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Article ; Online: Anchoring fins of fully covered self-expandable metal stents affect pull-out force and stent migration.

Brinkmann, Franz / Uhlig, Kai / Sambale, Anna / Stommel, Markus / Berning, Marco / Babatz, Jana / Sulk, Stefan / Krasz, Susanne / Schmelz, Renate / Brückner, Stefan / Hampe, Jochen / Zeissig, Sebastian

Gastrointestinal endoscopy

2023 Volume 99, Issue 3, Page(s) 377–386.e3

Abstract: Background and aims: Stent migration and subsequent adverse events are frequently observed in the use of fully covered self-expandable metal stents (FCSEMSs) for distal biliary stenosis. In this study, we identified predictors for stent migration based ... ...

Abstract	Background and aims: Stent migration and subsequent adverse events are frequently observed in the use of fully covered self-expandable metal stents (FCSEMSs) for distal biliary stenosis. In this study, we identified predictors for stent migration based on biomechanical stent characteristics and associated these findings with clinical outcomes. Methods: The migration resistance of FCSEMSs was quantified by measuring the pull-out force. We analyzed a single-center retrospective cohort of 178 FCSEMSs for treatment success and adverse events occurring during 180 days of follow-up. Results: Biomechanical measurements revealed a 4-fold higher migration resistance of FCSEMSs with anchoring fins (AF-FCSEMSs; F Conclusions: The pull-out force as a biomechanical stent property predicts the migration resistance of FCSEMSs in distal biliary stenosis and may thus be used to classify stents for this application. AF-FCSEMSs showed a significantly lower rate of migration and adverse events compared with FE-FCSEMSs.
MeSH term(s)	Humans ; Retrospective Studies ; Constriction, Pathologic/etiology ; Stents/adverse effects ; Self Expandable Metallic Stents/adverse effects ; Cholestasis/etiology ; Cholestasis/surgery ; Treatment Outcome
Language	English
Publishing date	2023-10-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2023.10.036
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Article ; Online: Cheilostomatida (Bryozoa) from the Ionian Apulian coast (Italy) with the description of new species

D. Pica / B. Berning / R. Calicchio

The European Zoological Journal, Vol 89, Iss 1, Pp 371-

2022 Volume 422

Abstract: ... the shallow water and the deep-sea communities, in which photophilic framework builders (e.g. coralline red algae ... Neopycnodonte cochlear. In this habitat the framework-forming organisms produce a hard substrate with a high topographic ...

Abstract	The mesophotic zone is a relatively poorly studied area of the Mediterranean Sea, drawing great interest by the scientific community in the last years. This zone represents a connection between the shallow water and the deep-sea communities, in which photophilic framework builders (e.g. coralline red algae) are gradually replaced by heterotrophic ones, such as ahermatypic corals and the bivalve Neopycnodonte cochlear. In this habitat the framework-forming organisms produce a hard substrate with a high topographic complexity, hosting a great biodiversity of secondary structuring taxa like bryozoans. During a survey on coralligenous banks in the mesophotic zone in c. 60 m depth off Gallipoli (southern Apulia), epibiotic aggregations of N. cochlear were found on the fans of the hexacoral Savalia savaglia. In the present paper the diversity of cheilostomatid bryozoans hosted by these bivalve aggregations is described and compared with published information on similar nearby habitats. A total of 48 taxa were found, six of which are newly described: Crassimarginatella matildae sp. nov., Micropora biopesiula sp. nov., Haplopoma celeste sp. nov., Schizomavella (Schizomavella) cerranoi sp. nov., Schizomavella (Calvetomavella) biancae sp. nov., and Schizoporella adelaide sp. nov. The species richness known from the southern Apulian shelf at this depth (47 species) is hereby raised to 83 cheilostomatid bryozoans. Moreover, only 12 species are shared with the other localities studied previously, while 36 are restricted to Gallipoli, supporting the hypothesis of a high rate of exclusivity among Apulian sites in terms of species composition. The differences in faunal composition, and particularly the presence of several new species discovered at Gallipoli, show once more that our knowledge of the bryozoan fauna in certain Mediterranean habitats is still incomplete and warrants further studies.https://doi.org/urn:lsid:zoobank.org:pub:DDC82039-EF44-4169-8198-C67F60B14BA0
Keywords	Neopycnodonte cochlear ; Mediterranean Sea ; animal forest ; biogenic structures ; Savalia savaglia ; Zoology ; QL1-991
Subject code	590
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Disseminated inflammation of the central nervous system associated with acute hepatitis E: a case report.

