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  1. Article ; Online: A joint Bayesian hierarchical model for estimating SARS-CoV-2 genomic and subgenomic RNA viral dynamics and seroconversion.

    Dong, Tracy Q / Brown, Elizabeth R

    Biostatistics (Oxford, England)

    2023  Volume 25, Issue 2, Page(s) 336–353

    Abstract: Understanding the viral dynamics of and natural immunity to the severe acute respiratory syndrome coronavirus 2 is crucial for devising better therapeutic and prevention strategies for coronavirus disease 2019 (COVID-19). Here, we present a Bayesian ... ...

    Abstract Understanding the viral dynamics of and natural immunity to the severe acute respiratory syndrome coronavirus 2 is crucial for devising better therapeutic and prevention strategies for coronavirus disease 2019 (COVID-19). Here, we present a Bayesian hierarchical model that jointly estimates the genomic RNA viral load, the subgenomic RNA (sgRNA) viral load (correlated to active viral replication), and the rate and timing of seroconversion (correlated to presence of antibodies). Our proposed method accounts for the dynamical relationship and correlation structure between the two types of viral load, allows for borrowing of information between viral load and antibody data, and identifies potential correlates of viral load characteristics and propensity for seroconversion. We demonstrate the features of the joint model through application to the COVID-19 post-exposure prophylaxis study and conduct a cross-validation exercise to illustrate the model's ability to impute the sgRNA viral trajectories for people who only had genomic RNA viral load data.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19 ; Subgenomic RNA ; Seroconversion ; Bayes Theorem ; Antibodies, Viral ; Genomics
    Chemical Substances Subgenomic RNA ; Antibodies, Viral
    Language English
    Publishing date 2023-07-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2031500-4
    ISSN 1468-4357 ; 1465-4644
    ISSN (online) 1468-4357
    ISSN 1465-4644
    DOI 10.1093/biostatistics/kxad016
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  2. Article ; Online: An unexpected cause of weight loss in a teenaged girl.

    Dong, Elizabeth E / Joshi, Neha / Tse, Gabriel

    Journal of paediatrics and child health

    2023  Volume 59, Issue 7, Page(s) 922–924

    MeSH term(s) Adolescent ; Female ; Humans ; Diagnosis, Differential ; Weight Loss
    Language English
    Publishing date 2023-05-12
    Publishing country Australia
    Document type Case Reports ; Research Support, N.I.H., Extramural
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/jpc.16424
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  3. Article: Synchronized Incidental Affect Changes Ambiguity Preferences.

    Sambrano, Deshawn / Dong, Bryan / Glimcher, Paul / Phelps, Elizabeth A

    Research square

    2024  

    Abstract: Decisions under uncertainty are prevalent, but come under two distinct types. Risk, which has unknown outcomes but known probabilities for those outcomes and ambiguity which contains both unknown outcomes and unknown probabilities. Although there have ... ...

    Abstract Decisions under uncertainty are prevalent, but come under two distinct types. Risk, which has unknown outcomes but known probabilities for those outcomes and ambiguity which contains both unknown outcomes and unknown probabilities. Although there have been several studies linking affect and aversion to ambiguity, there have been no studies that have to identify how changing one's affective response can change their choices. A total of 166 adults (
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3873970/v1
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  4. Article ; Online: Divergent Recommen-dations for Management of Gastric Intestinal Metaplasia vs Barrett's Esophagus: A Matter of Social Justice.

    Dong, Elizabeth / Wu, Bechien U

    The American journal of gastroenterology

    2021  Volume 116, Issue 4, Page(s) 842–843

    MeSH term(s) Barrett Esophagus/diagnosis ; Barrett Esophagus/therapy ; Disease Management ; Humans ; Metaplasia/diagnosis ; Metaplasia/therapy ; Social Justice ; Stomach/pathology ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/therapy
    Language English
    Publishing date 2021-05-12
    Publishing country United States
    Document type Letter
    ZDB-ID 390122-1
    ISSN 1572-0241 ; 0002-9270
    ISSN (online) 1572-0241
    ISSN 0002-9270
    DOI 10.14309/ajg.0000000000000977
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  5. Book ; Online: A joint Bayesian hierarchical model for estimating SARS-CoV-2 diagnostic and subgenomic RNA viral dynamics and seroconversion

    Dong, Tracy Q. / Brown, Elizabeth R.

    2023  

    Abstract: Understanding the viral dynamics and immunizing antibodies of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for devising better therapeutic and prevention strategies for COVID-19. Here, we present a Bayesian hierarchical ... ...

