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Article ; Online: [(F

Kouton, Aniffa / Pepin, Robert / Maciulis, Nicholas Alexander / Gao, Xinfeng / Carta, Veronica / Siedle, Allen R

ACS omega

2024 Volume 9, Issue 5, Page(s) 5395–5405

Abstract: Highly fluorinated [(F ...

Abstract	Highly fluorinated [(F
Language	English
Publishing date	2024-01-23
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c06550
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Article ; Online: Gene's expression underpinning the divergent predictive value of [18F]F-fluorodeoxyglucose and prostate-specific membrane antigen positron emission tomography in primary prostate cancer: a bioinformatic and experimental study.

Journal of translational medicine

2023 Volume 21, Issue 1, Page(s) 3

Abstract: ... PCa with different aggressiveness were used to compare [18F]F-PSMA-1007 and [18F]F-FDG uptake kinetics ...

Abstract	Background: Positron Emission Tomography (PET) imaging with Prostate-Specific Membrane Antigen (PSMA) and Fluorodeoxyglucose (FDG) represent promising biomarkers for risk-stratification of Prostate Cancer (PCa). We verified whether the expression of genes encoding for PSMA and enzymes regulating FDG cellular uptake are independent and additive prognosticators in PCa. Methods: mRNA expression of genes involved in glucose metabolism and PSMA regulation obtained from primary PCa specimens were retrieved from open-source databases and analyzed using an integrative bioinformatics approach. Machine Learning (ML) techniques were used to create predictive Progression-Free Survival (PFS) models. Cellular models of primary PCa with different aggressiveness were used to compare [18F]F-PSMA-1007 and [18F]F-FDG uptake kinetics in vitro. Confocal microscopy, immunofluorescence staining, and quantification analyses were performed to assess the intracellular and cellular membrane PSMA expression. Results: ML analyses identified a predictive functional network involving four glucose metabolism-related genes: ALDOB, CTH, PARP2, and SLC2A4. By contrast, FOLH1 expression (encoding for PSMA) did not provide any additive predictive value to the model. At a cellular level, the increase in proliferation rate and migratory potential by primary PCa cells was associated with enhanced FDG uptake and decreased PSMA retention (paralleled by the preferential intracellular localization). Conclusions: The overexpression of a functional network involving four glucose metabolism-related genes identifies a higher risk of disease progression since the earliest phases of PCa, in agreement with the acknowledged prognostic value of FDG PET imaging. By contrast, the prognostic value of PSMA PET imaging is independent of the expression of its encoding gene FOLH1. Instead, it is influenced by the protein docking to the cell membrane, regulating its accessibility to tracer binding.
MeSH term(s)	Humans ; Male ; Fluorodeoxyglucose F18 ; Glucose/metabolism ; Positron-Emission Tomography/methods ; Prostate/diagnostic imaging ; Prostate/metabolism ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Machine Learning
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Glucose (IY9XDZ35W2) ; FOLH1 protein, human (EC 3.4.17.21)
Language	English
Publishing date	2023-01-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-022-03846-1
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Article: C–F Bond Activation in the Solid State: Functionalization of Carbon through Reactions of Graphite Fluoride with Amines

Siedle, Allen R / Losovyj, Yaroslav / Karty, Jonathan A / Chen, Dennis / Chatterjee, Kaustav / Carta, Veronica / Stein, Barry D / Werner-Zwanziger, Ulrike

Journal of physical chemistry. 2021 May 11, v. 125, no. 19

2021

Abstract: Functionalization of carbon can be achieved by reactions of graphite fluoride with organic amines. Two exemplary amines, benzylamine and tetramethylethylenediamine, have been investigated. The dominant process is hydrodefluorination to form carbonaceous ... ...

Abstract	Functionalization of carbon can be achieved by reactions of graphite fluoride with organic amines. Two exemplary amines, benzylamine and tetramethylethylenediamine, have been investigated. The dominant process is hydrodefluorination to form carbonaceous solids and hydrogen fluoride. Oxidative dehydrogenation of the amines provides hydrogen and concomitantly generates imines. The reactions are considered to proceed through a series of proton coupled electron transfer (PCET) steps with graphite fluoride acting as an oxidizing agent. Intermediate radicals react with the carbonaceous solids to introduce sp² and sp³ nitrogen-containing groups into the carbon.
Keywords	benzylamines ; dehydrogenation ; electron transfer ; fluorides ; graphene ; hydrofluoric acid ; hydrogen ; imines ; tetramethylethylenediamine
Language	English
Dates of publication	2021-0511
Size	p. 10326-10333.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ISSN	1932-7455
DOI	10.1021/acs.jpcc.1c00734
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Incomplete APOBEC3G/F Neutralization by HIV-1 Vif Mutants Facilitates the Genetic Evolution from CCR5 to CXCR4 Usage.

