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  1. Article ; Online: Transurethral Renal Pelvic Denervation: A Feasibility Trial in Patients with Uncontrolled Hypertension.

    Hering, Dagmara / Nikoleishvili, David / Imedadze, Avtandil / Dughashvili, Gvantsa / Klimiashvili, Zurab / Bekaia, Eter / Shengelia, Tamar / Kobalava, Mamuka / Goguadze, Otar / Emukhvari, Tamar / Druker, Vitaly / Sackner-Bernstein, Jonathan / Weber, Michael A

    Hypertension (Dallas, Tex. : 1979)

    2022  Volume 79, Issue 12, Page(s) 2787–2795

    Abstract: Background: Endovascular renal denervation reduces blood pressure (BP). We explored an alternative approach to renal denervation using radiofrequency energy delivered across the renal pelvis utilizing the natural orifice of the urethra and the ureters.!# ...

    Abstract Background: Endovascular renal denervation reduces blood pressure (BP). We explored an alternative approach to renal denervation using radiofrequency energy delivered across the renal pelvis utilizing the natural orifice of the urethra and the ureters.
    Methods: This open-label, single-arm feasibility study enrolled patients with uncontrolled hypertension despite antihypertensive drug therapy. The primary effectiveness endpoint was the change in ambulatory daytime systolic BP (SBP) 2 months following renal pelvic denervation.
    Results: The 18 patients (mean age 56±12 years) enrolled were taking an average of 2.7 antihypertensive drugs daily. Renal pelvic denervation reduced mean daytime SBP by 19.4 mm Hg (95% CI, -24.9 to -14.0,
    Conclusions: Based on these initial findings, a well-powered, sham-controlled trial of renal pelvic denervation to more fully establish its safety and effectiveness is now justified in patients with uncontrolled hypertension despite drug therapy.
    Registration: URL: https://www.
    Clinicaltrials: gov; Unique identifier: NCT05440513.
    MeSH term(s) Adult ; Aged ; Humans ; Middle Aged ; Antihypertensive Agents/therapeutic use ; Blood Pressure/physiology ; Blood Pressure Monitoring, Ambulatory ; Denervation/methods ; Feasibility Studies ; Hypertension/diagnosis ; Hypertension/surgery ; Hypertension/drug therapy ; Kidney ; Kidney Pelvis/surgery ; Renal Artery ; Sympathectomy/methods ; Treatment Outcome
    Chemical Substances Antihypertensive Agents
    Language English
    Publishing date 2022-10-18
    Publishing country United States
    Document type Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 423736-5
    ISSN 1524-4563 ; 0194-911X ; 0362-4323
    ISSN (online) 1524-4563
    ISSN 0194-911X ; 0362-4323
    DOI 10.1161/HYPERTENSIONAHA.122.20048
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Dietary Intervention for Overweight and Obese Adults: Comparison of Low-Carbohydrate and Low-Fat Diets. A Meta-Analysis.

    Sackner-Bernstein, Jonathan / Kanter, David / Kaul, Sanjay

    PloS one

    2015  Volume 10, Issue 10, Page(s) e0139817

    Abstract: Background: Reduced calorie, low fat diet is currently recommended diet for overweight and obese adults. Prior data suggest that low carbohydrate diets may also be a viable option for those who are overweight and obese.: Purpose: Compare the effects ... ...

