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Article ; Online: Psychotropic Drug-Induced Glaucoma: A Practical Guide to Diagnosis and Management.

Jain, Neeranjali S / Ruan, Claire W / Dhanji, Shanil R / Symes, Richard J

2021 Volume 35, Issue 3, Page(s) 283–289

Abstract: This article provides a practical review of the diagnosis and management of angle closure induced by psychotropic agents, including tricyclic antidepressants, antipsychotics and anticonvulsants. Selective serotonin reuptake inhibitors, serotonin- ... ...

Abstract	This article provides a practical review of the diagnosis and management of angle closure induced by psychotropic agents, including tricyclic antidepressants, antipsychotics and anticonvulsants. Selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, monoamine oxidase inhibitors and antipsychotics may trigger angle closure by influencing pupil configuration through adrenergic, anticholinergic, serotonergic or dopaminergic mechanisms. Patients with narrow iridocorneal angles are at risk, and these are more common in people with hypermetropia (near-sightedness), older people and individuals with an Asian background. These patients may benefit from a laser peripheral iridotomy, either prophylactically or to relieve an acute angle-closure episode. An idiosyncratic reaction to medications such as topiramate may lead to angle closure through an alternate mechanism, leading to a uveal effusion. Ophthalmological review may be considered prior to commencing medications in high-risk patients.
MeSH term(s)	Acute Disease ; Animals ; Anticonvulsants/adverse effects ; Glaucoma/chemically induced ; Glaucoma/diagnosis ; Humans ; Psychotropic Drugs/adverse effects ; Topiramate/adverse effects
Chemical Substances	Anticonvulsants ; Psychotropic Drugs ; Topiramate (0H73WJJ391)
Language	English
Publishing date	2021-02-19
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	1203800-3
ISSN	1179-1934 ; 1172-7047
ISSN (online)	1179-1934
ISSN	1172-7047
DOI	10.1007/s40263-020-00790-w
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Article ; Online: Normal tension glaucoma management: a survey of contemporary practice.

Symes, Richard J / Mikelberg, Frederick S

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

2017 Volume 52, Issue 4, Page(s) 361–365

Abstract: Objective: The aim of this study was to investigate contemporary practice patterns with respect to normal tension glaucoma (NTG) management and to determine whether the 2 largest NTG trials have influenced ophthalmologists' clinical practice.: Methods! ...

Abstract	Objective: The aim of this study was to investigate contemporary practice patterns with respect to normal tension glaucoma (NTG) management and to determine whether the 2 largest NTG trials have influenced ophthalmologists' clinical practice. Methods: A survey questionnaire was sent to ophthalmologists via the American Glaucoma Society, the Canadian Glaucoma Society, and the Canadian Ophthalmological Society. The questionnaire was designed to investigate ophthalmologists' usual practice with respect to NTG and the extent to which practice has been influenced by the Collaborative Normal Tension Glaucoma Study (CNTGS) and the Low pressure Glaucoma Treatment Study (LoGTS). Results: In total, 419 ophthalmologists completed the survey. Of these, 264 respondents were glaucoma subspecialists. The survey showed that 95% and 64% of ophthalmologists were familiar with the CNTGS and the LoGTS, respectively. Of the respondents, 70% indicated that they would initiate treatment in mild-to-moderate NTG without waiting for documented disease progression. Of the respondents, 61% of the total surveyed and 50% of the glaucoma subspecialists felt that the LoGTS results had no impact on their usual clinical practice. The first-choice topical drug for NTG was a prostaglandin analogue (88% of respondents) or brimonidine (10% of respondents). Conclusions: Most ophthalmologists treat NTG more aggressively than recommended by the CTNGS protocol. Most ophthalmologists felt that the LoGTS results had no impact on their normal clinical practice. The prostaglandin analogues are, by far, the most popular choice of drug for contemporary management of NTG.
MeSH term(s)	Canada ; Clinical Competence ; Disease Management ; Female ; Health Surveys/methods ; Humans ; Intraocular Pressure ; Low Tension Glaucoma/diagnosis ; Low Tension Glaucoma/physiopathology ; Low Tension Glaucoma/therapy ; Male ; Ophthalmologists/standards ; United States ; Visual Field Tests ; Visual Fields
Language	English
Publishing date	2017-08
Publishing country	England
Document type	Journal Article ; Multicenter Study
ZDB-ID	80091-0
ISSN	1715-3360 ; 0008-4182
ISSN (online)	1715-3360
ISSN	0008-4182
DOI	10.1016/j.jcjo.2016.12.008
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Zs.A 588: Show issues

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Article ; Online: Outcomes of Isolated Digital Flexor Tenolysis: A Systematic Review.

