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  1. Article ; Online: Sensational site: the sodium pump ouabain-binding site and its ligands.

    Blaustein, Mordecai P / Hamlyn, John M

    American journal of physiology. Cell physiology

    2024  Volume 326, Issue 4, Page(s) C1120–C1177

    Abstract: Cardiotonic steroids (CTS), used by certain insects, toads, and rats for protection from predators, became, thanks to Withering's trailblazing 1785 monograph, the mainstay of heart failure (HF) therapy. In the 1950s and 1960s, we learned that the CTS ... ...

    Abstract Cardiotonic steroids (CTS), used by certain insects, toads, and rats for protection from predators, became, thanks to Withering's trailblazing 1785 monograph, the mainstay of heart failure (HF) therapy. In the 1950s and 1960s, we learned that the CTS receptor was part of the sodium pump (NKA) and that the Na
    MeSH term(s) Humans ; Rats ; Animals ; Ouabain/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism ; Ligands ; Digoxin/pharmacology ; Cardiotonic Agents/pharmacology ; Hypertension/drug therapy ; Heart Failure/drug therapy ; Enzyme Inhibitors/pharmacology ; Calcium Signaling ; Binding Sites
    Chemical Substances Ouabain (5ACL011P69) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13) ; Ligands ; Digoxin (73K4184T59) ; Cardiotonic Agents ; Enzyme Inhibitors
    Language English
    Publishing date 2024-01-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00273.2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Reply to "Letter to the editor: Comments on Blaustein (2018): 'The pump, the exchanger, and the holy spirit: origins and 40-year evolution of ideas about the ouabain-Na

    Blaustein, Mordecai P

    American journal of physiology. Cell physiology

    2018  Volume 314, Issue 5, Page(s) C641–C642

    MeSH term(s) Endocrine System ; Ouabain ; Sodium ; Sodium-Potassium-Exchanging ATPase
    Chemical Substances Ouabain (5ACL011P69) ; Sodium (9NEZ333N27) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13)
    Language English
    Publishing date 2018-05-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00069.2018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Correction: Evolution of our understanding of cell volume regulation by the pump-leak mechanism.

    Kay, Alan R / Blaustein, Mordecai P

    The Journal of general physiology

    2019  Volume 151, Issue 4, Page(s) 606–607

    Language English
    Publishing date 2019-03-06
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 3118-5
    ISSN 1540-7748 ; 0022-1295
    ISSN (online) 1540-7748
    ISSN 0022-1295
    DOI 10.1085/jgp.20181227402282019c
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  4. Article ; Online: Ouabain, endogenous ouabain and ouabain-like factors: The Na

    Blaustein, Mordecai P / Hamlyn, John M

    Cell calcium

    2020  Volume 86, Page(s) 102159

    Abstract: In this brief review we discuss some aspects of the ... ...

    Abstract In this brief review we discuss some aspects of the Na
    MeSH term(s) Animals ; Binding Sites ; Cardiac Glycosides/metabolism ; Humans ; Ouabain/metabolism ; Sodium-Calcium Exchanger/metabolism ; Sodium-Potassium-Exchanging ATPase/metabolism
    Chemical Substances Cardiac Glycosides ; Sodium-Calcium Exchanger ; cardiac glycoside receptors ; Ouabain (5ACL011P69) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13)
    Language English
    Publishing date 2020-01-09
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 757687-0
    ISSN 1532-1991 ; 0143-4160
    ISSN (online) 1532-1991
    ISSN 0143-4160
    DOI 10.1016/j.ceca.2020.102159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: How does pressure overload cause cardiac hypertrophy and dysfunction? High-ouabain affinity cardiac Na

    Blaustein, Mordecai P

    American journal of physiology. Heart and circulatory physiology

    2017  Volume 313, Issue 5, Page(s) H919–H930

    Abstract: Left ventricular hypertrophy is frequently observed in hypertensive patients and is believed to be due to the pressure overload and cardiomyocyte stretch. Three recent reports on mice with genetically engineered ... ...

    Abstract Left ventricular hypertrophy is frequently observed in hypertensive patients and is believed to be due to the pressure overload and cardiomyocyte stretch. Three recent reports on mice with genetically engineered Na
    MeSH term(s) Animals ; Blood Pressure/drug effects ; Cardiomegaly/etiology ; Cardiomegaly/physiopathology ; Cardiotonic Agents/metabolism ; Hypertension/complications ; Hypertension/physiopathology ; Mice ; Myocardium/metabolism ; Ouabain/pharmacology ; Protein Engineering ; Sodium-Potassium-Exchanging ATPase/drug effects ; Sodium-Potassium-Exchanging ATPase/genetics ; Sodium-Potassium-Exchanging ATPase/metabolism
    Chemical Substances Cardiotonic Agents ; Ouabain (5ACL011P69) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13)
    Language English
    Publishing date 2017-07-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00131.2017
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  6. Article ; Online: The pump, the exchanger, and the holy spirit: origins and 40-year evolution of ideas about the ouabain-Na

    Blaustein, Mordecai P

    American journal of physiology. Cell physiology

    2017  Volume 314, Issue 1, Page(s) C3–C26

    Abstract: Two prescient 1953 publications set the stage for the elucidation of a novel endocrine system: Schatzmann's report that cardiotonic steroids (CTSs) are all ... ...

