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Article ; Online: S-adenosylmethionine-dependent protein methylation is required for expression of selenoprotein P and gluconeogenic enzymes in HepG2 human hepatocytes.

Jackson, Matthew I / Cao, Jay / Zeng, Huawei / Uthus, Eric / Combs, Gerald F

2012 Volume 287, Issue 43, Page(s) 36455–36464

Abstract: ... of selenoprotein P (SEPP1) have been positively correlated with insulin resistance. Increased expression ... upon adequate S-adenosylmethionine (SAM) and inhibited by S-adenosylhomocysteine (SAH). We treated a human ...

Abstract	Cellular methylation processes enable expression of gluconeogenic enzymes and metabolism of the nutrient selenium. Selenium status has been proposed to relate to type II diabetes risk, and plasma levels of selenoprotein P (SEPP1) have been positively correlated with insulin resistance. Increased expression of gluconeogenic enzymes glucose-6-phosphatase (G6PC) and phosphoenolpyruvate carboxykinase 1 (PCK1) has negative consequences for blood glucose management in type II diabetics. Transcriptional regulation of SEPP1 is directed by the same transcription factors that control the expression of G6PC and PCK1, and these factors are activated by methylation of arginine residues. We sought to determine whether expression of SEPP1 and the aforementioned glucoconeogenic enzymes are regulated by protein methylation, the levels of which are reliant upon adequate S-adenosylmethionine (SAM) and inhibited by S-adenosylhomocysteine (SAH). We treated a human hepatocyte cell line, HepG2, with inhibitors of adenosylhomocysteine hydrolase (AHCY) known to increase concentration of SAH before analysis of G6PC, PCK1, and SEPP1 expression. Increasing SAH decreased 1) the SAM/SAH ratio, 2) protein-arginine methylation, and 3) expression of SEPP1, G6PC, and PCK1 transcripts. Furthermore, hormone-dependent induction of gluconeogenic enzymes was reduced by inhibition of protein methylation. When protein-arginine methyltransferase 1 expression was reduced by siRNA treatment, G6PC expression was inhibited. These findings demonstrate that hepatocellular SAM-dependent protein methylation is required for both SEPP1 and gluconeogenic enzyme expression and that inhibition of protein arginine methylation might provide a route to therapeutic interventions in type II diabetes.
MeSH term(s)	Adenosylhomocysteinase/biosynthesis ; Adenosylhomocysteinase/genetics ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Diabetes Mellitus, Type 2/therapy ; Gene Expression Regulation ; Gluconeogenesis ; Glucose-6-Phosphate/genetics ; Glucose-6-Phosphate/metabolism ; Hep G2 Cells ; Humans ; Intracellular Signaling Peptides and Proteins/biosynthesis ; Intracellular Signaling Peptides and Proteins/genetics ; Methylation ; Phosphoenolpyruvate Carboxykinase (GTP)/biosynthesis ; Phosphoenolpyruvate Carboxykinase (GTP)/genetics ; Protein-Arginine N-Methyltransferases/biosynthesis ; Protein-Arginine N-Methyltransferases/genetics ; S-Adenosylmethionine/genetics ; S-Adenosylmethionine/metabolism ; Selenoprotein P/biosynthesis ; Selenoprotein P/genetics
Chemical Substances	Intracellular Signaling Peptides and Proteins ; Selenoprotein P ; Glucose-6-Phosphate (56-73-5) ; S-Adenosylmethionine (7LP2MPO46S) ; Protein-Arginine N-Methyltransferases (EC 2.1.1.319) ; Adenosylhomocysteinase (EC 3.3.1.1) ; PCK1 protein, human (EC 4.1.1.32) ; Phosphoenolpyruvate Carboxykinase (GTP) (EC 4.1.1.32)
Language	English
Publishing date	2012-08-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M112.412932
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Article: S-Adenosylmethionine-dependent Protein Methylation Is Required for Expression of Selenoprotein P and Gluconeogenic Enzymes in HepG2 Human Hepatocytes

