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Article ; Online: Should aspirin be used for prophylaxis of COVID-19-induced coagulopathy?

Mohamed-Hussein, Aliae A R / Aly, Karim M E / Ibrahim, Mohamed-Eltaher A A

2020 Volume 144, Page(s) 109975

MeSH term(s)	Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Anticoagulants/therapeutic use ; Aspirin/therapeutic use ; Autopsy ; Blood Coagulation Disorders/prevention & control ; Blood Coagulation Disorders/virology ; COVID-19/complications ; Hemorrhage/prevention & control ; Hemorrhage/virology ; Humans ; Models, Theoretical ; Stroke/complications ; Stroke/prevention & control ; COVID-19 Drug Treatment
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Anticoagulants ; Aspirin (R16CO5Y76E)
Keywords	covid19
Language	English
Publishing date	2020-06-08
Publishing country	United States
Document type	Letter
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2020.109975
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Article: Should aspirin be used for prophylaxis of COVID-19-induced coagulopathy?

Mohamed-Hussein, Aliae A R / Aly, Karim M E / Ibrahim, Mohamed-Eltaher A A

Med Hypotheses

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #594981
Database	COVID19

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Article ; Online: Should aspirin be used for prophylaxis of COVID-19-induced coagulopathy?

Mohamed-Hussein, Aliae A.R. / Aly, Karim M.E. / Ibrahim, Mohamed-Eltaher A.A.

Medical Hypotheses

2020 Volume 144, Page(s) 109975

Keywords	General Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2020.109975
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A meta analysis on the utility of Anakinra in severe COVID-19 disease.

Mohamed Hussein, Aliae A R / Sayad, Reem / Abdelshafi, Abdelrahman / Hammam, Islam Abdelaal / Kedwany, Ahmed M / Elkholy, Shrouk Alaa-Eldein / Ibrahim, Islam H

Cytokine

2023 Volume 169, Page(s) 156311

Abstract: Background and objective: The most important presentation of COVID-19 is hyper inflammatory condition and cytokine storm that occurs due to excessive increase of the inflammatory mediators specially, pro-inflammatory interleukins such as IL-1β, IL-6 and ...

Abstract	Background and objective: The most important presentation of COVID-19 is hyper inflammatory condition and cytokine storm that occurs due to excessive increase of the inflammatory mediators specially, pro-inflammatory interleukins such as IL-1β, IL-6 and tumor necrosis factor-α which have an important role in the cytokine storm pathway. Up till now there is not a definitive treatment for COVID-19 disease, but according to the pathophysiology of the disease, Anakinra (Interleukin- 1 inhibitor) is an adjuvant treatment option in patients with severe COVID-19 by blocking the effect of IL-1. So, we aimed to summarize the studies that evaluated the safety and efficacy of Anakinra in patients diagnosed with COVID-19. Methods: We performed a search in PubMed, Cochrane Library, Scopus, and Web of Science (WOS) databases from inception till 7 Jan 2022. Additionally, we searched randomized and non-randomized clinical trials, cohort, case series, case control, case report more than 3 patients which contain confirmed cases of COVID-19 who received Anakinra (Interleukin- 1 inhibitor) for the management of hyper-inflammatory condition associated with COVID-19 disease. A meta-analysis was conducted using review manager 5.4. Results: We included 44 articles in the systematic review. Ultimately, 23 studies were incorporated in the meta-analysis with a total number of 3179 patients. Our analysis showed statistically significant difference in the following outcomes: duration of ICU stays [MD = -0.65, 95% CI (-1.09, -0.03), p = 0.04], the number of patients who needed invasive mechanical ventilation [RR = 0.57, 95% CI (0.39, 0.84), p = 0.004], and number of deaths [RR = 0.80, 95% CI (0.66, 0.99), p = 0.04]. Our analysis showed no statistically significant difference in the following outcomes: length of hospital stays [MD = -0.16, 95% CI (-0.42, 0.11), p = 0.26], oxygen-free days [MD = -0.81, 95% CI (-3.81, 2.20), p = 0.60], and the number of patients who needed non-invasive mechanical ventilation [RR = 1.09, 95% CI (0.47, 2.52), p = 0.84]. Conclusion: Anakinra showed some promising results in important outcomes related to COVID-19 as it significantly reduced the rate of mortality and the need of invasive mechanical ventilation. It should be used in severe cases more than mild and moderate cases to avoid possible immunosuppression complications. Anakinra use is safe in cases of COVID-19 at dose less than 100 mg. Another important outcome was significant reduction is the D-dimer level. Anakinra may be effective in the treatment of specific immunocompromised cases, but it should be used cautiously.
MeSH term(s)	Humans ; COVID-19/therapy ; Cytokine Release Syndrome/drug therapy ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Respiration, Artificial ; Tumor Necrosis Factor-alpha
Chemical Substances	Interleukin 1 Receptor Antagonist Protein ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2023-08-01
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2023.156311
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Article: Emergence of Nosocomial Pneumonia Caused by Colistin-Resistant

