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Article ; Online: The fatal contribution of serine protease-related genetic variants to COVID-19 outcomes.

Martínez-Gómez, Laura Edith / Martinez-Armenta, Carlos / Tusie-Luna, Teresa / Vázquez-Cárdenas, Paola / Vidal-Vázquez, Rosa P / Ramírez-Hinojosa, Juan P / Gómez-Martín, Diana / Vargas-Alarcón, Gilberto / Posadas-Sánchez, Rosalinda / Fragoso, José Manuel / de la Peña, Aurora / Rodríguez-Pérez, José Manuel / Mata-Miranda, Mónica M / Vázquez-Zapién, Gustavo J / Martínez-Cuazitl, Adriana / Martínez-Ruiz, Felipe de J / Zayago-Angeles, Dulce M / Ramos-Tavera, Luis / Méndez-Aguilera, Alberto /

Camacho-Rea, María Del C / Ordoñez-Sánchez, María L / Segura-Kato, Yayoi / Suarez-Ahedo, Carlos / Olea-Torres, Jessel / Herrera-López, Brígida / Pineda, Carlos / Martínez-Nava, Gabriela A / López-Reyes, Alberto

Frontiers in immunology

2024 Volume 15, Page(s) 1335963

Abstract: Introduction: Serine proteases play a critical role during SARS-CoV-2 infection. Therefore, polymorphisms of transmembrane protease serine 2 (: Methods: To evaluate the genetic variants of the genes previously associated with COVID-19 outcomes, we ... ...

Abstract	Introduction: Serine proteases play a critical role during SARS-CoV-2 infection. Therefore, polymorphisms of transmembrane protease serine 2 ( Methods: To evaluate the genetic variants of the genes previously associated with COVID-19 outcomes, we performed a cross-sectional study in which 1536 SARS-CoV-2-positive participants were enrolled. Results: According to our codominant model, the GA genotype of rs2227667 (OR=0.55; 95% CI = 0.36-0.84; Discussion: Our data suggest that the rs75603675
MeSH term(s)	Humans ; COVID-19/genetics ; Serine Proteases ; SARS-CoV-2 ; Diabetes Mellitus, Type 2 ; Cross-Sectional Studies
Chemical Substances	Serine Proteases (EC 3.4.-)
Language	English
Publishing date	2024-03-27
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1335963
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Article ; Online: Good clinical practice recommendations for the diagnosis and treatment of gastroesophageal reflux disease. An expert review from the Asociación Mexicana de Gastroenterología.

Valdovinos Díaz, M A / Amieva-Balmori, M / Carmona-Sánchez, R / Coss-Adame, E / Gómez-Escudero, O / González-Martínez, M / Huerta-Iga, F / Morel-Cerda, E / Remes-Troche, J M / Tamayo-de la Cuesta, J L / Torres-Villalobos, G / Valdovinos-García, L R / Vázquez-Elizondo, G / Villar-Chávez, A S / Arenas-Martínez, J A

Revista de gastroenterologia de Mexico (English)

2024 Volume 89, Issue 1, Page(s) 121–143

Abstract: Introduction: Gastroesophageal reflux disease (GERD) is very prevalent in the general population, with a broad spectrum of clinical manifestations, requiring accurate diagnosis and treatment.: Aim: The aim of this expert review is to establish good ... ...

