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  1. Article ; Online: Progenitor diversity defines monocyte roles.

    Goodridge, Helen S

    Blood

    2023  Volume 142, Issue 7, Page(s) 617–619

    MeSH term(s) Monocytes ; Epigenesis, Genetic
    Language English
    Publishing date 2023-08-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023021298
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  2. Article ; Online: Aging of classical monocyte subsets.

    Goodridge, Helen S

    Aging

    2023  Volume 15, Issue 2, Page(s) 290–292

    MeSH term(s) Monocytes ; Lipopolysaccharide Receptors ; Flow Cytometry
    Chemical Substances Lipopolysaccharide Receptors
    Language English
    Publishing date 2023-01-16
    Publishing country United States
    Document type Editorial
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204493
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Microbial Sensing by Hematopoietic Stem and Progenitor Cells.

    Barman, Pijus K / Goodridge, Helen S

    Stem cells (Dayton, Ohio)

    2022  Volume 40, Issue 1, Page(s) 14–21

    Abstract: Balanced production of immune cells is critical for the maintenance of steady-state immune surveillance, and increased production of myeloid cells is sometimes necessary to eliminate pathogens. Hematopoietic stem and progenitor cell (HSPC) sensing of ... ...

    Abstract Balanced production of immune cells is critical for the maintenance of steady-state immune surveillance, and increased production of myeloid cells is sometimes necessary to eliminate pathogens. Hematopoietic stem and progenitor cell (HSPC) sensing of commensal microbes and invading pathogens has a notable impact on hematopoiesis. In this review, we examine how commensal microbes regulate bone marrow HSPC activity to maintain balanced hematopoiesis in the steady state, and how HSPCs proliferate and differentiate during emergency myelopoiesis in response to infection. HSPCs express a variety of pattern recognition receptors and cytokine receptors that they use to sense the presence of microbes, either directly via detection of microbial components and metabolites, or indirectly by responding to cytokines produced by other host cells. We describe direct and indirect mechanisms of microbial sensing by HSPCs and highlight evidence demonstrating long-term effects of acute and chronic microbial stimuli on HSPCs. We also discuss a possible connection between myeloid-biased hematopoiesis and elevated levels of circulating microbiome-derived components in the context of aging and metabolic stress. Finally, we highlight the prospect of trained immunity-based vaccines that could exploit microbial stimulation of HSPCs.
    MeSH term(s) Cytokines/metabolism ; Hematopoiesis ; Hematopoietic Stem Cells/metabolism ; Myeloid Cells/metabolism
    Chemical Substances Cytokines
    Language English
    Publishing date 2022-04-29
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1143556-2
    ISSN 1549-4918 ; 1066-5099
    ISSN (online) 1549-4918
    ISSN 1066-5099
    DOI 10.1093/stmcls/sxab007
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  4. Article ; Online: Role of hematopoietic aging in cognitive decline

    Helen S. Goodridge

    Translational Medicine of Aging, Vol 4, Iss , Pp 99-

    2020  Volume 102

    Abstract: ... of neurodegenerative diseases such as Alzheimer’s and Parkinson’s. ...

    Abstract We recently demonstrated that transplantation of young bone marrow cells rescued hippocampal learning and memory in old recipient mice. Our study also implicated CCL11/eotaxin-1 in microglial reactivity during aging, which likely underlies neurotoxicity and synapse loss. CCL11 was reduced in the circulation of old recipients of young bone marrow, which likely contributed to their improved cognitive function. Thus, targeting CCL11 or its receptor may be an effective strategy for the treatment of neurodegenerative diseases such as Alzheimer’s and Parkinson’s.
    Keywords Aging ; Cognitive decline ; Young/old blood ; Bone marrow transplant ; CCL11 ; Medicine ; R
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Heterogeneity and origins of myeloid cells.

    Yáñez, Alberto / Bono, Cristina / Goodridge, Helen S

    Current opinion in hematology

    2022  Volume 29, Issue 4, Page(s) 201–208

    Abstract: Purpose of review: Myeloid cells - granulocytes, monocytes, macrophages and dendritic cells (DCs) - are innate immune cells that play key roles in pathogen defense and inflammation, as well as in tissue homeostasis and repair. Over the past 5 years, in ... ...