Rahmig, Jan / Grey, Arne / Berning, Marco / Schaefer, Jochen / Lesser, Martin / Reichmann, Heinz / Puetz, Volker / Barlinn, Kristian / Siepmann, Timo

BMC neurology

2020 Volume 20, Issue 1, Page(s) 391

Abstract: Background: Hepatitis E infection affects over 20 million people worldwide. Reports of neurological manifestations are largely limited to the peripheral nervous system. We report a middle-aged genotype 3c male patient with acute hepatitis E virus (HEV) ... ...

Abstract	Background: Hepatitis E infection affects over 20 million people worldwide. Reports of neurological manifestations are largely limited to the peripheral nervous system. We report a middle-aged genotype 3c male patient with acute hepatitis E virus (HEV) infection and severe neurological deficits with evidence of multiple disseminated inflammatory lesions of the central nervous system. Case presentation: A 42-year-old male patient presented to our emergency department with musculoskeletal weakness, bladder and bowel retention, blurred vision and ascending hypoesthesia up to the level of T8. Serology showed elevated liver enzymes and positive IgM-titers of hepatitis E. Analysis of cerebrospinal fluid (CSF) showed mild pleocytosis and normal levels of glucose, lactate and protein. HEV-RNA-copies were detected in the CSF and stool. Within 3 days after admission the patient became paraplegic, had complete visual loss and absent pupillary reflexes. MRI showed inflammatory demyelination of the optic nerve sheaths, multiple subcortical brain regions and the spinal cord. Electrophysiology revealed axonal damage of the peroneal nerve on both sides with absent F-waves. Treatment was performed with methylprednisolone, two cycles of plasma exchange (PLEX), one cycle of intravenous immunoglobulins (IVIG) and ribavirin which was used off-label. Liver enzymes normalized after 1 week and serology was negative for HEV-RNA after 3 weeks. Follow-up MRI showed progressive demyelination and new leptomeningeal enhancement at the thoracic spine and cauda equina 4 weeks after admission. Four months later, after rehabilitation was completed, repeated MRI showed gliotic transformation of the spinal cord without signs of an active inflammation. Treatment with rituximab was initiated. The patient remained paraplegic and hypoesthesia had ascended up to T5. Nevertheless, he regained full vision. Conclusions: Our case indicates a possible association of acute HEV infection with widespread disseminated central nervous system inflammation. Up to now, no specific drugs have been approved for the treatment of acute HEV infection. We treated our patient off-label with ribavirin and escalated immunomodulatory therapy considering clinical progression and the possibility of an autoimmune response targeting nerve cell structures. While response to treatment was rather limited in our case, detection of HEV in patients with acute neurological deficits might help optimize individual treatment strategies.
MeSH term(s)	Acute Disease ; Adult ; Brain/pathology ; Genotype ; Hepatitis E/diagnosis ; Hepatitis E/immunology ; Hepatitis E/virology ; Hepatitis E virus/genetics ; Hepatitis E virus/immunology ; Humans ; Inflammation/diagnosis ; Magnetic Resonance Imaging ; Male
Language	English
Publishing date	2020-10-27
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2041347-6
ISSN	1471-2377 ; 1471-2377
ISSN (online)	1471-2377
ISSN	1471-2377
DOI	10.1186/s12883-020-01952-5
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Book ; Online ; Thesis: Tetracyclin-Resistenz in Helicobacter pylori