    Abstract Two prescient 1953 publications set the stage for the elucidation of a novel endocrine system: Schatzmann's report that cardiotonic steroids (CTSs) are all Na
    MeSH term(s) Animals ; Blood Pressure ; Calcium Signaling ; Endocrine System/metabolism ; Endocrine System/physiopathology ; Heart Failure/metabolism ; Heart Failure/physiopathology ; Hemodynamics ; Humans ; Hypertension/etiology ; Hypertension/metabolism ; Hypertension/physiopathology ; Natriuresis ; Ouabain/metabolism ; Signal Transduction ; Sodium Chloride, Dietary/adverse effects ; Sodium Chloride, Dietary/metabolism ; Sodium-Calcium Exchanger/metabolism ; Sodium-Potassium-Exchanging ATPase/genetics ; Sodium-Potassium-Exchanging ATPase/metabolism
    Chemical Substances Sodium Chloride, Dietary ; Sodium-Calcium Exchanger ; Ouabain (5ACL011P69) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13)
    Language English
    Publishing date 2017-11-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00196.2017
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  7. Article ; Online: Essential contributions of the α2-Na

    Blaustein, Mordecai P / Hamlyn, John M / Leenen, Frans H H

    American journal of physiology. Heart and circulatory physiology

    2021  Volume 321, Issue 6, Page(s) H1117–H1118

    MeSH term(s) Binding Sites ; Humans ; Ouabain ; Protein Binding ; Sodium-Potassium-Exchanging ATPase/metabolism ; Ventricular Remodeling
    Chemical Substances Ouabain (5ACL011P69) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13)
    Language English
    Publishing date 2021-11-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00548.2021
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  8. Article ; Online: Letter to the Editor concerning Baecher et al. (Clin Chim Acta 2014;431:87-92).

    Blaustein, Mordecai P

    Clinica chimica acta; international journal of clinical chemistry

    2015  Volume 448, Page(s) 248–249

    MeSH term(s) Cardiotonic Agents/blood ; Humans ; Ouabain/blood
    Chemical Substances Cardiotonic Agents ; Ouabain (5ACL011P69)
    Language English
    Publishing date 2015-08-25
    Publishing country Netherlands
    Document type Comment ; Letter
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2015.07.011
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  9. Article ; Online: Evolution of our understanding of cell volume regulation by the pump-leak mechanism.

    Kay, Alan R / Blaustein, Mordecai P

    The Journal of general physiology

    2019  Volume 151, Issue 4, Page(s) 407–416

    Abstract: All animal cells are surrounded by a flexible plasma membrane that is permeable to water and to small ions. Cells thus face a fundamental problem: the considerable tension that their membranes would experience if the osmotic influx of water, driven by ... ...

    Abstract All animal cells are surrounded by a flexible plasma membrane that is permeable to water and to small ions. Cells thus face a fundamental problem: the considerable tension that their membranes would experience if the osmotic influx of water, driven by the presence of impermeant intracellular ions, was left unopposed. The pivotal study that described the cell's remedy for this impending osmotic catastrophe-the "pump-leak mechanism" (PLM)-was published in the
    MeSH term(s) Animals ; Cell Membrane/metabolism ; Cell Physiological Phenomena/physiology ; Cells/metabolism ; Ion Channels/physiology ; Ion Transport/physiology
    Chemical Substances Ion Channels
    Language English
    Publishing date 2019-02-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3118-5
    ISSN 1540-7748 ; 0022-1295
    ISSN (online) 1540-7748
    ISSN 0022-1295
    DOI 10.1085/jgp.201812274
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  10. Article ; Online: Whither digitalis? What we can still learn from cardiotonic steroids about heart failure and hypertension.

    Blaustein, Mordecai P / Gottlieb, Stephen S / Hamlyn, John M / Leenen, Frans H H

    American journal of physiology. Heart and circulatory physiology

    2022  Volume 323, Issue 6, Page(s) H1281–H1295

    Abstract: Cloning of the " ... ...

    Abstract Cloning of the "Na
    MeSH term(s) Digitalis ; Cardiac Glycosides ; Ligands ; Heart Failure/drug therapy ; Hypertension/drug therapy
    Chemical Substances Cardiac Glycosides ; Ligands
    Language English
    Publishing date 2022-11-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00362.2022
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