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  1. Book: Dornröschen. Der Pfefferkuchenmann. [Adapted from the orig. by Anne McKie. Ill. by Ken McKie]

    MacKie, Anne / MacKie, Ken

    (Beliebte Kindermärchen)

    1991  

    Title variant Der Pfefferkuchenmann
    Series title Beliebte Kindermärchen
    Size [28] S, zahlr. Ill
    Edition Dt. Ausg
    Publisher Xenos-Verl.-Ges
    Publishing place Hamburg
    Document type Book
    Note Aus dem Engl. übers.
    ISBN 3821210249 ; 9783821210247
    Database Former special subject collection: coastal and deep sea fishing

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  2. Book: Gullivers Reisen. Der Froschkönig. [Adapted from the orig. by Anne McKie. Ill. by Ken McKie]

    MacKie, Anne / MacKie, Ken

    (Beliebte Kindermärchen)

    1991  

    Title variant Der Froschkönig
    Series title Beliebte Kindermärchen
    Size [20] S, zahlr. Ill
    Edition Dt. Ausg
    Publisher Xenos-Verl.-Ges
    Publishing place Hamburg
    Document type Book
    Note Aus dem Engl. übers.
    ISBN 3821210214 ; 9783821210216
    Database Former special subject collection: coastal and deep sea fishing

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  3. Book: Des Kaisers neue Kleider. Rumpelstilzchen. [Adapted from the orig. by Anne McKie. Ill. by Ken McKie]

    MacKie, Anne / MacKie, Ken

    (Beliebte Kindermärchen)

    1991  

    Title variant Rumpelstilzchen
    Series title Beliebte Kindermärchen
    Size [20] S, zahlr. Ill
    Edition Dt. Ausg
    Publisher Xenos-Verl.-Ges
    Publishing place Hamburg
    Document type Book
    Note Aus dem Engl. übers.
    ISBN 3821210230 ; 9783821210230
    Database Former special subject collection: coastal and deep sea fishing

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  4. Book: Hänsel und Gretel. Der Rattenfänger von Hameln. [Adapted from the orig. by Anne McKie. Ill. by Ken McKie]

    MacKie, Anne / MacKie, Ken

    (Beliebte Kindermärchen)

    1991  

    Title variant Der Rattenfänger von Hameln
    Series title Beliebte Kindermärchen
    Size [20] S, zahlr. Ill
    Publisher Xenos Verl.-Ges
    Publishing place Hamburg
    Document type Book
    Note Aus d. Engl. übers.
    ISBN 3821209739 ; 9783821209739
    Database Former special subject collection: coastal and deep sea fishing

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  5. Article ; Online: Western Blotting of the Endocannabinoid System.

    Wager-Miller, Jim / Mackie, Ken

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2576, Page(s) 385–393

    Abstract: Measuring protein levels of receptors and enzymes involved in endocannabinoid metabolism is an important step for understanding the distribution, function, and regulation of these components of the endocannabinoid system. A common approach for detecting ... ...

    Abstract Measuring protein levels of receptors and enzymes involved in endocannabinoid metabolism is an important step for understanding the distribution, function, and regulation of these components of the endocannabinoid system. A common approach for detecting proteins from complex biological systems is western blotting. In this chapter, we describe a general approach to western blotting protein components of the endocannabinoid system using sodium dodecyl sulfate-polyacrylamide gel electrophoresis and nitrocellulose membranes with a focus on detecting type 1 cannabinoid (CB
    MeSH term(s) Blotting, Western ; Cannabinoids ; Collodion ; Endocannabinoids/metabolism ; Sodium Dodecyl Sulfate
    Chemical Substances Cannabinoids ; Endocannabinoids ; Sodium Dodecyl Sulfate (368GB5141J) ; Collodion (9004-70-0)
    Language English
    Publishing date 2022-09-24
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2728-0_32
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  6. Article ; Online: Quantitation of Plasma Membrane (G Protein-Coupled) Receptor Trafficking in Cultured Cells.

    Wager-Miller, Jim / Mackie, Ken

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2576, Page(s) 395–406

    Abstract: Measuring the functional behavior of G protein-coupled receptors (GPCRs) has been a major focus of academic and pharmaceutical research for many decades. These efforts have led to the development of many assays to measure the downstream effects of ligand ...

    Abstract Measuring the functional behavior of G protein-coupled receptors (GPCRs) has been a major focus of academic and pharmaceutical research for many decades. These efforts have led to the development of many assays to measure the downstream effects of ligand binding on receptor activity. In this chapter, we describe an internalization/recycling assay that can be used to track changes in receptor number at the plasma membrane. Used in concert with other assays, this antibody-based technique can provide dynamic information on GPCR activation by receptor-specific ligands.
    MeSH term(s) Cell Membrane/metabolism ; Cells, Cultured ; GTP-Binding Proteins/metabolism ; Ligands ; Receptors, G-Protein-Coupled/metabolism
    Chemical Substances Ligands ; Receptors, G-Protein-Coupled ; GTP-Binding Proteins (EC 3.6.1.-)
    Language English
    Publishing date 2022-09-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2728-0_33
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  7. Article ; Online: Cannabinoid Receptor Type 1 Activation Causes a Water Diuresis by Inducing an Acute Central Diabetes Insipidus in Mice.

