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Article ; Online: Recurrent obstructive salivary disease after sialendoscopy. A narrative literature review.

Capaccio, Pasquale / Gaffuri, Michele / Canzi, Pietro / Pignataro, Lorenzo

Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale

2023 Volume 43, Issue Suppl 1, Page(s) S95–S102

Language	English
Publishing date	2023-09-12
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	604898-5
ISSN	1827-675X ; 0392-100X
ISSN (online)	1827-675X
ISSN	0392-100X
DOI	10.14639/0392-100X-suppl.1-43-2023-12
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Article ; Online: Image-guided and sialendoscopy-assisted transoral approach for parotid duct stenosis and megaduct.

Gaffuri, Michele / Battilocchi, Ludovica / Pignataro, Lorenzo / Capaccio, Pasquale

The Journal of laryngology and otology

2023 Volume 138, Issue 5, Page(s) 581–583

Abstract: Objective: The aim of this communication was to introduce a novel combined image (magnetic resonance and computed tomography-guided and sialendoscopy-assisted transoral approach for the treatment of a parotid duct stenosis with megaduct.: Methods: A ... ...

Abstract	Objective: The aim of this communication was to introduce a novel combined image (magnetic resonance and computed tomography-guided and sialendoscopy-assisted transoral approach for the treatment of a parotid duct stenosis with megaduct. Methods: A 46-year-old woman was referred to our department for recurrent infections of the right parotid gland following unsuccessful multiple transoral surgical approaches for a Stensen's duct stricture with megaduct. An image (magnetic resonance and computed tomography)-guided and sialendoscopy-assisted transoral sialodochoplasty was planned and performed. Results: No complications occurred. The patient was discharged 2 days after surgery. No more swelling or infections occurred. The patient is currently symptom-free after a follow up of 11 months. Conclusion: Although imaging navigation means more technical effort and costs, this novel approach can be considered a viable surgical opportunity for distal and mid-third parotid duct stenosis with concomitant megaduct, particularly in cases of persistent inflammation or iatrogenic scars due to previous surgery.
MeSH term(s)	Humans ; Female ; Middle Aged ; Constriction, Pathologic/surgery ; Salivary Ducts/surgery ; Salivary Ducts/pathology ; Tomography, X-Ray Computed ; Magnetic Resonance Imaging/methods ; Endoscopy/methods ; Parotid Diseases/surgery ; Parotid Diseases/diagnostic imaging ; Parotid Gland/surgery ; Parotid Gland/pathology ; Surgery, Computer-Assisted/methods ; Treatment Outcome
Language	English
Publishing date	2023-10-09
Publishing country	England
Document type	Journal Article ; Case Reports
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S0022215123001731
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Ul II Zs.64: Show issues

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Article ; Online: SARS-CoV-2 tropism across the upper aerodigestive tract.

Torretta, Sara / Pignataro, Lorenzo / Marchisio, Paola / Capaccio, Pasquale

International journal of immunopathology and pharmacology

2022 Volume 35, Page(s) 20587384211056840

MeSH term(s)	Angiotensin-Converting Enzyme 2/metabolism ; COVID-19/metabolism ; COVID-19/virology ; Epithelial Cells/metabolism ; Epithelial Cells/virology ; Humans ; Nasopharynx/metabolism ; Nasopharynx/virology ; Respiratory Mucosa/metabolism ; Respiratory Mucosa/virology ; SARS-CoV-2/physiology ; Viral Tropism/physiology
Chemical Substances	Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Language	English
Publishing date	2022-01-07
Publishing country	England
Document type	Letter
ZDB-ID	645171-8
ISSN	2058-7384 ; 0394-6320
ISSN (online)	2058-7384
ISSN	0394-6320
DOI	10.1177/20587384211056840
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Zs.A 2537: Show issues

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Article ; Online: The piercing-stretching suture technique for the treatment of simple oral floor ranula.

Gaffuri, M / Torretta, S / Pignataro, L / Capaccio, P

The Journal of laryngology and otology

2021 Volume 136, Issue 1, Page(s) 68–72

Abstract: Background: Oral floor ranulas are pseudocysts located in the floor of the mouth that result from the extravasation of mucus from a sublingual gland. Historically, there has been little consensus on the ideal first-line treatment. Currently, definitive ... ...

