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Article: Hydrogeologist J. Martins Carvalho: professional, professor and gentleman

Environmental earth sciences. 2015 Mar., v. 73, no. 6

2015

Abstract: Hydrogeologist EurGeol José Martins Carvalho (BSc, PhD, DSc) gave his last lecture at the School of Engineering of Polytechnic of Porto in January 2014, bringing to a formal close an outstanding career in multidisciplinary hydrogeology teaching and ... ...

Abstract	Hydrogeologist EurGeol José Martins Carvalho (BSc, PhD, DSc) gave his last lecture at the School of Engineering of Polytechnic of Porto in January 2014, bringing to a formal close an outstanding career in multidisciplinary hydrogeology teaching and practice (in Europe, Africa, Middle-East, Asia, South America) and in applied research. Nowadays, he is Emeritus Professor of the Polytechnic of Porto and Consultant Hydrogeologist. He has had a career spanning 50 years in military hydrogeology, exploration hydrogeology, environmental hydrogeology, groundwater engineering, hydrogeotechnics, urban water supply, water resources management and geothermics. This brief note aims to present the key milestones in his multifaceted professional career, acting as a geologist, a professor and a researcher of groundwater science. The essence of his long career over the last five decades was to promote the practice, teaching and research of hydrogeology to solve social problems and challenges via an environmental, sustainable and ethical approach. In his own words: “Water is a unique resource: a drop can save a life, in war and peace”.
Keywords	engineering ; ethics ; groundwater ; hydrogeology ; social problems ; water management ; water supply ; Africa ; Asia ; Europe ; Middle East ; South America
Language	English
Dates of publication	2015-03
Size	p. 2521-2529.
Publishing place	Springer-Verlag
Document type	Article
ZDB-ID	2493699-6
ISSN	1866-6299 ; 1866-6280
ISSN (online)	1866-6299
ISSN	1866-6280
DOI	10.1007/s12665-014-3982-2
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: A Química: o primeiro século na Universidade de Coimbra e o progresso desta ciência

Redinha, J. Simões

2020

Abstract: A matriz reflexiva deste escrito é constituída pela evolução da Química na Universidade de Coimbra e nos países cientificamente mais avançados no decurso do primeiro século desta ciência, no que ... ...

Abstract	A matriz reflexiva deste escrito é constituída pela evolução da Química na Universidade de Coimbra e nos países cientificamente mais avançados no decurso do primeiro século desta ciência, no que respeita
Size	1 electronic resource (238 pages)
Publisher	Coimbra University Press
Document type	Book ; Online
Note	Portuguese ; Open Access
HBZ-ID	HT020678661
ISBN	9789892618746 ; 9892618742
DOI	10.14195/978-989-26-1875-3
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Occupation pattern of a harbor inlet by the estuarine dolphin, Sotalia guianensis (P. J. Van Bénéden, 1864) (Cetacea, Delphinidae)

Marta Jussara Cremer / Paulo César Simões-Lopes / José Salatiel Rodrigues Pires

Brazilian Archives of Biology and Technology, Vol 52, Iss 3, Pp 765-

2009 Volume 774

Abstract: The occupation pattern of Sotalia guianensis in São Francisco do Sul harbor inlet, in Babitonga bay, southern Brazil, was studied between September 1996 and June 1998. A total of 200 h of naturalistic observations and 141.2 h of estuarine dolphin ... ...

Abstract	The occupation pattern of Sotalia guianensis in São Francisco do Sul harbor inlet, in Babitonga bay, southern Brazil, was studied between September 1996 and June 1998. A total of 200 h of naturalistic observations and 141.2 h of estuarine dolphin systematic observations were made using binoculars 7 x 50. At each three minutes interval, data about number of individuals and behavior were registered. The population used the harbor inlet intensively, mainly for fishing activities. Ebb tide was responsible for a higher occupation index. Considering the months analyzed, the higher occupation index occurred in May, and in January the lower occurrence was observed. The mean group size was four individuals. Os padrões de ocupação da enseada do porto de cargas de São Francisco do Sul, no interior da Baía da Babitonga, sul do Brasil, pela população de botos cinza Sotalia guianensis foi estudada entre setembro/1996 e junho/1998. Totalizou-se 200 horas de observações naturalísticas e 141.2 horas de observação sistemática na área, utilizando-se binoculares 7 x 50. Foram registrados a cada intervalo de 3 minutos dados sobre o número de indivíduos presentes e comportamento. A população utilizou intensamente a enseada do porto, principalmente para atividades de pesca. A maré enchente foi responsável por maiores taxas de ocupação. Dentre os meses analisados, maio foi o mês com maior média nas taxas de ocupação, e janeiro o mês de menor ocorrência. O tamanho de grupo médio na área foi de quatro indivíduos.
Keywords	Sotalia guianensis ; occupation index ; Babitonga bay ; harbor use ; behavior ; Biotechnology ; TP248.13-248.65 ; Chemical technology ; TP1-1185 ; Technology ; T ; DOAJ:Biotechnology ; DOAJ:Life Sciences ; DOAJ:Biology and Life Sciences
Language	English
Publishing date	2009-06-01T00:00:00Z
Publisher	Tecpar
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Morfologia do sincrânio do boto-cinza, Sotalia guianensis (P.J. van Bénéden) (Cetacea, Delphinidae) Syncranial morphology of the estuarine dolphin Sotalia guianensis (P.J. van Bénéden) (Cetacea, Delphinidae)

