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  1. Article ; Online: Looking under the bonnet of bronchopulmonary dysplasia with MRI.

    Prayle, Andrew / Rosenow, Tim

    Thorax

    2020  Volume 75, Issue 2, Page(s) 100

    MeSH term(s) Bronchopulmonary Dysplasia ; Humans ; Infant, Newborn ; Infant, Premature ; Magnetic Resonance Imaging
    Language English
    Publishing date 2020-01-24
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thoraxjnl-2019-213421
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui III Zs.83: Show issues Location:
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  2. Article ; Online: The Clinical Research Bias Index (CRBI): A novel journal ranking method applied to child health respiratory studies.

    Vairavan, Manishaa / Prayle, Andrew / Davies, Patrick

    Health science reports

    2022  Volume 5, Issue 5, Page(s) e739

    Abstract: Background and aims: Journal impact factor has historically been taken as a proxy for quality. However, this is open to significant manipulation and bias. There is currently not widely adopted, robust journal and paper ranking metric which is focused ... ...

    Abstract Background and aims: Journal impact factor has historically been taken as a proxy for quality. However, this is open to significant manipulation and bias. There is currently not widely adopted, robust journal and paper ranking metric which is focused solely on risk of bias.
    Methods: Risk of bias data was extracted from all Cochrane database systematic reviews in Child Health, Lungs, and Airways for the years 2017-2019. A novel paper quality score, the Clinical Research Bias Index (CRBI), was applied. Individual paper data were pooled for each journal. A comparison was made to journal impact factors, individual paper citations, reads, and altmetric scores.
    Results: 927 papers were analyzed for risk of bias. 119 (12·8%) scored a CRBI of 100%, with a mean score of 70%. A journal's overall CRBI risk of bias score was poorly correlated with impact factor (
    Conclusion: The novel research quality tool CRBI demonstrates the poor correlation between journal impact factor, citations, and risk of bias. Journal and paper ranking metrics should ensure that they are fit for purpose, and enable the dissemination of high-quality research for the benefit of patients. We propose the CRBI as a potential solution which is resistant to manipulation and will reward the creation and publication of bias-free research.
    Language English
    Publishing date 2022-08-07
    Publishing country United States
    Document type Journal Article
    ISSN 2398-8835
    ISSN (online) 2398-8835
    DOI 10.1002/hsr2.739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Prebiotics for people with cystic fibrosis.

    Williams, Neil C / Jayaratnasingam, Jacob / Prayle, Andrew P / Nevitt, Sarah J / Smyth, Alan R

    The Cochrane database of systematic reviews

    2023  Volume 9, Page(s) CD015236

    Abstract: Background: Cystic fibrosis (CF) is a multisystem disease; the importance of growth and nutritional status is well established given their implications for lung function and overall survivability. Furthermore, it has been established that intestinal ... ...

    Abstract Background: Cystic fibrosis (CF) is a multisystem disease; the importance of growth and nutritional status is well established given their implications for lung function and overall survivability. Furthermore, it has been established that intestinal microbial imbalance and inflammation are present in people with CF. Oral prebiotics are commercially available substrates that are selectively utilised by host intestinal micro-organisms and may improve both intestinal and overall health.
    Objectives: To evaluate the benefits and harms of prebiotics for improving health outcomes in children and adults with CF.
    Search methods: We searched the Cochrane Cystic Fibrosis Trials Register compiled from electronic database searches and handsearching of journals and conference abstract books. We also searched the reference lists of relevant articles and reviews. Date of last search: 19 October 2022. We also searched PubMed and online trials registries. Date of last search: 13 January 2023.
    Selection criteria: Randomised controlled trials (RCTs) and quasi-RCTs assessing the efficacy of prebiotics in children and adults with CF. We planned to only include the first treatment period from cross-over RCTs, regardless of washout period.
    Data collection and analysis: We did not identify any relevant trials.
    Main results: We did not identify any relevant trials for inclusion in this review.
    Authors' conclusions: This review did not find any evidence for the use of prebiotics in people with CF. Until such evidence is available, it is reasonable for clinicians to follow any local guidelines and to discuss the use of dietary prebiotics with their patients. Large and robust RCTs assessing the dietary prebiotics of inulin or galacto-oligosaccharides or fructo-oligosaccharides, or any combination of these, are needed. Such studies should be of at least 12 months in duration and assess outcomes such as growth and nutrition, gastrointestinal symptoms, pulmonary exacerbations, lung function, inflammatory biomarkers, hospitalisations, intestinal microbial profiling, and faecal short-chain fatty acids. Trials should include both children and adults and aim to be adequately powered to allow for subgroup analysis by age.
    MeSH term(s) Adult ; Child ; Humans ; Cystic Fibrosis ; Feces ; Hospitalization ; Inflammation ; Nutritional Status ; Prebiotics
    Chemical Substances Prebiotics
    Language English
    Publishing date 2023-09-27
    Publishing country England
    Document type Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ISSN 1469-493X
    ISSN (online) 1469-493X
    DOI 10.1002/14651858.CD015236.pub2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Bronchopulmonary dysplasia prediction models: a systematic review and meta-analysis with validation.

