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  1. Book: Molecular biology of RNA processing and decay in prokaryotes

    Condon, Ciaran

    (Progress in molecular biology and translational science ; 85)

    2009  

    Author's details ed. by Ciaran Condon
    Series title Progress in molecular biology and translational science ; 85
    Collection
    Language English
    Size VIII, 510 S. : Ill., graph. Darst.
    Publisher Elsevier Acad. Press
    Publishing place Amsterdam u.a
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT015889673
    ISBN 978-0-12-374761-7 ; 0-12-374761-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uc I Zs 357 -85- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Marc Dreyfus (1948-2022).

    Iost, Isabelle / Condon, Ciarán

    Molecular microbiology

    2023  Volume 119, Issue 3, Page(s) 378–380

    Language English
    Publishing date 2023-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 619315-8
    ISSN 1365-2958 ; 0950-382X
    ISSN (online) 1365-2958
    ISSN 0950-382X
    DOI 10.1111/mmi.15022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2502: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Effect of tRNA Maturase Depletion on Levels and Stabilities of Ribosome Assembly Cofactor and Other mRNAs in Bacillus subtilis.

    Trinquier, Aude / Condon, Ciarán / Braun, Frédérique

    Microbiology spectrum

    2023  , Page(s) e0513422

    Abstract: The impact of translation on mRNA stability can be varied, ranging from a protective effect of ribosomes that shield mRNA from RNases to preferentially exposing sites of RNase cleavage. These effects can change depending on whether ribosomes are actively ...

    Abstract The impact of translation on mRNA stability can be varied, ranging from a protective effect of ribosomes that shield mRNA from RNases to preferentially exposing sites of RNase cleavage. These effects can change depending on whether ribosomes are actively moving along the mRNA or stalled at particular sequences or structures or awaiting charged tRNAs. We recently observed that depleting Bacillus subtilis cells of their tRNA maturation enzymes RNase P and RNase Z led to altered mRNA levels of a number of assembly factors involved in the biogenesis of the 30S ribosomal subunit. Here, we extended this study to other assembly factor and non-assembly factor mRNAs in B. subtilis. We additionally identified multiple transcriptional and translational layers of regulation of the
    Language English
    Publishing date 2023-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.05134-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: RNases and Helicases in Gram-Positive Bacteria.

    Durand, Sylvain / Condon, Ciaran

    Microbiology spectrum

    2018  Volume 6, Issue 2

    Abstract: RNases are key enzymes involved in RNA maturation and degradation. Although they play a crucial role in all domains of life, bacteria, archaea, and eukaryotes have evolved with their own sets of RNases and proteins modulating their activities. In ... ...

    Abstract RNases are key enzymes involved in RNA maturation and degradation. Although they play a crucial role in all domains of life, bacteria, archaea, and eukaryotes have evolved with their own sets of RNases and proteins modulating their activities. In bacteria, these enzymes allow modulation of gene expression to adapt to rapidly changing environments. Today, >20 RNases have been identified in both
    MeSH term(s) Bacterial Proteins ; DNA Helicases/physiology ; Endoribonucleases/physiology ; Gene Expression Regulation, Bacterial ; Gram-Positive Bacteria/enzymology ; Gram-Positive Bacteria/genetics ; RNA Stability ; Ribonucleases/classification ; Ribonucleases/physiology ; Substrate Specificity
    Chemical Substances Bacterial Proteins ; Endoribonucleases (EC 3.1.-) ; Ribonucleases (EC 3.1.-) ; DNA Helicases (EC 3.6.4.-)
    Language English
    Publishing date 2018-04-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2165-0497
    ISSN (online) 2165-0497
    DOI 10.1128/microbiolspec.RWR-0003-2017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Airpnp: Auto- and Integrated Regulation of Polynucleotide Phosphorylase.

    Condon, Ciarán

    Journal of bacteriology

    2015  Volume 197, Issue 24, Page(s) 3748–3750

    Abstract: The properties and expression of polynucleotide phosphorylase (PNPase), capable of both RNA degradation and polymerization, have been studied for 60 years. In this issue of the Journal of Bacteriology, Park et al. (H. Park, H. Yakhnin, M. Connolly, T. ... ...