Berning, Marco

Herstellung und Charakterisierung von definierten 16S-rRNA-Mutanten und Etablierung eines Realtime-PCR-Ansatzes zur schnellen Resistenzbestimmung

2005

Author's details	vorgelegt von Marco Berning
Language	German
Size	Online-Ressource
Document type	Book ; Online ; Thesis
Thesis / German Habilitation thesis	Univ., Diss--Freiburg (Breisgau), 2005
Note	Erscheinungsjahr an der Haupttitelstelle: 2004
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Cheilostomatida (Bryozoa) from the Ionian Apulian coast (Italy) with the description of new species

Pica, D. / Berning, B. / Calicchio, R.

The European Zoological Journal. 2022 Dec. 31, v. 89, no. 1 p.371-422

2022

Abstract	The mesophotic zone is a relatively poorly studied area of the Mediterranean Sea, drawing great interest by the scientific community in the last years. This zone represents a connection between the shallow water and the deep-sea communities, in which photophilic framework builders (e.g. coralline red algae) are gradually replaced by heterotrophic ones, such as ahermatypic corals and the bivalve Neopycnodonte cochlear. In this habitat the framework-forming organisms produce a hard substrate with a high topographic complexity, hosting a great biodiversity of secondary structuring taxa like bryozoans. During a survey on coralligenous banks in the mesophotic zone in c. 60 m depth off Gallipoli (southern Apulia), epibiotic aggregations of N. cochlear were found on the fans of the hexacoral Savalia savaglia. In the present paper the diversity of cheilostomatid bryozoans hosted by these bivalve aggregations is described and compared with published information on similar nearby habitats. A total of 48 taxa were found, six of which are newly described: Crassimarginatella matildae sp. nov., Micropora biopesiula sp. nov., Haplopoma celeste sp. nov., Schizomavella (Schizomavella) cerranoi sp. nov., Schizomavella (Calvetomavella) biancae sp. nov., and Schizoporella adelaide sp. nov. The species richness known from the southern Apulian shelf at this depth (47 species) is hereby raised to 83 cheilostomatid bryozoans. Moreover, only 12 species are shared with the other localities studied previously, while 36 are restricted to Gallipoli, supporting the hypothesis of a high rate of exclusivity among Apulian sites in terms of species composition. The differences in faunal composition, and particularly the presence of several new species discovered at Gallipoli, show once more that our knowledge of the bryozoan fauna in certain Mediterranean habitats is still incomplete and warrants further studies. https://doi.org/urn:lsid:zoobank.org:pub:DDC82039-EF44-4169-8198-C67F60B14BA0
Keywords	Bivalvia ; Cheilostomata ; coasts ; fauna ; habitats ; new species ; species richness ; surveys ; topography ; Italy ; Mediterranean Sea ; Neopycnodonte cochlear ; animal forest ; biogenic structures ; Savalia savaglia
Language	English
Dates of publication	2022-1231
Size	p. 371-422.
Publishing place	Taylor & Francis
Document type	Article ; Online
ISSN	2475-0263
DOI	10.1080/24750263.2022.2032849
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Macroscopic, histologic, and clinical assessment of acute graft-versus-host disease of the upper gastrointestinal tract within 6 weeks after allogeneic hematopoietic cell transplantation.

Sarraf, Abed A / Schetelig, Johannes / Baldauf, Henning / Stölzel, Friedrich / Middeke, Jan Moritz / Sockel, Katja / Teipel, Raphael / Brückner, Stefan / Berning, Marco / Zeissig, Sebastian / Babatz, Jana / Baretton, Gustavo B / Hampe, Jochen / Bornhäuser, Martin / Aust, Daniela / Schmelz, Renate

Experimental hematology

2022 Volume 108, Page(s) 36–45

Abstract: Acute graft-versus-host-disease (aGVHD) is the main cause of morbidity and nonrelapse mortality (NRM) following allogeneic hematopoietic cell transplantation (alloHCT). Nausea, vomiting, and anorexia after alloHCT can be early signs of aGVHD of the ... ...

