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  1. Book: NF-KappaB

    Hayden, Matthew S. / Ghosh, Sankar

    (Immunological reviews ; 246)

    2012  

    Title variant NF-KB
    Author's details Matthew S. Hayden & Sankar Ghosh, guest ed
    Series title Immunological reviews ; 246
    Collection
    Language English
    Size 400 S. : Ill.
    Publisher Wiley-Blackwell
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT017434952
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 160 -246- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Gene editing in dermatology: Harnessing CRISPR for the treatment of cutaneous disease.

    Baker, Catherine / Hayden, Matthew S

    F1000Research

    2020  Volume 9, Page(s) 281

    Abstract: The discovery of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system has revolutionized gene editing research. Through the repurposing of programmable RNA-guided CRISPR-associated (Cas) nucleases, CRISPR-based genome editing ... ...

    Abstract The discovery of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system has revolutionized gene editing research. Through the repurposing of programmable RNA-guided CRISPR-associated (Cas) nucleases, CRISPR-based genome editing systems allow for the precise modification of specific sites in the human genome and inspire novel approaches for the study and treatment of inherited and acquired human diseases. Here, we review how CRISPR technologies have stimulated key advances in dermatologic research.  We discuss the role of CRISPR in genome editing for cutaneous disease and highlight studies on the use of CRISPR-Cas technologies for genodermatoses, cutaneous viruses and bacteria, and melanoma. Additionally, we examine key limitations of current CRISPR technologies, including the challenges these limitations pose for the widespread therapeutic application of CRISPR-based therapeutics.
    MeSH term(s) CRISPR-Cas Systems ; Clustered Regularly Interspaced Short Palindromic Repeats ; Dermatology ; Gene Editing ; Genetic Therapy ; Humans ; Skin Diseases/genetics ; Skin Diseases/therapy
    Language English
    Publishing date 2020-04-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.23185.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Genomic selection for target traits in the Australian lentil breeding program.

    Gebremedhin, Alem / Li, Yongjun / Shunmugam, Arun S K / Sudheesh, Shimna / Valipour-Kahrood, Hossein / Hayden, Matthew J / Rosewarne, Garry M / Kaur, Sukhjiwan

    Frontiers in plant science

    2024  Volume 14, Page(s) 1284781

    Abstract: Genomic selection (GS) uses associations between markers and phenotypes to predict the breeding values of individuals. It can be applied early in the breeding cycle to reduce the cross-to-cross generation interval and thereby increase genetic gain per ... ...

    Abstract Genomic selection (GS) uses associations between markers and phenotypes to predict the breeding values of individuals. It can be applied early in the breeding cycle to reduce the cross-to-cross generation interval and thereby increase genetic gain per unit of time. The development of cost-effective, high-throughput genotyping platforms has revolutionized plant breeding programs by enabling the implementation of GS at the scale required to achieve impact. As a result, GS is becoming routine in plant breeding, even in minor crops such as pulses. Here we examined 2,081 breeding lines from Agriculture Victoria's national lentil breeding program for a range of target traits including grain yield, ascochyta blight resistance, botrytis grey mould resistance, salinity and boron stress tolerance, 100-grain weight, seed size index and protein content. A broad range of narrow-sense heritabilities was observed across these traits (0.24-0.66). Genomic prediction models were developed based on 64,781 genome-wide SNPs using Bayesian methodology and genomic estimated breeding values (GEBVs) were calculated. Forward cross-validation was applied to examine the prediction accuracy of GS for these targeted traits. The accuracy of GEBVs was consistently higher (0.34-0.83) than BLUP estimated breeding values (EBVs) (0.22-0.54), indicating a higher expected rate of genetic gain with GS. GS-led parental selection using early generation breeding materials also resulted in higher genetic gain compared to BLUP-based selection performed using later generation breeding lines. Our results show that implementing GS in lentil breeding will fast track the development of high-yielding cultivars with increased resistance to biotic and abiotic stresses, as well as improved seed quality traits.
    Language English
    Publishing date 2024-01-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1284781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Intraoperative margin assessment for basal cell carcinoma with deep learning and histologic tumor mapping to surgical site.

