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Article ; Online: Participation Predicts Cognitive Functioning in Older Adults Using the PART-O Transformed Scores Systems.

Sanchez-Lara, Encarnacion / Lozano-Ruiz, Alvaro / Rute-Perez, Sandra / Saez-Sanz, Noelia / Bombin, Igor / Caracuel, Alfonso

Journal of applied gerontology : the official journal of the Southern Gerontological Society

2022 Volume 41, Issue 4, Page(s) 1081–1089

Abstract: Participation has been shown to be a protective factor for cognition in older adults, but instruments to assess it are limited. The main objective was to determine the validity of two scoring systems (direct vs transformed) for the Participation ... ...

Abstract	Participation has been shown to be a protective factor for cognition in older adults, but instruments to assess it are limited. The main objective was to determine the validity of two scoring systems (direct vs transformed) for the Participation Assessment with Recombined Tools-Objective (PART-O) by applying structural equation modeling to the relationship between the subscales and the cognitive functions, in a sample of 245 people over 60 years of age. The transformed scores model showed stronger relationships and larger explained variance in overall participation (55.4% vs 37.4%), especially in the Social Relations subscale (31.4% vs 14.6%
MeSH term(s)	Aged ; Cognition ; Humans ; Middle Aged ; Social Participation
Language	English
Publishing date	2022-02-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	155897-3
ISSN	1552-4523 ; 0733-4648
ISSN (online)	1552-4523
ISSN	0733-4648
DOI	10.1177/07334648211057096
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Article: Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis.

Rapado-Castro, Marta / Villar-Arenzana, Mara / Janssen, Joost / Fraguas, David / Bombin, Igor / Castro-Fornieles, Josefina / Mayoral, Maria / González-Pinto, Ana / de la Serna, Elena / Parellada, Mara / Moreno, Dolores / Paya, Beatriz / Graell, Montserrat / Baeza, Inmaculada / Pantelis, Christos / Arango, Celso

Journal of clinical medicine

2021 Volume 10, Issue 17

Abstract: Cognitive maturation during adolescence is modulated by brain maturation. However, it is unknown how these processes intertwine in early onset psychosis (EOP). Studies examining longitudinal brain changes and cognitive performance in psychosis lend ... ...

Abstract	Cognitive maturation during adolescence is modulated by brain maturation. However, it is unknown how these processes intertwine in early onset psychosis (EOP). Studies examining longitudinal brain changes and cognitive performance in psychosis lend support for an altered development of high-order cognitive functions, which parallels progressive gray matter (GM) loss over time, particularly in fronto-parietal brain regions. We aimed to assess this relationship in a subsample of 33 adolescents with first-episode EOP and 47 matched controls over 2 years. Backwards stepwise regression analyses were conducted to determine the association and predictive value of longitudinal brain changes over cognitive performance within each group. Fronto-parietal GM volume loss was positively associated with decreased working memory in adolescents with psychosis (frontal left (B = 0.096,
Language	English
Publishing date	2021-08-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm10173929
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Article ; Online: Evaluación neuropsicológica de las funciones ejecutivas mediante realidad virtual.

Climent-Martínez, Gema / Luna-Lario, Pilar / Bombín-González, Igor / Cifuentes-Rodríguez, Alicia / Tirapu-Ustárroz, Javier / Díaz-Orueta, Unai

Revista de neurologia

2014 Volume 58, Issue 10, Page(s) 465–475

Abstract: Executive functions include a wide range of self regulatory functions that allow control, organization and coordination of other cognitive functions, emotional responses and behaviours. The traditional approach to evaluate these functions, by means of ... ...

