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  1. Article ; Online: Pharmaceutical Industry Payments to Medical Oncologists in the Netherlands: Trends and Patterns Provided by an Open-Access Transparency Data Set.

    Schnog, J B / Samson, M J / Gersenbluth, I / Duits, A J

    JCO oncology practice

    2024  , Page(s) OP2300533

    Abstract: Purpose: Health care expenditure related to oncologic treatments is skyrocketing although many treatments offer marginal, if any, clinical benefit. Financial conflicts of interest (fCOI) resulting from pharmaceutical industry (pharma) payments to ... ...

    Abstract Purpose: Health care expenditure related to oncologic treatments is skyrocketing although many treatments offer marginal, if any, clinical benefit. Financial conflicts of interest (fCOI) resulting from pharmaceutical industry (pharma) payments to physicians is increasingly recognized as a predictive factor for regulatory board approval and guideline incorporation of low-value treatments. We sought to study the extent to which pharma payments to medical oncologists occur in the Netherlands, the amount of money involved, and whether these occur more frequently and are higher for key opinion leaders (KOLs).
    Methods: In our cross-sectional retrospective database study, we used several Dutch open-access databases and extracted data registered between 2019 and 2021.
    Results: A cumulative amount of €899,863 was paid to 48.8% of the 408 registered medical oncologists. Over time, there was a marked decline in both the proportion of medical oncologists receiving payments (from 40.4% in 2019 to 19.1% in 2021) and the mean annual value of payments (from €2,962 in 2019 to €2,188 in 2021) with the latter mainly resulting from a decline in hospitality-related transactions. KOLs were more likely to receive industry payments and received a higher median payment value.
    Discussion: Our findings should contribute to the increasing awareness in the Netherlands of the potential effects of fCOI.
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.23.00533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: An analytical view of the BJH publication of 'a clinician's view of voxelotor'.

    Schnog, John-John B / Samson, Michael J / Duits, Ashley J

    British journal of haematology

    2023  Volume 200, Issue 6, Page(s) e56–e57

    MeSH term(s) Humans ; Benzaldehydes ; Pyrazines ; Pyrazoles
    Chemical Substances voxelotor (3ZO554A4Q8) ; Benzaldehydes ; Pyrazines ; Pyrazoles
    Language English
    Publishing date 2023-01-12
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18647
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  3. Article ; Online: Contemporary oncology trials, drug approvals and the physician-patient relationship.

    Schnog, John-John B / Samson, Michael J / Duits, Ashley J

    Lancet regional health. Americas

    2022  Volume 11, Page(s) 100247

    Language English
    Publishing date 2022-04-03
    Publishing country England
    Document type Journal Article
    ISSN 2667-193X
    ISSN (online) 2667-193X
    DOI 10.1016/j.lana.2022.100247
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  4. Article ; Online: Trastuzumab Deruxtecan in HER2-Low Breast Cancer.

    Schnog, John-John B / Samson, Michael J / Duits, Ashley J

    The New England journal of medicine

    2022  Volume 387, Issue 12, Page(s) 1143–1144

    MeSH term(s) Breast Neoplasms/drug therapy ; Camptothecin/analogs & derivatives ; Female ; Humans ; Immunoconjugates ; Trastuzumab/therapeutic use
    Chemical Substances Immunoconjugates ; trastuzumab deruxtecan (5384HK7574) ; Trastuzumab (P188ANX8CK) ; Camptothecin (XT3Z54Z28A)
    Language English
    Publishing date 2022-09-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2210368
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  5. Article ; Online: Financiële belangen en oncologische geneesmiddelen.

    Schnog, John-John B / Samson, Michael J / Duits, Ashley J

    Nederlands tijdschrift voor geneeskunde

    2022  Volume 166

    Abstract: The number of new oncological treatments is increasing rapidly, even though many offer limited benefit to patients. In these cases, the scientific research leading to approvals is marred by shortcomings. Nonetheless, many drugs of limited value are ... ...

    Title translation Financial conflict of interest and anti-cancer drugs: Why the NTVG's stance to exclude pharma-advertisement is of importance.
    Abstract The number of new oncological treatments is increasing rapidly, even though many offer limited benefit to patients. In these cases, the scientific research leading to approvals is marred by shortcomings. Nonetheless, many drugs of limited value are approved by regulatory agencies. One of the factors contributing thereto is financial conflict of interest (FCI) with the pharmaceutical industry (Pharma). This occurs at different levels, including researchers, opinion leaders and editors of medical journals. FCI contributes to patient exposure to treatments that offer limited or no benefit and to unjust spending of valuable resources while providing large revenues for Pharma. The important step of the 'NederlandsTijdschriftvoorGeneeskunde' (NTVG) to omit all pharmaceutical advertisement as well as advertisement for pharmaceutical industry sponsored medical education sends an important signal and is a first step to revalue the important relationship with the pharmaceutical industry.
    MeSH term(s) Humans ; Conflict of Interest ; Advertising ; Drug Industry ; Antineoplastic Agents/therapeutic use ; Pharmaceutical Preparations
    Chemical Substances Antineoplastic Agents ; Pharmaceutical Preparations
    Language Dutch
    Publishing date 2022-07-28
    Publishing country Netherlands
    Document type English Abstract ; Journal Article
    ZDB-ID 82073-8
    ISSN 1876-8784 ; 0028-2162
    ISSN (online) 1876-8784
    ISSN 0028-2162
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  6. Article ; Online: Untoward global effects of current guideline formulation of stereotactic radiotherapy for symptomatic brain metastases by international medical societies.

    de Vocht, Dorien E C M / Schnog, John-John B / Merkies, Ingemar S / Samson, Michael J

    Lancet regional health. Americas

    2023  Volume 25, Page(s) 100584

    Abstract: The quality of evidence leading to new oncological treatments suffers shortcomings, as has recently been addressed for drug approvals. In this 'Personal view', we evaluate the unintended effects of adopting stereotactic radiosurgery as the standard of ... ...

