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  1. Article ; Online: What the BTBR/J mouse has taught us about diabetes and diabetic complications.

    Keller, Mark P / Hudkins, Kelly L / Shalev, Anath / Bhatnagar, Sushant / Kebede, Melkam A / Merrins, Matthew J / Davis, Dawn Belt / Alpers, Charles E / Kimple, Michelle E / Attie, Alan D

    iScience

    2023  Volume 26, Issue 7, Page(s) 107036

    Abstract: ... of obesity-prone type 2 diabetes, the BTBR (Black and Tan Brachyury) mouse (BTBR T+ Itpr3tf/J, 2018) carrying the ...

    Abstract Human and mouse genetics have delivered numerous diabetogenic loci, but it is mainly through the use of animal models that the pathophysiological basis for their contribution to diabetes has been investigated. More than 20 years ago, we serendipidously identified a mouse strain that could serve as a model of obesity-prone type 2 diabetes, the BTBR (Black and Tan Brachyury) mouse (BTBR T+ Itpr3tf/J, 2018) carrying the
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2023.107036
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  2. Article ; Online: Protein coding variation in the J:ARC and J:DO outbred laboratory mouse stocks provides a molecular basis for distinct research applications.

    Cornes, Belinda K / Paisie, Carolyn / Swanzey, Emily / Fields, Peter D / Schile, Andrew / Brackett, Kelly / Reinholdt, Laura G / Srivastava, Anuj

    G3 (Bethesda, Md.)

    2023  Volume 13, Issue 4

    Abstract: ... coding variation in a newly established population of Swiss-derived outbred stock (J:ARC) that is closely ... architecture of the J:ARC population including heterozygosity, minor allele frequency, LD decay, and we defined ... J:DO). We found that the more recently derived, multiparent outbred stock has significantly higher ...

    Abstract Outbred laboratory mice (Mus musculus) are readily available and have high fecundity, making them a popular choice in biomedical research, especially toxicological and pharmacological applications. Direct high throughput genome sequencing (HTS) of these widely used research animals is an important genetic quality control measure that enhances research reproducibility. HTS data have been used to confirm the common origin of outbred stocks and to molecularly define distinct outbred populations. But these data have also revealed unexpected population structure and homozygosity in some populations; genetic features that emerge when outbred stocks are not properly maintained. We used exome sequencing to discover and interrogate protein-coding variation in a newly established population of Swiss-derived outbred stock (J:ARC) that is closely related to other, commonly used CD-1 outbred populations. We used these data to describe the genetic architecture of the J:ARC population including heterozygosity, minor allele frequency, LD decay, and we defined novel, protein-coding sequence variation. These data reveal the expected genetic architecture for a properly maintained outbred stock and provide a basis for the on-going genetic quality control. We also compared these data to protein-coding variation found in a multiparent outbred stock, the Diversity Outbred (J:DO). We found that the more recently derived, multiparent outbred stock has significantly higher interindividual variability, greater overall genetic variation, higher heterozygosity, and fewer novel variants than the Swiss-derived J:ARC stock. However, among the novel variants found in the J:DO stock, significantly more are predicted to be protein-damaging. The fact that individuals from this population can tolerate a higher load of potentially damaging variants highlights the buffering effects of allelic diversity and the differing selective pressures in these stocks. While both outbred stocks offer significant individual heterozygosity, our data provide a molecular basis for their intended applications, where the J:DO are best suited for studies requiring maximum, population-level genetic diversity and power for mapping, while the J:ARC are best suited as a general-purpose outbred stock with robust fecundity, relatively low allelic diversity, and less potential for extreme phenotypic variability.
    MeSH term(s) Mice ; Animals ; Reproducibility of Results ; Gene Frequency ; Heterozygote ; Homozygote ; Alleles ; Genetic Variation
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2629978-1
    ISSN 2160-1836 ; 2160-1836
    ISSN (online) 2160-1836
    ISSN 2160-1836
    DOI 10.1093/g3journal/jkad015
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  3. Article: A Hands-on Activity for V(D)J Recombination in an Undergraduate Immunology Class.

    Hallstrom, Kelly N / Knapp, Gwendowlyn S

    Journal of microbiology & biology education

    2022  Volume 24, Issue 1

    Abstract: This learning activity teaches the difficult concept of V(D)J recombination as it occurs in B cells ...