    Rein, Joshua L / Mackie, Ken / Kleyman, Thomas R / Satlin, Lisa M

    American journal of physiology. Renal physiology

    2024  

    Abstract: Cannabis and synthetic cannabinoid consumption is increasing worldwide. Cannabis contains numerous phytocannabinoids that act on the G-protein-coupled cannabinoid receptors type 1 (CB1R) and type 2 (CB2R) expressed throughout the body, including the ... ...

    Abstract Cannabis and synthetic cannabinoid consumption is increasing worldwide. Cannabis contains numerous phytocannabinoids that act on the G-protein-coupled cannabinoid receptors type 1 (CB1R) and type 2 (CB2R) expressed throughout the body, including the kidney. Essentially every organ, including the kidney, produces endocannabinoids (ECs), endogenous ligands to these receptors. Cannabinoids acutely increase urine output in rodents and humans, thus potentially influencing total-body water and electrolyte homeostasis. As the kidney collecting duct (CD) regulates total body water, acid/base, and electrolyte balance through specific functions of principal cells (PCs) and intercalated cells (ICs), we examined the cell-specific immunolocalization of CB1R in the mouse CD. Antibodies against either the C-terminus or N-terminus of CB1R consistently labeled AQP2(-) cells in the cortical and medullary CD, and thus presumably ICs. Given the well-established role of ICs in urinary acidification, we utilized a clearance approach in mice that were acid-loaded with 280 mM NH
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00320.2022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: SGIP1 in axons prevents internalization of desensitized CB1R and modifies its function.

    Durydivka, Oleh / Mackie, Ken / Blahos, Jaroslav

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1213094

    Abstract: In the central nervous system (CNS), cannabinoid receptor 1 (CB1R) is preferentially expressed in axons where it has a unique property, namely resistance to agonist-driven endocytosis. This review aims to summarize what we know about molecular mechanisms ...

    Abstract In the central nervous system (CNS), cannabinoid receptor 1 (CB1R) is preferentially expressed in axons where it has a unique property, namely resistance to agonist-driven endocytosis. This review aims to summarize what we know about molecular mechanisms of CB1R cell surface stability in axonal compartments, how these impact CB1R signaling, and to consider their physiological consequences. This review then focuses on a potential candidate for maintaining axonal CB1R at the cell surface, Src homology 3-domain growth factor receptor-bound 2-like endophilin interacting protein 1 (SGIP1). SGIP1 may contribute to the polarized distribution of CB1R and modify its signaling in axons. In addition, deletion of SGIP1 results in discrete behavioral changes in modalities controlled by the endocannabinoid system
    Language English
    Publishing date 2023-07-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1213094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Hexahydrocannabinol (HHC) and Δ

    Durydivka, Oleh / Palivec, Petr / Gazdarica, Matej / Mackie, Ken / Blahos, Jaroslav / Kuchar, Martin

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 9181

    Abstract: The Cannabis sativa plant has been used for centuries as a recreational drug and more recently in the treatment of patients with neurological or psychiatric disorders. In many instances, treatment goals include relief from posttraumatic disorders, ... ...

    Abstract The Cannabis sativa plant has been used for centuries as a recreational drug and more recently in the treatment of patients with neurological or psychiatric disorders. In many instances, treatment goals include relief from posttraumatic disorders, anxiety, or to support treatment of chronic pain. Ligands acting on cannabinoid receptor 1 (CB1R) are also potential targets for the treatment of other health conditions. Using an evidence-based approach, pharmacological investigation of CB1R agonists is timely, with the aim to provide chronically ill patients relief using well-defined and characterized compounds from cannabis. Hexahydrocannabinol (HHC), currently available over the counter in many countries to adults and even children, is of great interests to policy makers, legal administrators, and healthcare regulators, as well as pharmacologists. Herein, we studied the pharmacodynamics of HHC epimers, which activate CB1R. We compared their key CB1R-mediated signaling pathway activities and compared them to the pathways activated by Δ
    MeSH term(s) Dronabinol/pharmacology ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB1/agonists ; Signal Transduction/drug effects ; Humans ; Cannabinol/pharmacology ; Animals ; Cannabinoid Receptor Agonists/pharmacology ; HEK293 Cells ; Mice
    Chemical Substances Dronabinol (7J8897W37S) ; Receptor, Cannabinoid, CB1 ; Cannabinol (7UYP6MC9GH) ; Cannabinoid Receptor Agonists
    Language English
    Publishing date 2024-04-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-58845-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: CB

    Watkins, Joshua / Aradi, Petra / Hahn, Rachel / Katona, Istvan / Mackie, Ken / Makriyannis, Alexandros / Hohmann, Andrea G

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Recreational use of synthetic cannabinoid agonists (i.e., "Spice" compounds) that target the Cannabinoid Type 1 receptor ( ... ...

    Abstract Recreational use of synthetic cannabinoid agonists (i.e., "Spice" compounds) that target the Cannabinoid Type 1 receptor (CB
    Language English
    Publishing date 2024-03-13
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.03.12.584260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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