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Article ; Online: Enhanced electrochemical treatment of humic acids and metal ions in leachate concentrate: Experimental and molecular mechanism investigations.

Hu, Peng / Li, Huankai / Tan, Yunkai / Adeleye, Adeyemi S / Hao, Tianwei

2023 Volume 462, Page(s) 132774

Abstract: Membrane technologies are effective for treating leachate, but they generate leachate concentrates (LCs), which contain elevated humic acids (HAs) and metals. LCs are very challenging and expensive to treat; but in-situ coagulation-electrochemical ... ...

Abstract	Membrane technologies are effective for treating leachate, but they generate leachate concentrates (LCs), which contain elevated humic acids (HAs) and metals. LCs are very challenging and expensive to treat; but in-situ coagulation-electrochemical oxidation (CO-EO) treatment is promising. We previously hypothesized and proved that substituting the widely used graphite cathode with an Al cathode will generate Al(OH)
Language	English
Publishing date	2023-10-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2023.132774
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A green approach to copper biodetoxification and sustainable agriculture application by vermicomposting in pig manure.

Zhou, Yong / Russel, Mohammad / Guo, Wenwei / Zheng, Zuhong / Hu, Chao / Li, Changchun / Li, Huankai

The Science of the total environment

2023 Volume 873, Page(s) 162329

Abstract: A green approach of copper (Cu) contaminated pig manure composting by earthworm Eisenia fetida was optimized. This work aims to assess the relationship between the bio-fertility properties and bioaccumulation of Cu during vermicomposting with five ... ...

Abstract	A green approach of copper (Cu) contaminated pig manure composting by earthworm Eisenia fetida was optimized. This work aims to assess the relationship between the bio-fertility properties and bioaccumulation of Cu during vermicomposting with five different doses of Cu. The optimal concentration of copper largely promoted the enrichment of nitrogen, phosphorus, and potassium, but the biological activities of earthworms could be inhibited once the Cu concentration exceed the threshold. When the Cu doses at 300 mg kg
MeSH term(s)	Swine ; Animals ; Copper/analysis ; Manure/microbiology ; Agriculture ; Oligochaeta/physiology ; Nitrogen ; Phosphorus ; Soil
Chemical Substances	Copper (789U1901C5) ; Manure ; Nitrogen (N762921K75) ; Phosphorus (27YLU75U4W) ; Soil
Language	English
Publishing date	2023-02-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.162329
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Article ; Online: A green approach to copper biodetoxification and sustainable agriculture application by vermicomposting in pig manure

Zhou, Yong / Russel, Mohammad / Guo, Wenwei / Zheng, Zuhong / Hu, Zhao / Li, Changchun / Li, Huankai

Science of the Total Environment. 2023 May, v. 873 p.162329-

2023

Abstract	A green approach of copper (Cu) contaminated pig manure composting by earthworm Eisenia fetida was optimized. This work aims to assess the relationship between the bio-fertility properties and bioaccumulation of Cu during vermicomposting with five different doses of Cu. The optimal concentration of copper largely promoted the enrichment of nitrogen, phosphorus, and potassium, but the biological activities of earthworms could be inhibited once the Cu concentration exceed the threshold. When the Cu doses at 300 mg kg⁻¹, the nutrient recovery rate (Iᵣₑcₒᵥₑᵣy) of available nitrogen, phosphorus and potassium reached their highest value, concomitant with largest C/N ratio reduced at 46.01 %. Moreover, nutrients recovery mechanism of total phosphorus increased up to 0.11 % h⁻¹ and higher bioaccumulations in faces and intestine were detected by 1.79 and 0.99, respectively, during vermicomposting. The maximal enzyme activity rates (kₘₐₓ) indicate that the enzyme activities, such as ROS and SOD, are sensitive bioindicators, which can be used to estimate the stress response of earthworms and Cu biotoxicity. The maximum specific growth rate (μₘₐₓ) of the actinomycetes (TAcₜ) increased gradually from 0.02 to 0.04 with the increase of Cu doses, but total fungi (TF) showed different response to μₘₐₓ, which decreased firstly and then increased. It was demonstrated that Cu influenced the gut microbial community to vary the bio-fertility properties and bioaccumulation of Cu in the pig manure. All the findings refer that the vermicomposting could be the sustainable agricultural practices.
Keywords	Eisenia fetida ; bioaccumulation ; copper ; earthworms ; environment ; enzyme activity ; enzymes ; intestinal microorganisms ; intestines ; microbial communities ; nitrogen ; phosphorus ; pig manure ; potassium ; specific growth rate ; stress response ; sustainable agriculture ; total phosphorus ; vermicomposting
Language	English
Dates of publication	2023-05
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.162329
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Article ; Online: A simple method to generate arbitrary laser shapes for stimulated Raman adiabatic passage.