Kher, Sachin / Graham, David J / Symes, Michael / Lawson, Richard / Sivakumar, Brahman S

The journal of hand surgery Asian-Pacific volume

2021 Volume 26, Issue 4, Page(s) 580–587

Abstract: ... ...

Abstract	Background
MeSH term(s)	Adult ; Child, Preschool ; Hand Injuries ; Humans ; Male ; Retrospective Studies ; Tendon Injuries/surgery ; Tendons/surgery ; Tissue Adhesions
Language	English
Publishing date	2021-11-17
Publishing country	Singapore
Document type	Journal Article ; Systematic Review
ZDB-ID	2848651-1
ISSN	2424-8363 ; 2424-8355
ISSN (online)	2424-8363
ISSN	2424-8355
DOI	10.1142/S2424835521500557
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Article ; Online: Topical difluprednate monotherapy for uveitic macular edema.

Symes, Richard J / Forooghian, Farzin

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie

2016 Volume 51, Issue 1, Page(s) 47–49

Abstract: Objective: To describe the use of topical difluprednate for the treatment of uveitic macular edema.: Design: Retrospective review of 3 consecutive cases of uveitic macular edema.: Methods: Patients were treated with topical difluprednate ... ...

Abstract	Objective: To describe the use of topical difluprednate for the treatment of uveitic macular edema. Design: Retrospective review of 3 consecutive cases of uveitic macular edema. Methods: Patients were treated with topical difluprednate monotherapy. Results: All patients experienced complete resolution of uveitic macular edema within 2-4 weeks. We observed a statistically significant improvement in central subfield macular thickness (p = 0.04). There was an overall improvement in visual acuity, but this result was not statistically significant (p = 0.33). Conclusions: Topical difluprednate can be effective for uveitic macular edema. Further investigation of this therapy in prospective randomized controlled trials is warranted.
MeSH term(s)	Administration, Topical ; Adult ; Female ; Fluprednisolone/analogs & derivatives ; Fluprednisolone/therapeutic use ; Glucocorticoids/therapeutic use ; Humans ; Macular Edema/diagnosis ; Macular Edema/drug therapy ; Macular Edema/physiopathology ; Male ; Ophthalmic Solutions ; Retrospective Studies ; Tomography, Optical Coherence ; Uveitis, Anterior/diagnosis ; Uveitis, Anterior/drug therapy ; Uveitis, Anterior/physiopathology ; Uveitis, Intermediate/diagnosis ; Uveitis, Intermediate/drug therapy ; Uveitis, Intermediate/physiopathology ; Visual Acuity/drug effects
Chemical Substances	Glucocorticoids ; Ophthalmic Solutions ; Fluprednisolone (9H05937G3X) ; difluprednate (S8A06QG2QE)
Language	English
Publishing date	2016-02
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	80091-0
ISSN	1715-3360 ; 0008-4182
ISSN (online)	1715-3360
ISSN	0008-4182
DOI	10.1016/j.jcjo.2015.10.007
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Article ; Online: Temporal trends in the management of metacarpal and phalangeal fractures in the 21st century: an analysis of Australian population-based data.

Sivakumar, Brahman S / An, Vincent V G / Symes, Michael J / Graham, David J / Lawson, Richard D / Clarke, Elizabeth

ANZ journal of surgery

2022 Volume 92, Issue 10, Page(s) 2655–2660

Abstract: Background: Fractures of the hand, specifically the metacarpals and phalanges, are a common injury. Whilst many of these fractures can be treated non-operatively, a number of advances have led to the increase in popularity of surgical intervention. The ... ...

Abstract	Background: Fractures of the hand, specifically the metacarpals and phalanges, are a common injury. Whilst many of these fractures can be treated non-operatively, a number of advances have led to the increase in popularity of surgical intervention. The aim of this study was to assess and describe trends in management of phalangeal and metacarpal fractures in Australia over the last two decades. Methods: A review was conducted of the Medicare Benefits Scheme (MBS), specifically querying the item numbers pertaining to the management of metacarpal and phalanx fractures. Data was recorded as the incidence per 100 000 patients. Results: Overall, there was a statistically significant decrease in the incidence of closed reduction of metacarpal and phalanx fractures, with a converse statistically significant increase in open reduction internal fixation. Conclusion: This study demonstrates that over the last 20 years, there has been a decrease in closed reduction of intra- and extra-articular phalangeal and metacarpal fractures, with a converse but smaller increase in open reduction and fixation. These trends are likely multi-factorial in aetiology, and should be monitored to guide resource allocation and health provision in the future.
MeSH term(s)	Aged ; Australia/epidemiology ; Finger Phalanges/surgery ; Fracture Fixation, Internal ; Fractures, Bone/epidemiology ; Fractures, Bone/surgery ; Hand Injuries/surgery ; Humans ; Metacarpal Bones/surgery ; National Health Programs
Language	English
Publishing date	2022-07-03
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2050749-5
ISSN	1445-2197 ; 1445-1433 ; 0004-8682
ISSN (online)	1445-2197
ISSN	1445-1433 ; 0004-8682
DOI	10.1111/ans.17818
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Zs.A 180: Show issues

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Article ; Online: Infective Necrotizing Scleritis After XEN Gel Stent With Mitomycin-C.