Abstract	Acute graft-versus-host-disease (aGVHD) is the main cause of morbidity and nonrelapse mortality (NRM) following allogeneic hematopoietic cell transplantation (alloHCT). Nausea, vomiting, and anorexia after alloHCT can be early signs of aGVHD of the gastrointestinal tract (GIT) but may also reflect lasting mucosal damage or side effects of drugs. If upper GIT aGVHD is suspected, upper endoscopic evaluation and histological examination are crucial. Still, the interpretation of clinical symptoms, macroscopical alterations, and histological findings can be challenging. Therefore, we conducted a retrospective analysis on single-center data from 174 patients with suspected aGVHD of the upper GIT who underwent upper endoscopy within the first 6 weeks after alloHCT, to study the distribution of aGVHD-related histological findings in relation to clinical symptoms and macroscopic findings and to correlate the severity of changes with data on relapse and NRM. Our data suggest that biopsies of the duodenum reveal the severity of upper GIT aGVHD most accurately. While the histological grading correlated weakly with the severity of macroscopic changes, we found a tight correlation between histological and clinical grades of upper GIT aGVHD (p < 0.001). Although correlation of histological grading of upper GIT aGVHD with the risk for NRM missed statistical significance (HR 1.53, Lerner ≥1° versus <1º, p = 0.13), overall clinical aGVHD severity correlated with NRM (HR 4.3, IIIº-IVº versus 0-Iº, p < 0.01). In conclusion, biopsies from the duodenum are most sensitive in excluding aGVHD in patients with normal macroscopic findings at esophagogastroduodenoscopy. Clinical grading of aGVHD predicts NRM better than histological grading.
MeSH term(s)	Acute Disease ; Biopsy ; Graft vs Host Disease/diagnosis ; Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Retrospective Studies ; Upper Gastrointestinal Tract
Language	English
Publishing date	2022-01-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	185107-x
ISSN	1873-2399 ; 0531-5573 ; 0301-472X
ISSN (online)	1873-2399
ISSN	0531-5573 ; 0301-472X
DOI	10.1016/j.exphem.2022.01.005
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Article ; Online: A transient protein folding response targets aggregation in the early phase of TDP-43-mediated neurodegeneration.

San Gil, Rebecca / Pascovici, Dana / Venturato, Juliana / Brown-Wright, Heledd / Mehta, Prachi / Madrid San Martin, Lidia / Wu, Jemma / Luan, Wei / Chui, Yi Kit / Bademosi, Adekunle T / Swaminathan, Shilpa / Naidoo, Serey / Berning, Britt A / Wright, Amanda L / Keating, Sean S / Curtis, Maurice A / Faull, Richard L M / Lee, John D / Ngo, Shyuan T /

Lee, Albert / Morsch, Marco / Chung, Roger S / Scotter, Emma / Lisowski, Leszek / Mirzaei, Mehdi / Walker, Adam K

Nature communications

2024 Volume 15, Issue 1, Page(s) 1508

Abstract: Understanding the mechanisms that drive TDP-43 pathology is integral to combating amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD) and other neurodegenerative diseases. Here we generated a longitudinal quantitative proteomic ... ...