Title translation	Neuropsychological evaluation of the executive functions by means of virtual reality.
Abstract	Executive functions include a wide range of self regulatory functions that allow control, organization and coordination of other cognitive functions, emotional responses and behaviours. The traditional approach to evaluate these functions, by means of paper and pencil neuropsychological tests, shows a greater than expected performance within the normal range for patients whose daily life difficulties would predict an inferior performance. These discrepancies suggest that classical neuropsychological tests may not adequately reproduce the complexity and dynamic nature of real life situations. Latest developments in the field of virtual reality offer interesting options for the neuropsychological assessment of many cognitive processes. Virtual reality reproduces three-dimensional environments with which the patient interacts in a dynamic way, with a sense of immersion in the environment similar to the presence and exposure to a real environment. Furthermore, the presentation of these stimuli, as well as distractors and other variables, may be controlled in a systematic way. Moreover, more consistent and precise answers may be obtained, and an in-depth analysis of them is possible. The present review shows current problems in neuropsychological evaluation of executive functions and latest advances in the consecution of higher preciseness and validity of the evaluation by means of new technologies and virtual reality, with special mention to some developments performed in Spain.
MeSH term(s)	Cognition Disorders/diagnosis ; Cognition Disorders/physiopathology ; Cognition Disorders/psychology ; Computer Simulation ; Executive Function/physiology ; Humans ; Intelligence Tests ; Memory/physiology ; Memory Disorders/diagnosis ; Memory Disorders/physiopathology ; Memory Disorders/psychology ; Models, Neurological ; Models, Psychological ; Nerve Net/physiology ; Neurodegenerative Diseases/diagnosis ; Neurodegenerative Diseases/physiopathology ; Neurodegenerative Diseases/psychology ; Neuropsychological Tests ; Prefrontal Cortex/physiology ; Psychomotor Performance ; Reproducibility of Results ; User-Computer Interface
Language	Spanish
Publishing date	2014-05-16
Publishing country	Spain
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1468278-3
ISSN	1576-6578 ; 0210-0010
ISSN (online)	1576-6578
ISSN	0210-0010
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Article ; Online: Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis

Marta Rapado-Castro / Mara Villar-Arenzana / Joost Janssen / David Fraguas / Igor Bombin / Josefina Castro-Fornieles / Maria Mayoral / Ana González-Pinto / Elena de la Serna / Mara Parellada / Dolores Moreno / Beatriz Paya / Montserrat Graell / Inmaculada Baeza / Christos Pantelis / Celso Arango

Journal of Clinical Medicine, Vol 10, Iss 3929, p

2021 Volume 3929

Abstract	Cognitive maturation during adolescence is modulated by brain maturation. However, it is unknown how these processes intertwine in early onset psychosis (EOP). Studies examining longitudinal brain changes and cognitive performance in psychosis lend support for an altered development of high-order cognitive functions, which parallels progressive gray matter (GM) loss over time, particularly in fronto-parietal brain regions. We aimed to assess this relationship in a subsample of 33 adolescents with first-episode EOP and 47 matched controls over 2 years. Backwards stepwise regression analyses were conducted to determine the association and predictive value of longitudinal brain changes over cognitive performance within each group. Fronto-parietal GM volume loss was positively associated with decreased working memory in adolescents with psychosis (frontal left (B = 0.096, p = 0.008); right (B = 0.089, p = 0.015); parietal left (B = 0.119, p = 0.007), right (B = 0.125, p = 0.015)) as a function of age. A particular decrease in frontal left GM volume best predicted a significant amount (22.28%) of the variance of decreased working memory performance over time, accounting for variance in age (14.9%). No such association was found in controls. Our results suggest that during adolescence, EOP individuals seem to follow an abnormal neurodevelopmental trajectory, in which fronto-parietal GM volume reduction is associated with the differential age-related working memory dysfunction in this group.
Keywords	working memory ; attention ; executive function ; early onset psychosis ; brain volume ; adolescence ; Medicine ; R
Subject code	150 ; 616
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Validez ecologica y entornos multitarea en la evaluacion de las funciones ejecutivas.

Bombín-González, Igor / Cifuentes-Rodríguez, Alicia / Climent-Martínez, Gema / Luna-Lario, Pilar / Cardas-Ibáñez, Jaione / Tirapu-Ustárroz, Javier / Díaz-Orueta, Unai

Revista de neurologia

2014 Volume 59, Issue 2, Page(s) 77–87

Abstract: Evaluation of executive functions is a major issue of neuropsychological assessment, due to the role displayed by these on a cognitive, behavioural and emotional level, and the implication of these functions in daily life functioning. In order to perform ...

