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Article ; Online: TCR-α/β CD4

Rodríguez-Rodríguez, Noé / Flores-Mendoza, Giovanna / Apostolidis, Sokratis A / Rosetti, Florencia / Tsokos, George C / Crispín, José C

Journal of leukocyte biology

2020 Volume 108, Issue 3, Page(s) 851–857

Abstract: The cellular origin of ... ...

Abstract	The cellular origin of CD4
MeSH term(s)	Adoptive Transfer ; Animals ; CD4 Antigens/analysis ; CD8 Antigens/analysis ; CD8 Antigens/biosynthesis ; CD8 Antigens/genetics ; CD8-Positive T-Lymphocytes/classification ; CD8-Positive T-Lymphocytes/cytology ; Cell Lineage ; Lymphoid Tissue/cytology ; Lymphoid Tissue/immunology ; Lymphopoiesis ; Mice ; Receptors, Antigen, T-Cell, alpha-beta/analysis ; Specific Pathogen-Free Organisms ; T-Lymphocyte Subsets/cytology ; Up-Regulation
Chemical Substances	CD4 Antigens ; CD8 Antigens ; Receptors, Antigen, T-Cell, alpha-beta
Language	English
Publishing date	2020-02-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1002/JLB.1AB0120-548R
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Zs.A 603: Show issues

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Article ; Online: Empowering Regulatory T Cells in Autoimmunity.

Kasper, Isaac R / Apostolidis, Sokratis A / Sharabi, Amir / Tsokos, George C

Trends in molecular medicine

2016 Volume 22, Issue 9, Page(s) 784–797

Abstract: Regulatory T cells (Tregs) are capable of dampening immune-mediated inflammation and avert the destructive effects of uncontrolled inflammation. Distinct molecules and pathways, including various transcription factors, phosphatases, and kinases, impact ... ...

Abstract	Regulatory T cells (Tregs) are capable of dampening immune-mediated inflammation and avert the destructive effects of uncontrolled inflammation. Distinct molecules and pathways, including various transcription factors, phosphatases, and kinases, impact the ability of Tregs to function as negative regulators of the immune response, and are presumably amenable to therapeutic manipulation. Here, we discuss recently identified molecular networks and the therapeutic potential for treating autoimmune diseases.
MeSH term(s)	Animals ; Autoimmune Diseases/genetics ; Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; Autoimmunity ; Epigenesis, Genetic ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/immunology ; Humans ; Inflammation/genetics ; Inflammation/immunology ; Inflammation/pathology ; Lymphocyte Activation ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; T-Lymphocytes, Regulatory/pathology
Chemical Substances	FOXP3 protein, human ; Forkhead Transcription Factors
Language	English
Publishing date	2016-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2036490-8
ISSN	1471-499X ; 1471-4914
ISSN (online)	1471-499X
ISSN	1471-4914
DOI	10.1016/j.molmed.2016.07.003
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Zs.A 4345: Show issues

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Article ; Online: Update on the role of Interleukin 17 in rheumatologic autoimmune diseases.

Konya, Christine / Paz, Ziv / Apostolidis, Sokratis A / Tsokos, George C

Cytokine

2015 Volume 75, Issue 2, Page(s) 207–215

Abstract: Interleukin 17 is a proinflammatory cytokine produced by CD4+ T cells when in the presence of a distinct set of cytokines and other cells. Preclinical and clinical studies have assigned a role to IL-17 in tissue inflammation and damage in patients with ... ...

Abstract	Interleukin 17 is a proinflammatory cytokine produced by CD4+ T cells when in the presence of a distinct set of cytokines and other cells. Preclinical and clinical studies have assigned a role to IL-17 in tissue inflammation and damage in patients with rheumatoid arthritis, psoriasis and psoriatic arthritis, ankylosing spondylitis and systemic lupus erythematosus. Antibodies blocking the action of IL-17 have already been approved to treat patients with psoriasis and it is expected that they may also benefit patients with other rheumatic diseases.
MeSH term(s)	Arthritis, Psoriatic/drug therapy ; Arthritis, Psoriatic/immunology ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/immunology ; Autoimmune Diseases/drug therapy ; Autoimmune Diseases/immunology ; CD4-Positive T-Lymphocytes/immunology ; Humans ; Inflammation/immunology ; Interleukin-17/antagonists & inhibitors ; Interleukin-17/immunology ; Lupus Erythematosus, Systemic/drug therapy ; Lupus Erythematosus, Systemic/immunology ; Signal Transduction/immunology ; Spondylitis, Ankylosing/drug therapy ; Spondylitis, Ankylosing/immunology
Chemical Substances	Interleukin-17
Language	English
Publishing date	2015-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2015.01.003
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Zs.A 2840: Show issues

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Article ; Online: Multisystem Inflammation and Organ Dysfunction After BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccination.