    Abstract Background: Reduced calorie, low fat diet is currently recommended diet for overweight and obese adults. Prior data suggest that low carbohydrate diets may also be a viable option for those who are overweight and obese.
    Purpose: Compare the effects of low carbohydrate versus low fats diet on weight and atherosclerotic cardiovascular disease risk in overweight and obese patients.
    Data sources: Systematic literature review via PubMed (1966-2014).
    Study selection: Randomized controlled trials with ≥8 weeks follow up, comparing low carbohydrate (≤120gm carbohydrates/day) and low fat diet (≤30% energy from fat/day).
    Data extraction: Data were extracted and prepared for analysis using double data entry. Prior to identification of candidate publications, the outcomes of change in weight and metabolic factors were selected as defined by Cochrane Collaboration. Assessment of the effects of diets on predicted risk of atherosclerotic cardiovascular disease risk was added during the data collection phase.
    Data synthesis: 1797 patients were included from 17 trials with <1 year follow up in 12. Compared with low fat diet, low carbohydrate was associated with significantly greater reduction in weight (Δ = -2.0 kg, 95% CI: -3.1, -0.9) and significantly lower predicted risk of atherosclerotic cardiovascular disease events (p<0.03). Frequentist and Bayesian results were concordant. The probability of greater weight loss associated with low carbohydrate was >99% while the reduction in predicted risk favoring low carbohydrate was >98%.
    Limitations: Lack of patient-level data and heterogeneity in dropout rates and outcomes reported.
    Conclusions: This trial-level meta-analysis of randomized controlled trials comparing LoCHO diets with LoFAT diets in strictly adherent populations demonstrates that each diet was associated with significant weight loss and reduction in predicted risk of ASCVD events. However, LoCHO diet was associated with modest but significantly greater improvements in weight loss and predicted ASCVD risk in studies from 8 weeks to 24 months in duration. These results suggest that future evaluations of dietary guidelines should consider low carbohydrate diets as effective and safe intervention for weight management in the overweight and obese, although long-term effects require further investigation.
    MeSH term(s) Adult ; Diet, Carbohydrate-Restricted ; Diet, Fat-Restricted ; Humans ; Obesity/diet therapy ; Overweight/diet therapy ; Treatment Outcome
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0139817
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  3. Article: Management of diuretic-refractory, volume-overloaded patients with acutely decompensated heart failure.

    Sackner-Bernstein, Jonathan D

    Current cardiology reports

    2005  Volume 7, Issue 3, Page(s) 204–210

    Abstract: Fluid overload is a common presentation for decompensated heart failure, yet management strategies are poorly defined because of relatively few randomized clinical trials that delineate an optimal strategy. Patients refractory to diuretic therapy may be ... ...

    Abstract Fluid overload is a common presentation for decompensated heart failure, yet management strategies are poorly defined because of relatively few randomized clinical trials that delineate an optimal strategy. Patients refractory to diuretic therapy may be considered for treatment with inotropes or vasodilators, and others may be considered for venovenous ultrafiltration. The rationale for use of each therapy is reviewed.
    MeSH term(s) Cardiotonic Agents/therapeutic use ; Diuretics/therapeutic use ; Dobutamine/therapeutic use ; Edema/drug therapy ; Edema/etiology ; Heart Failure/physiopathology ; Heart Failure/therapy ; Hemofiltration ; Humans ; Patient Care Management ; Renal Dialysis ; Treatment Outcome ; Vasodilator Agents/therapeutic use
    Chemical Substances Cardiotonic Agents ; Diuretics ; Vasodilator Agents ; Dobutamine (3S12J47372)
    Language English
    Publishing date 2005-03-31
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055373-0
    ISSN 1523-3782
    ISSN 1523-3782
    DOI 10.1007/s11886-005-0078-3
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  4. Article: Practical guidelines to optimize effectiveness of beta-blockade in patients postinfarction and in those with chronic heart failure.

    Sackner-Bernstein, Jonathan D

    The American journal of cardiology

    2004  Volume 93, Issue 9A, Page(s) 69B–73B

    Abstract: Antiadrenergic therapy reduces the risks of death and major morbidity in patients postinfarction and in those with chronic heart failure. Despite the common perception, these benefits are not attributable to a class effect, and clinical trials reveal ... ...

