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Article ; Online: Is this the end of colonoscopy screening for colorectal cancer? An Asia-Pacific perspective.

Lui, Rashid N / Wong, Sunny H / Ding, Nik Sheng / Sekiguchi, Masau / Yu, Jun / Ang, Tiing-Leong / Yeoh, Khay-Guan / Chiu, Han-Mo / Sung, Joseph J Y

Journal of gastroenterology and hepatology

2023 Volume 38, Issue 5, Page(s) 671–677

MeSH term(s)	Humans ; Early Detection of Cancer ; Asia/epidemiology ; Colonoscopy ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/prevention & control ; Mass Screening ; Occult Blood
Language	English
Publishing date	2023-03-28
Publishing country	Australia
Document type	Editorial ; Comment
ZDB-ID	632882-9
ISSN	1440-1746 ; 0815-9319
ISSN (online)	1440-1746
ISSN	0815-9319
DOI	10.1111/jgh.16182
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Zs.A 2180: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 299: Show issues

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Article ; Online: An Interpretable Intensive Care Unit Mortality Risk Calculator.

Ang, Eugene T Y / Nambiar, Mila / Soh, Yong Sheng / Tan, Vincent Y F

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2021 Volume 2021, Page(s) 4152–4158

Abstract: Mortality risk is a major concern to patients who have just been discharged from the intensive care unit (ICU). Many studies have been directed to construct machine learning models to predict such risk. Although these models are highly accurate, they are ...

Abstract	Mortality risk is a major concern to patients who have just been discharged from the intensive care unit (ICU). Many studies have been directed to construct machine learning models to predict such risk. Although these models are highly accurate, they are less amenable to interpretation and clinicians are typically unable to gain further insights into the patients' health conditions and the underlying factors that influence their mortality risk. In this paper, we use patients' profiles extracted from the MIMIC-III clinical database to construct risk calculators based on different machine learning techniques such as logistic regression, decision trees, random forests, k-nearest neighbors and multilayer perceptrons. We perform an extensive benchmarking study that compares the most salient features as predicted by various methods. We observe a high degree of agreement across the considered machine learning methods; in particular, age, blood urea nitrogen level and the indicator variable - whether the patient is discharged from the cardiac surgery recovery unit are commonly predicted to be the most salient features for determining patients' mortality risks. Our work has the potential to help clinicians interpret risk predictions.
MeSH term(s)	Databases, Factual ; Humans ; Intensive Care Units ; Logistic Models ; Machine Learning ; Neural Networks, Computer
Language	English
Publishing date	2021-12-05
Publishing country	United States
Document type	Journal Article
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC46164.2021.9631058
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Article ; Online: A tumour-resident Lgr5

Fatehullah, A / Terakado, Y / Sagiraju, S / Tan, T L / Sheng, T / Tan, S H / Murakami, K / Swathi, Y / Ang, N / Rajarethinam, R / Ming, T / Tan, P / Lee, B / Barker, N

Nature cell biology

2021 Volume 23, Issue 12, Page(s) 1299–1313

Abstract: Gastric cancer is among the most prevalent and deadliest of cancers globally. To derive mechanistic insight into the pathways governing this disease, we generated a Claudin18-IRES-CreERT2 allele to selectively drive conditional dysregulation of the Wnt, ... ...