El-Mokhtar, Mohamed A / Daef, Enas / Mohamed Hussein, Aliae A R / Hashem, Maiada K / Hassan, Hebatallah M

Antibiotics (Basel, Switzerland)

2021 Volume 10, Issue 3

Abstract: 1) Background: Colistin is a last-resort antibiotic used in treating multidrug-resistant Gram-negative infections. The growing emergence of colistin resistance ... ...

Abstract	(1) Background: Colistin is a last-resort antibiotic used in treating multidrug-resistant Gram-negative infections. The growing emergence of colistin resistance in
Language	English
Publishing date	2021-02-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics10030226
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Article ; Online: Association between hand grip strength with weaning and intensive care outcomes in COPD patients: A pilot study.

Mohamed-Hussein, Aliae A R / Makhlouf, Hoda A / Selim, Zahraa I / Gamaleldin Saleh, Waleed

The clinical respiratory journal

2018 Volume 12, Issue 10, Page(s) 2475–2479

Abstract: ... between baseline hand grip and duration of MV (P = .047, r = -.343). The mean day 5 hand grip was ...

Abstract	Background: In COPD, weight loss and muscle wasting contribute significantly to morbidity, disability, and handicap. Dominant-handgrip strength for evaluation of muscle strength has not been tested as a parameter to predict outcome of weaning from mechanical ventilation (MV). Objectives: To evaluate the association between handgrip strength and the duration and success of weaning and extubation outcome. Materials and methods: This prospective study included 34 COPD patients requiring MV for at least 48 hours. Recovery from sedation and muscle relaxants was assessed before recruitment. Serial meseaurment of handgrip strength were assessed by trained personnel. Results: There was a significant negative correlation between baseline hand grip and duration of MV (P = .047, r = -.343). The mean day 5 hand grip was significantly lower in person who died compared to survivors (5.7 ± 5.5 vs 18.2 ± 14.5, P = .044). The mean day 5 hand grip was significantly lower in patients who needed reintubation compared to those in patients who did not need reintubation (2.8 ± 2 vs 17.2 ± 13.9, P = .029). There was no significant difference in the mean baseline, day 2, day 3, day 4 and day 5 hand grip in weaning success compared to those in failure (P > .05). Conclusion: Handgrip strength may be good predictor for duration of MV, extubation outcome, ICU mortality and prognosis.
MeSH term(s)	Aged ; Airway Extubation/methods ; Cohort Studies ; Disability Evaluation ; Egypt ; Female ; Hand Strength/physiology ; Hospital Mortality ; Hospitals, University ; Humans ; Intensive Care Units ; Length of Stay ; Male ; Middle Aged ; Pilot Projects ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/mortality ; Pulmonary Disease, Chronic Obstructive/therapy ; Respiration, Artificial/methods ; Risk Assessment ; Survival Rate ; Ventilator Weaning/methods
Language	English
Publishing date	2018-09-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2442214-9
ISSN	1752-699X ; 1752-6981
ISSN (online)	1752-699X
ISSN	1752-6981
DOI	10.1111/crj.12921
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Article: Corona-like illness: Did we get it before who announcement of the disease? A cross-sectional survey

Mohamed-Hussein, Aliae A. R. / Makhlouf, Nahed A. / Yassa, Heba / Makhlouf, Hoda A.