    Abstract This learning activity teaches the difficult concept of V(D)J recombination as it occurs in B cells. Following the traditional lecture, this hands-on activity uses pipe cleaners of various colors representing variable, joining, and diversity gene segments and recombination signal sequences. Students are provided with instructions for using the pipe cleaners to assemble specific light and heavy immunoglobulin chains. Students each assemble their own light and heavy chains and compare the products made by classmates. This activity uses materials that are easy and affordable to acquire and provides a tactile approach to reinforcing concepts that students often struggle to visualize and master from lecture and textbook material alone.
    Language English
    Publishing date 2022-12-21
    Publishing country United States
    Document type Journal Article
    ISSN 1935-7877
    ISSN 1935-7877
    DOI 10.1128/jmbe.00145-22
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  4. Article ; Online: Under-dosing and over-dosing of neuromuscular blocking drugs and reversal agents. Response to Br J Anaesth 2024; 132: 461-5.

    Michaelsen, Kelly / Jelacic, Srdjan / Bowdle, T Andrew

    British journal of anaesthesia

    2024  

    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Letter
    ZDB-ID 80074-0
    ISSN 1471-6771 ; 0007-0912
    ISSN (online) 1471-6771
    ISSN 0007-0912
    DOI 10.1016/j.bja.2024.02.030
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  5. Article ; Online: Erratum: "The quaternary question: Determining allostery in spastin through dynamics classification learning and bioinformatics" [J. Chem. Phys. 158, 125102 (2023)].

    Kelly, Maria S / Macke, Amanda C / Kahawatte, Shehani / Stump, Jacob E / Miller, Abigail R / Dima, Ruxandra I

    The Journal of chemical physics

    2024  Volume 160, Issue 14

    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0208392
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  6. Article ; Online: Response to Letters to the Editor by Gregory J, Rice K, McCarthy K, et al. 2023 Regarding: "Guidelines for Qualifications of Neurodiagnostic Personnel: A Joint Position Statement of the American Clinical Neurophysiology Society, the American Association of Neuromuscular & Electrodiagnostic Medicine, the American Society of Neurophysiological Monitoring, and ASET-The Neurodiagnostic Society".

    López, Jaime R / Kelly, Linda / Ahn-Ewing, Judy / Emerson, Ron / Ford, Carrie / Gale, Clare / Gertsch, Jeffery H / Husain, Aatif / Kincaid, John / Kise, Meledy / Kornegay, Adam / Moreira, Joseph J / Nuwer, Marc / Schneider, Anita / Sullivan, Lucy R / Toleikis, J Richard / Wall, Lois / Herman, Susan

    Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society

    2024  Volume 41, Issue 2, Page(s) 188–189

    MeSH term(s) United States ; Humans ; Oryza ; Neurophysiology ; Societies ; Neurophysiological Monitoring
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605640-4
    ISSN 1537-1603 ; 0736-0258
    ISSN (online) 1537-1603
    ISSN 0736-0258
    DOI 10.1097/WNP.0000000000001059
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    Zs.A 1921: Show issues Location:
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  7. Article ; Online: A Hands-on Activity for V(D)J Recombination in an Undergraduate Immunology Class

    Kelly N. Hallstrom / Gwendowlyn S. Knapp

    Journal of Microbiology & Biology Education, Vol 24, Iss

    2023  Volume 1

    Abstract: ABSTRACT This learning activity teaches the difficult concept of V(D)J recombination as it occurs ...

    Abstract ABSTRACT This learning activity teaches the difficult concept of V(D)J recombination as it occurs in B cells. Following the traditional lecture, this hands-on activity uses pipe cleaners of various colors representing variable, joining, and diversity gene segments and recombination signal sequences. Students are provided with instructions for using the pipe cleaners to assemble specific light and heavy immunoglobulin chains. Students each assemble their own light and heavy chains and compare the products made by classmates. This activity uses materials that are easy and affordable to acquire and provides a tactile approach to reinforcing concepts that students often struggle to visualize and master from lecture and textbook material alone.
    Keywords immunology laboratory ; remote learning activities ; tactile learning ; undergraduate immunology ; V(D)J recombination ; Special aspects of education ; LC8-6691 ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher American Society for Microbiology
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: CASTLE score versus J-CTO score for the prediction of technical success in chronic total occlusion percutaneous revascularisation.