Ming, Hu / Wang, Yaning / Zhu, Lingxiao / Wang, Guochao / Jia, Aiai / Li, Qixue / Zhang, Xu / Zhang, Huankai / Yan, Shuhua / Yang, Jun

The Review of scientific instruments

2021 Volume 92, Issue 6, Page(s) 63206

Abstract: Stimulated Raman adiabatic passage (STIRAP) is an effective technique to transfer state coherently with the features of both high fidelity and robustness in the field of quantum information and quantum precise measurement. In this note, we present a ... ...

Abstract	Stimulated Raman adiabatic passage (STIRAP) is an effective technique to transfer state coherently with the features of both high fidelity and robustness in the field of quantum information and quantum precise measurement. In this note, we present a simple method to generate arbitrary laser shapes for STIRAP by controlling the modulation depth of the electro-optic modulator (EOM) and the diffraction efficiency of the acoustic-optic modulator (AOM) simultaneously. The EOM and AOM are used to control the power ratio between the two Raman lasers (pumping laser and Stokes laser) and the total power, respectively. Compared with the traditional method by combining two Raman lasers separated in space, this method has the advantage of simple structure and insensitivity to the environment disturbance, which would degrade the relative phase noise between two Raman lasers.
Language	English
Publishing date	2021-07-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0055161
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Article ; Online: Measuring the phase noise of Raman lasers with an atom-based method.

Wang, Yaning / Yan, Shuhua / Xu, Dongyang / Hu, Mei / Li, Qixue / Zhang, Xu / Zhang, Huankai / Lv, Mengjie / Jia, Aiai / Wang, Guochao / Zhu, Lingxiao / Yang, Jun

The Review of scientific instruments

2021 Volume 92, Issue 3, Page(s) 33203

Abstract: Phase noise of Raman lasers is a major source of noise for a Raman-type cold atom interferometer, which is traditionally measured using the signal source analyzer. We report here an atom-based method to measure the phase noise performance between two ... ...

Abstract	Phase noise of Raman lasers is a major source of noise for a Raman-type cold atom interferometer, which is traditionally measured using the signal source analyzer. We report here an atom-based method to measure the phase noise performance between two Raman lasers. By analyzing and calibrating the system noise sources, we can characterize the contribution of phase noise from the total deviation of the relative atom population at the middle of the interference fringe. Knowing the transfer function specified by the operation sequence of the interferometer, we can obtain the transfer function and power spectrum density of the phase noise term. By varying the time sequences of the interferometer, we can measure the white phase noise floor and the phase noise performance over a large range of Fourier frequencies from 1 to 100 000 Hz with a minor difference of 1 dB compared with results from the traditional method using a signal analyzer, which proves the validity of the atom-based method. Compared with the traditional measurement method, the atom-based method can have higher accuracy and have the ability of self-calibrating.
Language	English
Publishing date	2021-04-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0037422
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Article ; Online: Shape Memory-Enhanced Electrical Self-Healing of Stretchable Electrodes

Hongsheng Luo / Huaquan Wang / Huankai Zhou / Xingdong Zhou / Jinlian Hu / Guobin Yi / Zhifeng Hao / Wenjing Lin

Applied Sciences, Vol 8, Iss 3, p

2018 Volume 392

Abstract: A novel shape memory-based self-healable stretchable electrode was explored by embedding the silver nanowires (AgNWs) network into a healable polymer matrix. Unlike the traditional shape memory-assisted self-healing, pre-stretching to the temporary ... ...

