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  1. Article: Extensive myiasis of the leg in a patient with filarial lymphedema: implications for morbidity care in filariasis elimination program.

    Kuttiatt, Vijesh S / Venkatesan, Shakila / Srinivasan, Vaishnavi / De Britto, Lourduraj / Rahi, Manju / Kumar, Ashwani

    Journal of vector borne diseases

    2022  Volume 58, Issue 4, Page(s) 391–393

    Abstract: Myiasis, infestation of the human body by larva of flies is an under-recognized and ignored medical condition. Not only is this condition unsightly and extremely distressing to the patient, but it also generates a ghastly feeling in care givers and ... ...

    Abstract Myiasis, infestation of the human body by larva of flies is an under-recognized and ignored medical condition. Not only is this condition unsightly and extremely distressing to the patient, but it also generates a ghastly feeling in care givers and health care workers as well. The authors report extensive myiasis of the leg in a patient with filarial lymphedema from southern India, which is rarely illustrated in published literature. Treatment of myiasis is described in brief. There is a need for strengthening morbidity management in filariasis elimination program.
    MeSH term(s) Elephantiasis, Filarial/complications ; Humans ; Leg ; Lymphedema ; Morbidity ; Myiasis/diagnosis
    Language English
    Publishing date 2022-04-05
    Publishing country India
    Document type Case Reports
    ZDB-ID 2161218-3
    ISSN 0972-9062
    ISSN 0972-9062
    DOI 10.4103/0972-9062.318314
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  2. Article ; Online: Should Schools Reopen Early or Late? - Transmission Dynamics of COVID-19 in Children.

    Kuttiatt, Vijesh S / Menon, Ramesh P / Abraham, Philip Raj / Sharma, Shilpa

    Indian journal of pediatrics

    2020  Volume 87, Issue 9, Page(s) 755–756

    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Child ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; Risk ; SARS-CoV-2 ; Schools
    Keywords covid19
    Language English
    Publishing date 2020-06-16
    Publishing country India
    Document type Letter
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-020-03401-0
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  4. Article ; Online: Should Schools Reopen Early or Late? – Transmission Dynamics of COVID-19 in Children

    Kuttiatt, Vijesh S / Menon, Ramesh P / Abraham, Philip Raj / Sharma, Shilpa

    The Indian Journal of Pediatrics

    2020  Volume 87, Issue 9, Page(s) 755–756

    Keywords Pediatrics, Perinatology, and Child Health ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-020-03401-0
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  5. Article ; Online: Evaluation of the mosquitocidal efficacy of fluralaner, a potential candidate for drug based vector control.

    Shah, Harish Kumar / Srinivasan, Vaishnavi / Venkatesan, Shakila / Balakrishnan, Vijayakumar / Candasamy, Sadanandane / Mathew, Nisha / Kumar, Ashwani / Kuttiatt, Vijesh Sreedhar

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5628

    Abstract: Vector control is a key intervention against mosquito borne diseases. However, conventional methods have several limitations and alternate strategies are in urgent need. Vector control with endectocides such as ivermectin is emerging as a novel strategy. ...

    Abstract Vector control is a key intervention against mosquito borne diseases. However, conventional methods have several limitations and alternate strategies are in urgent need. Vector control with endectocides such as ivermectin is emerging as a novel strategy. The short half-life of ivermectin is a limiting factor for its application as a mass therapy tool for vector control. Isoxazoline compounds like fluralaner, a class of veterinary acaricides with long half-life hold promise as an alternative. However, information about their mosquitocidal effect is limited. We explored the efficacy of fluralaner against laboratory reared vector mosquitoes-Aedes aegypti, Anopheles stephensi, and, Culex quinquefasciatus. 24 h post-blood feeding, fluralaner showed a significant mosquitocidal effect with LC
    MeSH term(s) Animals ; Ivermectin/pharmacology ; Insecticides/pharmacology ; Mosquito Vectors ; Larva ; Culex ; Anopheles ; Aedes ; Plant Extracts/pharmacology ; Isoxazoles
    Chemical Substances Ivermectin (70288-86-7) ; A1443 compound ; Insecticides ; Plant Extracts ; Isoxazoles
    Language English
    Publishing date 2024-03-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56053-x
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  6. Article ; Online: Frequency and Clinical Significance of Localized Adverse Events following Mass Drug Administration for Lymphatic Filariasis in an Endemic Area in South India.

    Kuttiatt, Vijesh Sreedhar / Somani, Roopali K / Swaminathan, Subramanian / Krishnamoorthy, Kaliannagounder / Weil, Gary J / Purushothaman, Jambulingam

    The American journal of tropical medicine and hygiene

    2019  Volume 102, Issue 1, Page(s) 96–99

    Abstract: Fear of adverse events (AEs) negatively affects compliance to mass drug administration (MDA) for lymphatic filariasis (LF) elimination program. Systemic AEs are believed to occur because of killing of microfilariae, whereas localized soft tissue ... ...