    Levy, Joshua J / Davis, Matthew J / Chacko, Rachael S / Davis, Michael J / Fu, Lucy J / Goel, Tarushii / Pamal, Akash / Nafi, Irfan / Angirekula, Abhinav / Suvarna, Anish / Vempati, Ram / Christensen, Brock C / Hayden, Matthew S / Vaickus, Louis J / LeBoeuf, Matthew R

    NPJ precision oncology

    2024  Volume 8, Issue 1, Page(s) 2

    Abstract: Successful treatment of solid cancers relies on complete surgical excision of the tumor either for definitive treatment or before adjuvant therapy. Intraoperative and postoperative radial sectioning, the most common form of margin assessment, can lead to ...

    Abstract Successful treatment of solid cancers relies on complete surgical excision of the tumor either for definitive treatment or before adjuvant therapy. Intraoperative and postoperative radial sectioning, the most common form of margin assessment, can lead to incomplete excision and increase the risk of recurrence and repeat procedures. Mohs Micrographic Surgery is associated with complete removal of basal cell and squamous cell carcinoma through real-time margin assessment of 100% of the peripheral and deep margins. Real-time assessment in many tumor types is constrained by tissue size, complexity, and specimen processing / assessment time during general anesthesia. We developed an artificial intelligence platform to reduce the tissue preprocessing and histological assessment time through automated grossing recommendations, mapping and orientation of tumor to the surgical specimen. Using basal cell carcinoma as a model system, results demonstrate that this approach can address surgical laboratory efficiency bottlenecks for rapid and complete intraoperative margin assessment.
    Language English
    Publishing date 2024-01-03
    Publishing country England
    Document type Journal Article
    ISSN 2397-768X
    ISSN 2397-768X
    DOI 10.1038/s41698-023-00477-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Fluorescence-activated protoplast sorting for crop improvement.

    Sahab, Sareena / Tibbits, Josquin / Spangenberg, German / Mason, John / Hayden, Matthew

    Trends in plant science

    2024  

    Language English
    Publishing date 2024-01-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1305448-x
    ISSN 1878-4372 ; 1360-1385
    ISSN (online) 1878-4372
    ISSN 1360-1385
    DOI 10.1016/j.tplants.2023.12.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 2005/719: Show issues

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  6. Article ; Online: Gene editing in dermatology

    Catherine Baker / Matthew S. Hayden

    F1000Research, Vol

    Harnessing CRISPR for the treatment of cutaneous disease [version 1; peer review: 2 approved]

    2020  Volume 9

    Abstract: The discovery of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system has revolutionized gene editing research. Through the repurposing of programmable RNA-guided CRISPR-associated (Cas) nucleases, CRISPR-based genome editing ... ...

    Abstract The discovery of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system has revolutionized gene editing research. Through the repurposing of programmable RNA-guided CRISPR-associated (Cas) nucleases, CRISPR-based genome editing systems allow for the precise modification of specific sites in the human genome and inspire novel approaches for the study and treatment of inherited and acquired human diseases. Here, we review how CRISPR technologies have stimulated key advances in dermatologic research. We discuss the role of CRISPR in genome editing for cutaneous disease and highlight studies on the use of CRISPR-Cas technologies for genodermatoses, cutaneous viruses and bacteria, and melanoma. Additionally, we examine key limitations of current CRISPR technologies, including the challenges these limitations pose for the widespread therapeutic application of CRISPR-based therapeutics.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: Gene editing in dermatology

    Catherine Baker / Matthew S. Hayden

    F1000Research, Vol

    Harnessing CRISPR for the treatment of cutaneous disease [version 2; peer review: 2 approved]

    2020  Volume 9

    Abstract: The discovery of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system has revolutionized gene editing research. Through the repurposing of programmable RNA-guided CRISPR-associated (Cas) nucleases, CRISPR-based genome editing ... ...

