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  1. Article: Does a Uni "Feel Better" than a Total Knee? Not Necessarily, When Using Modern Implant Designs.

    Ast, Michael P / Kolin, David A / Carroll, Kaitlin M / Davis, Destiny / Pearle, Andrew D / Mayman, David J / Ong, Alvin C

    HSS journal : the musculoskeletal journal of Hospital for Special Surgery

    2022  Volume 19, Issue 1, Page(s) 32–36

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2022-10-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2250601-9
    ISSN 1556-3324 ; 1556-3316
    ISSN (online) 1556-3324
    ISSN 1556-3316
    DOI 10.1177/15563316221131251
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6398: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  2. Article ; Online: Catalysts for Change: The Role of Nonprofits in Solving Single Ventricle Heart Disease.

    Davis, Kaitlin A / Pickles, Diane M / Keller, Kirstie E

    Journal of cardiovascular development and disease

    2022  Volume 9, Issue 7

    Abstract: Single ventricle (SV) heart disease comprises a spectrum of complex congenital heart defects (CHDs), including hypoplastic left heart syndrome (HLHS), one of the most common causes of death amongst infants with CHD. Despite its incompletely defined ... ...

    Abstract Single ventricle (SV) heart disease comprises a spectrum of complex congenital heart defects (CHDs), including hypoplastic left heart syndrome (HLHS), one of the most common causes of death amongst infants with CHD. Despite its incompletely defined etiology and a dearth of curative solutions, SV is a solvable problem that can be addressed by unifying a nascent field that is ripe for investment, in part due to its high economic impact and growth potential. Here, we explore the landscape of SV and identify areas of opportunity that will yield an outsized impact through strategic investment that focuses on synchronization across disciplines, community involvement, and infrastructure development, and argue that nonprofits are the appropriate catalyst to spark transformative innovation and impact in the form of functional cures.
    Language English
    Publishing date 2022-07-08
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd9070220
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  3. Article ; Online: Establishment of a Genetically Diverse, Disease-Resistant Acacia koa A. Gray Seed Orchard in Kokee, Kauai

    Nicklos Dudley / Tyler Jones / Kaitlin Gerber / Amy L. Ross-Davis / Richard A. Sniezko / Phil Cannon / John Dobbs

    Forests, Vol 11, Iss 1276, p

    Early Growth, Form, and Survival

    2020  Volume 1276

    Abstract: Background and Objectives: Koa ( Acacia koa A. Gray) is an economically, ecologically, and culturally valuable tree species endemic to Hawaii. A vascular wilt disease caused by the fungal pathogen Fusarium oxysporum f. sp. koae Gardner (FOXY) induces ... ...

    Abstract Background and Objectives: Koa ( Acacia koa A. Gray) is an economically, ecologically, and culturally valuable tree species endemic to Hawaii. A vascular wilt disease caused by the fungal pathogen Fusarium oxysporum f. sp. koae Gardner (FOXY) induces high rates of mortality in plantings and threatens native koa forests as well. Landowners are reluctant to consider koa for reforestation purposes in many areas due to the risk of mortality caused by FOXY. Producing seeds with genetic resistance to FOXY is vital to successful koa reforestation and restoration. The Hawaii Agriculture Research Center (HARC), with both public and private partners, operates a tree improvement program to develop wilt-resistant koa populations in Hawaii. The population genetics of koa is poorly understood and seed zones are evolving. Thus, HARC uses provisional seed zones based on genetic and biogeographic variables and has selected wilt-resistant koa populations that are locally found in Kokee, Kauai (eco-regions) of Hawaii. Materials and Methods: To make these selections, virulent FOXY isolates were used in previous seedling inoculation trials to evaluate resistance levels among koa families in greenhouse experiments, and the most resistant families were used in the field trial reported here. Results: In this trial, survival rates two years after planting varied by family, and ranged from 45% to 95%, but all resistant families had greater survival rates than the susceptible control (25%). The trial has been converted to a seed orchard. Conclusions: The higher survival rates of the families are encouraging and seeds coming from the orchard will improve the success of future restoration and reforestation efforts. Within these resistant families it was also possible to make some selections based on height, growth, diameter, and stem form. Thus, the establishment of a wilt-resistant seed orchard results in locally adapted, eco-region specific, disease-resistant koa seed that will allow for the restoration of this iconic species and provide ...
    Keywords Hawaii ; koa ; wilt-resistance ; ecoregion ; seed orchard ; survival ; Plant ecology ; QK900-989
    Subject code 580
    Language English
    Publishing date 2020-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Establishment of a Genetically Diverse, Disease-Resistant Acacia koa A. Gray Seed Orchard in Kokee, Kauai: Early Growth, Form, and Survival