Abstract	Background: Oral floor ranulas are pseudocysts located in the floor of the mouth that result from the extravasation of mucus from a sublingual gland. Historically, there has been little consensus on the ideal first-line treatment. Currently, definitive treatment involves sublingual gland excision, which can injure the lingual nerve and submandibular duct. Minimally invasive surgical techniques have been proposed, but so far have been associated with a high rate of recurrence. Methods: The so-called piercing-stretching suture technique was performed in 14 naïve adult and paediatric patients (6 females, with a mean age of 20.3 years (range, 7-55 years)). Clinical and ultrasonographic evaluations were performed in all patients; post-operative sialendoscopy was conducted in two paediatric patients. Results: The surgical procedure was successful in all patients, and complete recovery of the ranula was seen in all but one of the patients who underwent suture replacement. No major or minor complications were encountered. Conclusion: This minimally invasive procedure may be considered a reliable and first-line treatment for management of simple oral floor ranulas.
MeSH term(s)	Adolescent ; Adult ; Child ; Female ; Humans ; Male ; Middle Aged ; Ranula/surgery ; Suture Techniques ; Young Adult
Language	English
Publishing date	2021-10-27
Publishing country	England
Document type	Journal Article
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S0022215121003327
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Article: The Flex Robotic System in Head and Neck Surgery: A Review.

Riva, Giuseppe / Cravero, Ester / Briguglio, Marco / Capaccio, Pasquale / Pecorari, Giancarlo

Cancers

2022 Volume 14, Issue 22

Abstract: The Flex Robotic System is a device intended for robot-assisted visualization and surgical site access to the head and neck. The aim of this review is to summarize the current knowledge about the Flex Robotic System in head and neck transoral robotic ... ...

Abstract	The Flex Robotic System is a device intended for robot-assisted visualization and surgical site access to the head and neck. The aim of this review is to summarize the current knowledge about the Flex Robotic System in head and neck transoral robotic surgery (TORS). The primary search was performed using the term "Flex Robot" across several databases (PubMed, Embase, Cochrane, Scopus). Patients were treated for both benign and malignant diseases. The oropharynx was the most frequent site of disease, followed by the supraglottic larynx, hypopharynx, glottic larynx, oral cavity, and salivary glands. Most of the studies did not reveal major intra- or post-operative complications. Bleeding incidence was low (1.4-15.7%). Visualization of the lesion was 95-100%, while surgical success was 91-100%. In conclusion, lesions of the oropharynx, hypopharynx, or larynx can be successfully resected, thus making the Flex Robotic System a safe and effective tool, reducing the morbidity associated with traditional open surgery.
Language	English
Publishing date	2022-11-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers14225541
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Article: Minimally invasive transoral robotic surgery for hiloparenchymal submandibular stone: Technical note on Flex Robotic System.

Capaccio, Pasquale / Riva, Giuseppe / Cammarota, Raffaella / Gaffuri, Michele / Pecorari, Giancarlo

Clinical case reports

2022 Volume 10, Issue 1, Page(s) e04529

Abstract: Flex Robotic System allows a minimally invasive approach for transoral removal of submandibular salivary stones. ...

Abstract	Flex Robotic System allows a minimally invasive approach for transoral removal of submandibular salivary stones.
Language	English
Publishing date	2022-01-24
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.4529
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Article ; Online: Topical administration of S. salivarius 24SMB-S. oralis 89a in children with adenoidal disease: a double-blind controlled trial.

Folino, Francesco / Di Pasquale, Daniele / Marchisio, Paola / Pignataro, Lorenzo / Capaccio, Pasquale / Gaini, Lorenzo / Battilocchi, Ludovica / Bosis, Samantha / Torretta, Sara

European journal of pediatrics

2023 Volume 183, Issue 1, Page(s) 289–294

Abstract: ... reduction in the blockage of nasopharynx space by hypertrophic adenoids (0.002 < p-value < 0.007) compared ...