Alteri, Claudia / Surdo, Matteo / Bellocchi, Maria Concetta / Saccomandi, Patrizia / Continenza, Fabio / Armenia, Daniele / Parrotta, Lucia / Carioti, Luca / Costa, Giosuè / Fourati, Slim / Di Santo, Fabiola / Scutari, Rossana / Barbaliscia, Silvia / Fedele, Valentina / Carta, Stefania / Balestra, Emanuela / Alcaro, Stefano / Marcelin, Anne Genevieve / Calvez, Vincent /

Ceccherini-Silberstein, Francesca / Artese, Anna / Perno, Carlo Federico / Svicher, Valentina

Antimicrobial agents and chemotherapy

2015 Volume 59, Issue 8, Page(s) 4870–4881

Abstract: Incomplete APOBEC3G/F neutralization by a defective HIV-1Vif protein can promote genetic ... usage, contains several putative APOBEC3G/F target sites. Here, we determined if APOBEC3G/F ... protein), 81.A-VifE45G, or 81.A-VifK22E (known to incompletely/partially neutralize APOBEC3G/F). The rate ...

Abstract	Incomplete APOBEC3G/F neutralization by a defective HIV-1Vif protein can promote genetic diversification by inducing G-to-A mutations in the HIV-1 genome. The HIV-1 Env V3 loop, critical for coreceptor usage, contains several putative APOBEC3G/F target sites. Here, we determined if APOBEC3G/F, in the presence of Vif-defective HIV-1 virus, can induce G-to-A mutations at V3 positions critical to modulation of CXCR4 usage. Peripheral blood mononuclear cells (PBMC) and monocyte-derived macrophages (MDM) from 2 HIV-1-negative donors were infected with CCR5-using 81.A-VifWT virus (i.e., with wild-type [WT] Vif protein), 81.A-VifE45G, or 81.A-VifK22E (known to incompletely/partially neutralize APOBEC3G/F). The rate of G-toA mutations was zero or extremely low in 81.A-VifWT- and 81.A-VifE45G-infected PBMC from both donors. Conversely, G-to-A enrichment was detected in 81.A-VifK22E-infected PBMC (prevalence ranging from 2.18% at 7 days postinfection [dpi] to 3.07% at 21 dpi in donor 1 and from 10.49% at 7 dpi to 8.69% at 21 dpi in donor 2). A similar scenario was found in MDM. G-to-A mutations occurred at 8 V3 positions, resulting in nonsynonymous amino acid substitutions. Of them, G24E and E25K strongly correlated with phenotypically/genotypically defined CXCR4-using viruses (P = 0.04 and 5.5e-7, respectively) and increased the CXCR4 N-terminal binding affinity for V3 (WT, -40.1 kcal/mol; G24E, -510 kcal/mol; E25K, -522 kcal/mol). The analysis of paired V3 and Vif DNA sequences from 84 HIV-1-infected patients showed that the presence of a Vif-defective virus correlated with CXCR4 usage in proviral DNA (P = 0.04). In conclusion, incomplete APOBEC3G/F neutralization by a single Vif amino acid substitution seeds a CXCR4-using proviral reservoir. This can have implications for the success of CCR5 antagonist-based therapy, as well as for the risk of disease progression.
MeSH term(s)	APOBEC Deaminases ; Amino Acid Sequence ; Amino Acid Substitution/genetics ; Base Sequence ; Cell Line ; Cytidine Deaminase ; Cytosine Deaminase/genetics ; Evolution, Molecular ; HEK293 Cells ; HIV Infections/genetics ; HIV Infections/virology ; HIV-1/genetics ; Humans ; Leukocytes, Mononuclear/virology ; Mutation/genetics ; Receptors, CCR5/genetics ; Receptors, CXCR4/genetics
Chemical Substances	CCR5 protein, human ; CXCR4 protein, human ; Receptors, CCR5 ; Receptors, CXCR4 ; Cytosine Deaminase (EC 3.5.4.1) ; APOBEC Deaminases (EC 3.5.4.5) ; APOBEC3 proteins, human (EC 3.5.4.5) ; Cytidine Deaminase (EC 3.5.4.5)
Language	English
Publishing date	2015-06-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.00137-15
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Article ; Online: Novel 3-Substituted 7-Phenylpyrrolo[3,2-f]quinolin-9(6H)-ones as Single Entities with Multitarget Antiproliferative Activity.