Paulo C. Simões-Lopes

Revista Brasileira de Zoologia, Vol 23, Iss 3, Pp 652-

2006 Volume 660

Abstract: Apresenta-se uma descrição da morfologia comparada do sincrânio de Sotalia guianensis (P.J. van ... of the syncranium of Sotalia guianensis (P.J. van Bénéden, 1864), including ontogenic aspects and intraspecific ...

Abstract	Apresenta-se uma descrição da morfologia comparada do sincrânio de Sotalia guianensis (P.J. van Bénéden, 1864), incluindo suas variações ontogenéticas e intra-específicas. As descrições foram baseadas em 51 crânios completos ou parciais depositados na coleção do laboratório de Mamíferos Aquáticos, do Departamento de Ecologia e Zoologia, CCB, Universidade Federal de Santa Catarina. O sincrânio é bastante homogêneo e manifesta sua assimetria na morfologia dos ossos, passagens nasais e forames. O rostro é proporcionalmente estreito em relação aos outros Delphinidae do mesmo porte. A região temporal é circular em indivíduos jovens, mas se torna oval nos adultos onde se forma uma crista temporal evidente. O forame elíptico do periótico está presente tanto em indivíduos jovens quanto adultos. Os nasais são bipartidos e podem ocorrer ossos suturais entre os frontais. O processo hamular dos pterigóides é bastante inflado e fenestrado. A sínfise mandibular alcança de 19 de 19-23% do comprimento do dentário. Cada pré-maxilar e maxilar possui de 30-35 dentes e cada dentário de 30-38 dentes. Morphological and comparative description of the syncranium of Sotalia guianensis (P.J. van Bénéden, 1864), including ontogenic aspects and intraspecific variations are presented. The descriptions were based on the examination of 51 complete or partial skulls, kept at the Marine Mammals Lab. Collection from the Departamento de Ecologia e Zoologia, CCB, at the Federal University of Santa Catarina. The sincranium is very homogeneous and manifests its asymmetry in the morphology of the bones, nasal passages and foramina. The rostrum is proportionally narrow in relation to other Delphinidae of the same size. The temporal region is circular in young specimens, but it becomes oval in the adults were it forms a well marked temporal crest. The elliptical foramen of the periotic bone is present both in young and adult individuals. The nasals are bipartite and one may find sutural bones between the frontals. The hamular process of the pterygoids is inflated and somewhat fenestrated. The mandibular symphysis covers from 19-23% of the dentary length. Each premaxilla and maxilla has 30-35 teeth and each dentary exhibits 30-38 teeth.
Keywords	Anatomia ; morfologia do crânio ; ontogenia ; pequenos cetáceos ; variações intra-específicas ; anatomy ; intraspecific variations ; ontogeny ; skull morphology ; small cetaceans ; Science ; Q ; Zoology ; QL1-991
Language	English
Publishing date	2006-09-01T00:00:00Z
Publisher	Sociedade Brasileira de Zoologia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Occupation pattern of a harbor inlet by the estuarine dolphin, Sotalia guianensis (P. J. Van Bénéden, 1864) (Cetacea, Delphinidae)

Cremer, Marta Jussara(Universidade Federal de São Carlos Laboratório de Análise e Planejamento Ambiental Departamento de Hidrobiologia, Universidade da Região de Joinville Laboratório de Nectologia Departamento de Ciências Biológicas) / Simões-Lopes, Paulo César(Universidade Federal de Santa Catarina Laboratório de Mamíferos Aquáticos Departamento de Ecologia e Zoologia) / Pires, José Salatiel Rodrigues(Universidade Federal de São Carlos Laboratório de Análise e Planejamento Ambiental Departamento de Hidrobiologia)