Electro. J. Gen. Med.

Abstract: Background: In Wuhan, cases with pneumonia of unknown etiology were reported in December 2019 and Coronavirus, called SARS-CoV-2 was detected in the lower respiratory tract samples of these patients. WHO has declared the infection a Pandemic on March 11, ...

Abstract	Background: In Wuhan, cases with pneumonia of unknown etiology were reported in December 2019 and Coronavirus, called SARS-CoV-2 was detected in the lower respiratory tract samples of these patients. WHO has declared the infection a Pandemic on March 11, 2020. The most common symptoms of COVID-19 were fever, dry cough, fatigue, and dyspnea, myalgia. The aim of the study: To determine the frequency of people who assume they got, “Corona-like illness” before WHO announcement of the disease. Describe their demography and character of the disease. Material and Methods: This cross-sectional web-based anonymous survey study included participants who were fulfilling online designed questionnaire. Results: Most of the individuals that fill the questionnaire were in the age group (31-40 years old), most of them were from Egypt 91.5%, 10.7% were smokers, 6.7% of them with cardiac – hypertension and myocardial ischemia, 47.9% of them with allergic rhinitis and 23.4% with asthma. In total, 55.2% of those who fill the questionnaire have the experience of symptoms like coronavirus symptoms in October, November and early December. About 25.9% need to be admitted to ER. Conclusion: Many people may have experienced the disease before the announcement of WHO, especially that the new virus spreads as easily as “Flu”. This may explain the spread of the disease among the families as it is very difficult to stop influenza transmission. The antibodies testing would allow us to check blood samples for antibodies against coronavirus to tell whether remote immunity is found in the population or not.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #727578
Database	COVID19

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Article ; Online: Beta 2 Adrenergic Receptor Genetic Polymorphisms in Bronchial Asthma: Relationship to Disease Risk, Severity, and Treatment Response.

Mohamed-Hussein, Aliaë A R / Sayed, Suzan S / Eldien, Heba M Saad / Assar, Azza M / Yehia, Fatma E

Lung

2018 Volume 196, Issue 6, Page(s) 673–680

Abstract: Background: The β: Objective: The purpose of the study was to determine the association between β: Subjects and methods: 58 asthmatic patients and 38 healthy subjects were included. The β: Results: The allelic frequencies for the Arg16Gly ... ...

Abstract	Background: The β Objective: The purpose of the study was to determine the association between β Subjects and methods: 58 asthmatic patients and 38 healthy subjects were included. The β Results: The allelic frequencies for the Arg16Gly polymorphism were 15.5%, 48.3%, and 36.2% for the homozygous A wild, heterozygous, and homozygous G mutant alleles in asthmatics (P < 0.01) and 5.3%, 47.4%, and 47.4% in healthy subjects (P < 0.01). For the Gln27Glu polymorphism, the allelic frequencies for the homozygous C wild, heterozygous and homozygous G mutant alleles were 51.7%, 41.4%, and 6.9% in asthmatics (P < 0.01) and 44.7%, 39.5%, and 15.8% in healthy subjects (P < 0.01). The heterozygous Arg16Gly and Gln27Glu were found in most of severe asthma cases (7/13, 53.8% each). While homozygous wild and mutant seemed to be protective and associated with mild disease in both alleles. Finally, 75% of Arg16Gly heterozygous group were good responders (P < 0.01), 81% of homozygous G mutant were bad responders. For Gln27Glu polymorphism, 60% of C wild group were good responders and 75% of G mutant group were bad responders. Conclusions: The findings suggest that the Arg16Gly and Gln27Glu polymorphisms in the β2-AR gene are associated with asthma severity and response to therapy and might be used in personalized treatment for these patients in the future. This work is registered in ClinicalTrial.gov with ID: NCT03118869.
MeSH term(s)	Adolescent ; Adult ; Asthma/drug therapy ; Asthma/genetics ; Case-Control Studies ; Female ; Gene Frequency ; Heterozygote ; Homozygote ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Receptors, Adrenergic, beta-2/genetics ; Risk Factors ; Severity of Illness Index ; Treatment Outcome ; Young Adult
Chemical Substances	Receptors, Adrenergic, beta-2
Language	English
Publishing date	2018-09-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	6165-7
ISSN	1432-1750 ; 0341-2040
ISSN (online)	1432-1750
ISSN	0341-2040
DOI	10.1007/s00408-018-0153-3
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Article ; Online: Interleukin-18 and interferon-γ single nucleotide polymorphisms in Egyptian patients with tuberculosis.