    Abstract The properties and expression of polynucleotide phosphorylase (PNPase), capable of both RNA degradation and polymerization, have been studied for 60 years. In this issue of the Journal of Bacteriology, Park et al. (H. Park, H. Yakhnin, M. Connolly, T. Romeo, and P. Babitzke, J Bacteriol 197:3751-3759, 2015, http://dx.doi.org/10.1128/JB.00721-15) write the latest chapter on the complex regulation of pnp gene expression involving CsrA. I describe how this new piece of the puzzle fits into the global scheme of PNPase autoregulation and how this is influenced by central carbon metabolism at both the posttranscriptional level and that of enzyme activity.
    MeSH term(s) Escherichia coli/enzymology ; Escherichia coli Proteins/metabolism ; Gene Expression Regulation, Bacterial/genetics ; Polyribonucleotide Nucleotidyltransferase/genetics ; RNA-Binding Proteins/metabolism ; Repressor Proteins/metabolism ; Ribonuclease III/genetics
    Chemical Substances Escherichia coli Proteins ; RNA-Binding Proteins ; Repressor Proteins ; Polyribonucleotide Nucleotidyltransferase (EC 2.7.7.8) ; Ribonuclease III (EC 3.1.26.3)
    Language English
    Publishing date 2015-12
    Publishing country United States
    Document type Comment ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/JB.00794-15
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  6. Article: Lessons from lockdown: Virtual Clinics and service reorganisation in fracture management during COVID 19 experience of an Irish Regional Trauma Unit.

    Stanley, Ciaran / Kelly, Martin / Elzaki, Mohamed / Butler, Audrey / Condon, Finbarr / Lenehan, Brian

    The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland

    2021  Volume 19, Issue 6, Page(s) e325–e330

    Abstract: Background: Trauma places a burden on healthcare services accounting for a large proportion of Emergency Department presentations. COVID-19 spread rapidly affecting over 30 million worldwide. To manage trauma presentations the Department of Trauma & ... ...

    Abstract Background: Trauma places a burden on healthcare services accounting for a large proportion of Emergency Department presentations. COVID-19 spread rapidly affecting over 30 million worldwide. To manage trauma presentations the Department of Trauma & Orthopaedic Surgery reorganised service delivery.
    Aim: To assess the impact of service reorganisation and Virtual Clinics on patients in a Regional Unit in Ireland.
    Methods: A retrospective review of trauma activity following introduction of Virtual Fracture Clinics and Theatre COVID Pathways for a 10 week period in comparison with the same 2019 period. All patients underwent both nasopharyngeal and oropharyngeal swabs PCR testing prior to operations. Theatre and outpatient activity were evaluated. Clinic data were accumulated using the Integrated Patient Management System.
    Results: Theatre Activity: 242 patients underwent surgery in our trauma unit (mean 2.98 per list) during the COVID- 19 period. 29 cases were performed in repurposed elective hospital giving a total of 271 during the 2020 study period. 371 cases were performed in the same 2019 period (mean 4.58 per list). Outpatient Activity: We noted a 25.86% fracture clinic referral reduction during the COVID 19 period compared to 2019. There was a 150.77% increase in patients managed through Trauma Assessment Clinic. 639 patients were managed through the Virtual Fracture Clinic Pathway during COVID 19 period.
    Conclusions: Over one in four fracture clinic patients can be managed virtually. A new dedicated Acute Fracture Unit within our institution permitted streamlining of care and social distancing. The "Non-COVID" pathway for ambulatory trauma was essential in managing the growing presentations of these injuries.
    MeSH term(s) COVID-19 ; Communicable Disease Control ; Humans ; Retrospective Studies ; SARS-CoV-2 ; Trauma Centers
    Language English
    Publishing date 2021-03-04
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 2102927-1
    ISSN 1479-666X
    ISSN 1479-666X
    DOI 10.1016/j.surge.2021.02.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5756: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  7. Article ; Online: rRNA operon multiplicity as a bacterial genome stability insurance policy.

    Fleurier, Sebastien / Dapa, Tanja / Tenaillon, Olivier / Condon, Ciarán / Matic, Ivan

    Nucleic acids research

    2022  Volume 50, Issue 22, Page(s) 12601–12620

    Abstract: Quick growth restart after upon encountering favourable environmental conditions is a major fitness contributor in natural environment. It is widely assumed that the time required to restart growth after nutritional upshift is determined by how long it ... ...