Kahn, Benjamin / Apostolidis, Sokratis A / Bhatt, Vatsal / Greenplate, Allison R / Kallish, Staci / LaCava, Anthony / Lucas, Alfredo / Meyer, Nuala J / Negoianu, Dan / Ogdie, Alexis R / Shashaty, Michael G S / Takach, Patricia A / Zuroff, Leah / Wherry, E John / Anesi, George L

Critical care explorations

2021 Volume 3, Issue 11, Page(s) e0578

Abstract: The U.S. Food and Drug Administration has to date granted approval or emergency use authorization to three vaccines against severe acute respiratory syndrome coronavirus 2 and coronavirus disease 2019. In clinical trials and real-use observational ... ...

Abstract	The U.S. Food and Drug Administration has to date granted approval or emergency use authorization to three vaccines against severe acute respiratory syndrome coronavirus 2 and coronavirus disease 2019. In clinical trials and real-use observational studies, the Pfizer-BioNTech BNT162b2 messenger RNA coronavirus disease 2019 vaccine, as well as the Moderna mRNA-1273 messenger RNA coronavirus disease 2019 vaccine, have demonstrated high efficacy and few adverse events. Case summary: A 20-year-old male college student in good health developed tinnitus and hematuria shortly after vaccination and progressed swiftly to a syndrome of: systemic inflammation; acute kidney injury requiring hemodialysis; acute, bilateral, complete sensorineural hearing loss; radiographic evidence of acute multifocal ischemic strokes; pericardial effusion complicated by tamponade physiology requiring pericardial evacuation; pleural effusions requiring evacuation; and systemic capillary leak. An extensive clinical and research investigation, including cytokine analysis, whole blood cytometry by time of flight, and whole exome sequencing, did not reveal a definitive explanatory mechanism. Conclusion: While the overall safety profile of the BNT162b2 coronavirus disease 2019 vaccine remains excellent for the general population, rare serious events have been reported. In this report, we describe a case of multisystem inflammation and organ dysfunction of unknown mechanism beginning shortly after administration of the first dose of BNT162b2 coronavirus disease 2019 vaccine in a previously healthy recipient.
Language	English
Publishing date	2021-11-05
Publishing country	United States
Document type	Case Reports
ISSN	2639-8028
ISSN (online)	2639-8028
DOI	10.1097/CCE.0000000000000578
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Article ; Online: Single Cell RNA Sequencing Identifies HSPG2 and APLNR as Markers of Endothelial Cell Injury in Systemic Sclerosis Skin.

Apostolidis, Sokratis A / Stifano, Giuseppina / Tabib, Tracy / Rice, Lisa M / Morse, Christina M / Kahaleh, Bashar / Lafyatis, Robert

Frontiers in immunology

2018 Volume 9, Page(s) 2191

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Apelin Receptors/genetics ; Apelin Receptors/metabolism ; Base Sequence ; Biomarkers/metabolism ; Biopsy ; Complement Activation ; Endothelial Cells/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Extracellular Matrix/genetics ; Extracellular Matrix/metabolism ; Gene Expression ; Heparan Sulfate Proteoglycans/genetics ; Heparan Sulfate Proteoglycans/metabolism ; Humans ; Immunohistochemistry ; Matrix Metalloproteinases/metabolism ; Neovascularization, Pathologic/metabolism ; Scleroderma, Systemic/genetics ; Scleroderma, Systemic/metabolism ; Scleroderma, Systemic/pathology ; Sequence Analysis, RNA ; Vascular System Injuries/pathology
Chemical Substances	APLNR protein, human ; Apelin Receptors ; Biomarkers ; Heparan Sulfate Proteoglycans ; perlecan (143972-95-6) ; Matrix Metalloproteinases (EC 3.4.24.-)
Language	English
Publishing date	2018-10-01
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2018.02191
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Article ; Online: PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine.