    Abstract Antiadrenergic therapy reduces the risks of death and major morbidity in patients postinfarction and in those with chronic heart failure. Despite the common perception, these benefits are not attributable to a class effect, and clinical trials reveal evidence of specific agents that provide clinical advantages. To optimize patient outcome in the postinfarction setting, propranolol or timolol should be used in the setting of preserved ventricular function, and carvedilol should be used in patients with impaired ventricular function, with or without clinical evidence of heart failure. Patients with chronic heart failure are at lower risk of death when treated with carvedilol, which is also associated with a lower incidence of developing diabetes mellitus-related adverse events. This article reviews the scientific evidence for the hierarchy of antiadrenergic agents and addresses practical issues associated with initiation of therapy and long-term management.
    MeSH term(s) Adrenergic beta-Antagonists/therapeutic use ; Chronic Disease ; Clinical Trials as Topic ; Heart Failure/drug therapy ; Heart Failure/physiopathology ; Humans ; Myocardial Infarction/drug therapy ; Myocardial Infarction/physiopathology
    Chemical Substances Adrenergic beta-Antagonists
    Language English
    Publishing date 2004-05-06
    Publishing country United States
    Document type Guideline ; Journal Article
    ZDB-ID 80014-4
    ISSN 1879-1913 ; 0002-9149
    ISSN (online) 1879-1913
    ISSN 0002-9149
    DOI 10.1016/j.amjcard.2004.01.029
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  5. Article: New evidence from the CAPRICORN Trial: the role of carvedilol in high-risk, post-myocardial infarction patients.

    Sackner-Bernstein, Jonathan D

    Reviews in cardiovascular medicine

    2003  Volume 4 Suppl 3, Page(s) S25–9

    Abstract: The CAPRICORN (Carvedilol Post-Infarct Survival Control in Left Ventricular Dysfunction) trial established that the beta-blocker carvedilol reduces the risk of death in patients with left ventricular dysfunction post myocardial infarction, whether or not ...

    Abstract The CAPRICORN (Carvedilol Post-Infarct Survival Control in Left Ventricular Dysfunction) trial established that the beta-blocker carvedilol reduces the risk of death in patients with left ventricular dysfunction post myocardial infarction, whether or not the infarct is complicated by clinical heart failure. Thus, the utility of the beta-blocker carvedilol is confirmed in the modern era as an adjunct to revascularization, angiotensin-converting enzyme inhibitors, aspirin, and statins. In addition, the results prompt us to review the prior studies of beta-blockers postinfarction. Critical review of CAPRICORN and earlier beta-blocker studies suggests that specific beta-blockers should be matched to specific clinical scenarios. The COMET (Carvedilol or Metoprolol European Trial) study reinforces this view by establishing that beta-blockers are not simply interchangeable agents.
    MeSH term(s) Adrenergic beta-Antagonists/therapeutic use ; Carbazoles/therapeutic use ; Drug Therapy, Combination ; Humans ; Myocardial Infarction/drug therapy ; Myocardial Infarction/mortality ; Myocardial Infarction/physiopathology ; Propanolamines/therapeutic use ; Randomized Controlled Trials as Topic ; Recurrence ; Ventricular Dysfunction, Left/drug therapy ; Ventricular Dysfunction, Left/mortality ; Ventricular Dysfunction, Left/physiopathology
    Chemical Substances Adrenergic beta-Antagonists ; Carbazoles ; Propanolamines ; carvedilol (0K47UL67F2)
    Language English
    Publishing date 2003
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2108910-3
    ISSN 1530-6550
    ISSN 1530-6550
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  6. Article ; Online: Risk of death associated with nesiritide in patients with acutely decompensated heart failure.

    Aaronson, Keith D / Sackner-Bernstein, Jonathan

    JAMA

    2006  Volume 296, Issue 12, Page(s) 1465–1466

    MeSH term(s) Heart Failure/drug therapy ; Heart Failure/mortality ; Humans ; Meta-Analysis as Topic ; Natriuretic Agents/adverse effects ; Natriuretic Agents/therapeutic use ; Natriuretic Peptide, Brain/adverse effects ; Natriuretic Peptide, Brain/therapeutic use ; Proportional Hazards Models ; Risk
    Chemical Substances Natriuretic Agents ; Natriuretic Peptide, Brain (114471-18-0)
    Language English
    Publishing date 2006-09-27
    Publishing country United States
    Document type Letter
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.296.12.1465
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  7. Article: Nesiritide for acute decompensated heart failure: does the benefit justify the risk?