Carta, Davide / Bortolozzi, Roberta / Hamel, Ernest / Basso, Giuseppe / Moro, Stefano / Viola, Giampietro / Ferlin, Maria Grazia

Journal of medicinal chemistry

2015 Volume 58, Issue 20, Page(s) 7991–8010

Abstract: A series of chemically modified 7-phenylpyrrolo[3,2-f]quinolinones was synthesized and evaluated ...

Abstract	A series of chemically modified 7-phenylpyrrolo[3,2-f]quinolinones was synthesized and evaluated as anticancer agents. Among them, the most cytotoxic (subnanomolar GI50 values) amidic derivative 5f was shown to act as an inhibitor of tubulin polymerization (IC50, 0.99 μM) by binding to the colchicine site with high affinity. Moreover, 5f induced cell cycle arrest in the G2/M phase of the cell cycle in a concentration dependent manner, followed by caspase-dependent apoptotic cell death. Compound 5f also showed lower toxicity in nontumoral cells, suggesting selectivity toward cancer cells. Additional experiments revealed that 5f inhibited the enzymatic activity of multiple kinases, including AURKA, FLT3, GSK3A, MAP3K, MEK, RSK2, RSK4, PLK4, ULK1, and JAK1. Computational studies showed that 5f can be properly accommodated in the colchicine binding site of tubulin as well as in the ATP binding clefts of all examined kinases. Our data indicate that the excellent antiproliferative profile of 5f may be derived from its interactions with multiple cellular targets.
MeSH term(s)	Adenosine Triphosphate/metabolism ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Binding Sites/drug effects ; Cell Cycle/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Colchicine/metabolism ; Drug Interactions ; HeLa Cells ; Humans ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/pharmacology ; Pyrroles/chemical synthesis ; Pyrroles/pharmacology ; Quinolones/chemical synthesis ; Quinolones/pharmacology ; Structure-Activity Relationship ; Tubulin/biosynthesis ; Tubulin/drug effects ; Tubulin Modulators/chemical synthesis ; Tubulin Modulators/pharmacology
Chemical Substances	3-(cyclopropylmethanone)-7-phenyl-H-pyrrolo(3,2-f)quinolin-9(6H)-one ; Antineoplastic Agents ; Protein Kinase Inhibitors ; Pyrroles ; Quinolones ; Tubulin ; Tubulin Modulators ; Adenosine Triphosphate (8L70Q75FXE) ; Colchicine (SML2Y3J35T)
Language	English
Publishing date	2015-10-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.5b00805
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Article ; Online: Mechanochemical ignition of self-propagating reactions in equimolar Al-Ni powder mixtures and multilayers.

Carta, Maria / Delogu, Francesco

Physical chemistry chemical physics : PCCP

2024 Volume 26, Issue 16, Page(s) 12316–12323

Abstract: This work addresses a long standing question in the field of mechanochemistry, namely the role of mesostructure in the initiation of self-propagating high-temperature reactions in exothermic chemical systems, commonly referred to as ignition. In an ... ...

Abstract	This work addresses a long standing question in the field of mechanochemistry, namely the role of mesostructure in the initiation of self-propagating high-temperature reactions in exothermic chemical systems, commonly referred to as ignition. In an attempt to find robust evidence in this regard, we compare the ignition behaviour of equimolar Al-Ni powder mixtures and equimolar Al-Ni multilayers. To achieve the best possible control of experimental conditions and allowing high reproducibility, we used elemental powders sieved in the range between 20 μm and 44 μm, and multilayers with bi-layer thickness between 10 nm and 800 nm. We carried out systematic ball milling experiments involving pristine powder mixtures and multilayers as well as a mix of pristine material and material prone to ignition suitably prepared. Experimental findings suggest that pristine powder mixtures and multilayers with bi-layer thickness of 240 nm have analogous ignition behaviour. Along the same lines, data suggest that pristine powder mixtures undergo ignition when they attain a mesostructure similar to that of multilayers with bi-layer thickness of 10 nm.
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d3cp05401b
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Article ; Online: L’avvio del servizio di Infermiere di Famiglia: l’esperienza dell’Azienda ULSS 3 Serenissima.