Abstract	Understanding the mechanisms that drive TDP-43 pathology is integral to combating amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD) and other neurodegenerative diseases. Here we generated a longitudinal quantitative proteomic map of the cortex from the cytoplasmic TDP-43 rNLS8 mouse model of ALS and FTLD, and developed a complementary open-access webtool, TDP-map ( https://shiny.rcc.uq.edu.au/TDP-map/ ). We identified distinct protein subsets enriched for diverse biological pathways with temporal alterations in protein abundance, including increases in protein folding factors prior to disease onset. This included increased levels of DnaJ homolog subfamily B member 5, DNAJB5, which also co-localized with TDP-43 pathology in diseased human motor cortex. DNAJB5 over-expression decreased TDP-43 aggregation in cell and cortical neuron cultures, and knockout of Dnajb5 exacerbated motor impairments caused by AAV-mediated cytoplasmic TDP-43 expression in mice. Together, these findings reveal molecular mechanisms at distinct stages of ALS and FTLD progression and suggest that protein folding factors could be protective in neurodegenerative diseases.
MeSH term(s)	Animals ; Humans ; Mice ; Amyotrophic Lateral Sclerosis/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Frontotemporal Dementia/metabolism ; Frontotemporal Lobar Degeneration/metabolism ; Neurons/metabolism ; Proteomics ; TDP-43 Proteinopathies/metabolism ; Protein Aggregates
Chemical Substances	DNA-Binding Proteins ; TARDBP protein, human ; Tardbp protein, mouse ; Protein Aggregates
Language	English
Publishing date	2024-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-45646-9
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Article ; Online: Due South: The evolutionary history of Sub-Antarctic and Antarctic Tritoniidae nudibranchs.

Moles, Juan / Berning, Maria I / Hooker, Yuri / Padula, Vinicius / Wilson, Nerida G / Schrödl, Michael

Molecular phylogenetics and evolution

2021 Volume 162, Page(s) 107209

Abstract: ... yet a well-developed phylogenetic framework for this family is still incomplete. In this study, we explored ...

Abstract	The Tritoniidae provides one of the most famous model species for neurophysiology and behaviour, yet a well-developed phylogenetic framework for this family is still incomplete. In this study, we explored the species-level taxonomy, phylogenetic relationships, and geographic distributions of the tritoniid nudibranchs. During numerous expeditions, specimens from southern South America, Sub-Antarctic Islands, and Antarctica were collected, documented alive, and fixed for anatomical descriptions and genetic sequencing. DNA from 167 specimens were extracted and sequenced for mitochondrial (COI, 16S) and nuclear (H3) markers. An additional 109 sequences of all available tritoniids plus additional outgroups were downloaded from GenBank for comparative purposes. Maximum Likelihood under the GHOST model of evolution and Bayesian inference using the GTR + GAMMA model produced congruent topologies from concatenated alignments. The results of ABGD, GMYC, bPTP, and mPTP species delimitation analyses suggest many separately evolving units that do not coincide with traditionally recognized species limits. Southern Ocean Tritoniella and Tritonia species split into several previously unrecognized species. This result is in accordance with the limited dispersal abilities of some southern tritoniids. Along with the most complete phylogeny of Tritoniidae to date, we also provided many taxonomic notes at the species and genus level. Tritoniidae species are yet another example of under-recognized diversity in the Southern Ocean.
MeSH term(s)	Animals ; Antarctic Regions ; Bayes Theorem ; Gastropoda/classification ; Gastropoda/genetics ; Phylogeny ; South America
Language	English
Publishing date	2021-05-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	33610-5
ISSN	1095-9513 ; 1055-7903
ISSN (online)	1095-9513
ISSN	1055-7903
DOI	10.1016/j.ympev.2021.107209
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Article ; Online: The WHO High 5s project: medication reconciliation in a German university hospital. A prospective observational cohort study.

Schmitz, Katharina / Lenssen, Rebekka / Rückbeil, Marcia / Berning, Daniel / Thomeczek, Christian / Brokmann, Jörg Christian / Jaehde, Ulrich / Eisert, Albrecht

Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen

2022 Volume 168, Page(s) 27–32

Abstract: Background: Ensuring medication accuracy during transitions in care is one of the five highly prevalent patient safety problems focused on within the World Health Organization High 5s Project. Medication reconciliation is a standardized patient care ... ...

