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  1. Article ; Online: How an intrinsically disordered regulatory subunit assembles a PP1:eIF2 complex.

    Jones, Alexander C / Wu, Jian / Taylor, Susan S

    Cell reports

    2024  Volume 43, Issue 4, Page(s) 114011

    Abstract: Fatalska et al. ...

    Abstract Fatalska et al.
    MeSH term(s) Protein Phosphatase 1/metabolism ; Humans ; Eukaryotic Initiation Factor-2/metabolism ; Intrinsically Disordered Proteins/metabolism ; Intrinsically Disordered Proteins/chemistry ; Protein Binding ; Phosphorylation ; Protein Subunits/metabolism ; Protein Subunits/chemistry ; Mutation
    Chemical Substances Protein Phosphatase 1 (EC 3.1.3.16) ; Eukaryotic Initiation Factor-2 ; Intrinsically Disordered Proteins ; Protein Subunits
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.114011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A tribute to Eddy Fischer (April 6, 1920-August 27, 2021): Passionate biochemist and mentor.

    Taylor, Susan S / Hunter, Tony / Changeux, Jean-Pierre

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 3

    MeSH term(s) Allosteric Regulation ; Biochemistry ; Humans ; Mentors ; Neoplasms/metabolism ; Phosphorylation ; Tyrosine/metabolism
    Chemical Substances Tyrosine (42HK56048U)
    Language English
    Publishing date 2022-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2121815119
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
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  3. Article ; Online: Efficacy and Safety of LetibotulinumtoxinA in the Treatment of Moderate and Severe Glabellar Lines in Females 35 to 50 Years of Age: Post Hoc Analyses of the Phase 3 Clinical Study Data.

    Gold, Michael / Taylor, Susan / Mueller, Daniel S / Adelglass, Jeffrey / Kaufman-Janette, Joely / Cox, Sue E / Cecerle, Michael / Frank, Konstantin / Nestor, Mark

    Aesthetic surgery journal. Open forum

    2024  Volume 6, Page(s) ojae010

    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article
    ISSN 2631-4797
    ISSN (online) 2631-4797
    DOI 10.1093/asjof/ojae010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The "violin model": Looking at community networks for dynamic allostery.

    Madan, Lalima K / Welsh, Colin L / Kornev, Alexandr P / Taylor, Susan S

    The Journal of chemical physics

    2023  Volume 158, Issue 8, Page(s) 81001

    Abstract: Allosteric regulation of proteins continues to be an engaging research topic for the scientific community. Models describing allosteric communication have evolved from focusing on conformation-based descriptors of protein structural changes to ... ...

    Abstract Allosteric regulation of proteins continues to be an engaging research topic for the scientific community. Models describing allosteric communication have evolved from focusing on conformation-based descriptors of protein structural changes to appreciating the role of internal protein dynamics as a mediator of allostery. Here, we explain a "violin model" for allostery as a contemporary method for approaching the Cooper-Dryden model based on redistribution of protein thermal fluctuations. Based on graph theory, the violin model makes use of community network analysis to functionally cluster correlated protein motions obtained from molecular dynamics simulations. This Review provides the theory and workflow of the methodology and explains the application of violin model to unravel the workings of protein kinase A.
    MeSH term(s) Humans ; Community Networks ; Allosteric Regulation ; Molecular Dynamics Simulation ; Motion
    Language English
    Publishing date 2023-03-01
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0138175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 49/16: Show issues

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  5. Article ; Online: Corrigendum to "Novel LRR-ROC Motif That Links the N- and C-terminal Domains in LRRK2 Undergoes an Order-Disorder Transition Upon Activation" [J. Mol. Biol. 435(12) (2023) 1-17].

    Weng, Jui-Hung / Trilling, Chiara R / Kaila Sharma, Pallavi / Störmer, Eliza / Wu, Jian / Herberg, Friedrich W / Taylor, Susan S

    Journal of molecular biology

    2024  Volume 436, Issue 6, Page(s) 168485

    Language English
    Publishing date 2024-02-17
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 80229-3
    ISSN 1089-8638 ; 0022-2836
    ISSN (online) 1089-8638
    ISSN 0022-2836
    DOI 10.1016/j.jmb.2024.168485
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 867: Show issues Location:
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  6. Article ; Online: A new Australian species of invasive psyllid, Acizzia convector Burckhardt & Taylor, sp. nov. (Psylloidea: Psyllidae) associated with Acacia auriculiformis and A. mangium (Fabaceae).