    Abstract Purpose of review: Myeloid cells - granulocytes, monocytes, macrophages and dendritic cells (DCs) - are innate immune cells that play key roles in pathogen defense and inflammation, as well as in tissue homeostasis and repair. Over the past 5 years, in part due to more widespread use of single cell omics technologies, it has become evident that these cell types are significantly more heterogeneous than was previously appreciated. In this review, we consider recent studies that have demonstrated heterogeneity among neutrophils, monocytes, macrophages and DCs in mice and humans. We also discuss studies that have revealed the sources of their heterogeneity.
    Recent findings: Recent studies have confirmed that ontogeny is a key determinant of diversity, with specific subsets of myeloid cells arising from distinct progenitors. However, diverse microenvironmental cues also strongly influence myeloid fate and function. Accumulating evidence therefore suggests that a combination of these mechanisms underlies myeloid cell diversity.
    Summary: Consideration of the heterogeneity of myeloid cells is critical for understanding their diverse activities, such as the role of macrophages in tissue damage versus repair, or tumor growth versus elimination. Insights into these mechanisms are informing the design of novel therapeutic approaches.
    MeSH term(s) Animals ; Dendritic Cells ; Granulocytes ; Humans ; Inflammation ; Macrophages ; Mice ; Monocytes ; Myeloid Cells
    Language English
    Publishing date 2022-03-11
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1153887-9
    ISSN 1531-7048 ; 1065-6251
    ISSN (online) 1531-7048
    ISSN 1065-6251
    DOI 10.1097/MOH.0000000000000716
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  6. Article ; Online: Editorial: Bone marrow progenitors share their experiences with their offspring.

    Goodridge, Helen S

    Journal of leukocyte biology

    2014  Volume 95, Issue 2, Page(s) 201–204

    MeSH term(s) Animals ; Bone Marrow Cells/cytology ; Bone Marrow Transplantation ; Dendritic Cells/cytology ; Dendritic Cells/immunology ; Dendritic Cells/radiation effects ; Dinoprostone/pharmacology ; Female ; Graft Survival/immunology ; Stem Cells/cytology ; Stem Cells/immunology ; Ultraviolet Rays
    Chemical Substances Dinoprostone (K7Q1JQR04M)
    Language English
    Publishing date 2014-02
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 605722-6
    ISSN 1938-3673 ; 0741-5400
    ISSN (online) 1938-3673
    ISSN 0741-5400
    DOI 10.1189/jlb.0813464
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    Zs.A 603: Show issues Location:
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  7. Article ; Online: Mast Cells Reveal Their Past Selves.

    Wolf, Anja A / Goodridge, Helen S

    Immunity

    2018  Volume 48, Issue 6, Page(s) 1065–1067

    Abstract: Mast cells have been thought to derive from bone marrow hematopoietic stem cells. In this issue of Immunity, Gentek et al. (2018) reveal that mast cells have dual developmental origins in primitive and definitive hematopoiesis and that adult mast cell ... ...

    Abstract Mast cells have been thought to derive from bone marrow hematopoietic stem cells. In this issue of Immunity, Gentek et al. (2018) reveal that mast cells have dual developmental origins in primitive and definitive hematopoiesis and that adult mast cell maintenance is largely bone marrow independent.
    MeSH term(s) Adult ; Bone Marrow ; Bone Marrow Cells ; Hematopoiesis ; Hematopoietic Stem Cells ; Humans ; Mast Cells
    Language English
    Publishing date 2018-07-29
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2018.05.014
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    Zs.A 4227: Show issues Location:
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    Zs.MG 69: Show issues

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  8. Article ; Online: Induced pluripotent stem cell-derived myeloid phagocytes: disease modeling and therapeutic applications.

    Goodridge, Helen S

    Drug discovery today

    2014  Volume 19, Issue 6, Page(s) 774–780

    Abstract: Myeloid phagocytes (neutrophils, monocytes, macrophages and dendritic cells) have key roles in immune defense, as well as in tissue repair and remodeling. Defective or dysregulated myeloid phagocyte production or function can cause immune dysfunction, ... ...

