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Article ; Online: Reply to Joshua A. Linscott, Angela B. Smith, and Jesse D. Sammon's Letter to the Editor re: Woonyoung Choi, Andrea Ochoa, David J. McConkey, et al. Genetic Alterations in the Molecular Subtypes of Bladder Cancer: Illustration in the Cancer Genome Atlas Dataset. Eur Urol 2017;72:354-65.

Choi, Woonyoung / McConkey, David

2017 Volume 73, Issue 4, Page(s) e104–e105

MeSH term(s)	Humans ; Male ; Mutation ; Urinary Bladder Neoplasms/genetics
Language	English
Publishing date	2017-11-23
Publishing country	Switzerland
Document type	Letter ; Research Support, N.I.H., Extramural ; Comment
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2017.11.003
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 294: Show issues

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Article ; Online: Monitoring Microbial Populations and Antibiotic Resistance Gene Enrichment Associated with Arctic Waste Stabilization Ponds.

Gromala, Monica / Neufeld, Josh D / McConkey, Brendan J

Applied and environmental microbiology

2021 Volume 87, Issue 7

Abstract: Wastewater management in the Canadian Arctic is challenging due to climate extremes, small population sizes, and lack of conventional infrastructure for wastewater treatment. Although many northern communities use waste stabilization ponds (WSPs) as ... ...

Abstract	Wastewater management in the Canadian Arctic is challenging due to climate extremes, small population sizes, and lack of conventional infrastructure for wastewater treatment. Although many northern communities use waste stabilization ponds (WSPs) as their primary form of wastewater treatment, few studies have explored WSP microbial communities and assessed effluent impacts on receiving waters from a microbiological perspective. Here, we used 16S rRNA gene and metagenome sequencing to characterize WSP and receiving water microbial communities for two time points bracketing the spring WSP thaw in Baker Lake (Nunavut) and compared these results to other Nunavut WSPs in Cambridge Bay and Kugluktuk. Most amplicon sequence variants (ASVs) recovered from these WSP samples belonged to the phylum
MeSH term(s)	Bacteria/drug effects ; Bacteria/genetics ; Drug Resistance, Bacterial/genetics ; Metagenome ; Microbiota ; Nunavut ; RNA, Bacterial/analysis ; RNA, Ribosomal, 16S/analysis ; Sequence Analysis, RNA ; Waste Disposal, Fluid ; Waste Water/microbiology
Chemical Substances	RNA, Bacterial ; RNA, Ribosomal, 16S ; Waste Water
Language	English
Publishing date	2021-03-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	223011-2
ISSN	1098-5336 ; 0099-2240
ISSN (online)	1098-5336
ISSN	0099-2240
DOI	10.1128/AEM.02914-20
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Zs.B 201: Show issues

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Article: Intra-articular Soft Tissue Pathology of the Postpartum Hip: A Systematic Review.

Hoffer, Alexander J / Kingwell, Doug / Leith, Jordan / McConkey, Mark / Ayeni, Olufemi R / Lodhia, Parth

Current reviews in musculoskeletal medicine

2022 Volume 15, Issue 6, Page(s) 659–666

Abstract: Purpose of review: Pregnancy-related lumbopelvic and hip pain affects over half of postpartum females and has multiple aetiologies. The relative contribution of intra-articular soft tissue pathology to pregnancy-related hip pain is unknown. The current ... ...