Abstract	Gastric cancer is among the most prevalent and deadliest of cancers globally. To derive mechanistic insight into the pathways governing this disease, we generated a Claudin18-IRES-CreERT2 allele to selectively drive conditional dysregulation of the Wnt, Receptor Tyrosine Kinase and Trp53 pathways within the gastric epithelium. This resulted in highly reproducible metastatic, chromosomal-instable-type gastric cancer. In parallel, we developed orthotopic cancer organoid transplantation models to evaluate tumour-resident Lgr5
MeSH term(s)	Animals ; Biomarkers/metabolism ; Claudins/genetics ; Disease Models, Animal ; Gastric Mucosa/pathology ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neoplastic Stem Cells/pathology ; Organoids/transplantation ; Receptors, G-Protein-Coupled/genetics ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Protein p53/metabolism ; Wnt Proteins/metabolism
Chemical Substances	Biomarkers ; CLDN18 protein, human ; Claudins ; LGR5 protein, human ; Receptors, G-Protein-Coupled ; TP53 protein, human ; Tumor Suppressor Protein p53 ; Wnt Proteins
Language	English
Publishing date	2021-12-02
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1474722-4
ISSN	1476-4679 ; 1465-7392
ISSN (online)	1476-4679
ISSN	1465-7392
DOI	10.1038/s41556-021-00793-9
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Zs.A 5169: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 12: Show issues

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Article ; Online: GPR55 regulates the responsiveness to, but does not dimerise with, α

Walsh, Sarah K / Lipina, Christopher / Ang, Sheng Y / Sato, Masaaki / Chia, Ling Yeong / Kocan, Martina / Hutchinson, Dana S / Summers, Roger J / Wainwright, Cherry L

Biochemical pharmacology

2021 Volume 188, Page(s) 114560

Abstract: Emerging evidence suggests that G protein coupled receptor 55 (GPR55) may influence adrenoceptor function/activity in the cardiovascular system. Whether this reflects direct interaction (dimerization) between receptors or signalling crosstalk has not ... ...

Abstract	Emerging evidence suggests that G protein coupled receptor 55 (GPR55) may influence adrenoceptor function/activity in the cardiovascular system. Whether this reflects direct interaction (dimerization) between receptors or signalling crosstalk has not been investigated. This study explored the interaction between GPR55 and the alpha 1A-adrenoceptor (α
MeSH term(s)	Adrenergic alpha-1 Receptor Agonists/pharmacology ; Animals ; Animals, Newborn ; CHO Cells ; Cells, Cultured ; Cricetinae ; Cricetulus ; Female ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Organ Culture Techniques ; Pregnancy ; Protein Multimerization/drug effects ; Protein Multimerization/physiology ; Rats ; Rats, Sprague-Dawley ; Receptors, Adrenergic, alpha-1/genetics ; Receptors, Adrenergic, alpha-1/metabolism ; Receptors, Cannabinoid/deficiency ; Receptors, Cannabinoid/genetics
Chemical Substances	Adrenergic alpha-1 Receptor Agonists ; GPR55 protein, mouse ; Receptors, Adrenergic, alpha-1 ; Receptors, Cannabinoid
Language	English
Publishing date	2021-05-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208787-x
ISSN	1873-2968 ; 0006-2952
ISSN (online)	1873-2968
ISSN	0006-2952
DOI	10.1016/j.bcp.2021.114560
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Zs.A 19: Show issues

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Article ; Online: Graph convolutional networks fusing motif-structure information.

Wang, Bin / Cheng, LvHang / Sheng, JinFang / Hou, ZhengAng / Chang, YaoXing

Scientific reports

2022 Volume 12, Issue 1, Page(s) 10735

Abstract: With the advent of the wave of big data, the generation of more and more graph data brings great pressure to the traditional deep learning model. The birth of graph neural network fill the gap of deep learning in graph data. At present, graph ... ...

Abstract	With the advent of the wave of big data, the generation of more and more graph data brings great pressure to the traditional deep learning model. The birth of graph neural network fill the gap of deep learning in graph data. At present, graph convolutional networks (GCN) have surpassed traditional methods such as network embedding in node classification. However, The existing graph convolutional networks only consider the edge structure information of first-order neighbors as the bridge of information aggregation in a convolution operation, which undoubtedly loses the higher-order structure information in complex networks. In order to capture more abundant information of the graph topology and mine the higher-order information in complex networks, we put forward our own graph convolutional networks model fusing motif-structure information. By identifying the motif-structure in the network, our model fuses the motif-structure information of nodes to study the aggregation feature weights, which enables nodes to aggregate higher-order network information, thus improving the capability of GCN model. Finally, we conduct node classification experiments in several real networks, and the experimental results show that the GCN model fusing motif-structure information can improve the accuracy of node classification.
Language	English
Publishing date	2022-06-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-13277-z
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Article ; Online: Dual molecules engineered carbon nitride for achieving outstanding photocatalytic H