Hassuna, Noha A / El Feky, Mohamed / Hussein, Aliae A R Mohamed / Mahmoud, Manal A / Idriss, Naglaa K / Abdelwahab, Sayed F / Ibrahim, Maggie A

PloS one

2021 Volume 16, Issue 1, Page(s) e0244949

Abstract: Background: Interleukin-18 (IL-18) and interferon-γ (IFN-γ) are cytokines of crucial role in inflammation and immune reactions. There is a growing evidence supporting important roles for IL-18 and IFN γ in tuberculosis (TB) infection and anti- ... ...

Abstract	Background: Interleukin-18 (IL-18) and interferon-γ (IFN-γ) are cytokines of crucial role in inflammation and immune reactions. There is a growing evidence supporting important roles for IL-18 and IFN γ in tuberculosis (TB) infection and anti-tuberculosis immunity. Objective: To evaluate the role of polymorphisms in IL-18-607 and -137 and INF-γ +874 in susceptibility to TB infection among Egyptian patients. Methods: A case control study was conducted to investigate the polymorphism at IL-18-607, -137 and INF-γ+874 by sequence specific primer-polymerase chain reaction (SSP- PCR) in 105 patients with pulmonary and extra pulmonary tuberculosis and 106 controls. Results: A significant protective effect against TB was found in homozygous CC genotype at IL-18 -137G/C, in addition to a 7-fold risk with GG and GC genotypes in the recessive model. Apart from a decreased risk with the AC genotype, no association was detected between the susceptibility to TB and different genotypes or alleles at the IL-18 -607A/C site. The homozygous AA genotype in INF-γ+874 showed a significant higher risk to TB than the homozygous TT or heterozygous AT genotypes with nearly a 2-fold risk of TB infection with the A allele. Regarding haplotype association, the GC haplotype was strongly associated with TB infection compared to other haplotypes. Conclusion: These findings suggest; for the first time in Egypt; a significant risk to TB infection with SNP at the IL-18-137G/C with no LD with SNP at the IL-18-607 site. The homozygous AA genotype in INF-γ+874 showed a significant higher risk to TB than the homozygous TT or heterozygous AT genotypes.
MeSH term(s)	Adult ; Alleles ; Antitubercular Agents/therapeutic use ; Case-Control Studies ; Egypt ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Humans ; Interferon-gamma/genetics ; Interleukin-18/genetics ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Tuberculosis/drug therapy ; Tuberculosis/genetics ; Young Adult
Chemical Substances	Antitubercular Agents ; Interleukin-18 ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2021-01-07
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0244949
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Article ; Online: Acceptance of COVID-19 vaccines among medical teams in Egypt.

Mohamed Hussein, Aliae A R / Galal, Islam / Makhlouf, Nahed A / Makhlouf, Hoda A / Abd-Elaal, Howaida K / Kholief, Karima M S / Saad, Mahmoud M / Attay, Dina A E / Tawab, Doaa A Abdel

Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

2021 Volume 22, Issue 4, Page(s) 323–324

MeSH term(s)	COVID-19 ; COVID-19 Vaccines ; Egypt ; Humans ; SARS-CoV-2 ; Vaccination
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2021-09-14
Publishing country	Egypt
Document type	Editorial
ZDB-ID	2502114-X
ISSN	2090-2387 ; 1687-1979
ISSN (online)	2090-2387
ISSN	1687-1979
DOI	10.1016/j.ajg.2021.09.001
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