Abstract	Purpose of review: Pregnancy-related lumbopelvic and hip pain affects over half of postpartum females and has multiple aetiologies. The relative contribution of intra-articular soft tissue pathology to pregnancy-related hip pain is unknown. The current review investigates the available evidence regarding underlying intra-articular soft tissue aetiologies of hip pain in females during pregnancy and in the acute postpartum period. Recent findings: Three online databases (Embase, PubMed and Ovid [MEDLINE]) were searched from database inception until 11 April 2021. All titles, relevant abstracts and full-text articles were screened by two reviewers independently. The methodological quality of the included studies was assessed using the Methodological Index for Non-Randomized Studies (MINORS) instrument. Descriptive study characteristics are presented in a narrative summary. Five level IV evidence articles were eligible for inclusion. Twenty-two females were included. Twenty patients presented with labral pathology, 15 of which necessitated hip arthroscopy with labral debridement or repair with or without acetabuloplasty and/or femoroplasty. One patient presented with an incidental labral tear in the context of osteitis condensans illi. One patient presented with posttraumatic osteoarthritis necessitating a hip arthroplasty. The contribution of intra-articular soft tissue injury is a documented, albeit sparse, aetiology contributing to pregnancy-related hip pain. Further research to better delineate the prevalence, natural history and optimal management options for females who sustained these injuries at a life-altering juncture is necessary to advance the care of these patients.
Language	English
Publishing date	2022-11-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2407827-X
ISSN	1935-9748 ; 1935-973X
ISSN (online)	1935-9748
ISSN	1935-973X
DOI	10.1007/s12178-022-09804-0
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Article ; Online: Influence of two management practices in the Canadian Prairies on radiative forcing.

Liu, J / Worth, D E / Desjardins, R L / Haak, D / McConkey, B / Cerkowniak, D

The Science of the total environment

2020 Volume 765, Page(s) 142701

Abstract: Surface albedo and soil carbon sequestration are influenced by agricultural management practices which impact the Earth's radiation budget and climate change. In this study we investigate the impact of reduced summer fallowing and reduced tillage in the ... ...

Abstract	Surface albedo and soil carbon sequestration are influenced by agricultural management practices which impact the Earth's radiation budget and climate change. In this study we investigate the impact of reduced summer fallowing and reduced tillage in the Canadian Prairies on climate change by estimating the change in radiative forcing due to albedo and soil carbon sequestration. Seasonal variations of albedo, which are dependent on agricultural management practices and soil colour in three soil zones, were derived from 10-day composite 250-m Moderate Resolution Imaging Spectroradiometer (MODIS) data. Using this information, we found an overall increase of surface albedo due to the conversion from summer fallowing to continuous cropping and from conventional tillage (CT) to either no-tillage (NT) or reduced tillage (RT). The increase was dependent on soil brightness, type of vegetation and snow cover. Using data from the Census of Agriculture and taking into consideration both albedo and soil carbon changes, we estimated that from 1981 to 2016, the total radiative forcing for the cropland area in the Canadian Prairies was -405 μW m
Language	English
Publishing date	2020-10-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2020.142701
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Zs.A 949: Show issues

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Article ; Online: Dismantling "Race" in Health Research.

Dordunoo, Dzifa / Abernethy, Paivi / Kayuni, Jenipher / McConkey, Stephanie / Aviles-G, Martha L

The Canadian journal of nursing research = Revue canadienne de recherche en sciences infirmieres

2022 Volume 54, Issue 3, Page(s) 239–245

Abstract: In this era of confronting racism in public space, it is critical to keep addressing the covert systemic racism in the healthcare system. We want to bring attention to the continued unscientific practice of race-based medicine and the absurdity of ... ...

Abstract	In this era of confronting racism in public space, it is critical to keep addressing the covert systemic racism in the healthcare system. We want to bring attention to the continued unscientific practice of race-based medicine and the absurdity of treating race as a biological indicator in the 21st century. We believe race is a social construct that does not qualify as a scientific biological indicator for predicting health outcomes. In this paper, we first present arguments for inappropriate use of race in health research and then discuss alternative explanations for health disparity findings that use race as a predictor. Our main concern centers on two specific aspects of the concept of "race": (1) its fundamental lack of scientific basis as a predictor for health outcomes, (2) the misguided narrative that the term creates, placing the onus of racial discrimination on the victim, instead of highlighting the act of discrimination and the role researchers play in actively reinforcing racism when using "race" as a variable. We conclude by proposing that "race" be replaced by the variable "racism" in health.
MeSH term(s)	Delivery of Health Care ; Environmental Biomarkers ; Racism/prevention & control
Chemical Substances	Environmental Biomarkers
Language	English
Publishing date	2022-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1036826-7
ISSN	1705-7051 ; 0844-5621
ISSN (online)	1705-7051
ISSN	0844-5621
DOI	10.1177/08445621221074849
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Zs.A 2582: Show issues

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Article ; Online: Methylation signatures in clinically variable syndromic disorders: a familial DNMT3A variant in two adults with Tatton-Brown-Rahman syndrome.