    Dudley, Nicklos / Jones, Tyler / Gerber, Kaitlin / Ross-Davis, Amy L / Sniezko, Richard A / Cannon, Phil / Dobbs, John

    Forests. 2020 Nov. 28, v. 11, no. 12

    2020  

    Abstract: Background and Objectives: Koa (Acacia koa A. Gray) is an economically, ecologically, and culturally valuable tree species endemic to Hawaii. A vascular wilt disease caused by the fungal pathogen Fusarium oxysporum f. sp. koae Gardner (FOXY) induces high ...

    Abstract Background and Objectives: Koa (Acacia koa A. Gray) is an economically, ecologically, and culturally valuable tree species endemic to Hawaii. A vascular wilt disease caused by the fungal pathogen Fusarium oxysporum f. sp. koae Gardner (FOXY) induces high rates of mortality in plantings and threatens native koa forests as well. Landowners are reluctant to consider koa for reforestation purposes in many areas due to the risk of mortality caused by FOXY. Producing seeds with genetic resistance to FOXY is vital to successful koa reforestation and restoration. The Hawaii Agriculture Research Center (HARC), with both public and private partners, operates a tree improvement program to develop wilt-resistant koa populations in Hawaii. The population genetics of koa is poorly understood and seed zones are evolving. Thus, HARC uses provisional seed zones based on genetic and biogeographic variables and has selected wilt-resistant koa populations that are locally found in Kokee, Kauai (eco-regions) of Hawaii. Materials and Methods: To make these selections, virulent FOXY isolates were used in previous seedling inoculation trials to evaluate resistance levels among koa families in greenhouse experiments, and the most resistant families were used in the field trial reported here. Results: In this trial, survival rates two years after planting varied by family, and ranged from 45% to 95%, but all resistant families had greater survival rates than the susceptible control (25%). The trial has been converted to a seed orchard. Conclusions: The higher survival rates of the families are encouraging and seeds coming from the orchard will improve the success of future restoration and reforestation efforts. Within these resistant families it was also possible to make some selections based on height, growth, diameter, and stem form. Thus, the establishment of a wilt-resistant seed orchard results in locally adapted, eco-region specific, disease-resistant koa seed that will allow for the restoration of this iconic species and provide plant material for commercial reforestation opportunities at the landscape level.
    Keywords Acacia koa ; Fusarium oxysporum ; Kauai ; agriculture ; diameter ; disease resistance ; ecoregions ; field experimentation ; forests ; fungi ; genetic resistance ; geographical distribution ; greenhouse experimentation ; height ; landowners ; landscapes ; materials ; objectives ; pathogens ; plant improvement ; planting ; population ; population genetics ; reforestation ; research ; risk ; seed orchards ; seedlings ; seeds ; stem form ; survival rate ; trees ; vascular wilt ; virulence
    Language English
    Dates of publication 2020-1128
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2527081-3
    ISSN 1999-4907
    ISSN 1999-4907
    DOI 10.3390/f11121276
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Correction: Implementation of genomic medicine for rare disease in a tertiary healthcare system: Mayo Clinic Program for Rare and Undiagnosed Diseases (PRaUD).