Wei, Wei / Zou, Leilei / Li, Jin / Hou, Fengming / Sheng, Zekai / Li, Yihang / Guo, Zhipeng / Wei, Ang

Journal of colloid and interface science

2023 Volume 636, Page(s) 537–548

Abstract: Molecular engineering of carbon nitride (CN) was considered as a suitable and compelling strategy to overcome the intrinsic imperfections and enhance photocatalytic ... ...

Abstract	Molecular engineering of carbon nitride (CN) was considered as a suitable and compelling strategy to overcome the intrinsic imperfections and enhance photocatalytic H
Language	English
Publishing date	2023-01-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	241597-5
ISSN	1095-7103 ; 0021-9797
ISSN (online)	1095-7103
ISSN	0021-9797
DOI	10.1016/j.jcis.2023.01.046
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Z 71/707: Show issues

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Article ; Online: Electrochemical aerobic Wacker-type oxygenation of triaryl substituted alkenes to 1,2,2-triarylethanones.

Zhang, Zhou / Li, Jin / Cai, Zhiwei / Kang, Songyao / Wang, Jian / Cui, Yue / Han, Siyuan / Sheng, Lei / Yin, Qing / Dai, Ang / Zhao, Weining / Zhao, Fangyuan

Chemical communications (Cambridge, England)

2024 Volume 60, Issue 22, Page(s) 3035–3038

Abstract: An effective synthetic approach for various 1,2,2-triarylethanones from triaryl substituted alkenes has been ... ...

Abstract	An effective synthetic approach for various 1,2,2-triarylethanones from triaryl substituted alkenes has been developed
Language	English
Publishing date	2024-03-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc05770d
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Article: [Effect of acupuncture on expression of endoplasmic reticulum Ca

Zhang, Hui / Ma, Yun / Wu, Xu / Liu, Zhen-Bang / Wu, Sheng-Bing / Ang, Wen-Ping / Yang, Fan

Zhen ci yan jiu = Acupuncture research

2022 Volume 47, Issue 8, Page(s) 673–677

Abstract: Objective: To observe the effect of acupuncture on endoplasmic reticulum calcium, apoptosis number and Caspase-12 protein expression in hippocampal neurons of convulsive rats, so as to explore its mechanisms underlying improvement of convulsion.: ... ...

Abstract	Objective: To observe the effect of acupuncture on endoplasmic reticulum calcium, apoptosis number and Caspase-12 protein expression in hippocampal neurons of convulsive rats, so as to explore its mechanisms underlying improvement of convulsion. Methods: SD rats were randomly divided into normal control, model and acupuncture groups, with 36 rats in each group. Rats in the normal control group received intraperitoneal injection (i.p.) of normal saline (2 mL), and those of the other 2 groups received i.p. of pentylenetetrazole (50 mg/kg) for establishing convulsion model. Manual acupuncture stimulation was applied to "Baihui"(GV20) and "Dazhui"(GV14) for 30 min after modeling. The hippocampal tissues were taken at 2, 12 and 48 h after modeling. The endoplasmic reticulum Ca Results: In comparison with the normal group, the number of apoptotic cells of hippocampal neurons and the expression levels of Caspase-12 protein in hippocampus at 2, 12 and 48 h after seizures were obviously increased ( Conclusion: Acupuncture intervention is effective in reducing the apoptosis of hippocampal neurons in convulsion rats, which may be related to its functions in down-regulating Caspase-12 expression and promoting influx of Ca
MeSH term(s)	Acupuncture Therapy ; Animals ; Brain Injuries ; Calcium/metabolism ; Caspase 12 ; Endoplasmic Reticulum ; Hippocampus ; Neurons ; Rats ; Rats, Sprague-Dawley ; Seizures
Chemical Substances	Caspase 12 (EC 3.4.22.-) ; Calcium (SY7Q814VUP)
Language	Chinese
Publishing date	2022-02-14
Publishing country	China
Document type	Journal Article
ZDB-ID	1283179-7
ISSN	1000-0607
ISSN	1000-0607
DOI	10.13702/j.1000-0607.20210570
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Zs.A 4364: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Valorization of thermally hydrolyzed sludge with clay for sintering of ceramic tiles.