Herati, Ramin Sedaghat / Knorr, David A / Vella, Laura A / Silva, Luisa Victoria / Chilukuri, Lakshmi / Apostolidis, Sokratis A / Huang, Alexander C / Muselman, Alexander / Manne, Sasikanth / Kuthuru, Oliva / Staupe, Ryan P / Adamski, Sharon A / Kannan, Senthil / Kurupati, Raj K / Ertl, Hildegund C J / Wong, Jeffrey L / Bournazos, Stylianos / McGettigan, Suzanne / Schuchter, Lynn M /

Kotecha, Ritesh R / Funt, Samuel A / Voss, Martin H / Motzer, Robert J / Lee, Chung-Han / Bajorin, Dean F / Mitchell, Tara C / Ravetch, Jeffrey V / Wherry, E John

Nature immunology

2022 Volume 23, Issue 8, Page(s) 1183–1192

Abstract: Anti-programmed death-1 (anti-PD-1) immunotherapy reinvigorates CD8 T cell responses in patients with cancer but PD-1 is also expressed by other immune cells, including follicular helper CD4 T cells (Tfh) which are involved in germinal centre responses. ... ...

Abstract	Anti-programmed death-1 (anti-PD-1) immunotherapy reinvigorates CD8 T cell responses in patients with cancer but PD-1 is also expressed by other immune cells, including follicular helper CD4 T cells (Tfh) which are involved in germinal centre responses. Little is known, however, about the effects of anti-PD-1 immunotherapy on noncancer immune responses in humans. To investigate this question, we examined the impact of anti-PD-1 immunotherapy on the Tfh-B cell axis responding to unrelated viral antigens. Following influenza vaccination, a subset of adults receiving anti-PD-1 had more robust circulating Tfh responses than adults not receiving immunotherapy. PD-1 pathway blockade resulted in transcriptional signatures of increased cellular proliferation in circulating Tfh and responding B cells compared with controls. These latter observations suggest an underlying change in the Tfh-B cell and germinal centre axis in a subset of immunotherapy patients. Together, these results demonstrate dynamic effects of anti-PD-1 therapy on influenza vaccine responses and highlight analytical vaccination as an approach that may reveal underlying immune predisposition to adverse events.
MeSH term(s)	Adult ; Humans ; Immunity, Humoral ; Influenza Vaccines ; Seasons ; T-Lymphocytes, Helper-Inducer ; Vaccination
Chemical Substances	Influenza Vaccines
Language	English
Publishing date	2022-07-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-022-01274-3
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Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies.

Painter, Mark M / Johnston, Timothy S / Lundgreen, Kendall A / Santos, Jefferson J S / Qin, Juliana S / Goel, Rishi R / Apostolidis, Sokratis A / Mathew, Divij / Fulmer, Bria / Williams, Justine C / McKeague, Michelle L / Pattekar, Ajinkya / Goode, Ahmad / Nasta, Sean / Baxter, Amy E / Giles, Josephine R / Skelly, Ashwin N / Felley, Laura E / McLaughlin, Maura /

Weaver, Joellen / Kuthuru, Oliva / Dougherty, Jeanette / Adamski, Sharon / Long, Sherea / Kee, Macy / Clendenin, Cynthia / da Silva Antunes, Ricardo / Grifoni, Alba / Weiskopf, Daniela / Sette, Alessandro / Huang, Alexander C / Rader, Daniel J / Hensley, Scott E / Bates, Paul / Greenplate, Allison R / Wherry, E John

bioRxiv : the preprint server for biology

2023

Abstract: SARS-CoV-2 infection of vaccinated individuals is increasingly common but rarely results in severe disease, likely due to the enhanced potency and accelerated kinetics of memory immune responses. However, there have been few opportunities to rigorously ... ...

Abstract	SARS-CoV-2 infection of vaccinated individuals is increasingly common but rarely results in severe disease, likely due to the enhanced potency and accelerated kinetics of memory immune responses. However, there have been few opportunities to rigorously study early recall responses during human viral infection. To better understand human immune memory and identify potential mediators of lasting vaccine efficacy, we used high-dimensional flow cytometry and SARS-CoV-2 antigen probes to examine immune responses in longitudinal samples from vaccinated individuals infected during the Omicron wave. These studies revealed heightened Spike-specific responses during infection of vaccinated compared to unvaccinated individuals. Spike-specific CD4 T cells and plasmablasts expanded and CD8 T cells were robustly activated during the first week. In contrast, memory B cell activation, neutralizing antibody production, and primary responses to non-Spike antigens occurred during the second week. Collectively, these data demonstrate the functionality of vaccine-primed immune memory and highlight memory T cells as rapid responders during SARS-CoV-2 infection.
Language	English
Publishing date	2023-02-06
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.02.05.527215
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Article: Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19.