    Abstract The discovery of the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) system has revolutionized gene editing research. Through the repurposing of programmable RNA-guided CRISPR-associated (Cas) nucleases, CRISPR-based genome editing systems allow for the precise modification of specific sites in the human genome and inspire novel approaches for the study and treatment of inherited and acquired human diseases. Here, we review how CRISPR technologies have stimulated key advances in dermatologic research. We discuss the role of CRISPR in genome editing for cutaneous disease and highlight studies on the use of CRISPR-Cas technologies for genodermatoses, cutaneous viruses and bacteria, and melanoma. Additionally, we examine key limitations of current CRISPR technologies, including the challenges these limitations pose for the widespread therapeutic application of CRISPR-based therapeutics.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher F1000 Research Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Article ; Online: Evaluating Therapeutic Inertia in Two Telehealth Interventions for Type 2 Diabetes: Secondary Analyses of a Randomized Trial.

    Duffy, Ryan A / Jeffreys, Amy S / Coffman, Cynthia J / Alexopoulos, Anastasia-Stefania / Tarkington, Phillip E / Bosworth, Hayden / Edelman, David / Crowley, Matthew J

    Telemedicine journal and e-health : the official journal of the American Telemedicine Association

    2024  

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2035659-6
    ISSN 1556-3669 ; 1530-5627
    ISSN (online) 1556-3669
    ISSN 1530-5627
    DOI 10.1089/tmj.2023.0453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4576: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: CAS12e (CASX2) CLEAVAGE OF CCR5: IMPACT OF GUIDE RNA LENGTH AND PAM SEQUENCE ON CLEAVAGE ACTIVITY.

    Armstrong, David A / Hudson, Taylor R / Hodge, Christine A / Hampton, Thomas H / Howell, Alexandra L / Hayden, Matthew S

    bioRxiv : the preprint server for biology

    2023  

    Abstract: CRISPR/Cas is under development as a therapeutic tool for the cleavage, excision, and/or modification of genes in eukaryotic cells. While much effort has focused on CRISPR/Cas ... ...

    Abstract CRISPR/Cas is under development as a therapeutic tool for the cleavage, excision, and/or modification of genes in eukaryotic cells. While much effort has focused on CRISPR/Cas from
    Language English
    Publishing date 2023-01-02
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.01.02.522476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: PlmCas12e (CasX2) cleavage of CCR5: impact of guide RNA spacer length and PAM sequence on cleavage activity.

    Armstrong, David A / Hudson, Taylor R / Hodge, Christine A / Hampton, Thomas H / Howell, Alexandra L / Hayden, Matthew S

    RNA biology

    2023  Volume 20, Issue 1, Page(s) 296–305

    Abstract: Gene editing using CRISPR/Cas (clustered regularly interspaced palindromic repeats/CRISPR-associated) is under development as a therapeutic tool for the modification of genes in eukaryotic cells. While much effort has focused on CRISPR/Cas9 systems ... ...

    Abstract Gene editing using CRISPR/Cas (clustered regularly interspaced palindromic repeats/CRISPR-associated) is under development as a therapeutic tool for the modification of genes in eukaryotic cells. While much effort has focused on CRISPR/Cas9 systems from
    MeSH term(s) Humans ; CRISPR-Cas Systems ; Gene Editing ; Mutation ; RNA/genetics ; Nucleotides ; Receptors, CCR5/genetics
    Chemical Substances RNA (63231-63-0) ; Nucleotides ; CCR5 protein, human ; Receptors, CCR5
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2159587-2
    ISSN 1555-8584 ; 1555-8584
    ISSN (online) 1555-8584
    ISSN 1555-8584
    DOI 10.1080/15476286.2023.2221510
    Database MEDical Literature Analysis and Retrieval System OnLINE

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