Wen, Lei / Lin, Lin / Fan, Yi-Ang / Luo, Yang / Ma, Sheng-Shou / Zhou, Ying / Yang, Chao / Shih, Kaimin / Li, Xiao-Yan

The Science of the total environment

2023 Volume 877, Page(s) 162871

Abstract: The disposal of wastewater sludge is one of the most challenging environmental problems for large cities. Wastewater sludge may be utilized as a feasible substitute for clay to sinter ceramics, given their similar mineralogical composition. However, the ... ...

Abstract	The disposal of wastewater sludge is one of the most challenging environmental problems for large cities. Wastewater sludge may be utilized as a feasible substitute for clay to sinter ceramics, given their similar mineralogical composition. However, the organics in sludge will be wasted, while their release during sintering will leave cracks in the ceramic products. In this research, after the thermal treatment for effective organic recovery, the thermally hydrolyzed sludge (THS) is incorporated with clay for the sintering of construction ceramics. The experimental results showed that a THS dosing ratio up to 40 % can be achieved for mixing with montmorillonite clay to make ceramic tiles. The sintered tiles (THS-40) had an intact shape and structure, and the tile performance was close to that made from single montmorillonite (THS-0), with water absorption of 0.4 % vs. 0.2 %, compressive strength of 136.8 vs. 140.7 MPa, and undetected heavy metal leaching. Further addition of THS would lead to a considerable deterioration of the quality of the tiles to a compressive strength of as low as 5.0 MPa for the THS only product (THS-100). Comparing with the tiles incorporated with raw sludge (RS-40), the THS-40 tiles had a more intact and denser structure with a 10 % improved compressive strength. Cristobalite, aluminum phosphate, mullite, and hematite dominated in the THS-born ceramics, which are typical components of ceramics, and the amount of hematite increased with the THS dosing ratio. Sintering at a high temperature of 1200 °C enabled efficient phase transformation from quartz to cristobalite and from muscovite to mullite, which ensured the toughness and compactness of the THS-born ceramic tiles.
Language	English
Publishing date	2023-03-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.162871
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Zs.A 949: Show issues

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Article ; Online: Discovery of segmented Fermi surface induced by Cooper pair momentum.

Zhu, Zhen / Papaj, Michał / Nie, Xiao-Ang / Xu, Hao-Ke / Gu, Yi-Sheng / Yang, Xu / Guan, Dandan / Wang, Shiyong / Li, Yaoyi / Liu, Canhua / Luo, Jianlin / Xu, Zhu-An / Zheng, Hao / Fu, Liang / Jia, Jin-Feng

Science (New York, N.Y.)

2021 Volume 374, Issue 6573, Page(s) 1381–1385

Abstract: A sufficiently large supercurrent can close the energy gap in a superconductor and create gapless quasiparticles through the Doppler shift of quasiparticle energy caused by finite Cooper pair momentum. In this gapless superconducting state, zero-energy ... ...

Abstract	A sufficiently large supercurrent can close the energy gap in a superconductor and create gapless quasiparticles through the Doppler shift of quasiparticle energy caused by finite Cooper pair momentum. In this gapless superconducting state, zero-energy quasiparticles reside on a segment of the normal-state Fermi surface, whereas the remaining Fermi surface is still gapped. We use quasiparticle interference to image the field-controlled Fermi surface of bismuth telluride (Bi
Language	English
Publishing date	2021-10-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.abf1077
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Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 77: Show issues

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