    Pinto E Vairo, Filippo / Kemppainen, Jennifer L / Vitek, Carolyn R Rohrer / Whalen, Denise A / Kolbert, Kayla J / Sikkink, Kaitlin J / Kroc, Sarah A / Kruisselbrink, Teresa / Shupe, Gabrielle F / Knudson, Alyssa K / Burke, Elizabeth M / Loftus, Elle C / Bandel, Lorelei A / Prochnow, Carri A / Mulvihill, Lindsay A / Thomas, Brittany / Gable, Dale M / Graddy, Courtney B / Garzon, Giovanna G Moreno /
    Ekpoh, Idara U / Porquera, Eva M Carmona / Fervenza, Fernando C / Hogan, Marie C / El Ters, Mireille / Warrington, Kenneth J / Davis, John M / Koster, Matthew J / Orandi, Amir B / Basiaga, Matthew L / Vella, Adrian / Kumar, Seema / Creo, Ana L / Lteif, Aida N / Pittock, Siobhan T / Tebben, Peter J / Abate, Ejigayehu G / Joshi, Avni Y / Ristagno, Elizabeth H / Patnaik, Mrinal S / Schimmenti, Lisa A / Dhamija, Radhika / Sabrowsky, Sonia M / Wierenga, Klaas J / Keddis, Mira T / Samadder, Niloy Jewel J / Presutti, Richard J / Robinson, Steven I / Stephens, Michael C / Roberts, Lewis R / Faubion, William A / Driscoll, Sherilyn W / Wong-Kisiel, Lily C / Selcen, Duygu / Flanagan, Eoin P / Ramanan, Vijay K / Jackson, Lauren M / Mauermann, Michelle L / Ortega, Victor E / Anderson, Sarah A / Aoudia, Stacy L / Klee, Eric W / McAllister, Tammy M / Lazaridis, Konstantinos N

    Journal of translational medicine

    2024  Volume 22, Issue 1, Page(s) 400

    Language English
    Publishing date 2024-04-30
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/s12967-024-05185-9
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  6. Article ; Online: Exploring the catalytic role of the guanidine TBD in carboxylative cyclizations.

    Isfeld, Kaitlin A / Killeen, Charles / Konowalchuk, Dawson J / Davis, Rebecca L

    Organic & biomolecular chemistry

    2022  Volume 20, Issue 29, Page(s) 5730–5734

    Abstract: Employing a combination of mechanistic, kinetic and computational studies we have examined the mechanism of the TBD-catalyzed carboxylative cyclization of indole derivatives. Our studies provide insight into the role of the guanidine superbase TBD in ... ...

    Abstract Employing a combination of mechanistic, kinetic and computational studies we have examined the mechanism of the TBD-catalyzed carboxylative cyclization of indole derivatives. Our studies provide insight into the role of the guanidine superbase TBD in catalyzing C-C bond formation between indole derivatives and CO
    MeSH term(s) Catalysis ; Cyclization ; Guanidine/chemistry ; Guanidines ; Indoles
    Chemical Substances Guanidines ; Indoles ; Guanidine (JU58VJ6Y3B)
    Language English
    Publishing date 2022-07-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d2ob01012g
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  7. Article ; Online: The optimization of poly(vinyl)-alcohol-alginate beads with a slow-release compound for the aerobic cometabolism of chlorinated aliphatic hydrocarbons.

    Harris, Conor G / Gedde, Hannah K / Davis, Audrey A / Semprini, Lewis / Rochefort, Willie E / Fogg, Kaitlin C

    RSC sustainability

    2024  Volume 2, Issue 4, Page(s) 1101–1117

    Abstract: Chlorinated aliphatic hydrocarbons (CAHs), such ... ...

    Abstract Chlorinated aliphatic hydrocarbons (CAHs), such as
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article
    ISSN 2753-8125
    ISSN (online) 2753-8125
    DOI 10.1039/d3su00409k
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  8. Article: A standardized instrument quantifying risk factors associated with bi-directional transmission of SARS-CoV-2 and other zoonotic pathogens: The COVID-19 human-animal interactions survey (CHAIS).