    Abstract Understanding the viral dynamics and immunizing antibodies of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for devising better therapeutic and prevention strategies for COVID-19. Here, we present a Bayesian hierarchical model that jointly estimates the diagnostic RNA viral load reflecting genomic materials of SARS-CoV-2, the subgenomic RNAs (sgRNA) viral load reflecting active viral replication, and the rate and timing of seroconversion reflecting presence of antibodies. Our proposed method accounts for the dynamical relationship and correlation structure between the two types of viral load, allows for borrowing of information between viral load and antibody data, and identifies potential correlates of viral load characteristics and propensity for seroconversion. We demonstrate the features of the joint model through application to the COVID-19 PEP study and conduct a cross-validation exercise to illustrate the model's ability to impute the sgRNA viral trajectories for people who only had diagnostic viral load data.
    Keywords Statistics - Applications ; Quantitative Biology - Biomolecules ; Statistics - Methodology
    Publishing date 2023-01-09
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Technology-Based Postural Apparel as a Sustainable and Cost-Effective Solution to Musculoskeletal Pain and Injury in the Dermatologic Surgeon.

    Lleonart, Elizabeth / Dong, Joanna / Abrouk, Michael / Chesnut, Cameron

    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

    2022  Volume 47, Issue 9, Page(s) 1326–1328

    MeSH term(s) Clothing ; Cost-Benefit Analysis ; Dermatologic Surgical Procedures ; Humans ; Musculoskeletal Pain/prevention & control ; Occupational Diseases/prevention & control ; Posture ; Surgeons
    Language English
    Publishing date 2022-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1227586-4
    ISSN 1524-4725 ; 1076-0512
    ISSN (online) 1524-4725
    ISSN 1076-0512
    DOI 10.1097/DSS.0000000000003084
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  7. Article ; Online: Aqueous/non-aqueous electrolyte tradeoffs in charge transfer and electrochromics of pseudocapacitive oxide films.

    Benhaddouch, Tinsley Elizabeth / Bhansali, Shekhar / Dong, Dongmei

    RSC advances

    2022  Volume 12, Issue 48, Page(s) 31264–31275

    Abstract: Environmental sustainability, safety, cost, and performance are the driving metrics for modern technological developments. Progress in these realms has been made for electrochromic (EC) devices by optimizing anode/cathode electrode materials. Yet, by ... ...

    Abstract Environmental sustainability, safety, cost, and performance are the driving metrics for modern technological developments. Progress in these realms has been made for electrochromic (EC) devices by optimizing anode/cathode electrode materials. Yet, by these standards, the role of the electrolyte has remained unexplored. This investigation on charge transfer mechanisms at the electrolyte/electrode interface facilitates a contrast of the aqueous and non-aqueous electrolytes studied. A classic EC, high-performing, non-aqueous, lithium chlorine oxide in propylene carbonate (PC-LiClO
    Language English
    Publishing date 2022-11-01
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra05851k
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  8. Article ; Online: Aggregation-induced emission carbon dots as Al

    Hun Seo, Young / Elizabeth Aguilar Estrada, Diana / Jang, Dohyub / Baik, Seungyun / Lee, Jaeho / Ha Kim, Dong / Kim, Sehoon

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

    2024  Volume 310, Page(s) 123925

    Abstract: Worldwide abuse of tetracycline (TC) seriously threatens environmental safety and human health. Metal-TC complexes formed by residual TC in the environment can also contribute to the spread of antibiotic resistance. Therefore, monitoring of TC residues ... ...

    Abstract Worldwide abuse of tetracycline (TC) seriously threatens environmental safety and human health. Metal-TC complexes formed by residual TC in the environment can also contribute to the spread of antibiotic resistance. Therefore, monitoring of TC residues is still required. Here, we report novel aggregation-induced emission carbon dots (AIE-Cdots) as nanoaggregate probes for the rapid and selective detection of TC residue. Riboflavin precursors with rotational functional groups led to the development of AIE-Cdots. The aggregation of AIE-Cdots was induced selectively for Al
    MeSH term(s) Humans ; Carbon/chemistry ; Tetracycline ; Anti-Bacterial Agents ; Fluorescence ; Heterocyclic Compounds ; Fluorescent Dyes/chemistry ; Spectrometry, Fluorescence
    Chemical Substances Carbon (7440-44-0) ; Tetracycline (F8VB5M810T) ; Anti-Bacterial Agents ; Heterocyclic Compounds ; Fluorescent Dyes
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 210413-1
    ISSN 1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
    ISSN (online) 1873-3557
    ISSN 0370-8322 ; 0584-8539 ; 1386-1425
    DOI 10.1016/j.saa.2024.123925
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  9. Article ; Online: Development and characterization of a Gucy2d-cre mouse to selectively manipulate a subset of inhibitory spinal dorsal horn interneurons.

    Serafin, Elizabeth K / Yoo, Judy J / Li, Jie / Dong, Xinzhong / Baccei, Mark L

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0300282

    Abstract: Recent transcriptomic studies identified Gucy2d (encoding guanylate cyclase D) as a highly enriched gene within inhibitory dynorphin interneurons in the mouse spinal dorsal horn. To facilitate investigations into the role of the Gucy2d+ population in ... ...