Title translation	Ecological validity and multitasking environments in the evaluation of the executive functions.
Abstract	Evaluation of executive functions is a major issue of neuropsychological assessment, due to the role displayed by these on a cognitive, behavioural and emotional level, and the implication of these functions in daily life functioning. In order to perform a reliable assessment, the strategy traditionally followed for the evaluation of executive functions has been their atomization in different cognitive subprocesses, which is useful in a clinical or a research context. However, in clinical practice it is frequently artificial to disintegrate a global and complex cognitive process, such as executive functions, in a variety of related components; thus, tests designed according to these theoretical processes have low value in clinical procedures (diagnosis, rehabilitation design) due to their poor correspondence with the subject's or patient's clinical reality. The aims of the present work are to revise the concept of ecological validity applied to the evaluation of executive functions, and to perform a critical review of executive functions assessment by means of multitask paradigms as a way to increase the ecological validity and predictive value of the subject's functional performance. After a historical journey around the (low) ecological validity of single-task tests, and the bet in favour of a multitask paradigm for the evaluation of executive functions, up-to-date existing multitask tests are presented meticulously (with their respective advantages and disadvantages). Finally, concrete recommendations about how to develop multitask tests in the future are presented, attending to concrete parameters related to the context, tasks, objectives, rules and scoring.
MeSH term(s)	Activities of Daily Living ; Cognition Disorders/diagnosis ; Cognition Disorders/psychology ; Executive Function ; Forecasting ; Humans ; Neuropsychological Tests ; Predictive Value of Tests ; Psychomotor Performance ; Reproducibility of Results
Language	Spanish
Publishing date	2014-07-16
Publishing country	Spain
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1468278-3
ISSN	1576-6578 ; 0210-0010
ISSN (online)	1576-6578
ISSN	0210-0010
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Article ; Online: Efectividad de la rehabilitación neuropsicologica en el daño cerebral adquirido (I): atención, velocidad de procesamiento, memoria y lenguaje.

de Noreña, David / Ríos-Lago, Marcos / Bombín-González, Igor / Sánchez-Cubillo, Ignacio / García-Molina, Alberto / Tirapu-Ustárroz, Javier

Revista de neurologia

2010 Volume 51, Issue 11, Page(s) 687–698

Abstract: Introduction: The consequences of acquired brain injury include impairments in cognition, emotion, and behaviour. Neuro-psychology provides techniques for treating these disorders, but it is still important to establish which of all the available tools ... ...

Title translation	Effectiveness of neuropsychological rehabilitation in acquired brain injury (I): attention, processing speed, memory and language.
Abstract	Introduction: The consequences of acquired brain injury include impairments in cognition, emotion, and behaviour. Neuro-psychology provides techniques for treating these disorders, but it is still important to establish which of all the available tools are most effective for this purpose. Development: This article reviews existing studies on the effectiveness of neuropsychological rehabilitation, focusing on those areas more often impaired due to acquired brain injury. The purpose of the article is to guide and orient neuro-psychological rehabilitation of these patients based on the strongest evidence available in the literature. This paper focuses on cognitive domains such as attention and neglect, memory and language. Conclusion: There is enough evidence to recommend the neuropsychological rehabilitation of the above processes in patients with acquired brain injury.
MeSH term(s)	Attention/physiology ; Brain Injuries/physiopathology ; Brain Injuries/rehabilitation ; Cognition Disorders/physiopathology ; Cognition Disorders/rehabilitation ; Humans ; Language ; Memory/physiology ; Memory Disorders/physiopathology ; Memory Disorders/rehabilitation ; Neuropsychological Tests ; Psychomotor Performance/physiology ; Reaction Time/physiology
Language	Spanish
Publishing date	2010-12-01
Publishing country	Spain
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1468278-3
ISSN	1576-6578 ; 0210-0010
ISSN (online)	1576-6578
ISSN	0210-0010
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Article ; Online: Efectividad de la rehabilitación neuropsicológica en el daño cerebral adquirido (II): Funciones ejecutivas, modificación de conducta y psicoterapia, y uso de nuevas tecnologias.

de Noreña, David / Sánchez-Cubillo, Ignacio / García-Molina, Alberto / Tirapu-Ustárroz, Javier / Bombín-González, Igor / Ríos-Lago, Marcos

Revista de neurologia

2010 Volume 51, Issue 12, Page(s) 733–744

Abstract: Introduction: The consequences of acquired brain injury include impairments in cognition, emotion and behaviour. Neuro-psychology provides techniques for treating these disorders, but it is still important to establish which of all the available tools ... ...