    Taylor, Gary S / Halbert, Susan E / Tripathy, Ashirwad / Burckhardt, Daniel

    Zootaxa

    2023  Volume 5228, Issue 1, Page(s) 61–72

    Abstract: Acizzia convector Burckhardt & Taylor, sp. nov., a psyllid originating from Australia, is described ...

    Abstract Acizzia convector Burckhardt & Taylor, sp. nov., a psyllid originating from Australia, is described from material from Australia (NT), South and Southeast Asia (Brunei, Cambodia, India, Laos, Malaysia [Sabah], Singapore and Thailand) and North America (USA [Florida from six counties]). The new species is diagnosed and illustrated, and a key is provided to identify the adults of Acizzia species adventive in the New World. The new species develops on Acacia auriculiformis and A. mangium (Fabaceae), two mimosoids planted and widely naturalised throughout the tropics. While the presence of A. convector sp. nov. in Florida is probably recent (earliest record from October 2014), it occurs in Southeast Asia at least since the 1980s. The wide distribution of the host plants in tropical Africa and South America would allow the psyllids also to occur there.
    MeSH term(s) Animals ; Acacia ; Fabaceae ; Hemiptera ; Australia ; Plants
    Language English
    Publishing date 2023-01-11
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.5228.1.3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Gauging Dynamics-driven Allostery Using a New Computational Tool: A CAP Case Study.

    Kornev, Alexandr P / Weng, Jui-Hung / Maillard, Rodrigo A / Taylor, Susan S

    Journal of molecular biology

    2023  Volume 436, Issue 2, Page(s) 168395

    Abstract: In this study, we utilize Protein Residue Networks (PRNs), constructed using Local Spatial Pattern (LSP) alignment, to explore the dynamic behavior of Catabolite Activator Protein (CAP) upon the sequential binding of cAMP. We employed the Degree ... ...

    Abstract In this study, we utilize Protein Residue Networks (PRNs), constructed using Local Spatial Pattern (LSP) alignment, to explore the dynamic behavior of Catabolite Activator Protein (CAP) upon the sequential binding of cAMP. We employed the Degree Centrality of these PRNs to investigate protein dynamics on a sub-nanosecond time scale, hypothesizing that it would reflect changes in CAP's entropy related to its thermal motions. We show that the binding of the first cAMP led to an increase in stability in the Cyclic-Nucleotide Binding Domain A (CNBD-A) and destabilization in CNBD-B, agreeing with previous reports explaining the negative cooperativity of cAMP binding in terms of an entropy-driven allostery. LSP-based PRNs also allow for the study of Betweenness Centrality, another graph-theoretical characteristic of PRNs, providing insights into global residue connectivity within CAP. Using this approach, we were able to correctly identify amino acids that were shown to be critical in mediating allosteric interactions in CAP. The agreement between our studies and previous experimental reports validates our method, particularly with respect to the reliability of Degree Centrality as a proxy for entropy related to protein thermal dynamics. Because LSP-based PRNs can be easily extended to include dynamics of small organic molecules, polynucleotides, or other allosteric proteins, the methods presented here mark a significant advancement in the field, positioning them as vital tools for a fast, cost-effective, and accurate analysis of entropy-driven allostery and identification of allosteric hotspots.
    MeSH term(s) Allosteric Regulation ; Cyclic AMP Receptor Protein/chemistry ; Entropy ; Molecular Dynamics Simulation ; Protein Binding ; Reproducibility of Results ; Sequence Alignment/methods
    Chemical Substances Cyclic AMP Receptor Protein
    Language English
    Publishing date 2023-12-13
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80229-3
    ISSN 1089-8638 ; 0022-2836
    ISSN (online) 1089-8638
    ISSN 0022-2836
    DOI 10.1016/j.jmb.2023.168395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 867: Show issues Location:
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  8. Article ; Online: Edmond Fischer's kinase legacy: History of the protein kinase inhibitor and protein kinase A.