    Abstract Recent transcriptomic studies identified Gucy2d (encoding guanylate cyclase D) as a highly enriched gene within inhibitory dynorphin interneurons in the mouse spinal dorsal horn. To facilitate investigations into the role of the Gucy2d+ population in somatosensation, Gucy2d-cre transgenic mice were created to permit chemogenetic or optogenetic manipulation of this subset of spinal neurons. Gucy2d-cre mice created via CRISPR/Cas9 genomic knock-in were bred to mice expressing a cre-dependent reporter (either tdTomato or Sun1.GFP fusion protein), and the resulting offspring were characterized. Surprisingly, a much wider population of spinal neurons was labeled by cre-dependent reporter expression than previous mRNA-based studies would suggest. Although the cre-dependent reporter expression faithfully labeled ~75% of cells expressing Gucy2d mRNA in the adult dorsal horn, it also labeled a substantial number of additional inhibitory neurons in which no Gucy2d or Pdyn mRNA was detected. Moreover, cre-dependent reporter was also expressed in various regions of the brain, including the spinal trigeminal nucleus, cerebellum, thalamus, somatosensory cortex, and anterior cingulate cortex. Injection of AAV-CAG-FLEX-tdTomato viral vector into adult Gucy2d-cre mice produced a similar pattern of cre-dependent reporter expression in the spinal cord and brain, which excludes the possibility that the unexpected reporter-labeling of cells in the deep dorsal horn and brain was due to transient Gucy2d expression during early stages of development. Collectively, these results suggest that Gucy2d is expressed in a wider population of cells than previously thought, albeit at levels low enough to avoid detection with commonly used mRNA-based assays. Therefore, it is unlikely that these Gucy2d-cre mice will permit selective manipulation of inhibitory signaling mediated by spinal dynorphin interneurons, but this novel cre driver line may nevertheless be useful to target a broader population of inhibitory spinal dorsal horn neurons.
    MeSH term(s) Mice ; Animals ; Dynorphins ; Spinal Cord Dorsal Horn ; Spinal Cord/metabolism ; Mice, Transgenic ; Interneurons/metabolism ; Posterior Horn Cells/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Guanylate Cyclase/metabolism ; Receptors, Cell Surface/metabolism ; Red Fluorescent Protein
    Chemical Substances Dynorphins (74913-18-1) ; tdTomato ; RNA, Messenger ; Gucy2d protein, mouse (EC 4.6.1.2) ; Guanylate Cyclase (EC 4.6.1.2) ; Receptors, Cell Surface ; Red Fluorescent Protein
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0300282
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  10. Article ; Online: Acute myeloid leukaemia relapse after allogeneic haematopoietic stem cell transplantation: Mechanistic diversity and therapeutic directions.

    Herrity, Elizabeth / Pereira, Mariana Pinto / Kim, Dennis Dong Hwan

    British journal of haematology

    2023  Volume 203, Issue 5, Page(s) 722–735

    Abstract: Emerging biological and clinical data, along with advances in new technologies, have exposed the mechanistic diversity in post-haematopoietic stem cell transplant (HCT) relapse. Post-HCT relapse mechanisms are relevant for guiding sophisticated selection ...

    Abstract Emerging biological and clinical data, along with advances in new technologies, have exposed the mechanistic diversity in post-haematopoietic stem cell transplant (HCT) relapse. Post-HCT relapse mechanisms are relevant for guiding sophisticated selection of therapeutic interventions and identification of areas for further research. Clonal evolution and emergence of resistant leukemic strains is a common mechanism shared by relapse post-chemotherapy and post-HCT, other mechanisms such as leukemic immune escape and donor T cell exhaustion are unique entities to post-HCT relapse. Due to diversity in the mechanisms behind post-HCT relapse, the subsequent clinical approach relies on clinician discretion, rather than objective evidence. Lack of standardized selection based on post-HCT relapse mechanism(s) could be a contributing factor to observed poor outcomes. Therapeutic strategies including donor lymphocyte infusion (DLI), second transplant, immunotherapies, hypomethylating agents, and targeted strategies are supported options and efficacy may be enhanced when post-HCT AML relapse mechanism is established and guides treatment selection. This review aims, through compilation of supporting studies, to describe mechanisms of post-HCT relapse and their implications for subsequent treatment selection and inspiration for future research.
    MeSH term(s) Humans ; Neoplasm Recurrence, Local/therapy ; Hematopoietic Stem Cell Transplantation ; Leukemia, Myeloid, Acute/therapy ; Transplantation, Homologous ; Immunotherapy ; Recurrence
    Language English
    Publishing date 2023-10-03
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19121
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