    Gass, Jonathon D / Waite, Kaitlin B / Hill, Nichola J / Dalton, Kathryn R / Sawatzki, Kaitlin / Runstadler, Jonathan A / Davis, Meghan F

    One health (Amsterdam, Netherlands)

    2022  Volume 15, Page(s) 100422

    Abstract: Similar to many zoonotic pathogens which transmit from animals to humans, SARS-CoV-2 (CoV-2), the virus responsible for the COVID-19 pandemic, most likely originated in Rhinolophus bats before spreading among humans globally. Early into the pandemic, ... ...

    Abstract Similar to many zoonotic pathogens which transmit from animals to humans, SARS-CoV-2 (CoV-2), the virus responsible for the COVID-19 pandemic, most likely originated in Rhinolophus bats before spreading among humans globally. Early into the pandemic, reports of CoV-2 diagnoses in animals from various countries emerged. While most CoV-2 positive animals were confirmed to have been in close contact with CoV-2 positive humans, there has been a paucity of published evidence to-date describing risk factors associated with CoV-2 transmission among humans and animals. The COVID-19 Human-Animal Interactions Survey (CHAIS) was developed to provide a standardized instrument describing human-animal interactions during the pandemic and to evaluate behavioral, spatiotemporal, and biological risk factors associated with bi-directional zoonotic transmission of CoV-2 within shared environments, predominantly households with limited information about human-wildlife or human-livestock interactions. CHAIS measures four broad domains of transmission risk: 1) risk and intensity of infection in human hosts, 2) spatial characteristics of shared environments, 3) behaviors and human-animal interactions, and 4) susceptible animal subpopulations. Following the development of CHAIS, with a One Health approach, a multidisciplinary group of experts (
    Language English
    Publishing date 2022-07-27
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2834831-X
    ISSN 2352-7714
    ISSN 2352-7714
    DOI 10.1016/j.onehlt.2022.100422
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  9. Article ; Online: Working memory development from early childhood to adolescence using two nationally representative samples.

    Ahmed, Sammy F / Ellis, Alexa / Ward, Kaitlin P / Chaku, Natasha / Davis-Kean, Pamela E

    Developmental psychology

    2022  Volume 58, Issue 10, Page(s) 1962–1973

    Abstract: We leveraged nationally representative data from the Panel study of Income Dynamics-Child Development Supplement ( ...

    Abstract We leveraged nationally representative data from the Panel study of Income Dynamics-Child Development Supplement (
    MeSH term(s) Adolescent ; Child Development ; Child, Preschool ; Female ; Humans ; Longitudinal Studies ; Male ; Memory, Short-Term
    Language English
    Publishing date 2022-06-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2066223-3
    ISSN 1939-0599 ; 0012-1649
    ISSN (online) 1939-0599
    ISSN 0012-1649
    DOI 10.1037/dev0001396
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  10. Article: Shutdown of interferon signaling by a viral-hijacked E3 ubiquitin ligase.

    Davis, Kaitlin A / Patton, John T

    Microbial cell (Graz, Austria)

    2017  Volume 4, Issue 11, Page(s) 387–389

    Abstract: ... report published by Davis ...

    Abstract Viruses manipulate cellular processes to create an environment favorable to replication. For most viruses, this includes subverting the expression of interferon (IFN), a signaling molecule that can stimulate production of a vast array of antiviral gene products. Rotavirus, a segmented double-stranded RNA virus that causes acute gastroenteritis in infants and young children, inhibits IFN expression through its nonstructural protein NSP1. This viral protein stifles IFN expression by inducing the degradation of host factors that are necessary for upregulating the activity of IFN genes. In the case of nearly all human and porcine rotavirus strains, NSP1 induces the ubiquitination-dependent proteasomal degradation of β-transducin repeat containing protein (β-TrCP), a host factor that plays an essential role in activating the IFN-transcription factor, NF-κB. Key to the process is the presence of a decoy sequence (degron) at the C-terminus of NSP1 that causes β-TrCP to mistakenly bind NSP1 instead of its natural target, inhibitor-of-κB (IκB). In a recent report published by Davis
    Language English
    Publishing date 2017-11-03
    Publishing country Austria
    Document type Journal Article ; Comment
    ZDB-ID 2814756-X
    ISSN 2311-2638
    ISSN 2311-2638
    DOI 10.15698/mic2017.11.600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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