    Abstract Fear of adverse events (AEs) negatively affects compliance to mass drug administration (MDA) for lymphatic filariasis (LF) elimination program. Systemic AEs are believed to occur because of killing of microfilariae, whereas localized soft tissue reactions might be due to the death of adult worms following therapy. Most AEs are mild and self-limited. However, localized AEs are sometimes more significant and of concern to participants. Here, we describe localized AEs that were noted during a large community study that evaluated the safety of a triple-drug regimen (ivermectin, diethylcarbamazine, and albendazole) for the treatment of LF in India. We have also discussed the importance of timely detection and careful management of AEs for preserving community confidence in MDA.
    MeSH term(s) Adolescent ; Adult ; Albendazole/administration & dosage ; Albendazole/adverse effects ; Albendazole/therapeutic use ; Anthelmintics/administration & dosage ; Anthelmintics/adverse effects ; Anthelmintics/therapeutic use ; Diethylcarbamazine/administration & dosage ; Diethylcarbamazine/adverse effects ; Diethylcarbamazine/therapeutic use ; Drug Therapy, Combination/adverse effects ; Elephantiasis, Filarial/prevention & control ; Female ; Humans ; India/epidemiology ; Ivermectin/administration & dosage ; Ivermectin/adverse effects ; Ivermectin/therapeutic use ; Male ; Mass Drug Administration
    Chemical Substances Anthelmintics ; Ivermectin (70288-86-7) ; Albendazole (F4216019LN) ; Diethylcarbamazine (V867Q8X3ZD)
    Language English
    Publishing date 2019-11-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.19-0532
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  7. Article ; Online: Detection of measles virus genotype B3, India.

    Kuttiatt, Vijesh S / Kalpathodi, Sanughosh / Gangadharan, Sindhu T / Kailas, Lalitha / Sreekumar, Easwaran / Sukumaran, Suja M / Nair, Radhakrishnan R

    Emerging infectious diseases

    2014  Volume 20, Issue 10, Page(s) 1764–1766

    MeSH term(s) Child ; Child, Preschool ; Female ; Genotype ; Humans ; India/epidemiology ; Infant ; Male ; Measles/epidemiology ; Measles/virology ; Measles virus/genetics ; Phylogeny
    Language English
    Publishing date 2014-07-31
    Publishing country United States
    Document type Letter
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2010.130742
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  8. Article ; Online: Detection of Measles Virus Genotype B3, India

    Vijesh S. Kuttiatt / Sanughosh Kalpathodi / Sindhu T. Gangadharan / Lalitha Kailas / Easwaran Sreekumar / Suja M. Sukumaran / Radhakrishnan R. Nair

    Emerging Infectious Diseases, Vol 20, Iss 10, Pp 1764-

    2014  Volume 1766

    Keywords measles ; virus ; genotype B3 ; Kerala ; India ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
    Language English
    Publishing date 2014-10-01T00:00:00Z
    Publisher Centers for Disease Control and Prevention
    Document type Article ; Online
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  9. Article ; Online: An open label, block randomized, community study of the safety and efficacy of co-administered ivermectin, diethylcarbamazine plus albendazole vs. diethylcarbamazine plus albendazole for lymphatic filariasis in India.

    Jambulingam, Purushothaman / Kuttiatt, Vijesh Sreedhar / Krishnamoorthy, Kaliannagounder / Subramanian, Swaminathan / Srividya, Adinarayanan / Raju, Hari Kishan K / Rahi, Manju / Somani, Roopali K / Suryaprakash, Mallanna K / Dwivedi, Gangeshwar P / Weil, Gary J

    PLoS neglected tropical diseases

    2021  Volume 15, Issue 2, Page(s) e0009069

    Abstract: Background: Better drug regimens for mass drug administration (MDA) could accelerate the Global Programme to Eliminate Lymphatic Filariasis (LF). This community study was designed to compare the safety and efficacy of MDA with IDA (ivermectin, ... ...