Jackson, Matthew I / Cao, Jay / Zeng, Huawei / Uthus, Eric / Combs, Gerald F

Journal of Biological Chemistry. 2012, v. 287, no. 43

2012

Abstract	Cellular methylation processes enable expression of gluconeogenic enzymes and metabolism of the nutrient selenium. Selenium status has been proposed to relate to type II diabetes risk, and plasma levels of selenoprotein P (SEPP1) have been positively correlated with insulin resistance. Increased expression of gluconeogenic enzymes glucose-6-phosphatase (G6PC) and phosphoenolpyruvate carboxykinase 1 (PCK1) has negative consequences for blood glucose management in type II diabetics. Transcriptional regulation of SEPP1 is directed by the same transcription factors that control the expression of G6PC and PCK1, and these factors are activated by methylation of arginine residues. We sought to determine whether expression of SEPP1 and the aforementioned glucoconeogenic enzymes are regulated by protein methylation, the levels of which are reliant upon adequate S-adenosylmethionine (SAM) and inhibited by S-adenosylhomocysteine (SAH). We treated a human hepatocyte cell line, HepG2, with inhibitors of adenosylhomocysteine hydrolase (AHCY) known to increase concentration of SAH before analysis of G6PC, PCK1, and SEPP1 expression. Increasing SAH decreased 1) the SAM/SAH ratio, 2) protein-arginine methylation, and 3) expression of SEPP1, G6PC, and PCK1 transcripts. Furthermore, hormone-dependent induction of gluconeogenic enzymes was reduced by inhibition of protein methylation. When protein-arginine methyltransferase 1 expression was reduced by siRNA treatment, G6PC expression was inhibited. These findings demonstrate that hepatocellular SAM-dependent protein methylation is required for both SEPP1 and gluconeogenic enzyme expression and that inhibition of protein arginine methylation might provide a route to therapeutic interventions in type II diabetes.
Keywords	S-adenosylmethionine ; blood glucose ; correlation ; enzyme inhibition ; gene induction ; glucose-6-phosphatase ; hepatocytes ; human cell lines ; humans ; insulin resistance ; metabolism ; methylation ; noninsulin-dependent diabetes mellitus ; nutritional status ; phosphoenolpyruvate carboxykinase (GTP) ; risk ; selenium ; selenoproteins ; small interfering RNA ; transcription factors
Language	English
Size	p. 36455-36464.
Document type	Article
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M112.412932
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Article ; Online: Single mothers' perceptions of neighborhood social cohesion, parenting stress, adverse childhood experiences in early childhood and Black children's behavior problems in middle childhood and adolescence.

Ray, Jennifer A / Preston, Kathleen S J / Jackson, Aurora P

Journal of community psychology

2024 Volume 52, Issue 4, Page(s) 599–610

Abstract: ... were significantly and negatively associated parenting stress (β = -0.34, p < 0.05); parenting stress ... was significantly and positively related to adverse childhood experiences (β = 0.40, p < 0.05) and ... behavior problems (β = 0.32, p < 0.05); Adverse childhood experiences were significantly and positively ...

Abstract	This study examined the roles of neighborhood social cohesion, adverse childhood experiences (ACEs), and parenting stress in early childhood on child behavioral outcomes in middle childhood and adolescence among socioeconomically disadvantaged Black families. To test a model linking perceptions of neighborhood social cohesion, single mothers' parenting stress, ACEs, and behavior problems in middle childhood and adolescence. We used four waves of longitudinal data from a subsample of 800 unmarried Black mothers and their children (at child birth and ages 3, 5, 9, and 15) from the Future of Families and Child Wellbeing Study, a nationally representative data set. Structural equation modeling with latent variables was used to measure direct and indirect effects. Mothers' perceptions of neighborhood social cohesion were significantly and negatively associated parenting stress (β = -0.34, p < 0.05); parenting stress was significantly and positively related to adverse childhood experiences (β = 0.40, p < 0.05) and behavior problems (β = 0.32, p < 0.05); Adverse childhood experiences were significantly and positively related to behavior problems (β = 0.26, p < 0.05); and behavior problems were indirectly influenced by neighborhood social cohesion through adverse childhood experiences (β = -0.14, p < 0.05) and parenting stress (β = 0.10, p < 0.05). Neighborhood factors may play a significant role in parenting stress, adverse childhood experiences in early childhood, and children's behavior problems in middle childhood and adolescence among some single mothers and children in economically and socially disadvantaged Black families. Interventions that enhance neighborhood social cohesion and foster supportive interactions among community members and organizations are recommended.
MeSH term(s)	Female ; Humans ; Child, Preschool ; Child ; Adolescent ; Parenting ; Adverse Childhood Experiences ; Social Cohesion ; Mothers ; Problem Behavior
Language	English
Publishing date	2024-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491194-2
ISSN	1520-6629 ; 0090-4392
ISSN (online)	1520-6629
ISSN	0090-4392
DOI	10.1002/jcop.23115
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Article: Effects of stage of maturity on P and S critical levels in subterranean clover