Title translation	Effectiveness of neuropsychological rehabilitation in acquired brain injury (II): Executive functions, behavioural modification and psychotherapy, and the use of the new technologies.
Abstract	Introduction: The consequences of acquired brain injury include impairments in cognition, emotion and behaviour. Neuro-psychology provides techniques for treating these disorders, but it is still important to establish which of all the available tools are most effective for this purpose. Development: This article reviews existing studies on the effectiveness of neuropsychological rehabilitation, focusing on those areas more often affected after acquired brain injury. The purpose of the article is to guide and orient neuro-psychological rehabilitation of these patients based on the strongest evidence available in the literature. In this second part, we will focus on the rehabilitation of executive functions, the behaviour modification, and psychotherapy applied in this area, as well as the application of new technologies. Conclusion: There is enough evidence to recommend the neuropsychological rehabilitation of executive functions, and the application of the above mentioned tools in patients with acquired brain injury.
MeSH term(s)	Behavior Therapy ; Brain Injuries/physiopathology ; Brain Injuries/rehabilitation ; Executive Function ; Humans ; Psychotherapy
Language	Spanish
Publishing date	2010-12-16
Publishing country	Spain
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1468278-3
ISSN	1576-6578 ; 0210-0010
ISSN (online)	1576-6578
ISSN	0210-0010
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Article: Significance and meaning of neurological signs in schizophrenia: two decades later.

Bombin, Igor / Arango, Celso / Buchanan, Robert W

Schizophrenia bulletin

2005 Volume 31, Issue 4, Page(s) 962–977

Abstract: Objective: Patients with schizophrenia are characterized by neurological abnormalities, which can be assessed by bedside clinical examination. These abnormalities have been argued to represent core features of the illness. We review studies published ... ...

Abstract	Objective: Patients with schizophrenia are characterized by neurological abnormalities, which can be assessed by bedside clinical examination. These abnormalities have been argued to represent core features of the illness. We review studies published since our last review in 1988 that address the validity of neurological signs as a trait feature of schizophrenia. Methods: We conducted a literature search in the following computer databases: MEDLINE, PSYCHLIT, EMBASE, and COCHRANE. The search was limited to articles published from January 1988 to May 2005. Results: Neurological signs occur in the majority of patients with schizophrenia. Their occurrence is independent of demographic and most medication variables. Neurological signs are strongly associated with negative symptoms and cognitive impairments. There is also evidence to suggest that their occurrence is under genetic control. Conclusions: There is compelling evidence to suggest the hypothesis that neurological signs represent a trait feature of schizophrenia.
MeSH term(s)	Antipsychotic Agents/therapeutic use ; Cognition Disorders ; Demography ; Humans ; Magnetic Resonance Imaging ; Nervous System Diseases/etiology ; Phenotype ; Prognosis ; Risk Factors ; Schizophrenia/complications ; Social Class
Chemical Substances	Antipsychotic Agents
Language	English
Publishing date	2005-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
ZDB-ID	439173-1
ISSN	1745-1701 ; 0586-7614
ISSN (online)	1745-1701
ISSN	0586-7614
DOI	10.1093/schbul/sbi028
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Article ; Online: Premorbid adjustment and clinical correlates of cognitive impairment in first-episode psychosis. The PEPsCog Study.

Cuesta, Manuel J / Sánchez-Torres, Ana M / Cabrera, Bibiana / Bioque, Miquel / Merchán-Naranjo, Jessica / Corripio, Iluminada / González-Pinto, Ana / Lobo, Antonio / Bombín, Igor / de la Serna, Elena / Sanjuan, Julio / Parellada, Mara / Saiz-Ruiz, Jerónimo / Bernardo, Miquel

Schizophrenia research

2015 Volume 164, Issue 1-3, Page(s) 65–73

Abstract: Background: The extent to which socio-demographic, clinical, and premorbid adjustment variables contribute to cognitive deficits in first-episode schizophrenia spectrum disorders remains to be ascertained.: Aims: To examine the pattern and magnitude ... ...