Kumps, Candy / D'haenens, Erika / Kerkhof, Jennifer / McConkey, Haley / Alders, Marielle / Sadikovic, Bekim / Vanakker, Olivier M

European journal of human genetics : EJHG

2023 Volume 31, Issue 12, Page(s) 1350–1354

MeSH term(s)	Adult ; Humans ; Abnormalities, Multiple/genetics ; DNA (Cytosine-5-)-Methyltransferases/genetics ; DNA Methylation ; Intellectual Disability/diagnosis ; Intellectual Disability/genetics ; Methylation
Chemical Substances	DNA (Cytosine-5-)-Methyltransferases (EC 2.1.1.37) ; DNMT3A protein, human
Language	English
Publishing date	2023-09-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1141470-4
ISSN	1476-5438 ; 1018-4813
ISSN (online)	1476-5438
ISSN	1018-4813
DOI	10.1038/s41431-023-01459-w
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Zs.A 3589: Show issues

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Article ; Online: Enfortumab Vedotin-related Cutaneous Toxicity and Radiographic Response in Patients with Urothelial Cancer: A Single-center Experience and Review of the Literature.

Vlachou, Evangelia / Matoso, Andres / McConkey, David / Jing, Yuezhou / Johnson, Burles Avner / Hahn, Noah M / Hoffman-Censits, Jean

European urology open science

2023 Volume 49, Page(s) 100–103

Abstract: Enfortumab vedotin (EV) is an antibody-drug conjugate approved for the treatment of refractory advanced urothelial cancer. Cutaneous toxicity is well described but has not been correlated with response. In this retrospective single-center study, data ... ...

Abstract	Enfortumab vedotin (EV) is an antibody-drug conjugate approved for the treatment of refractory advanced urothelial cancer. Cutaneous toxicity is well described but has not been correlated with response. In this retrospective single-center study, data from patients treated with more than one dose of EV between December 2017 and June 2022 were analyzed. Of 56 patients with a median age of 69 yr, 41 (73.2%) were male and 27 (48.2%) had any-grade skin toxicity. For all 51 patients evaluable by physician-assessed Response Evaluation Criteria in Solid Tumors (RECIST) criteria, the response rate was 41.2%. For those with cutaneous toxicity, the response rate was 57.7%; for those without cutaneous toxicity, it was 24.0% ( Patient summary: We evaluated patients with urothelial cancer who were treated at our institution with enfortumab vedotin (EV). We found that patients who experienced the common side effect of any type of skin toxicity, such as rash or itching, were more likely to have improvement in their cancer from EV treatment than those who did not experience skin toxicity. Patients with higher weight and body mass index when starting EV tended to have more skin toxicity. We conclude that presence of skin toxicity might help doctors make decisions about how to manage the care of patients with EV in the future.
Language	English
Publishing date	2023-02-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3040546-4
ISSN	2666-1683 ; 2058-4881
ISSN (online)	2666-1683
ISSN	2058-4881
DOI	10.1016/j.euros.2023.01.002
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Article ; Online: Does it matter whether a T1 high-grade tumor is molecularly classified?

Stenzl, Arnulf / McConkey, David / Bellmunt, Joaquim

European urology oncology

2019 Volume 4, Issue 5, Page(s) 837–842

Abstract: A 58-yr-old male, 20 pack-year smoker, with hypertension was diagnosed with a single left-side high-grade papillary tumor with peritumoral carcinoma in situ, but no tumor was visible outside the bladder. En bloc resection was performed, and repeat ... ...