    Kalogeropoulos, Andreas S / Alsanjari, Osama / Keeble, Thomas R / Tang, Kare H / Konstantinou, Klio / Katsikis, Athanasios / Jagathesan, Rohan / Aggarwal, Rajesh K / Clesham, Gerald J / Kelly, Paul A / Werner, Gerald S / Hildick-Smith, David / Davies, John R / Karamasis, Grigoris

    EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

    2020  Volume 15, Issue 18, Page(s) e1615–e1623

    Abstract: ... used Multicentre CTO Registry in Japan (J-CTO) score in predicting procedural success ... consecutive CTO PCIs (mean age 66±11 years, 84% male). The mean J-CTO and EuroCTO (CASTLE) scores were 1.86±1 ... 653-0.742, p<0.001 for J-CTO vs AUC 0.676, 95% CI: 0.627-0.725, p<0.001 for EuroCTO; AUC difference: 0 ...

    Abstract Aims: We sought to compare the efficiency of the novel EuroCTO (CASTLE) score with the commonly used Multicentre CTO Registry in Japan (J-CTO) score in predicting procedural success of percutaneous coronary intervention (PCI) for coronary chronic total occlusions (CTOs).
    Methods and results: We evaluated 660 consecutive CTO PCIs (mean age 66±11 years, 84% male). The mean J-CTO and EuroCTO (CASTLE) scores were 1.86±1.2 and 1.74±1.2, respectively. Antegrade wire escalation, antegrade dissection re-entry and retrograde approach were used in 82%, 14% and 37% of cases, respectively. Receiver operating characteristic analysis demonstrated equal overall discriminatory capacity between the two scores (AUC 0.698, 95% CI: 0.653-0.742, p<0.001 for J-CTO vs AUC 0.676, 95% CI: 0.627-0.725, p<0.001 for EuroCTO; AUC difference: 0.022, p=0.5). However, for more complex procedures (J-CTO ≥3 or EuroCTO [CASTLE] ≥4]), the predictive capacity of the EuroCTO (CASTLE) score appeared superior (AUC 0.588, 95% CI: 0.509-0.668, p=0.03 for EuroCTO [CASTLE] score vs AUC 0.473, 95% CI: 0.393-0.553, p=NS for the J-CTO score, AUC difference: 0.115, p=0.04).
    Conclusions: In this study, the novel EuroCTO (CASTLE) score was comparable to the J-CTO score in predicting CTO PCI outcome with a superior discriminatory capacity for the more complex cases.
    MeSH term(s) Aged ; Chronic Disease ; Coronary Angiography ; Coronary Occlusion/diagnosis ; Coronary Occlusion/diagnostic imaging ; Coronary Occlusion/mortality ; Coronary Occlusion/surgery ; Female ; Humans ; Japan ; Male ; Middle Aged ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/mortality ; Predictive Value of Tests ; ROC Curve ; Registries ; Reproducibility of Results ; Risk Assessment ; Risk Factors ; Severity of Illness Index ; Treatment Outcome
    Language English
    Publishing date 2020-04-03
    Publishing country France
    Document type Comparative Study ; Journal Article
    ZDB-ID 2457174-X
    ISSN 1969-6213 ; 1774-024X
    ISSN (online) 1969-6213
    ISSN 1774-024X
    DOI 10.4244/EIJ-D-19-00352
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    Zs.A 6680: Show issues Location:
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    Zs.MO 571: Show issues

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  9. Article ; Online: Corrigendum to "HIC2 regulates isoform switching during maturation of the cardiovascular system" [Journal of Molecular and Cellular Cardiology volume 114 (2018) P29-37/ https://doi.org/10.1016/j.yjmcc.2017.10.007].

    Dykes, Iain M / van Bueren, Kelly Lammerts / Scambler, Peter J

    Journal of molecular and cellular cardiology

    2023  Volume 183, Page(s) 102

    Language English
    Publishing date 2023-07-28
    Publishing country England
    Document type Published Erratum
    ZDB-ID 80157-4
    ISSN 1095-8584 ; 0022-2828
    ISSN (online) 1095-8584
    ISSN 0022-2828
    DOI 10.1016/j.yjmcc.2023.07.010
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  10. Article ; Online: Corrigendum to: "Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis" [J Hepatol (2020) 241-251].

    Parisinos, Constantinos A / Wilman, Henry R / Thomas, E Louise / Kelly, Matt / Nicholls, Rowan C / McGonigle, John / Neubauer, Stefan / Hingorani, Aroon D / Patel, Riyaz S / Hemingway, Harry / Bell, Jimmy D / Banerjee, Rajarshi / Yaghootkar, Hanieh

    Journal of hepatology

    2020  Volume 73, Issue 6, Page(s) 1594–1595

    Language English
    Publishing date 2020-09-18
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2020.08.030
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