Abstract	Introduction: Gastroesophageal reflux disease (GERD) is very prevalent in the general population, with a broad spectrum of clinical manifestations, requiring accurate diagnosis and treatment. Aim: The aim of this expert review is to establish good clinical practice recommendations for the diagnosis and personalized treatment of GERD. Methods: The good clinical practice recommendations were produced by a group of experts in GERD, members of the Asociación Mexicana de Gastroenterología (AMG), after carrying out an extensive review of the published literature and discussing each recommendation at a face-to-face meeting. This document does not aim to be a clinical practice guideline with the methodology such a document requires. Results: Fifteen experts on GERD formulated 27 good clinical practice recommendations for recognizing the symptoms and complications of GERD, the rational use of diagnostic tests and medical treatment, the identification and management of refractory GERD, the overlap with functional disorders, endoscopic and surgical treatment, and GERD in the pregnant woman, older adult, and the obese patient. Conclusions: An accurate diagnosis of GERD is currently possible, enabling the prescription of a personalized treatment in patients with this condition. The goal of the good clinical practice recommendations by the group of experts from the AMG presented in this document is to aid both the general practitioner and specialist in the process of accurate diagnosis and treatment, in the patient with GERD.
MeSH term(s)	Female ; Pregnancy ; Humans ; Aged ; Gastroesophageal Reflux/diagnosis ; Gastroesophageal Reflux/therapy ; Endoscopy
Language	English
Publishing date	2024-04-04
Publishing country	Mexico
Document type	Practice Guideline
ZDB-ID	2828765-4
ISSN	2255-534X ; 2255-534X
ISSN (online)	2255-534X
ISSN	2255-534X
DOI	10.1016/j.rgmxen.2023.12.002
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Article: Mathematical modeling for operative improvement of the decoloration of Acid Red 27 by a novel microbial consortium of

Martínez-Castillo, L A / González-Ramírez, C A / Cortazar-Martínez, A / González-Reyes, J R / Otazo-Sánchez, E M / Villagómez-Ibarra, J R / Velázquez-Jiménez, R / Vázquez-Cuevas, G M / Madariaga-Navarrete, A / Acevedo-Sandoval, O A / Romo-Gómez, C

Heliyon

2023 Volume 9, Issue 11, Page(s) e21793

Abstract: In this work, it is presented a first approach of a mathematical and kinetic analysis for improving the decoloration and further degradation process of an azo dye named acid red 27 (AR27), by means of a novel microbial consortium formed by the ... ...

Abstract	In this work, it is presented a first approach of a mathematical and kinetic analysis for improving the decoloration and further degradation process of an azo dye named acid red 27 (AR27), by means of a novel microbial consortium formed by the fungus
Language	English
Publishing date	2023-10-31
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e21793
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Article ; Online: In vivo selection of KPC-94 and KPC-95 in Klebsiella pneumoniae isolates from patients treated with ceftazidime/avibactam.

Guzmán-Puche, J / Pérez-Nadales, E / Pérez-Vázquez, M / Causse, M / Gracia-Ahufinger, I / Mendez-Natera, A / Allalou-Ruiz, Y / Elías, C / Oteo-Iglesias, J / Torre-Cisneros, J / Martínez-Martínez, L

International journal of antimicrobial agents

2022 Volume 59, Issue 2, Page(s) 106524

Abstract: Ceftazidime/avibactam (CZA) is used to treat infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp). Resistance to CZA is commonly related to point mutations in the ... ...

Abstract	Ceftazidime/avibactam (CZA) is used to treat infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp). Resistance to CZA is commonly related to point mutations in the bla
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Azabicyclo Compounds/pharmacology ; Azabicyclo Compounds/therapeutic use ; Bacterial Proteins/genetics ; Ceftazidime/pharmacology ; Ceftazidime/therapeutic use ; Drug Combinations ; Drug Resistance, Bacterial ; Humans ; Klebsiella Infections/drug therapy ; Klebsiella Infections/microbiology ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/genetics ; Microbial Sensitivity Tests ; beta-Lactamases/genetics
Chemical Substances	Anti-Bacterial Agents ; Azabicyclo Compounds ; Bacterial Proteins ; Drug Combinations ; avibactam (7352665165) ; Ceftazidime (9M416Z9QNR) ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2022-01-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1093977-5
ISSN	1872-7913 ; 0924-8579
ISSN (online)	1872-7913
ISSN	0924-8579
DOI	10.1016/j.ijantimicag.2022.106524
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Zs.A 3368: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: New strategies for decision making in prostate cancer. The role of oncotypedx.