Kingston, Ezekiel J / Zagora, Sophia L / Symes, Richard J / Raman, Pushpa / McCluskey, Peter J / Lusthaus, Jed A

Journal of glaucoma

2021 Volume 31, Issue 2, Page(s) 129–132

Abstract: Purpose: The purpose of this study was to report a case of infective necrotizing scleritis following XEN Gel Stent with mitomycin-C.: Methods: Case report. This is a case report of a 68-year-old woman.: Results: XEN Gel Stent glaucoma surgery ... ...

Abstract	Purpose: The purpose of this study was to report a case of infective necrotizing scleritis following XEN Gel Stent with mitomycin-C. Methods: Case report. This is a case report of a 68-year-old woman. Results: XEN Gel Stent glaucoma surgery enhanced with mitomycin-C 0.04% and combined with cataract surgery was performed at a regional center to manage the patient's primary open-angle glaucoma. Past medical history was significant for rheumatoid arthritis requiring treatment with methotrexate and adalimumab. Periocular pain and swelling developed 14 months after the initial operation, followed by a rapid deterioration of visual acuity to 20/60, intraocular pressure of 4 mm Hg, and worsening pain 5 months later. On initial presentation to Sydney Eye Hospital, 180 degrees of scleral necrosis was evident with a moderate anterior segment inflammatory reaction and a large temporal choroidal effusion due to hypotony. Empirical hourly topical ofloxacin and cephalothin 5% drops, with oral moxifloxacin, were initiated. Conjunctival swab grew Staphylococcus aureus and Staphylococcus lugdunensis. Significant clinical improvement occurred, but the XEN Gel Stent became exposed after 9 days of treatment with worsening hypotony. Urgent surgical revision was performed to remove the XEN Gel Stent and apply a tutoplast plug with overlying amniotic membrane graft. Intraocular pressure gradually improved over 6 weeks to 15 mm Hg with reversal of hypotonous changes, and visual acuity stabilized at 20/40. Conclusions: To our knowledge, this is the first reported case of necrotizing scleritis following XEN Gel Stent insertion. It is a reminder that infection should always be the primary differential diagnosis in patients with surgical-induced necrotizing scleritis.
MeSH term(s)	Aged ; Female ; Glaucoma Drainage Implants/adverse effects ; Glaucoma, Open-Angle/surgery ; Humans ; Intraocular Pressure ; Mitomycin ; Scleritis/diagnosis ; Scleritis/drug therapy ; Scleritis/etiology ; Stents ; Treatment Outcome
Chemical Substances	Mitomycin (50SG953SK6)
Language	English
Publishing date	2021-11-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	913494-3
ISSN	1536-481X ; 1057-0829
ISSN (online)	1536-481X
ISSN	1057-0829
DOI	10.1097/IJG.0000000000001959
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Article ; Online: Re: Hughes et al.: Cost-effectiveness analysis of adalimumab for the treatment of uveitis associated with juvenile idiopathic arthritis (Ophthalmology. 2019;126:415-424).

Symes, Richard J / Zagora, Sophia L / Younan, Christine / McCluskey, Peter J

Ophthalmology

2019 Volume 126, Issue 10, Page(s) e77

MeSH term(s)	Adalimumab ; Antirheumatic Agents ; Arthritis, Juvenile ; Cost-Benefit Analysis ; Humans ; Uveitis
Chemical Substances	Antirheumatic Agents ; Adalimumab (FYS6T7F842)
Language	English
Publishing date	2019-09-21
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	392083-5
ISSN	1549-4713 ; 0161-6420
ISSN (online)	1549-4713
ISSN	0161-6420
DOI	10.1016/j.ophtha.2019.04.039
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Article ; Online: Giant cell arteritis and scleritis: Does an association exist?