Drlica, D.M / Jackson, T.L

American Society of Agronomy. Agronomy journal. Sept/Oct 1979. v. 71 (5)

1979

Title variant	Effects of stage of maturity on P [phosphorus] and S [sulfur] critical levels in subterranean clover [Fertilization for pastures]
Keywords	phosphorus ; sulfur
Language	English
Dates of publication	1979-09
Size	p. 824-828., ill.
Document type	Article
ZDB-ID	410332-4
ISSN	1435-0645 ; 0002-1962
ISSN (online)	1435-0645
ISSN	0002-1962
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Article: Effects of Stage of Maturity on P and S Critical Levels in Subterranean Clover

Drlica, D. M / Jackson, T. L

Agronomy journal. 1979 Sept., v. 71, no. 5

1979

Abstract: ... available on the effects of stage of maturity on P and S critical levels. The response to P and S ... approximately 0.25% P. Sulfur fertilization increased yield 45% and more than doubled S concentration of mixed ... a Veneta silt loam, a moderately welldrained soil formed from old mixed alluvium. On both sites, the P ...

Abstract	Subterranean clover is widely used for pastures in western Oregon; however, little information is available on the effects of stage of maturity on P and S critical levels. The response to P and S fertilization, nutrient contents at different sampling dates, and total yields at harvest were evaluated at two locations in Oregon. The soil at one location is mapped as a complex of Oakland and Nonpareil series, which are well-drained, hillslope soils developed from sedimentary rock. The soil at the second location is a Veneta silt loam, a moderately welldrained soil formed from old mixed alluvium. On both sites, the P concentration of the mixed grass and clover forage at harvest was higher in plants that had received P fertilization (0.20%) than in plants that had not (0.14%). The concentration of P in the clover component remained relatively stable from mid-March to mid-April in both fertilized and unfertilized treatments. The critical level of P for subterranean clover leaflets and petioles collected between mid-March and mid-April was approximately 0.25% P. Sulfur fertilization increased yield 45% and more than doubled S concentration of mixed forage. Added S increased S concentrations in the clover at every sampling date. Sulfur concentrations were relatively constant from mid March to mid-April, and approximately 0.20% S was identified as the critical level for clover samples collected during this time.
Keywords	Oregon ; Trifolium subterraneum ; agronomy ; alluvium ; forage ; grasses ; sedimentary rocks ; silt loam soils ; sulfur ; topographic slope
Language	English
Dates of publication	1979-09
Size	p. 824-828.
Publishing place	American Society of Agronomy
Document type	Article
Note	NAL-AP-2-clean ; epub
ZDB-ID	410332-4
ISSN	1435-0645 ; 0002-1962
ISSN (online)	1435-0645
ISSN	0002-1962
DOI	10.2134/agronj1979.00021962007100050029x
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Article ; Online: Saving lives through infection prevention, healthcare epidemiology, and antimicrobial stewardship: Getting back to preventing healthcare-associated infections.

Yokoe, Deborah S / Jackson, Patricia

American journal of infection control

2023 Volume 52, Issue 1, Page(s) 1–2

MeSH term(s)	Humans ; Antimicrobial Stewardship ; Cross Infection/epidemiology ; Cross Infection/prevention & control ; Cross Infection/drug therapy ; Anti-Bacterial Agents/therapeutic use ; Health Facilities ; Delivery of Health Care
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-12-21
Publishing country	United States
Document type	Editorial
ZDB-ID	392362-9
ISSN	1527-3296 ; 0196-6553
ISSN (online)	1527-3296
ISSN	0196-6553
DOI	10.1016/j.ajic.2023.12.002
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Article ; Online: Using theater as an innovative knowledge translation approach for health research: a scoping review protocol.

Jackson, Poppy / Luke, Alison / Goudreau, Alex / Doucet, Shelley

JBI evidence synthesis

2024

Abstract: Objective: The objective of this review is to synthesize the existing literature on how theater has been used as a knowledge translation approach for health research and to identify the outcome measures employed for evaluation and the facilitators/ ... ...