Abstract	Chronic adenoiditis (CA) is generally sustained by some infectious foci mainly located within the nasopharynx or in the deep adenoidal pads and it is characterized by a complex interplay between bacterial species. The aim of this study was to assess the efficacy and safety of the topical nasal administration of a probiotic compound based on S. salivarius 24SMB and S. oralis 89a in children with CA in terms of reduction in: the number of acute adenoidal infections (primary outcome), and in the blockage of the nasopharynx space by hypertrophic adenoids (secondary outcome). A prospective, double-blind, 1:1 randomized controlled study was performed to test the effectiveness of a 90-day treatment with Rinogermina spray (DMD ITALIA s.r.l, Rome), 1 puff each nostril twice a day for 90 days, to nasal spray placebo in children with CA (in terms of number of acute exacerbations and blockage of nasopharynx space assessed after 90 days of treatment- T1, and 90 days later- T2). The final analysis was based on 152 children (males = 48.0%; mean age = 49.2 ± 14.1 months). Compared to the baseline, no significant differences in terms of number of acute exacerbations at T1 and T2 follow-up visits were detected in both groups. After treatment, a significant reduction in the blockage of nasopharynx space by hypertrophic adenoids (0.002 < p-value < 0.007) compared to the baseline was attested in the study group at T1 and T2, but not in the control group. Conclusions: Our findings document a positive effect of Rinogermina spray in achieving reduction in the blockage of nasopharynx space by hypertrophic adenoids, thus suggesting that its use into the integrated therapeutic management of children with CA could be of a certain utility. What is known: • Chronic adenoiditis in children results from an imablance in baterial homeostasis at the nasophaynx, with impairment in respiratory microbiota. • The modulatory effect of target transnasal bacteriotheray by means of S. salivarius has been considered in children with chronic adenoiditis in children with recurrent acute otitis media with preliminary positive results. What is new: • This randomized controlled study, specifically designed on a cohrt of children with chronic adenoiditis, documents a certain effectiveness of the probiotic treatment in achieving a reduction in the grade of adenoidal hypertropy, compared to placebo.
MeSH term(s)	Child ; Male ; Humans ; Child, Preschool ; Prospective Studies ; Administration, Topical ; Administration, Intranasal ; Adenoids ; Otitis Media ; Hypertrophy/drug therapy
Language	English
Publishing date	2023-10-24
Publishing country	Germany
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	194196-3
ISSN	1432-1076 ; 0340-6199 ; 0943-9676
ISSN (online)	1432-1076
ISSN	0340-6199 ; 0943-9676
DOI	10.1007/s00431-023-05192-w
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Article ; Online: Morphological and Metrical Relationships Between Sphenoid Sinus and Sella Turcica: Possible Applications in Transnasal Transsphenoidal Surgery.

Lazzeroni, Matteo / Accorona, Remo / Capaccio, Pasquale / Pignataro, Lorenzo / Cellina, Michaela Iva / Gibelli, Daniele Maria / Sforza, Chiarella

The Journal of craniofacial surgery

2023 Volume 34, Issue 4, Page(s) 1357–1360

Abstract: ... on each computed tomography-scan. Correlations among different measurements were assessed through Spearman test ( P ... assessed through Mann-Whitney test ( P <0.01).: Results: In males, pneumatization of the greater wings ... was related to smaller AP diameter ( P <0.01) and depth of ST ( P <0.01), whereas in females lower ...

Abstract	Introduction: Transsphenoidal surgeries imply the risk of intraoperative lesions to the neurovascular structures surrounding the sphenoid sinus (SS). Aim of the present study is to assess the metrical and morphologic relationships existing between SS and sella turcica (ST). Materials and methods: Two hundred computed tomography-scans of patients were selected. For each patient volumes of SS were calculated from their 3-dimensional models segmented through ITK-SNAP program. Variants of SS in pneumatisation and sellar diameters [antero-posterior (AP) diameter, depth, and length] were evaluated on each computed tomography-scan. Correlations among different measurements were assessed through Spearman test ( P <0.01), whereas associations between sellar parameters and presence of pneumatisation variants were assessed through Mann-Whitney test ( P <0.01). Results: In males, pneumatization of the greater wings was related to smaller AP diameter ( P <0.01) and depth of ST ( P <0.01), whereas in females lower values of depth were found in patients with pneumatization of the pterygoid processes ( P <0.01). In both sexes, a positive correlation was found between AP diameter and, respectively, length and depth of ST ( P <0.01), together with a negative correlation between volume of SS and depth of ST ( P <0.01). Lastly, in females a positive correlation was found between age and, respectively, length and depth of ST ( P <0.01). Conclusions: The present study highlighted new metrical and morphologic relationships between volume and pneumatisation of SS and diameters of ST. Knowledge of these correlations allows to understand more clearly, in the preoperative setting, the surgical working space. Further studies are needed, especially for what concerns the relationship between sellar measurements and age in females.
MeSH term(s)	Male ; Female ; Humans ; Sella Turcica/diagnostic imaging ; Sella Turcica/surgery ; Sella Turcica/anatomy & histology ; Sphenoid Sinus/diagnostic imaging ; Sphenoid Sinus/surgery ; Sphenoid Sinus/anatomy & histology ; Sphenoid Bone/diagnostic imaging ; Sphenoid Bone/surgery ; Sphenoid Bone/anatomy & histology ; Tomography, X-Ray Computed
Language	English
Publishing date	2023-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	1159501-2
ISSN	1536-3732 ; 1049-2275
ISSN (online)	1536-3732
ISSN	1049-2275
DOI	10.1097/SCS.0000000000009241
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Article ; Online: MR sialographic assessment of the masseter muscle and the ductal kinking in patients with recurrent parotitis.