    Taylor, Susan S / Herberg, Friedrich W / Veglia, Gianluigi / Wu, Jian

    IUBMB life

    2023  Volume 75, Issue 4, Page(s) 311–323

    Abstract: Although Fischer's extraordinary career came to focus mostly on the protein phosphatases, after his co-discovery of Phosphorylase Kinase with Ed Krebs he was clearly intrigued not only by cAMP-dependent protein kinase (PKA), but also by the heat-stable, ... ...

    Abstract Although Fischer's extraordinary career came to focus mostly on the protein phosphatases, after his co-discovery of Phosphorylase Kinase with Ed Krebs he was clearly intrigued not only by cAMP-dependent protein kinase (PKA), but also by the heat-stable, high-affinity protein kinase inhibitor (PKI). PKI is an intrinsically disordered protein that contains at its N-terminus a pseudo-substrate motif that binds synergistically and with high-affinity to the PKA catalytic (C) subunit. The sequencing and characterization of this inhibitor peptide (IP20) were validated by the structure of the PKA C-subunit solved first as a binary complex with IP20 and then as a ternary complex with ATP and two magnesium ions. A second motif, nuclear export signal (NES), was later discovered in PKI. Both motifs correspond to amphipathic helices that convey high-affinity binding. The dynamic features of full-length PKI, recently captured by NMR, confirmed that the IP20 motif becomes dynamically and sequentially ordered only in the presence of the C-subunit. The type I PKA regulatory (R) subunits also contain a pseudo-substrate ATPMg2-dependent high-affinity inhibitor sequence. PKI and PKA, especially the Cβ subunit, are highly expressed in the brain, and PKI expression is also cell cycle-dependent. In addition, PKI is now linked to several cancers. The full biological importance of PKI and PKA signaling in the brain, and their importance in cancer thus remains to be elucidated.
    MeSH term(s) Cyclic AMP-Dependent Protein Kinases/genetics ; Cyclic AMP-Dependent Protein Kinases/chemistry ; Protein Kinase Inhibitors ; Peptides/chemistry
    Chemical Substances Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11) ; Protein Kinase Inhibitors ; Peptides
    Language English
    Publishing date 2023-02-28
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1492141-8
    ISSN 1521-6551 ; 1521-6543
    ISSN (online) 1521-6551
    ISSN 1521-6543
    DOI 10.1002/iub.2714
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1611: Show issues Location:
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  9. Article ; Online: Calculation of centralities in protein kinase A.

    Kornev, Alexandr P / Aoto, Phillip C / Taylor, Susan S

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 47, Page(s) e2215420119

    Abstract: Topological analysis of protein residue networks (PRNs) is a common method that can help to understand the roles of individual residues. Here, we used protein kinase A as a study object and asked what already known functionally important residues can be ... ...

    Abstract Topological analysis of protein residue networks (PRNs) is a common method that can help to understand the roles of individual residues. Here, we used protein kinase A as a study object and asked what already known functionally important residues can be detected by network analysis. Along several traditional approaches to weight edges in PRNs we used local spatial pattern (LSP) alignment that assigns high weights to edges only if CαCβ vectors for the corresponding residues retain their mutual positions and orientation. Our results show that even short molecular dynamic simulations of 10 to 20 ns can give convergent values for betweenness and degree centralities calculated from the LSP-based PRNs. Using these centralities, we were able to clearly distinguish a group of residues that are highly conserved in protein kinases and play important functional and regulatory roles. In comparison, traditional methods based on cross-correlation and linear mutual information were much less efficient for this particular task. These results call for reevaluation of the current methods to generate PRNs.
    MeSH term(s) Cyclic AMP-Dependent Protein Kinases ; Molecular Dynamics Simulation
    Chemical Substances Cyclic AMP-Dependent Protein Kinases (EC 2.7.11.11)
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2215420119
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  10. Article: Sarcoidosis: An atypical mimicker of acne keloidalis nuchae.

    Roche, Fritzlaine C / Fischer, Andrew S / Taylor, Susan C

    JAAD case reports

    2020  Volume 6, Issue 5, Page(s) 397–399

    Language English
    Publishing date 2020-04-29
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2020.02.018
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