Toribio-Vázquez, C / Gómez Rivas, J / Yebes, Á / Carrión, D M / Yagüe Barrado, M / Álvarez-Maestro, M / Martinez-Piñeiro, L

Actas urologicas espanolas

2022 Volume 46, Issue 7, Page(s) 385–386

MeSH term(s)	Decision Making ; Humans ; Male ; Prognosis ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/therapy
Language	Spanish
Publishing date	2022-07-13
Publishing country	Spain
Document type	Editorial
ISSN	2173-5786
ISSN (online)	2173-5786
DOI	10.1016/j.acuroe.2022.01.005
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Article: [Repurposing the PICU for caring critically ill adult patients during the COVID-19 pandemic]

Vázquez Martínez, J. L. / Alonso García, R.

Anales de pediatria (Barcelona, Spain : 2003)

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #595130
Database	COVID19

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Article: Significance of an Interprofessional Healthy Aging Program for Community-Dwelling Older Adults: A Narrative Study.

Colón-Ramirez, Wanda I / Román-Oyola, Rosa L / Segarra-Vazquez, Bárbara / Mercado-Rolón, Karla J / Dávila Collazo, Emanuel / Camacho-Martínez, Alma J / Vélez-Jiménez, Lypzia M

Qualitative health research

2024 , Page(s) 10497323241228187

Abstract: Participation is widely recognized as an important health determinant for older adults. Exploring interventions to promote active participation of community-dwelling older adults is an important step in translating current knowledge into practice. Few ... ...

Abstract	Participation is widely recognized as an important health determinant for older adults. Exploring interventions to promote active participation of community-dwelling older adults is an important step in translating current knowledge into practice. Few studies have examined community-level interventions to support older adults' participation. The study purpose was to examine the significance of the lived experiences of community-dwelling older adults who participated in an interprofessional healthy aging promotion program. The specific aims were to uncover the narrative significance of the lived experiences and how they evolved and intertwined with the life histories of the older adults 2 years after the intervention ended. A narrative inquiry design was used. Four key informants participated in two semi-structured interviews and a member-checking process. The data were analyzed from a three-dimensional inquiry space of time and continuity, place and context, and social interactions. The findings affirmed three core threads that wove the participants' lived experiences within the program together with their life histories after the intervention. These were enjoyment, learning, and sharing. Four themes revealed the essential elements of the lived experience, and three others exposed participants' growth and life enrichment, all being fundamental to participation. The 3-year community-level intervention was valued and a novel opportunity for facilitating participation and successful aging. It allowed the participants to acquire an evolved vision of self, have meaningful interactions, develop the means to engage in future community activities, implement new self-care strategies, and establish memories and friendships significant for life participation.
Language	English
Publishing date	2024-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1275716-0
ISSN	1552-7557 ; 1049-7323
ISSN (online)	1552-7557
ISSN	1049-7323
DOI	10.1177/10497323241228187
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Article: Hospitalization budget impact during the COVID-19 pandemic in Spain.

Carrera-Hueso, F J / Álvarez-Arroyo, L / Poquet-Jornet, J E / Vázquez-Ferreiro, P / Martínez-Gonzalbez, R / El-Qutob, D / Ramón-Barrios, M A / Martínez-Martínez, F / Poveda-Andrés, J L / Crespo-Palomo, C

Health economics review

2021 Volume 11, Issue 1, Page(s) 43

Abstract: Objectives: The aim was to determine the direct impact of the COVID-19 pandemic on Spain's health budget.: Methods: Budget impact analyses based on retrospective data from patients with suspected severe acute respiratory syndrome coronavirus 2 (SARS- ... ...

Abstract	Objectives: The aim was to determine the direct impact of the COVID-19 pandemic on Spain's health budget. Methods: Budget impact analyses based on retrospective data from patients with suspected severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) admitted to a Spanish hospital between February 26 and May 21, 2020. Direct medical costs from the perspective of the hospital were calculated. We analyzed diagnostic tests, drugs, medical and nursing care, and isolation ward and ICU stays for three cohorts: patients seen in the emergency room only, hospitalized patients who tested positive for SARS-CoV-2, and patients who tested negative. Results: The impact on the hospital's budget for the 3 months was calculated at €15,633,180, 97.4% of which was related to health care and hospitalization. ICU stays accounted for 5.3% of the total costs. The mean cost per patient was €10,744. The main costs were staffing costs (10,131 to 11,357 €/patient for physicians and 10,274 to 11,215 €/patient for nurses). Scenario analysis showed that the range of hospital expenditure was between €14,693,256 and €16,524,924. The median impact of the pandemic on the Spanish health budget in the sensitivity analysis using bootstrapped individual data was €9357 million (interquartile range [IQR], 9071 to 9689) for the conservative scenario (113,588 hospital admissions and 11,664 ICU admissions) and €10,385 million (IQR, 110,030 to 10,758) for the worst-case scenario (including suspected cases). Conclusion: The impact of COVID-19 on the Spanish public health budget (12.3% of total public health expenditure) is greater than multiple sclerosis, cancer and diabetes cost.
Language	English
Publishing date	2021-11-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2634483-X
ISSN	2191-1991
ISSN	2191-1991
DOI	10.1186/s13561-021-00340-0
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Article ; Online: Prostatitis: A Review.

