlo

Database : the journal of biological databases and curation

2022 Volume 2022, Issue 2022

Abstract: The postsynaptic region is the receiving part of the synapse comprising thousands of proteins forming an elaborate and dynamically changing network indispensable for the molecular mechanisms behind fundamental phenomena such as learning and memory. ... ...

Abstract	The postsynaptic region is the receiving part of the synapse comprising thousands of proteins forming an elaborate and dynamically changing network indispensable for the molecular mechanisms behind fundamental phenomena such as learning and memory. Despite the growing amount of information about individual protein-protein interactions (PPIs) in this network, these data are mostly scattered in the literature or stored in generic databases that are not designed to display aspects that are fundamental to the understanding of postsynaptic functions. To overcome these limitations, we collected postsynaptic PPIs complemented by a high amount of detailed structural and biological information and launched a freely available resource, the Postsynaptic Interaction Database (PSINDB), to make these data and annotations accessible. PSINDB includes tens of thousands of binding regions together with structural features, mediating and regulating the formation of PPIs, annotated with detailed experimental information about each interaction. PSINDB is expected to be useful for various aspects of molecular neurobiology research, from experimental design to network and systems biology-based modeling and analysis of changes in the protein network upon various stimuli. Database URL https://psindb.itk.ppke.hu/.
MeSH term(s)	Databases, Protein ; Protein Interaction Mapping ; Protein Interaction Maps ; Proteins/chemistry
Chemical Substances	Proteins
Language	English
Publishing date	2022-05-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2496706-3
ISSN	1758-0463 ; 1758-0463
ISSN (online)	1758-0463
ISSN	1758-0463
DOI	10.1093/database/baac007
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Article ; Online: Recent breakthroughs in computational structural biology harnessing the power of sequences and structures.

Mészáros, Bálint / Park, Electa / Malinverni, Duccio / Sejdiu, Besian I / Immadisetty, Kalyan / Sandhu, Manbir / Lang, Benjamin / Babu, M Madan

Current opinion in structural biology

2023 Volume 80, Page(s) 102608

Abstract: Recent advances in computational approaches and their integration into structural biology enable tackling increasingly complex questions. Here, we discuss several key areas, highlighting breakthroughs and remaining challenges. Theoretical modeling has ... ...

Abstract	Recent advances in computational approaches and their integration into structural biology enable tackling increasingly complex questions. Here, we discuss several key areas, highlighting breakthroughs and remaining challenges. Theoretical modeling has provided tools to accurately predict and design protein structures on a scale currently difficult to achieve using experimental approaches. Molecular Dynamics simulations have become faster and more precise, delivering actionable information inaccessible by current experimental methods. Virtual screening workflows allow a high-throughput approach to discover ligands that bind and modulate protein function, while Machine Learning methods enable the design of proteins with new functionalities. Integrative structural biology combines several of these approaches, pushing the frontiers of structural and functional characterization to ever larger systems, advancing towards a complete understanding of the living cell. These breakthroughs will accelerate and significantly impact diverse areas of science.
MeSH term(s)	Computational Biology ; Proteins/chemistry ; Molecular Dynamics Simulation
Chemical Substances	Proteins
Language	English
Publishing date	2023-05-12
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1068353-7
ISSN	1879-033X ; 0959-440X
ISSN (online)	1879-033X
ISSN	0959-440X
DOI	10.1016/j.sbi.2023.102608
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Article ; Online: Soils in distress: The impacts and ecological risks of (micro)plastic pollution in the terrestrial environment.

Bodor, Attila / Feigl, Gábor / Kolossa, Bálint / Mészáros, Enikő / Laczi, Krisztián / Kovács, Etelka / Perei, Katalin / Rákhely, Gábor

Ecotoxicology and environmental safety

2023 Volume 269, Page(s) 115807

Abstract	Plastics have revolutionised human industries, thanks to their versatility and durability. However, their extensive use, coupled with inadequate waste disposal, has resulted in plastic becoming ubiquitous in every environmental compartment, posing potential risks to the economy, human health and the environment. Additionally, under natural conditions, plastic waste breaks down into microplastics (MPs<5 mm). The increasing quantity of MPs exerts a significant burden on the soil environment, particularly in agroecosystems, presenting a new stressor for soil-dwelling organisms. In this review, we delve into the effects of MP pollution on soil ecosystems, with a specific attention to (a) MP transport to soils, (b) potential changes of MPs under environmental conditions, (c) and their interaction with the physical, chemical and biological components of the soil. We aim to shed light on the alterations in the distribution, activity, physiology and growth of soil flora, fauna and microorganisms in response to MPs, offering an ecotoxicological perspective for environmental risk assessment of plastics. The effects of MPs are strongly influenced by their intrinsic traits, including polymer type, shape, size and abundance. By exploring the multifaceted interactions between MPs and the soil environment, we provide critical insights into the consequences of plastic contamination. Despite the growing body of research, there remain substantial knowledge gaps regarding the long-term impact of MPs on the soil. Our work underscores the importance of continued research efforts and the adoption of standardised approaches to address plastic pollution and ensure a sustainable future for our planet.
MeSH term(s)	Humans ; Soil ; Ecosystem ; Plastics/chemistry ; Environmental Monitoring ; Environmental Pollution/adverse effects
Chemical Substances	Soil ; Plastics
Language	English
Publishing date	2023-12-12
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2023.115807
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