Capaccio, Pasquale / Lazzeroni, Matteo / Lo Russo, Francesco / Torretta, Sara / Di Pasquale, Daniele / Conte, Giorgio / Firetto, Maria Cristina / Nicolino, Gabriele / Gaffuri, Michele / Carrafiello, Gianpaolo

La Radiologia medica

2024

Abstract: ... to contralateral unaffected parotid glands of patients with recurrent parotitis (p = 0.00134); male subjects ... with parotitis had a longer duct compared to the salivary glands of healthy patients (p = 0.00943 for affected ... glands and p = 0.00629 for the contralateral). A concordance between the evidence of an acute duct angle ...

Abstract	Dysfunction of the masseter muscle may cause pathological kinking of the parotid duct leading to parotitis; MR sialography is a non-invasive radiological examination that allows to evaluate dynamically the ductal system of the parotid glands. In the present study we aimed to assess the relationships between Stensen's duct and masseter muscle and their implications in the aetiopathogenesis of recurrent parotitis secondary to masseter muscle dysfunction. Forty-one patients with recurrent unilateral parotitis and nine with bilateral recurrent parotitis, all with a clinical suspicious of masseter muscle hypertrophy due to bruxism were enrolled. They underwent ultrasonography as a first line examination and then MR sialography and sialendoscopy. Different anatomical features were studied. Involved parotid glands had a wider duct compared to contralateral unaffected parotid glands of patients with recurrent parotitis (p = 0.00134); male subjects with parotitis had a longer duct compared to the salivary glands of healthy patients (p = 0.00943 for affected glands and p = 0.00629 for the contralateral). A concordance between the evidence of an acute duct angle during sialendoscopy and a wider duct in patients with parotitis was observed although not statistically significant. These initial findings suggest that the masticatory muscle dysfunction related to bruxism seems to condition alteration of parotid duct course and anatomy thus favouring the occurrence of recurrent parotitis. A specific diagnostic iter based on clinical evaluation, dynamic ultrasonography and MR sialography, is therefore, mandatory to confirm the relationship between masseter muscle anatomy and parotid duct anomalies; this is the premise for an adequate therapeutic approach to underlying masticatory muscle disorder.
Language	English
Publishing date	2024-03-21
Publishing country	Italy
Document type	Journal Article
ZDB-ID	205751-7
ISSN	1826-6983 ; 0033-8362
ISSN (online)	1826-6983
ISSN	0033-8362
DOI	10.1007/s11547-024-01802-1
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Article ; Online: Transoral robotic vertical partial laryngectomy (hemilaryngectomy) extended to the hypopharynx.

Meliante, Piero Giuseppe / Battilocchi, Ludovica / Costantino, Andrea / Lee, Kyuin / Moon, Seo Jin / Ralli, Massimo / Minni, Antonio / Capaccio, Pasquale / Pignataro, Lorenzo / de Vincentiis, Marco / Kim, Se-Heon

Head & neck

2024 Volume 46, Issue 3, Page(s) 708–712

Abstract: Locally advanced laryngeal cancers treatment often involves total laryngectomy, which some patients are unwilling to undergo, even if this choice reduces their survival probability. Therefore, the objective of laryngeal oncologic surgery is not only to ... ...

Abstract	Locally advanced laryngeal cancers treatment often involves total laryngectomy, which some patients are unwilling to undergo, even if this choice reduces their survival probability. Therefore, the objective of laryngeal oncologic surgery is not only to remove the tumor, but also to preserve the organ and its functions. To overcome these concerns, several partial laryngectomy techniques have been developed. This article describes the surgical technique and a case study of a 64-year-old male patient with locally advanced laryngeal squamous cell carcinoma who underwent vertical partial laryngectomy extending to the subglottis and hypopharynx using transoral robotic surgery (TORS) with a da Vinci Single Port surgical robot. The video and article provide a detailed description of the surgical technique, which resulted in successful tumor removal with excellent oncological and functional outcomes.
MeSH term(s)	Male ; Humans ; Middle Aged ; Robotics ; Robotic Surgical Procedures/methods ; Laryngectomy/methods ; Hypopharynx/surgery ; Hypopharynx/pathology ; Laryngeal Neoplasms/surgery ; Laryngeal Neoplasms/pathology ; Head and Neck Neoplasms/surgery ; Treatment Outcome
Language	English
Publishing date	2024-01-14
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.27634
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