Abstract	Objective: The objective of this review is to synthesize the existing literature on how theater has been used as a knowledge translation approach for health research and to identify the outcome measures employed for evaluation and the facilitators/challenges related to this approach. Introduction: The use of arts-based knowledge translation methods is relatively new in health research but has already shown to have positive impacts on knowledge, attitudes, policy, and practice. Specifically, theater has proven to be an effective approach for communicating research findings in a way which stimulates thought and discussion on important health-related topics. Inclusion criteria: This review will include scholarly literature on how theater is being used as a knowledge translation approach for health research. The review will not impose any limitations related to demographic variables, health issues, or settings. The review will consider papers using any study design, and will also consider other literature, such as protocols, descriptive papers, unpublished papers, and evaluation reports. Methods: This review will be conducted in accordance with the JBI methodology for scoping reviews. The databases to be searched will include CINAHL (EBSCOhost), Embase, MEDLINE (Ovid), Academic Search Premier (EBSCOhost), and Scopus. Google/Google Scholar and ProQuest Dissertations and Theses will also be searched for unpublished studies and gray literature. All literature identified in the search will be screened by 2 independent reviewers and the results will be presented in a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flow diagram. The data extracted from the included literature will be presented in both tabular and narrative format. This protocol has been registered on open science framework: https://doi.org/10.17605/OSF.IO/GBCPJ.
Language	English
Publishing date	2024-01-30
Publishing country	United States
Document type	Journal Article
ISSN	2689-8381
ISSN (online)	2689-8381
DOI	10.11124/JBIES-23-00312
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Article ; Online: Tepsin binds LC3B to promote ATG9A trafficking and delivery.

Wallace, Natalie S / Gadbery, John E / Cohen, Cameron I / Kendall, Amy K / Jackson, Lauren P

Molecular biology of the cell

2024 Volume 35, Issue 4, Page(s) ar56

Abstract: Tepsin is an established accessory protein found in Adaptor Protein 4 (AP-4) coated vesicles, but the biological role of tepsin remains unknown. AP-4 vesicles originate at ... ...

Abstract	Tepsin is an established accessory protein found in Adaptor Protein 4 (AP-4) coated vesicles, but the biological role of tepsin remains unknown. AP-4 vesicles originate at the
MeSH term(s)	Animals ; Humans ; Autophagosomes/metabolism ; Autophagy/genetics ; trans-Golgi Network/metabolism ; HeLa Cells ; Autophagy-Related Proteins/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Mammals/metabolism
Chemical Substances	Autophagy-Related Proteins ; Adaptor Proteins, Signal Transducing
Language	English
Publishing date	2024-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1098979-1
ISSN	1939-4586 ; 1059-1524
ISSN (online)	1939-4586
ISSN	1059-1524
DOI	10.1091/mbc.E23-09-0359-T
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Article ; Online: Complications and consequences: short-term harm has long-term impact.

Jackson, Alexander I R / Moonesinghe, S Ramani / Grocott, Michael P W

BJA open

2023 Volume 8, Page(s) 100233

Abstract: In this editorial, we discuss a large observational study demonstrating increased healthcare usage and higher mortality over 2 yr in patients who experienced specific postoperative complications. These findings are in keeping with the existing literature ...

Abstract	In this editorial, we discuss a large observational study demonstrating increased healthcare usage and higher mortality over 2 yr in patients who experienced specific postoperative complications. These findings are in keeping with the existing literature and draw into focus the need for ongoing work to understand and communicate these long-term consequences to patients.
Language	English
Publishing date	2023-10-19
Publishing country	England
Document type	Editorial ; Comment
ISSN	2772-6096
ISSN (online)	2772-6096
DOI	10.1016/j.bjao.2023.100233
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Article ; Online: Simultaneous Momentum and Position Measurement and the Instrumental Weyl-Heisenberg Group.

Jackson, Christopher S / Caves, Carlton M

Entropy (Basel, Switzerland)

2023 Volume 25, Issue 8

Abstract: The canonical commutation relation, [Q,P]=iℏ, stands at the foundation of quantum theory and ...

Abstract	The canonical commutation relation, [Q,P]=iℏ, stands at the foundation of quantum theory and the original Hilbert space. The interpretation of
Language	English
Publishing date	2023-08-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2014734-X
ISSN	1099-4300 ; 1099-4300
ISSN (online)	1099-4300
ISSN	1099-4300
DOI	10.3390/e25081221
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