Fontanel, Amalia / Carta, Antonello / Rossi, Francesca

Assistenza infermieristica e ricerca : AIR

2024 Volume 42, Issue 4, Page(s) 180–188

Abstract: The implementation of family nursing: the experience of a District of Venice.: Introduction: The need to provide district nursing care for patients with simple and complex chronic diseases requires planning and investment in the training of nurses.!# ...

Title translation	The implementation of Family Nursing: the experience of a District of Venice.
Abstract	. The implementation of family nursing: the experience of a District of Venice. Introduction: The need to provide district nursing care for patients with simple and complex chronic diseases requires planning and investment in the training of nurses. Objective: To describe the model of management of simple chronic care with the implementation of the Family Nursing in the Districts of the Azienda ULSS 3 Serenissima. Methods: After the analysis of the epidemiological and socio-demographic data of the resident population, and the stratification in classes homogeneous for resource use, according to the Adjusted Clinical Group model, the candidates for the family nurse's position were trained with an ad hoc course. Results: The preferred target for the experimental implementation of Family Nursing care was the elderly population with chronic diseases in District 1, not followed by other health services. At the end of 2022 12 Family Nurses candidates were identified. After a training course, they gradually took over patients with simple chronic conditions, starting with the District 1 with the highest prevalence. Conclusions: In the year 2022, 614 new patients started to be cared for by Family Nurses, in 2023 approximately 900 patients are being followed and monitored by the Family Nurse.
MeSH term(s)	Humans ; Aged ; Nurse's Role ; Family Nursing ; Chronic Disease
Language	Italian
Publishing date	2024-01-17
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	1480438-4
ISSN	2038-1778 ; 1120-3803
ISSN (online)	2038-1778
ISSN	1120-3803
DOI	10.1702/4178.41682
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Article: Carbonic anhydrase, its inhibitors and vascular function.

García-Llorca, Andrea / Carta, Fabrizio / Supuran, Claudiu T / Eysteinsson, Thor

Frontiers in molecular biosciences

2024 Volume 11, Page(s) 1338528

Abstract: It has been known for some time that Carbonic Anhydrase (CA, EC 4.2.1.1) plays a complex role in vascular function, and in the regulation of vascular tone. Clinically employed CA inhibitors (CAIs) are used primarily to lower intraocular pressure in ... ...

Abstract	It has been known for some time that Carbonic Anhydrase (CA, EC 4.2.1.1) plays a complex role in vascular function, and in the regulation of vascular tone. Clinically employed CA inhibitors (CAIs) are used primarily to lower intraocular pressure in glaucoma, and also to affect retinal blood flow and oxygen saturation. CAIs have been shown to dilate vessels and increase blood flow in both the cerebral and ocular vasculature. Similar effects of CAIs on vascular function have been observed in the liver, brain and kidney, while vessels in abdominal muscle and the stomach are unaffected. Most of the studies on the vascular effects of CAIs have been focused on the cerebral and ocular vasculatures, and in particular the retinal vasculature, where vasodilation of its vessels, after intravenous infusion of sulfonamide-based CAIs can be easily observed and measured from the fundus of the eye. The mechanism by which CAIs exert their effects on the vasculature is still unclear, but the classic sulfonamide-based inhibitors have been found to directly dilate isolated vessel segments when applied to the extracellular fluid. Modification of the structure of CAI compounds affects their efficacy and potency as vasodilators. CAIs of the coumarin type, which generally are less effective in inhibiting the catalytically dominant isoform hCA II and unable to accept NO, have comparable vasodilatory effects as the primary sulfonamides on pre-contracted retinal arteriolar vessel segments, providing insights into which CA isoforms are involved. Alterations of the lipophilicity of CAI compounds affect their potency as vasodilators, and CAIs that are membrane impermeant do not act as vasodilators of isolated vessel segments. Experiments with CAIs, that shed light on the role of CA in the regulation of vascular tone of vessels, will be discussed in this review. The role of CA in vascular function will be discussed, with specific emphasis on findings with the effects of CA inhibitors (CAI).
Language	English
Publishing date	2024-01-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2814330-9
ISSN	2296-889X
ISSN	2296-889X
DOI	10.3389/fmolb.2024.1338528
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Article ; Online: Mechanochemically Induced Solid-State Transformations of Levofloxacin.