Abstract	A novel shape memory-based self-healable stretchable electrode was explored by embedding the silver nanowires (AgNWs) network into a healable polymer matrix. Unlike the traditional shape memory-assisted self-healing, pre-stretching to the temporary shapes, which was fixed in a typical shape, memory thermo-mechanical programming significantly enhanced the thermo-triggered healing performance. The morphological as well as conduction variations during the healing process were investigated. The enhancing effect of the pre-stretching on the healing efficiency was emphasized, which was expected to attribute to the release of the pre-stored strain energy driving the closure of the scratch. The findings disclosed how to utilize the shape memory effect to improve the biomimetic properties for the stretchable electrodes, which may greatly benefit the application of the intelligent polymers in the field of multi-functional flexible electronics.
Keywords	shape memory polymers ; conductive ; self-healing ; stretching ; enhanced ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Language	English
Publishing date	2018-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Intraductal papillary mucinous neoplasm causing recurrent acute pancreatitis, necrotizing pancreatitis, and multifocal adenocarcinoma.

Warndorf, Matthew / Hu, Huankai / Papachristou, Georgios / Zureikat, Amer / Dasyam, Anil / Yadav, Dhiraj

Gastrointestinal endoscopy

2014 Volume 80, Issue 6, Page(s) 1181–2; discussion 1182

MeSH term(s)	Adenocarcinoma/etiology ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery ; Female ; Humans ; Middle Aged ; Necrosis/etiology ; Neoplasms, Cystic, Mucinous, and Serous/complications ; Neoplasms, Cystic, Mucinous, and Serous/diagnosis ; Neoplasms, Cystic, Mucinous, and Serous/surgery ; Neoplasms, Second Primary/etiology ; Neoplasms, Second Primary/pathology ; Neoplasms, Second Primary/surgery ; Pancreatic Neoplasms/complications ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/surgery ; Pancreatitis/etiology ; Recurrence
Language	English
Publishing date	2014-12
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	391583-9
ISSN	1097-6779 ; 0016-5107
ISSN (online)	1097-6779
ISSN	0016-5107
DOI	10.1016/j.gie.2014.09.022
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Zs.B 283: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 519: Show issues

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Article ; Online: Development of pyruvate dehydrogenase kinase inhibitors in medicinal chemistry with particular emphasis as anticancer agents.

Zhang, Shao-Lin / Hu, Xiaohui / Zhang, Wen / Yao, Huankai / Tam, Kin Yip

Drug discovery today

2015 Volume 20, Issue 9, Page(s) 1112–1119

Abstract: Many cancer cells demonstrate a high rate of glucose consumption via glycolysis to provide intermediates for macromolecule biosynthesis. To accomplish this metabolic change, the expression of pyruvate dehydrogenase kinases (PDKs) is rapidly increased in ... ...

Abstract	Many cancer cells demonstrate a high rate of glucose consumption via glycolysis to provide intermediates for macromolecule biosynthesis. To accomplish this metabolic change, the expression of pyruvate dehydrogenase kinases (PDKs) is rapidly increased in cancer cells. Inhibition of PDKs could promote the function of mitochondria by increasing the oxidative metabolism of pyruvate, resulting in the death of cancer cells. In this review, we provide an overview of the structural information available for PDKs and their connections to known therapeutic effects. We then describe the development of small molecule PDK inhibitors in medicinal chemistry with particular emphasis as anticancer agents. Finally, directions for further development of PDK inhibitors as potential anticancer agents are discussed.
MeSH term(s)	Antineoplastic Agents/pharmacology ; Chemistry, Pharmaceutical/methods ; Drug Design ; Glucose/metabolism ; Glycolysis/physiology ; Humans ; Mitochondria/drug effects ; Neoplasms/drug therapy ; Neoplasms/enzymology ; Protein Kinase Inhibitors/pharmacology ; Protein-Serine-Threonine Kinases/antagonists & inhibitors
Chemical Substances	Antineoplastic Agents ; Protein Kinase Inhibitors ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; pyruvate dehydrogenase (acetyl-transferring) kinase (EC 2.7.11.2) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2015-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1324988-5
ISSN	1878-5832 ; 1359-6446
ISSN (online)	1878-5832
ISSN	1359-6446
DOI	10.1016/j.drudis.2015.03.012
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4725: Show issues

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Article ; Online: Significance of Notch1-signaling pathway in human pancreatic development and carcinogenesis.