    Abstract The quality of evidence leading to new oncological treatments suffers shortcomings, as has recently been addressed for drug approvals. In this 'Personal view', we evaluate the unintended effects of adopting stereotactic radiosurgery as the standard of care for patients with limited number of symptomatic brain metastases and favourable prognostic factors in international guidelines in view of the limitations in the evidence of efficacy and effectiveness, with special focus on countries with relatively limited resources.
    Language English
    Publishing date 2023-09-01
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2667-193X
    ISSN (online) 2667-193X
    DOI 10.1016/j.lana.2023.100584
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Contemporary oncology trials, drug approvals and the physician-patient relationship

    John-John B. Schnog / Michael J. Samson / Ashley J. Duits

    The Lancet Regional Health. Americas, Vol 11, Iss , Pp 100247- (2022)

    2022  

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: An urgent call to raise the bar in oncology.

    Schnog, John-John B / Samson, Michael J / Gans, Rijk O B / Duits, Ashley J

    British journal of cancer

    2021  Volume 125, Issue 11, Page(s) 1477–1485

    Abstract: Important breakthroughs in medical treatments have improved outcomes for patients suffering from several types of cancer. However, many oncological treatments approved by regulatory agencies are of low value and do not contribute significantly to cancer ... ...

    Abstract Important breakthroughs in medical treatments have improved outcomes for patients suffering from several types of cancer. However, many oncological treatments approved by regulatory agencies are of low value and do not contribute significantly to cancer mortality reduction, but lead to unrealistic patient expectations and push even affluent societies to unsustainable health care costs. Several factors that contribute to approvals of low-value oncology treatments are addressed, including issues with clinical trials, bias in reporting, regulatory agency shortcomings and drug pricing. With the COVID-19 pandemic enforcing the elimination of low-value interventions in all fields of medicine, efforts should urgently be made by all involved in cancer care to select only high-value and sustainable interventions. Transformation of medical education, improvement in clinical trial design, quality, conduct and reporting, strict adherence to scientific norms by regulatory agencies and use of value-based scales can all contribute to raising the bar for oncology drug approvals and influence drug pricing and availability.
    MeSH term(s) Antineoplastic Agents/economics ; Antineoplastic Agents/therapeutic use ; Bias ; COVID-19/epidemiology ; Cost Control/ethics ; Cost Control/organization & administration ; Cost Control/standards ; Cultural Evolution ; Drug Approval/economics ; Drug Approval/legislation & jurisprudence ; Drug Approval/organization & administration ; Drug Costs/ethics ; Drug Costs/legislation & jurisprudence ; Humans ; Medical Oncology/economics ; Medical Oncology/ethics ; Medical Oncology/organization & administration ; Medical Oncology/standards ; Neoplasms/drug therapy ; Neoplasms/economics ; Neoplasms/mortality ; Organizational Innovation ; Pandemics
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2021-08-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-021-01495-7
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    Uh III Zs.142: Show issues Location:
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  9. Article ; Online: An unusual craving!

    Gerrits, E G / Schnog, J B

    The Netherlands journal of medicine

    2015  Volume 73, Issue 2, Page(s) 96

    MeSH term(s) Adult ; Anemia, Iron-Deficiency/complications ; Craving ; Female ; Humans ; Pica/etiology ; Talc/administration & dosage ; Talc/adverse effects
    Chemical Substances Talc (14807-96-6)
    Language English
    Publishing date 2015-02
    Publishing country Netherlands
    Document type Case Reports ; Letter
    ZDB-ID 193149-0
    ISSN 1872-9061 ; 0300-2977
    ISSN (online) 1872-9061
    ISSN 0300-2977
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    Zs.A 576: Show issues Location:
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  10. Article ; Online: Letter in response to: "Pulmonary thrombi are not detected by 3D magnetic resonance angiography in adults with sickle cell anemia and an elevated triscuspid regurgitant jet velocity".

    Van Beers, Eduard J / Biemond, Bart J / Schnog, John-John B

    American journal of hematology

    2010  Volume 85, Issue 3, Page(s) 217; author reply 217–8

    MeSH term(s) Adult ; Anemia, Sickle Cell/complications ; Blood Flow Velocity ; Child ; Humans ; Hypertension, Pulmonary/complications ; Hypertension, Pulmonary/diagnosis ; Imaging, Three-Dimensional ; Magnetic Resonance Angiography ; Nitric Oxide/deficiency ; Nitric Oxide/metabolism ; Pulmonary Embolism/diagnosis ; Pulmonary Embolism/diagnostic imaging ; Radionuclide Imaging ; Tricuspid Valve Insufficiency/complications ; Tricuspid Valve Insufficiency/physiopathology ; Ventilation-Perfusion Ratio
    Chemical Substances Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2010-03
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.21587
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