Abstract	Background: Ensuring medication accuracy during transitions in care is one of the five highly prevalent patient safety problems focused on within the World Health Organization High 5s Project. Medication reconciliation is a standardized patient care process that can be used to address this problem. The aim of the current study is to implement medication reconciliation in a German university hospital. Methods: The study was conducted at the Emergency Department of the University Hospital Aachen, Germany. All discrepancies between the Best Possible Medication History and the Admission Medication Order were documented and classified as documentation errors or medication errors. The type of error was also recorded. A negative binomial regression model was used to test several factors influencing the number of discrepancies. Results: The medications of 105 patients were reconciled. The mean number of discrepancies per patient was 4.6± 3.6, with a total of 298 medication errors and 189 documentation errors. The most common type of medication error was the omission of a drug (n=208; 69.8 %). In the negative binomial regression analysis, the care status (p=0.0015) as well as the number of preadmission drugs (p=0.0007) were significantly associated with medication errors. Discussion: A high number of discrepancies was detected and analysed. Patients admitted from nursing homes were less likely to have discrepancies in their medication reconciliation, perhaps because a structured documentation system for medications is already in place at nursing homes including error prone products (special dosage forms or food supplements). Conclusions: In this study, medication reconciliation was implemented at a German full-care university hospital. The actual number of discrepancies observed strongly indicates the need for medication reconciliation at hospital admission.
MeSH term(s)	Germany ; Hospitals, University ; Humans ; Medication Errors/prevention & control ; Medication Reconciliation ; Prospective Studies
Language	English
Publishing date	2022-02-09
Publishing country	Netherlands
Document type	Journal Article ; Observational Study
ZDB-ID	2412512-X
ISSN	2212-0289 ; 1865-9217
ISSN (online)	2212-0289
ISSN	1865-9217
DOI	10.1016/j.zefq.2021.11.006
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Article ; Online: Reproducibility of preoperative endoscopic injection of botulinum toxin into the sphincter of Oddi to prevent postoperative pancreatic fistula.

Volk, Andreas / Distler, Marius / Müssle, Benjamin / Berning, Marco / Hampe, Jochen / Brückner, Stefan / Weitz, Jürgen / Welsch, Thilo

Innovative surgical sciences

2018 Volume 3, Issue 1, Page(s) 69–75

Abstract: Background: A postoperative pancreatic fistula (POPF) is the most common and potentially life-threatening surgical complication in pancreatic surgery. One possible pharmacological treatment could be the endoscopic injection of botulinum toxin (BTX) into ...

Abstract	Background: A postoperative pancreatic fistula (POPF) is the most common and potentially life-threatening surgical complication in pancreatic surgery. One possible pharmacological treatment could be the endoscopic injection of botulinum toxin (BTX) into the sphincter of Oddi to prevent POPF. Promising data reported a significantly reduced rate of clinically relevant POPF. We analyzed the effect of BTX injection in our patients undergoing distal pancreatectomy (DP). Methods: A retrospective analysis of patients undergoing DP was performed. Patients with preoperative endoscopic injection of BTX into the sphincter of Oddi were included. The end points were postoperative outcomes including POPF. BTX patients were compared with a historical cohort and matched in a 1:1 ratio using a propensity score analysis. Results: A total of 19 patients were treated with endoscopic injection of BTX before open (n=8) or laparoscopic (n=11) DP. The median age of the patients was 67 years and the mean body mass index was 25.9 kg/m Conclusion: The present study could not reproduce the published results of a significant lowering of grade B/C POPF. The explanations could be the timing of BTX injection before surgery and the endoscopic technique of BTX injection. However, the conflicting results after BTX injection in two high-volume centers prompt a randomized controlled multicenter trial with trained endoscopists.
Language	English
Publishing date	2018-01-18
Publishing country	Germany
Document type	Journal Article
ISSN	2364-7485
ISSN (online)	2364-7485
DOI	10.1515/iss-2017-0040
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