    Sackner-Bernstein, Jonathan / Aaronson, Keith D

    Current cardiology reports

    2006  Volume 9, Issue 3, Page(s) 187–193

    Abstract: Nesiritide is US Food and Drug Administration-approved for the treatment of patients with acutely decompensated heart failure who suffer from symptoms at rest or with minimal exertion. Its approval was based on a clinical development program that focused ...

    Abstract Nesiritide is US Food and Drug Administration-approved for the treatment of patients with acutely decompensated heart failure who suffer from symptoms at rest or with minimal exertion. Its approval was based on a clinical development program that focused on surrogates and short-term effects on symptoms rather than clinical outcomes. The association between its use and subsequent risk of death raises the question of whether the endpoints assessed in the clinical development program were adequate, and provides the opportunity to evaluate the process of weighing risks with benefits. We conclude that with nesiritide, the risks of therapy outweigh the benefits demonstrated to date.
    MeSH term(s) Acute Disease ; Animals ; Biomarkers ; Clinical Trials as Topic ; Heart Failure/drug therapy ; Humans ; Natriuretic Agents/adverse effects ; Natriuretic Agents/therapeutic use ; Natriuretic Peptide, Brain/adverse effects ; Natriuretic Peptide, Brain/therapeutic use ; Renal Insufficiency/chemically induced ; Risk Factors
    Chemical Substances Biomarkers ; Natriuretic Agents ; Natriuretic Peptide, Brain (114471-18-0)
    Language English
    Publishing date 2006-06-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2055373-0
    ISSN 1523-3782
    ISSN 1523-3782
    DOI 10.1007/bf02938349
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  8. Article ; Online: Nesiritide--not verified.

    Sackner-Bernstein, Jonathan / Aaronson, Keith D

    The New England journal of medicine

    2005  Volume 353, Issue 14, Page(s) 1525–7; author reply 1525–7

    MeSH term(s) Drug Approval ; Dyspnea/drug therapy ; Heart Failure/drug therapy ; Humans ; Natriuretic Agents/adverse effects ; Natriuretic Peptide, Brain/adverse effects ; United States ; United States Food and Drug Administration
    Chemical Substances Natriuretic Agents ; Natriuretic Peptide, Brain (114471-18-0)
    Language English
    Publishing date 2005-10-06
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc052142
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  9. Article: What is the role of biventricular pacing the transplant candidate?

    Sackner-Bernstein, Jonathan / Farmer, D Michael

    Coronary artery disease

    2004  Volume 15, Issue 2, Page(s) 81–85

    MeSH term(s) Cardiac Pacing, Artificial/methods ; Cost-Benefit Analysis ; Heart Failure/physiopathology ; Heart Failure/therapy ; Heart Transplantation ; Humans ; Quality of Life
    Language English
    Publishing date 2004-02-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1047268-x
    ISSN 1473-5830 ; 0954-6928
    ISSN (online) 1473-5830
    ISSN 0954-6928
    DOI 10.1097/00019501-200403000-00002
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  10. Article: Racing away from bias.

    Sackner-Bernstein, Jonathan D / Skopicki, Hal A

    Journal of the American College of Cardiology

    2004  Volume 43, Issue 5, Page(s) 785–786

    MeSH term(s) African Americans ; Bias ; European Continental Ancestry Group ; Heart Failure/ethnology ; Heart Failure/genetics ; Heart Failure/therapy ; Hospitalization ; Humans
    Language English
    Publishing date 2004-03-03
    Publishing country United States
    Document type Comparative Study ; Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2003.12.013
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