Apostolidis, Sokratis A / Sarkar, Amrita / Giannini, Heather M / Goel, Rishi R / Mathew, Divij / Suzuki, Aae / Baxter, Amy E / Greenplate, Allison R / Alanio, Cécile / Abdel-Hakeem, Mohamed / Oldridge, Derek A / Giles, Josephine / Wu, Jennifer E / Chen, Zeyu / Huang, Yinghui Jane / Pattekar, Ajinkya / Manne, Sasikanth / Kuthuru, Oliva / Dougherty, Jeanette /

Weiderhold, Brittany / Weisman, Ariel R / Ittner, Caroline A G / Gouma, Sigrid / Dunbar, Debora / Frank, Ian / Huang, Alexander C / Vella, Laura A / Reilly, John P / Hensley, Scott E / Rauova, Lubica / Zhao, Liang / Meyer, Nuala J / Poncz, Mortimer / Abrams, Charles S / Wherry, E John

bioRxiv : the preprint server for biology

2021

Language	English
Publishing date	2021-05-03
Publishing country	United States
Document type	Preprint
DOI	10.1101/2021.05.01.442279
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Article: Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine.

Goel, Rishi R / Painter, Mark M / Lundgreen, Kendall A / Apostolidis, Sokratis A / Baxter, Amy E / Giles, Josephine R / Mathew, Divij / Pattekar, Ajinkya / Reynaldi, Arnold / Khoury, David S / Gouma, Sigrid / Hicks, Philip / Dysinger, Sarah / Hicks, Amanda / Sharma, Harsh / Herring, Sarah / Korte, Scott / Kc, Wumesh / Oldridge, Derek A /

Erickson, Rachel I / Weirick, Madison E / McAllister, Christopher M / Awofolaju, Moses / Tanenbaum, Nicole / Dougherty, Jeanette / Long, Sherea / D'Andrea, Kurt / Hamilton, Jacob T / McLaughlin, Maura / Williams, Justine C / Adamski, Sharon / Kuthuru, Oliva / Drapeau, Elizabeth M / Davenport, Miles P / Hensley, Scott E / Bates, Paul / Greenplate, Allison R / Wherry, E John

bioRxiv : the preprint server for biology

2022

Language	English
Publishing date	2022-02-22
Publishing country	United States
Document type	Preprint
DOI	10.1101/2022.02.20.481163
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Article ; Online: Protein phosphatase 2A B55β limits CD8+ T cell lifespan following cytokine withdrawal.

Rodríguez-Rodríguez, Noé / Madera-Salcedo, Iris K / Cisneros-Segura, J Alejandro / García-González, H Benjamín / Apostolidis, Sokratis A / Saint-Martin, Abril / Esquivel-Velázquez, Marcela / Nguyen, Tran / Romero-Rodríguez, Dámaris P / Tsokos, George C / Alcocer-Varela, Jorge / Rosetti, Florencia / Crispín, José C

The Journal of clinical investigation

2020 Volume 130, Issue 11, Page(s) 5989–6004

Abstract: How T cells integrate environmental cues into signals that limit the magnitude and length of immune responses is poorly understood. Here, we provide data that demonstrate that B55β, a regulatory subunit of protein phosphatase 2A, represents a molecular ... ...

Abstract	How T cells integrate environmental cues into signals that limit the magnitude and length of immune responses is poorly understood. Here, we provide data that demonstrate that B55β, a regulatory subunit of protein phosphatase 2A, represents a molecular link between cytokine concentration and apoptosis in activated CD8+ T cells. Through the modulation of AKT, B55β induced the expression of the proapoptotic molecule Hrk in response to cytokine withdrawal. Accordingly, B55β and Hrk were both required for in vivo and in vitro contraction of activated CD8+ lymphocytes. We show that this process plays a role during clonal contraction, establishment of immune memory, and preservation of peripheral tolerance. This regulatory pathway may represent an unexplored opportunity to end unwanted immune responses or to promote immune memory.
MeSH term(s)	Animals ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/immunology ; CD8-Positive T-Lymphocytes/immunology ; Immunologic Memory ; Mice ; Mice, Transgenic ; Neuropeptides/genetics ; Neuropeptides/immunology ; Protein Phosphatase 2/genetics ; Protein Phosphatase 2/immunology ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/immunology
Chemical Substances	Apoptosis Regulatory Proteins ; Hrk protein, mouse ; Neuropeptides ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Protein Phosphatase 2 (EC 3.1.3.16)
Language	English
Publishing date	2020-08-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3067-3
ISSN	1558-8238 ; 0021-9738
ISSN (online)	1558-8238
ISSN	0021-9738
DOI	10.1172/JCI129479
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