Brazilian Archives of Biology and Technology

2009/06

Abstract	The occupation pattern of Sotalia guianensis in São Francisco do Sul harbor inlet, in Babitonga bay, southern Brazil, was studied between September 1996 and June 1998. A total of 200 h of naturalistic observations and 141.2 h of estuarine dolphin systematic observations were made using binoculars 7 x 50. At each three minutes interval, data about number of individuals and behavior were registered. The population used the harbor inlet intensively, mainly for fishing activities. Ebb tide was responsible for a higher occupation index. Considering the months analyzed, the higher occupation index occurred in May, and in January the lower occurrence was observed. The mean group size was four individuals.
Language	English
Document type	Article
ISSN	1516-8913
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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Article ; Online: Respiratory Syncytial Virus Hospital-Based Burden of Disease in Children Younger Than 5 Years, 2015-2022.

Suss, Robert J / Simões, Eric A F

JAMA network open

2024 Volume 7, Issue 4, Page(s) e247125

Abstract: Importance: Respiratory syncytial virus (RSV) resurgences have been noted following the COVID-19 pandemic in many countries. Recent findings suggest that the 2021 and 2022 RSV seasons were more severe than in past seasons, and age distribution may have ... ...

Abstract	Importance: Respiratory syncytial virus (RSV) resurgences have been noted following the COVID-19 pandemic in many countries. Recent findings suggest that the 2021 and 2022 RSV seasons were more severe than in past seasons, and age distribution may have shifted toward older children in the younger than 5 years age group. Objectives: To estimate age-specific changes in RSV hospital-based burden of disease before and after the COVID-19 pandemic and to compare incidence by Medicaid use. Design, setting, and participants: This retrospective cohort study included children younger than 5 years diagnosed with RSV and bronchiolitis at 50 US children's hospitals in 10 US geographic regions. The included participants had an encounter in intensive care, inpatient, emergency, or observational units, between June 1, 2015, and March 31, 2023. Exposures: Diagnosis of RSV, bronchiolitis, or both at encounter. Main outcome and measures: Incidence rate ratio of hospital use within each care unit before vs after the COVID-19 pandemic. It was hypothesized a priori that incidence of hospital use would increase overall in 2021 and 2022 compared with 2015 to 2019 and that the increase would be greater among children 12 months and older. Results: Of 924 061 study participants (median [IQR] age, 8 (5-16) months; 535 619 [58.0%] male), 348 077 (37.7%) were diagnosed with RSV. Of these, 187 850 (54.0%) were hospitalized. Incidence rate ratios of hospitalization increased for all ages in 2021 and 2022 compared with 2015 to 2019. Children aged 24 to 59 months were 4.86 (95% CI, 4.75-4.98) times as likely to be hospitalized in 2022 compared with 2015 to 2019, whereas infants aged 0 to 5 months were 1.77 (95% CI, 1.74-1.80) times as likely. Medicaid patients were more likely to be hospitalized than non-Medicaid patients regardless of year. Conclusions and relevance: Hospitalizations for RSV and bronchiolitis demonstrated atypical seasonality in 2021 and 2022, with an overall increase in RSV encounters. Postpandemic RSV hospitalization increased for all ages, but especially among older children, whereas bronchiolitis hospitalization was decreased or unchanged compared with earlier seasons. These findings suggest some of the observed increase in RSV hospital use may be due to increased testing.
MeSH term(s)	Child, Preschool ; Female ; Humans ; Infant ; Male ; Bronchiolitis ; Cost of Illness ; COVID-19 ; Hospitals, Pediatric ; Pandemics ; Respiratory Syncytial Viruses ; Retrospective Studies ; United States
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2024.7125
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Decision Making in Severe Equine Asthma-Diagnosis and Monitoring.

Simões, Joana / Tilley, Paula

Animals : an open access journal from MDPI

2023 Volume 13, Issue 24

Abstract: Decision making consists of gathering quality data in order to correctly assess a situation and determine the best course of action. This process is a fundamental part of medicine and is what enables practitioners to accurately diagnose diseases and ... ...

Abstract	Decision making consists of gathering quality data in order to correctly assess a situation and determine the best course of action. This process is a fundamental part of medicine and is what enables practitioners to accurately diagnose diseases and select appropriate treatment protocols. Despite severe equine asthma (SEA) being a highly prevalent lower respiratory disease amongst equids, clinicians still struggle with the optimization of routine diagnostic procedures. The use of several ancillary diagnostic tests has been reported for disease identification and monitoring, but many are only suitable for research purposes or lack practicality for everyday use. The aim of this paper is to assist the equine veterinarian in the process of decision making associated with managing SEA-affected patients. This review will focus on disease diagnosis and monitoring, while also presenting a flow-chart which includes the basic data that the clinician must obtain in order to accurately identify severely asthmatic horses in their everyday routine practice. It is important to note that European and American board-certified specialists on equine internal medicine can provide assistance in the diagnosis and treatment plan of SEA-affected horses.
Language	English
Publishing date	2023-12-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13243872
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: New Horizons in Dermal and Transdermal Drug Delivery Systems.