Yebes, A / Toribio-Vazquez, C / Martinez-Perez, S / Quesada-Olarte, J M / Rodriguez-Serrano, A / Álvarez-Maestro, M / Martinez-Piñeiro, L

Current urology reports

2023 Volume 24, Issue 5, Page(s) 241–251

Abstract: Purpose of review: Pathologies of the prostate in men are one of the most prevalent clinical conditions today [1]. Specifically, pelvic inflammatory disease such as prostatitis can cause symptoms and syndromes different from urological ones, such as ... ...

Abstract	Purpose of review: Pathologies of the prostate in men are one of the most prevalent clinical conditions today [1]. Specifically, pelvic inflammatory disease such as prostatitis can cause symptoms and syndromes different from urological ones, such as bowel or nervous system manifestations. This has a largely negative impact on the quality of life of patients. Therefore, it is convenient to know and update the information about the therapeutic approach to prostatitis, which is a challenge that involves different medical specialties. The aim of this article is to provide summarized and focused evidence to help in the therapeutic approach of patients with prostatitis. A computer-based search of the PubMed and Cochrane Library databases was used to perform a comprehensive literature review on prostatitis, with special interest in recent findings and latest therapeutic guideline recommendations. Recent findings: Recent discoveries about the epidemiology and clinical classifications of prostatitis seem to incur in an increasingly individualized and directed management, with the aim of covering all the confluent factors in prostatic inflammatory pathology. In addition, the role of new drugs and combination with phytotherapy open up a range of new treatment possibilities, although future randomized studies will be necessary to better understand how to use all treatment modalities. Despite all the knowledge acquired about the pathophysiology of prostate diseases, and due to their interrelation with other pelvic systems and organs, there are still gaps that make it difficult for us to provide an optimal and standardized treatment in many of our patients. Being aware of the influence of all the factors potentially involved in prostate symptoms is crucial for a correct diagnosis and establishing an effective treatment plan.
MeSH term(s)	Male ; Humans ; Chronic Disease ; Prostatitis/diagnosis ; Quality of Life ; Pelvic Pain/therapy ; Phytotherapy/adverse effects
Language	English
Publishing date	2023-03-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057354-6
ISSN	1534-6285 ; 1527-2737
ISSN (online)	1534-6285
ISSN	1527-2737
DOI	10.1007/s11934-023-01150-z
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Article ; Online: Assessing sedation in PICU: clinical scales or BIS analysis?

Vázquez Martínez, J L

Minerva anestesiologica

2012 Volume 78, Issue 3, Page(s) 286–287

MeSH term(s)	Child Behavior ; Conscious Sedation ; Consciousness Monitors ; Drug Overdose/diagnosis ; Female ; Health Status Indicators ; Humans ; Hypnotics and Sedatives/administration & dosage ; Intensive Care Units, Pediatric ; Male ; Respiration, Artificial/psychology ; Stress, Psychological/prevention & control ; Suction/psychology
Chemical Substances	Hypnotics and Sedatives
Language	English
Publishing date	2012-03
Publishing country	Italy
Document type	Comment ; Editorial
ZDB-ID	123584-9
ISSN	1827-1596 ; 0026-4717 ; 0375-9393
ISSN (online)	1827-1596
ISSN	0026-4717 ; 0375-9393
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