Abstract	Background: The extent to which socio-demographic, clinical, and premorbid adjustment variables contribute to cognitive deficits in first-episode schizophrenia spectrum disorders remains to be ascertained. Aims: To examine the pattern and magnitude of cognitive impairment in first-episode psychosis patients, the profile of impairment across psychosis subtypes and the associations with premorbid adjustment. Methods: 226 first-episode psychosis patients and 225 healthy controls were assessed in the PEPsCog study, as part of the PEPs study. Results: Patients showed slight to moderate cognitive impairment, verbal memory being the domain most impaired compared to controls. Broad affective spectrum patients had better premorbid IQ and outperformed the schizophrenia and other psychosis groups in executive function, and had better global cognitive function than the schizophrenia group. Adolescent premorbid adjustment together with age, gender, parental socio-economic status, and mean daily antipsychotic doses were the factors that best explained patients' cognitive performance. General and adolescent premorbid adjustment, age and parental socio-economic status were the best predictors of cognitive performance in controls. Conclusions: Poorer premorbid adjustment together with socio-demographic factors and higher daily antipsychotic doses were related to a generalized cognitive impairment and to a lower premorbid intellectual reserve, suggesting that neurodevelopmental impairment was present before illness onset.
MeSH term(s)	Adolescent ; Adult ; Analysis of Variance ; Child ; Cognition Disorders/epidemiology ; Cognition Disorders/etiology ; Female ; Humans ; Male ; Neuropsychological Tests ; Psychiatric Status Rating Scales ; Psychotic Disorders/complications ; Psychotic Disorders/epidemiology ; Statistics as Topic ; Young Adult
Language	English
Publishing date	2015-05
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639422-x
ISSN	1573-2509 ; 0920-9964
ISSN (online)	1573-2509
ISSN	0920-9964
DOI	10.1016/j.schres.2015.02.022
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Article ; Online: Cognitive efficacy of quetiapine and olanzapine in early-onset first-episode psychosis.

Robles, Olalla / Zabala, Arantzazu / Bombín, Igor / Parellada, Mara / Moreno, Dolores / Ruiz-Sancho, Ana / Arango, Celso

Schizophrenia bulletin

2009 Volume 37, Issue 2, Page(s) 405–415

Abstract: The primary purpose of this study was to compare changes in cognition in early-onset psychosis after 6-months treatment with quetiapine or olanzapine. This is a randomized, single-blind, 6-month study in 50 adolescents with a diagnosis of early-onset ... ...

Abstract	The primary purpose of this study was to compare changes in cognition in early-onset psychosis after 6-months treatment with quetiapine or olanzapine. This is a randomized, single-blind, 6-month study in 50 adolescents with a diagnosis of early-onset psychosis. Patients were randomized to quetiapine (n = 24) or olanzapine (n =26). A thorough neuropsychological battery was administered at baseline and after 6-month treatment. Out of the total sample included in the study, 32 patients completed at least 6-months treatment with the assigned medication (quetiapine, n =16; olanzapine, n = 16). No changes were observed in cognitive performance after 6-month treatment with quetiapine or olanzapine. Although some trends toward cognitive improvement were observed for the olanzapine group after 6-month treatment, neither group showed statistically significant gains. Furthermore, there was no evidence of any differential efficacy of olanzapine or quetiapine on cognitive improvement in this sample of adolescents with psychosis.
MeSH term(s)	Adolescent ; Antipsychotic Agents/adverse effects ; Antipsychotic Agents/therapeutic use ; Benzodiazepines/adverse effects ; Benzodiazepines/therapeutic use ; Bipolar Disorder/diagnosis ; Bipolar Disorder/drug therapy ; Bipolar Disorder/psychology ; Cognition Disorders/diagnosis ; Cognition Disorders/drug therapy ; Cognition Disorders/psychology ; Dibenzothiazepines/adverse effects ; Dibenzothiazepines/therapeutic use ; Female ; Follow-Up Studies ; Humans ; Male ; Neuropsychological Tests/statistics & numerical data ; Olanzapine ; Psychometrics ; Psychotic Disorders/diagnosis ; Psychotic Disorders/drug therapy ; Psychotic Disorders/psychology ; Quetiapine Fumarate ; Schizophrenia/diagnosis ; Schizophrenia/drug therapy ; Schizophrenic Psychology ; Single-Blind Method ; Spain ; Treatment Outcome
Chemical Substances	Antipsychotic Agents ; Dibenzothiazepines ; Benzodiazepines (12794-10-4) ; Quetiapine Fumarate (2S3PL1B6UJ) ; Olanzapine (N7U69T4SZR)
Language	English
Publishing date	2009-08-25
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	439173-1
ISSN	1745-1701 ; 0586-7614
ISSN (online)	1745-1701
ISSN	0586-7614
DOI	10.1093/schbul/sbp062
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