    Abstract Quick growth restart after upon encountering favourable environmental conditions is a major fitness contributor in natural environment. It is widely assumed that the time required to restart growth after nutritional upshift is determined by how long it takes for cells to synthesize enough ribosomes to produce the proteins required to reinitiate growth. Here we show that a reduction in the capacity to synthesize ribosomes by reducing number of ribosomal RNA (rRNA) operons (rrn) causes a longer transition from stationary phase to growth of Escherichia coli primarily due to high mortality rates. Cell death results from DNA replication blockage and massive DNA breakage at the sites of the remaining rrn operons that become overloaded with RNA polymerases (RNAPs). Mortality rates and growth restart duration can be reduced by preventing R-loop formation and improving DNA repair capacity. The same molecular mechanisms determine the duration of the recovery phase after ribosome-damaging stresses, such as antibiotics, exposure to bile salts or high temperature. Our study therefore suggests that a major function of rrn operon multiplicity is to ensure that individual rrn operons are not saturated by RNAPs, which can result in catastrophic chromosome replication failure and cell death during adaptation to environmental fluctuations.
    MeSH term(s) Escherichia coli/metabolism ; Genome, Bacterial ; Operon ; Ribosomes/genetics ; Ribosomes/metabolism ; RNA, Bacterial/genetics ; RNA, Ribosomal/genetics ; RNA, Ribosomal/metabolism ; rRNA Operon ; Genomic Instability
    Chemical Substances RNA, Bacterial ; RNA, Ribosomal
    Language English
    Publishing date 2022-05-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkac332
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1067: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Shutdown of multidrug transporter

    Deves, Valentin / Trinquier, Aude / Gilet, Laetitia / Alharake, Jawad / Condon, Ciarán / Braun, Frédérique

    RNA (New York, N.Y.)

    2023  Volume 29, Issue 8, Page(s) 1108–1116

    Abstract: Rae1 is a well-conserved endoribonuclease among Gram-positive bacteria, cyanobacteria, and the chloroplasts of higher plants. We have previously shown that Rae1 cleaves ... ...

    Abstract Rae1 is a well-conserved endoribonuclease among Gram-positive bacteria, cyanobacteria, and the chloroplasts of higher plants. We have previously shown that Rae1 cleaves the
    MeSH term(s) Protein Biosynthesis ; Endoribonucleases/genetics ; Endoribonucleases/metabolism ; Open Reading Frames ; Ribosomes/genetics ; Ribosomes/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Membrane Transport Proteins/genetics ; Membrane Transport Proteins/metabolism
    Chemical Substances Endoribonucleases (EC 3.1.-) ; RNA, Messenger ; Membrane Transport Proteins
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1241540-6
    ISSN 1469-9001 ; 1355-8382
    ISSN (online) 1469-9001
    ISSN 1355-8382
    DOI 10.1261/rna.079692.123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4777: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Book: Molecular biology of RNA processing and decay in prokaryotes

    Condon, Ciaran

    (Progress in molecular biology and translational science ; 85)

    2009  

    Author's details ed. by Ciaran Condon
    Series title Progress in molecular biology and translational science ; 85
    Language English
    Size VIII, 510 S., Ill., graph. Darst.
    Publisher Elsevier, Acad. Press
    Publishing place Amsterdam u.a.
    Document type Book
    Note Literaturangaben
    ISBN 9780123747617 ; 0123747619
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  10. Book: Molecular biology of RNA processing and decay in prokaryotes

    Condon, Ciaran

    (Progress in molecular biology and translational science ; v. 85)

    2009  

    Author's details edited by Ciaran Condon
    Series title Progress in molecular biology and translational science ; v. 85
    Keywords Molecular biology. ; RNA. ; Prokaryotes.
    Language English
    Size viii, 510 p. :, ill. ;, 24 cm.
    Publisher Elsevier Academic Press
    Publishing place Amsterdam ; Boston
    Document type Book
    ISBN 0123747619 ; 9780123747617
    Database NAL-Catalogue (AGRICOLA)

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