Abstract	A 58-yr-old male, 20 pack-year smoker, with hypertension was diagnosed with a single left-side high-grade papillary tumor with peritumoral carcinoma in situ, but no tumor was visible outside the bladder. En bloc resection was performed, and repeat transurethral resection of the bladder at 4 wk found no residual tumor. He was prescribed bacillus Calmette-Guérin (BCG) plus maintenance therapy, and cystoscopy at 9 mo found a T1b high-grade tumor, this time right sided. Is it important that the tumor should be molecularly characterized before a treatment decision is made, or is clinicopathologic characterization still the only viable option at this time? PATIENT SUMMARY: We discussed how new methods in pathology may help us find molecular structures that would help clinicians decide safely between cystectomy and conservative bladder-sparing strategies. The primary superficially infiltrative tumor and its similar recurrence 9 mo later were categorized based on standard clinical criteria, but here we discuss whether recently discovered methods for defining the molecular structure of tumors could mean that more bladder-preserving treatments might be an option.
MeSH term(s)	Adjuvants, Immunologic/therapeutic use ; Administration, Intravesical ; Cystectomy ; Humans ; Male ; Neoplasm Staging ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/therapy
Chemical Substances	Adjuvants, Immunologic
Language	English
Publishing date	2019-08-03
Publishing country	Netherlands
Document type	Journal Article
ISSN	2588-9311
ISSN (online)	2588-9311
DOI	10.1016/j.euo.2019.07.009
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Article ; Online: "Advancing bladder preservation: Biomarkers, decision-making, and therapy".

McConkey, David / Best, Carolyn J M / Gumminger, Julia A / Olumi, Aria F

Urologic oncology

2021 Volume 39, Issue 4, Page(s) 199–200

MeSH term(s)	Biomarkers, Tumor ; Carcinoma, Transitional Cell/surgery ; Clinical Decision-Making ; Humans ; Organ Sparing Treatments ; Urinary Bladder Neoplasms/surgery
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2021-01-22
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1336505-8
ISSN	1873-2496 ; 1078-1439
ISSN (online)	1873-2496
ISSN	1078-1439
DOI	10.1016/j.urolonc.2020.11.028
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Zs.A 4817: Show issues

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Article ; Online: Life Cycle Assessment on Agricultural Production: A Mini Review on Methodology, Application, and Challenges.

Fan, Jianling / Liu, Cuiying / Xie, Jianan / Han, Lu / Zhang, Chuanhong / Guo, Dengwei / Niu, Junzhao / Jin, Hao / McConkey, Brian G

International journal of environmental research and public health

2022 Volume 19, Issue 16

Abstract: Agricultural Life Cycle Assessment (LCA) is an effective tool for the quantitative evaluation and analysis of agricultural materials production and operation activities in various stages of the agricultural system. Based on the concept of life cycle, it ... ...

Abstract	Agricultural Life Cycle Assessment (LCA) is an effective tool for the quantitative evaluation and analysis of agricultural materials production and operation activities in various stages of the agricultural system. Based on the concept of life cycle, it comprehensively summarizes the impact of agriculture on the environment, which is an effective tool to promote the sustainability and green development of agriculture. In recent years, agricultural LCA has been widely used in the agroecosystem for resource and environmental impacts analysis. However, some challenges still exist in agricultural LCA, i.e., the environmental impact assessment index system needs to be improved; its application in different production mode is limited; and combination research with other models needs more attention. This paper discusses the above-mentioned challenges and recommends research priorities for both scientific development and improvements in practical implementation. In summary, further research is needed to construct a regional heterogeneity database and develop innovated methodologies to develop more meaningful functional units for agricultural products to complement LCA by other models. These efforts will make agricultural LCA more robust and effective in environmental impacts assessment to support decision making from individual farm to regional or (inter)national for the sustainable future of agriculture.
MeSH term(s)	Agriculture/methods ; Animals ; Environment ; Farms ; Life Cycle Stages
Language	English
Publishing date	2022-08-09
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19169817
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