    Abstract Background: Better drug regimens for mass drug administration (MDA) could accelerate the Global Programme to Eliminate Lymphatic Filariasis (LF). This community study was designed to compare the safety and efficacy of MDA with IDA (ivermectin, diethylcarbamazine and albendazole) or DA (diethylcarbamazine and albendazole) in India.
    Methodology/principal findings: This two-armed, open-labelled, block randomised, community study was conducted in LF endemic villages in Yadgir district, Karnataka, India. Consenting participants ≥5 years of age were tested for circulating filarial antigenemia (CFA) and microfilaremia (Mf) before treatment with a single oral dose of IDA or DA. Adverse events (AEs) were monitored actively for two days and passively for five more days. Persons with positive CFA or Mf tests at baseline were retested 12-months post-treatment to assess treatment efficacy. Baseline CFA and Mf-rates were 26.4% and 6.9% in IDA and 24.5% and 6.4% in DA villages respectively. 4758 and 4160 participants received IDA and DA. Most AEs were mild after both treatments; fewer than 0.1% of participants experienced AEs with severity > grade 1. No serious AEs were observed. Fever, headache and dizziness were the most common AEs. AE rates were slightly higher after IDA than DA (8.3% vs. 6.4%, P<0.01). AEs were more frequent in females and Mf-positives after either treatment, but significantly more frequent after IDA (40.5% vs 20.2%, P < 0.001). IDA was more effective for clearing Mf than DA (84% vs. 61.8%, P < 0.001). Geometric mean Mf counts per 60μl in retested Mf-positives decreased by 96.4% from 11.8 after IDA and by 90.0% from 9.5 after DA. Neither treatment was effective for clearing CFA.
    Conclusions/significance: IDA had an acceptable safety profile and was more effective for clearing Mf than DA. With adequate compliance and medical support to manage AEs, IDA has the potential to accelerate LF elimination in India.
    Trial registration: Clinical Trial Registry of India (CTRI No/2016/10/007399).
    MeSH term(s) Adolescent ; Adult ; Albendazole/administration & dosage ; Albendazole/adverse effects ; Animals ; Child ; Diethylcarbamazine/administration & dosage ; Diethylcarbamazine/adverse effects ; Drug-Related Side Effects and Adverse Reactions ; Elephantiasis, Filarial/drug therapy ; Female ; Filaricides/administration & dosage ; Filaricides/adverse effects ; Humans ; India ; Ivermectin/administration & dosage ; Ivermectin/adverse effects ; Male ; Mass Drug Administration ; Wuchereria bancrofti/immunology ; Wuchereria bancrofti/isolation & purification
    Chemical Substances Filaricides ; Ivermectin (70288-86-7) ; Albendazole (F4216019LN) ; Diethylcarbamazine (V867Q8X3ZD)
    Language English
    Publishing date 2021-02-16
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2727
    ISSN (online) 1935-2735
    ISSN 1935-2727
    DOI 10.1371/journal.pntd.0009069
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  10. Article ; Online: Vaccination coverage and breakthrough infections of COVID-19 during the second wave among staff of selected medical institutions in India.

    Rahi, Manju / Yadav, Chander Prakash / Ahmad, Sundus Shafat / Nitika / Das, Payal / Sharma, Shweta / Baharia, Rajendra Kumar / Bhattacharya, Debdutta / Deshmukh, Pradeep / Dhatrak, Amey / Dogra, Sandeep / Eapen, Alex / Goel, Pawan / Faizi, Nafis / Khan, Siraj A / Kochar, Sanjay Kumar / Kochar, Aditya / Kumar, Ashwani / Mundra, Anuj /
    Narang, Rahul / Narain, Kanwar / Pandey, Krishna / Pati, Sanghamitra / Raghav, Pankaja / Ranjha, Ritesh / Shah, Salman / Singh, Kuldeep / Singh, Piyoosh Kumar / Singh, Raj Kumar / Kuttiatt, Vijesh Shreedhar / Soni, Ravinder / Sreehari, Uragayala / Malhotra, Sumit / Sharma, Amit

    PLOS global public health

    2023  Volume 3, Issue 4, Page(s) e0000946

    Abstract: India experienced the second wave of SARS-CoV-2 infection from April 3 to June 10, 2021. During the second wave, Delta variant B.1617.2 emerged as the predominant strain, spiking cases from 12.5 million to 29.3 million (cumulative) by the end of the ... ...

    Abstract India experienced the second wave of SARS-CoV-2 infection from April 3 to June 10, 2021. During the second wave, Delta variant B.1617.2 emerged as the predominant strain, spiking cases from 12.5 million to 29.3 million (cumulative) by the end of the surge in India. Vaccines against COVID-19 are a potent tool to control and end the pandemic in addition to other control measures. India rolled out its vaccination programme on January 16, 2021, initially with two vaccines that were given emergency authorization-Covaxin (BBV152) and Covishield (ChAdOx1 nCoV- 19). Vaccination was initially started for the elderly (60+) and front-line workers and then gradually opened to different age groups. The second wave hit when vaccination was picking up pace in India. There were instances of vaccinated people (fully and partially) getting infected, and reinfections were also reported. We undertook a survey of staff (front line health care workers and supporting) of 15 medical colleges and research institutes across India to assess the vaccination coverage, incidence of breakthrough infections, and reinfections among them from June 2 to July 10, 2021. A total of 1876 staff participated, and 1484 forms were selected for analysis after removing duplicates and erroneous entries (n = 392). We found that among the respondents at the time of response, 17.6% were unvaccinated, 19.8% were partially vaccinated (received the first dose), and 62.5% were fully vaccinated (received both doses). Incidence of breakthrough infections was 8.7% among the 801 individuals (70/801) tested at least 14 days after the 2nd dose of vaccine. Eight participants reported reinfection in the overall infected group and reinfection incidence rate was 5.1%. Out of (N = 349) infected individuals 243 (69.6%) were unvaccinated and 106 (30.3%) were vaccinated. Our findings reveal the protective effect of vaccination and its role as an essential tool in the struggle against this pandemic.
    Language English
    Publishing date 2023-04-07
    Publishing country United States
    Document type Journal Article
    ISSN 2767-3375
    ISSN (online) 2767-3375
    DOI 10.1371/journal.pgph.0000946
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