    Kwok, T'ng Chang / Batey, Natalie / Luu, Ka Ling / Prayle, Andrew / Sharkey, Don

    Pediatric research

    2023  Volume 94, Issue 1, Page(s) 43–54

    Abstract: Prediction models could identify infants at the greatest risk of bronchopulmonary dysplasia (BPD) and allow targeted preventative strategies. We performed a systematic review and meta-analysis with external validation of identified models. Studies using ... ...

    Abstract Prediction models could identify infants at the greatest risk of bronchopulmonary dysplasia (BPD) and allow targeted preventative strategies. We performed a systematic review and meta-analysis with external validation of identified models. Studies using predictors available before day 14 of life to predict BPD in very preterm infants were included. Two reviewers assessed 7628 studies for eligibility. Meta-analysis of externally validated models was followed by validation using 62,864 very preterm infants in England and Wales. A total of 64 studies using 53 prediction models were included totalling 274,407 infants (range 32-156,587/study). In all, 35 (55%) studies predated 2010; 39 (61%) were single-centre studies. A total of 97% of studies had a high risk of bias, especially in the analysis domain. Following meta-analysis of 22 BPD and 11 BPD/death composite externally validated models, Laughon's day one model was the most promising in predicting BPD and death (C-statistic 0.76 (95% CI 0.70-0.81) and good calibration). Six models were externally validated in our cohort with C-statistics between 0.70 and 0.90 but with poor calibration. Few BPD prediction models were developed with contemporary populations, underwent external validation, or had calibration and impact analyses. Contemporary, validated, and dynamic prediction models are needed for targeted preventative strategies. IMPACT: This review aims to provide a comprehensive assessment of all BPD prediction models developed to address the uncertainty of which model is sufficiently valid and generalisable for use in clinical practice and research. Published BPD prediction models are mostly outdated, single centre and lack external validation. Laughon's 2011 model is the most promising but more robust models, using contemporary data with external validation are needed to support better treatments.
    MeSH term(s) Infant ; Infant, Newborn ; Humans ; Infant, Premature ; Bronchopulmonary Dysplasia/diagnosis ; Infant, Very Low Birth Weight ; Infant, Premature, Diseases ; England
    Language English
    Publishing date 2023-01-09
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-022-02451-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 564: Show issues Location:
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    Zs.MO 373: Show issues

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  5. Article ; Online: You are what you read: bias, journal prestige and manipulation.

    Vairavan, Manishaa / Prayle, Andrew / Davies, Patrick

    Archives of disease in childhood. Education and practice edition

    2020  Volume 106, Issue 6, Page(s) 378–380

    Language English
    Publishing date 2020-10-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2148818-6
    ISSN 1743-0593 ; 1743-0585
    ISSN (online) 1743-0593
    ISSN 1743-0585
    DOI 10.1136/archdischild-2020-320246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Um IV Zs.106 -E.P.Ed.-: Show issues Location:
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  6. Article: β

    Yusuf, Fatima / Prayle, Andrew P / Yanney, Michael P

    Breathe (Sheffield, England)

    2019  Volume 15, Issue 4, Page(s) 273–276

    Abstract: Wheezy infants do not respond to bronchodilators despite evidence of functioning β-adrenoceptors. This is because the predominant aetiology, bronchiolitis, is characterised by small airway oedema and increased mucus, for which ... ...