Marto, Joana / Simões, Sandra

Pharmaceuticals (Basel, Switzerland)

2023 Volume 16, Issue 12

Abstract: Dermal and transdermal drug delivery represents an important strategy to target drugs towards the site of action or to noninvasively enhance treatment activity, circumventing the hepatic first passage and reducing toxicity [ ... ]. ...

Abstract	Dermal and transdermal drug delivery represents an important strategy to target drugs towards the site of action or to noninvasively enhance treatment activity, circumventing the hepatic first passage and reducing toxicity [...].
Language	English
Publishing date	2023-11-28
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph16121654
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Beyond Penicillin: The Potential of Filamentous Fungi for Drug Discovery in the Age of Antibiotic Resistance.

Correia, João / Borges, Anabela / Simões, Manuel / Simões, Lúcia C

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 8

Abstract: Antibiotics are a staple in current medicine for the therapy of infectious diseases. However, their extensive use and misuse, combined with the high adaptability of bacteria, has dangerously increased the incidence of multi-drug-resistant (MDR) bacteria. ...

Abstract	Antibiotics are a staple in current medicine for the therapy of infectious diseases. However, their extensive use and misuse, combined with the high adaptability of bacteria, has dangerously increased the incidence of multi-drug-resistant (MDR) bacteria. This makes the treatment of infections challenging, especially when MDR bacteria form biofilms. The most recent antibiotics entering the market have very similar modes of action to the existing ones, so bacteria rapidly catch up to those as well. As such, it is very important to adopt effective measures to avoid the development of antibiotic resistance by pathogenic bacteria, but also to perform bioprospecting of new molecules from diverse sources to expand the arsenal of drugs that are available to fight these infectious bacteria. Filamentous fungi have a large and vastly unexplored secondary metabolome and are rich in bioactive molecules that can be potential novel antimicrobial drugs. Their production can be challenging, as the associated biosynthetic pathways may not be active under standard culture conditions. New techniques involving metabolic and genetic engineering can help boost antibiotic production. This study aims to review the bioprospection of fungi to produce new drugs to face the growing problem of MDR bacteria and biofilm-associated infections.
Language	English
Publishing date	2023-07-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12081250
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mitochondrial targets in hyperammonemia: Addressing urea cycle function to improve drug therapies.

Moedas, Marco F / Simões, Ricardo J M / Silva, Margarida F B

Biochemical pharmacology

2024 Volume 222, Page(s) 116034

Abstract: The urea cycle (UC) is a critically important metabolic process for the disposal of nitrogen (ammonia) produced by amino acids catabolism. The impairment of this liver-specific pathway induced either by primary genetic defects or by secondary causes, ... ...

Abstract	The urea cycle (UC) is a critically important metabolic process for the disposal of nitrogen (ammonia) produced by amino acids catabolism. The impairment of this liver-specific pathway induced either by primary genetic defects or by secondary causes, namely those associated with hepatic disease or drug administration, may result in serious clinical consequences. Urea cycle disorders (UCD) and certain organic acidurias are the major groups of inherited rare diseases manifested with hyperammonemia (HA) with UC dysregulation. Importantly, several commonly prescribed drugs, including antiepileptics in monotherapy or polytherapy from carbamazepine to valproic acid or specific antineoplastic agents such as asparaginase or 5-fluorouracil may be associated with HA by mechanisms not fully elucidated. HA, disclosing an imbalance between ammoniagenesis and ammonia disposal via the UC, can evolve to encephalopathy which may lead to significant morbidity and central nervous system damage. This review will focus on biochemical mechanisms related with HA emphasizing some poorly understood perspectives behind the disruption of the UC and mitochondrial energy metabolism, namely: i) changes in acetyl-CoA or NAD
MeSH term(s)	Humans ; Hyperammonemia/drug therapy ; Hyperammonemia/etiology ; Hyperammonemia/metabolism ; Ammonia/metabolism ; Liver Diseases ; Urea/therapeutic use
Chemical Substances	Ammonia (7664-41-7) ; Urea (8W8T17847W)
Language	English
Publishing date	2024-02-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2024.116034
Database	MEDical Literature Analysis and Retrieval System OnLINE

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