Lock, Jane H / McCluskey, Peter / Symes, Richard J / Fraser, Clare L

Clinical & experimental ophthalmology

2019 Volume 48, Issue 2, Page(s) 266–267

MeSH term(s)	Female ; Giant Cell Arteritis/complications ; Giant Cell Arteritis/diagnosis ; Humans ; Male ; Scleritis/diagnosis ; Scleritis/etiology
Language	English
Publishing date	2019-10-28
Publishing country	Australia
Document type	Letter
ZDB-ID	2014008-3
ISSN	1442-9071 ; 1442-6404
ISSN (online)	1442-9071
ISSN	1442-6404
DOI	10.1111/ceo.13662
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Article ; Online: The Impact of COVID-19 on Hand Trauma.

Saleh, Serag / Faulkner, Harrison / Golledge, Kelsi / Graham, David J / Lawson, Richard D / Symes, Michael J / Sivakumar, Brahman S

Hand (New York, N.Y.)

2021 Volume 18, Issue 2, Page(s) 355–361

Abstract: Background: The Coronavirus Disease 2019 (COVID-19) pandemic has had a dramatic impact on individual and societal behaviors, as well as on health care systems. It confers a unique opportunity to examine the relationship among disease, policies, and ... ...

Abstract	Background: The Coronavirus Disease 2019 (COVID-19) pandemic has had a dramatic impact on individual and societal behaviors, as well as on health care systems. It confers a unique opportunity to examine the relationship among disease, policies, and patterns of activity, as well as their impacts on surgical unit functionality. This study aims to compare the distribution and patterns of injury at a tertiary hand surgery trauma center before and during the COVID-19 pandemic. Methods: A retrospective analysis of all patients presenting to the Royal North Shore Hospital hand surgery service in the 5-week period from March 16 to April 21 in 2019 and 2020 was undertaken, forming 2 cohorts for comparison. Demographic, injury, and operative data were collected and compared descriptively using comparative statistics. Results: There were 114 primary operative presentations during the 5-week period in 2020, representing a 27.4% decrease from the 157 presentations during the equivalent period in 2019. There was an increase in the proportion of emergency presentations from 73.9% in 2019 to 85.1% in 2020 ( Conclusions: The COVID-19 pandemic and consequent restrictions of activity have had substantial impacts on the patterns of hand trauma and its management. These insights have implications for staff and resource management during times of social disruption in the future.
MeSH term(s)	Humans ; COVID-19/epidemiology ; SARS-CoV-2 ; Pandemics ; Retrospective Studies ; Trauma Centers ; Hand Injuries/epidemiology ; Hand Injuries/surgery
Language	English
Publishing date	2021-07-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2277325-3
ISSN	1558-9455 ; 1558-9447
ISSN (online)	1558-9455
ISSN	1558-9447
DOI	10.1177/15589447211028918
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Article ; Online: Uveitis Registries - A Digital Tool for Patient Care, Education, Research, and Collaboration.

Zhang, Zheting / Ng Ming Sheng, Sean / Kempen, John H / Fabiani, Claudia / Arora, Atul / Gupta, Vishali / Tsui, Edmund / Cimino, Luca / Symes, Richard J / Dell, Jennifer / Finger, Robert P / Heinz, Carsten / Agrawal, Rupesh

Ocular immunology and inflammation

2022 Volume 31, Issue 9, Page(s) 1859–1869

Abstract: Purpose: Clinical registries are increasingly important in research and clinical advancement. This review explores and compares current uveitis registries and recommends future directions on how uveitis registries can complement one another for ... ...

Abstract	Purpose: Clinical registries are increasingly important in research and clinical advancement. This review explores and compares current uveitis registries and recommends future directions on how uveitis registries can complement one another for synergistic effect and benefit. Methods: From a systematic search, 861 citations were screened for longitudinal, non-interventional, and multicenter uveitis-specific registries. Additional registries were identified via consultations with uveitis experts. Characteristics of all registries were analyzed and compared. Results: Four registries were identified: Treatment Exit Options for Non-infectious Uveitis, AutoInflammatory Disease Alliance International Registry, Ocular Autoimmune Systemic Inflammatory Infectious Study, and Fight Uveitis Blindness!. Despite certain differences, these registries have the overarching goal of collecting large quantities of real-world, high-quality patient data to improve the understanding of uveitis. Conclusion: The four uveitis registries share similar goals and collect clinical data from overlapping geographical regions. There is vast potential for collaboration, including data sharing to further augment datasets for analysis.
MeSH term(s)	Humans ; Uveitis/therapy ; Uveitis/drug therapy ; Registries ; Eye ; Eye Infections ; Patient Care ; Multicenter Studies as Topic
Language	English
Publishing date	2022-11-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1193873-0
ISSN	1744-5078 ; 0927-3948
ISSN (online)	1744-5078
ISSN	0927-3948
DOI	10.1080/09273948.2022.2140062
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