    Abstract Wheezy infants do not respond to bronchodilators despite evidence of functioning β-adrenoceptors. This is because the predominant aetiology, bronchiolitis, is characterised by small airway oedema and increased mucus, for which β
    Language English
    Publishing date 2019-08-11
    Publishing country England
    Document type Editorial
    ZDB-ID 2562899-9
    ISSN 2073-4735 ; 1810-6838
    ISSN (online) 2073-4735
    ISSN 1810-6838
    DOI 10.1183/20734735.0255-2019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Observational Study of Pulse Transit Time in Children With Sleep Disordered Breathing.

    Yanney, Michael P / Prayle, Andrew P / Rowbotham, Nicola J / Kurc, Miguel / Tilbrook, Sean / Ali, Nabeel

    Frontiers in neurology

    2020  Volume 11, Page(s) 316

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2020-05-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2020.00316
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  8. Article ; Online: From pipeline to patient: new developments in cystic fibrosis therapeutics.

    Prayle, Andrew P / Smyth, Alan R

    Expert opinion on pharmacotherapy

    2013  Volume 14, Issue 3, Page(s) 323–329

    Abstract: Introduction: Cystic fibrosis (CF) is an inherited rare disease characterised by recurrent pulmonary infection, pancreatic malabsorption and a number of other multisystem effects. In the past few years new drugs specifically designed to treat CF have ... ...

    Abstract Introduction: Cystic fibrosis (CF) is an inherited rare disease characterised by recurrent pulmonary infection, pancreatic malabsorption and a number of other multisystem effects. In the past few years new drugs specifically designed to treat CF have entered the pipeline, and some are now used in clinical practice.
    Areas covered: Clinical trial results from CF trials reported or ongoing within the last 3 years are discussed. A literature and trials registry search of trials and meta-analyses involving patients with CF was conducted, from which the most exciting developments were selected.
    Expert opinion: Drugs to address the basic defect in CF have finally come to market, albeit for a limited number of patients with a specific genotype. Traditional areas of CF therapeutics continue to be developed, with modest success, including drugs to modulate the airway surface liquid, new pancreatic supplements, antibiotics and new treatments for endocrine complications of CF.
    MeSH term(s) Animals ; Anti-Bacterial Agents/therapeutic use ; Clinical Trials as Topic ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/physiopathology ; Drug Design ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2013-02-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2001535-5
    ISSN 1744-7666 ; 1465-6566
    ISSN (online) 1744-7666
    ISSN 1465-6566
    DOI 10.1517/14656566.2013.769958
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5130: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article ; Online: Antibiotic adjuvant therapy for pulmonary infection in cystic fibrosis.

    Hurley, Matthew N / Prayle, Andrew P

    Paediatric respiratory reviews

    2012  Volume 13, Issue 3, Page(s) 160–161

    MeSH term(s) Child ; Cystic Fibrosis/complications ; Disease Progression ; Drug Resistance, Microbial ; Humans ; Respiratory Tract Infections/complications ; Respiratory Tract Infections/drug therapy
    Language English
    Publishing date 2012-05-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2147664-0
    ISSN 1526-0550 ; 1526-0542
    ISSN (online) 1526-0550
    ISSN 1526-0542
    DOI 10.1016/j.prrv.2012.04.005
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    Zs.A 5919: Show issues Location:
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  10. Article ; Online: Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis.

    Hurley, Matthew N / Prayle, Andrew P / Flume, Patrick

    Paediatric respiratory reviews

    2015  Volume 16, Issue 4, Page(s) 246–248

    MeSH term(s) Administration, Inhalation ; Administration, Intravenous ; Administration, Oral ; Anti-Bacterial Agents/therapeutic use ; Cystic Fibrosis/drug therapy ; Disease Progression ; Drug Therapy, Combination ; Humans
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2015-09
    Publishing country England
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 2147664-0
    ISSN 1526-0550 ; 1526-0542
    ISSN (online) 1526-0550
    ISSN 1526-0542
    DOI 10.1016/j.prrv.2015.07.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5919: Show issues Location:
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