    Abstract Myeloid phagocytes (neutrophils, monocytes, macrophages and dendritic cells) have key roles in immune defense, as well as in tissue repair and remodeling. Defective or dysregulated myeloid phagocyte production or function can cause immune dysfunction, blood cell malignancies and inflammatory diseases. The tumor microenvironment can also condition myeloid phagocytes to promote tumor growth. Studies of their physiological and pathophysiological roles and the mechanisms regulating their production and function are crucial for the identification of novel therapeutic targets. In this review, we examine the use of induced pluripotent stem cells to study myeloid phagocytes in human diseases and develop future therapeutic strategies.
    MeSH term(s) Animals ; Humans ; Induced Pluripotent Stem Cells/physiology ; Induced Pluripotent Stem Cells/transplantation ; Macrophages/pathology ; Macrophages/physiology ; Myeloproliferative Disorders/pathology ; Myeloproliferative Disorders/therapy ; Phagocytes/pathology ; Phagocytes/physiology
    Language English
    Publishing date 2014-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1324988-5
    ISSN 1878-5832 ; 1359-6446
    ISSN (online) 1878-5832
    ISSN 1359-6446
    DOI 10.1016/j.drudis.2014.01.004
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    Zs.A 4725: Show issues Location:
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  9. Article ; Online: Identification and Isolation of Oligopotent and Lineage-committed Myeloid Progenitors from Mouse Bone Marrow.

    Yáñez, Alberto / Goodridge, Helen S

    Journal of visualized experiments : JoVE

    2018  , Issue 137

    Abstract: Myeloid progenitors that yield neutrophils, monocytes and dendritic cells (DCs) can be identified in and isolated from the bone marrow of mice for hematological and immunological analyses. For example, studies of the cellular and molecular properties of ... ...

    Abstract Myeloid progenitors that yield neutrophils, monocytes and dendritic cells (DCs) can be identified in and isolated from the bone marrow of mice for hematological and immunological analyses. For example, studies of the cellular and molecular properties of myeloid progenitor populations can reveal mechanisms underlying leukemic transformation, or demonstrate how the immune system responds to pathogen exposure. Previously described flow cytometry strategies for myeloid progenitor identification have enabled significant advances in many fields, but the fractions they identify are very heterogeneous. The most commonly used gating strategies define bone marrow fractions that are enriched for the desired populations, but also contain large numbers of "contaminating" progenitors. Our recent studies have resolved much of this heterogeneity, and the protocol we present here permits the isolation of 6 subpopulations of oligopotent and lineage-committed myeloid progenitors from 2 previously described bone marrow fractions. The protocol describes 3 stages: 1) isolation of bone marrow cells, 2) enrichment for hematopoietic progenitors by magnetic-activated cell sorting (lineage depletion by MACS), and 3) identification of myeloid progenitor subsets by flow cytometry (including fluorescence-activated cell sorting, FACS, if desired). This approach permits progenitor quantification and isolation for a variety of in vitro and in vivo applications, and has already yielded novel insight into pathways and mechanisms of neutrophil, monocyte, and DC differentiation.
    MeSH term(s) Animals ; Bone Marrow/metabolism ; Cell Differentiation ; Flow Cytometry ; Mice ; Myeloid Progenitor Cells/metabolism
    Language English
    Publishing date 2018-07-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/58061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Rejuvenating the blood and bone marrow to slow aging-associated cognitive decline and Alzheimer's disease.

    Kang, Seokjo / Moser, V Alexandra / Svendsen, Clive N / Goodridge, Helen S

    Communications biology

    2020  Volume 3, Issue 1, Page(s) 69

    MeSH term(s) Age Factors ; Aging/psychology ; Alzheimer Disease/etiology ; Alzheimer Disease/prevention & control ; Alzheimer Disease/psychology ; Animals ; Blood Transfusion/methods ; Bone Marrow Transplantation/methods ; Brain/physiology ; Clinical Trials as Topic ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/prevention & control ; Cognitive Dysfunction/psychology ; Humans ; Patient Outcome Assessment ; Plasma ; Rejuvenation ; Translational Medical Research
    Language English
    Publishing date 2020-02-13
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-020-0797-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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