Kadri, Lena / Carta, Maria / Lampronti, Giulio / Delogu, Francesco / Tajber, Lidia

Molecular pharmaceutics

2024

Abstract: Levofloxacin hemihydrate (LVXh) is a complex fluoroquinolone drug that exists in both hydrated and anhydrous/dehydrated forms. Due to the complexity of such a compound, the primary aim of this study was to investigate the amorphization capabilities and ... ...

Abstract	Levofloxacin hemihydrate (LVXh) is a complex fluoroquinolone drug that exists in both hydrated and anhydrous/dehydrated forms. Due to the complexity of such a compound, the primary aim of this study was to investigate the amorphization capabilities and solid-state transformations of LVXh when exposed to mechanical treatment using ball milling. Spray drying was utilized as a comparative method for investigating the capabilities of complete LVX amorphous (LVXam) formation. The solid states of the samples produced were comprehensively characterized by powder X-ray diffraction, thermal analysis, infrared spectroscopy, Rietveld method, and dynamic vapor sorption. The kinetics of the process and the quantification of phases at different time points were conducted by Rietveld refinement. The impact of the different mills, milling conditions, and parameters on the composition of the resulting powders was examined. A kinetic investigation of samples produced using both mills disclosed that it was in fact possible to partially amorphize LVXh upon mechanical treatment. It was discovered that LVXh first transformed to the anhydrous/dehydrated form γ (LVXγ), as an intermediate phase, before converting to LVXam. The mechanism of LVXam formation by ball milling was successfully revealed, and a new method of forming LVXγ and LVXam by mechanical forces was developed. Spray drying from water depicted that complete amorphization of LVXh was possible. The amorphous form of LVX had a glass transition temperature of 80 °C. The comparison of methods highlighted that the formation of LVXam is thus both mechanism- and process-dependent. Dynamic vapor sorption studies of both LVXam samples showed comparable stability properties and crystallized to the most stable hemihydrate form upon analysis. In summary, this work contributed to the detailed understanding of solid-state transformations of essential fluoroquinolones while employing greener and more sustainable manufacturing methods.
Language	English
Publishing date	2024-04-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2138405-8
ISSN	1543-8392 ; 1543-8384
ISSN (online)	1543-8392
ISSN	1543-8384
DOI	10.1021/acs.molpharmaceut.4c00008
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Article: Effect of Intravitreal Brolucizumab in the Treatment of Polypoidal Choroidal Vasculopathy With Foveal Lipid Exudation.

Carta, Valentina / Lixi, Filippo / Tatti, Filippo / Peiretti, Enrico

Cureus

2023 Volume 15, Issue 10, Page(s) e47942

Abstract: A 71-year-old woman with a history of blurred vision in her right eye for nearly two months came to our attention. A complete ophthalmological evaluation, including best-corrected visual acuity measurement, fundus examination, spectral-domain optical ... ...

Abstract	A 71-year-old woman with a history of blurred vision in her right eye for nearly two months came to our attention. A complete ophthalmological evaluation, including best-corrected visual acuity measurement, fundus examination, spectral-domain optical coherence tomography, fluorescein angiography, and indocyanine green angiography, was performed. Multimodal imaging showed the presence of a polypoidal choroidal vasculopathy (PCV) lesion surrounded by diffuse hard exudates in the macular area. Our patient received three monthly intravitreal injections of brolucizumab during the loading phase, followed by an intravitreal injection every eight weeks for a total of 48 weeks of follow-up. The therapy appeared to be effective for improving both visual and anatomical outcomes revealing an important regression of the PCV and an almost complete reabsorption of lipid exudates. Intravitreal brolucizumab could be considered an effective treatment in the management of lipid exudation in PCV patients.
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.47942
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