Hu, Huankai / Zhou, Lan / Awadallah, Amad / Xin, Wei

Applied immunohistochemistry & molecular morphology : AIMM

2012 Volume 21, Issue 3, Page(s) 242–247

Abstract: In animal studies, Notch1-signaling pathway plays an important role in the pancreatic embryogenesis by promoting pancreatic progenitor cells self-renewal and exocrine linage development. The persistent activation of Notch pathway could arrest the organ ... ...

Abstract	In animal studies, Notch1-signaling pathway plays an important role in the pancreatic embryogenesis by promoting pancreatic progenitor cells self-renewal and exocrine linage development. The persistent activation of Notch pathway could arrest the organ development and keep cells at an undifferentiated stage. Studies have shown that Notch1-signaling pathway is upregulated in invasive pancreatic ductal adenocarcinoma (PDAC). Here we examined the expression pattern of Notch1 and Hes1 in human fetal pancreatic tissues to elucidate the role of Notch1 in human pancreatic embryonic development. We also compared Notch1 expression in tissues from PDAC, chronic pancreatitis and pancreatic intraepithelial neoplasm. Our data show that Notch1/Hes1-signaling pathway is activated during early pancreatic embryogenesis and reaches the highest at birth. After pancreas is fully developed, Notch1/Hes1 pathway is inactivated even though Notch1 protein cell-surface expression is upregulated. We also showed that the expression of both Notch1 and Hes1 are present in 50% (33/66) of PDACs, but not in pancreatic intraepithelial neoplasms. These findings indicate that Notch1 activation is only apparent in late stage of pancreatic carcinogenesis, suggesting that treatment with Notch-signaling inhibitors including γ-secretase should be selectively used for PDACs with confirmed Notch1-signaling activation.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Carcinoma in Situ/genetics ; Carcinoma in Situ/metabolism ; Carcinoma in Situ/pathology ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Child ; Child, Preschool ; Embryonic Development ; Female ; Fetus ; Gene Expression Regulation, Developmental ; Gene Expression Regulation, Neoplastic ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; Humans ; Infant ; Male ; Middle Aged ; Pancreas/embryology ; Pancreas/metabolism ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Pancreatitis, Chronic/genetics ; Pancreatitis, Chronic/metabolism ; Pancreatitis, Chronic/pathology ; Pregnancy ; Receptor, Notch1/genetics ; Receptor, Notch1/metabolism ; Signal Transduction ; Transcription Factor HES-1
Chemical Substances	Basic Helix-Loop-Helix Transcription Factors ; Homeodomain Proteins ; NOTCH1 protein, human ; Receptor, Notch1 ; Transcription Factor HES-1 ; HES1 protein, human (149348-15-2)
Language	English
Publishing date	2012-12-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1473273-7
ISSN	1533-4058 ; 1062-3345 ; 1541-2016
ISSN (online)	1533-4058
ISSN	1062-3345 ; 1541-2016
DOI	10.1097/PAI.0b013e3182655ab7
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Zs.A 3783: Show issues

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Article ; Online: Perspectives on current tumor-node-metastasis (TNM) staging of cancers of the colon and rectum.

Hu, Huankai / Krasinskas, Alyssa / Willis, Joseph

Seminars in oncology

2011 Volume 38, Issue 4, Page(s) 500–510

Abstract: Improvements in classifications of cancers based on discovery and validation of important histopathological parameters and new molecular markers continue unabated. Though still not perfect, recent updates of classification schemes in gastrointestinal ... ...

Abstract	Improvements in classifications of cancers based on discovery and validation of important histopathological parameters and new molecular markers continue unabated. Though still not perfect, recent updates of classification schemes in gastrointestinal oncology by the American Joint Commission on Cancer (tumor-node-metastasis [TNM] staging) and the World Health Organization further stratify patients and guide optimization of treatment strategies and better predict patient outcomes. These updates recognize the heterogeneity of patient populations with significant subgrouping of each tumor stage and use of tumor deposits to significantly "up-stage" some cancers; change staging parameters for subsets of IIIB and IIIC cancers; and introduce of several new subtypes of colon carcinomas. By the nature of the process, recent discoveries that are important to improving even routine standards of patient care, especially new advances in molecular medicine, are not incorporated into these systems. Nonetheless, these classifications significantly advance clinical standards and are welcome enhancements to our current methods of cancer reporting.
MeSH term(s)	Carcinoma/diagnosis ; Carcinoma/pathology ; Colonic Neoplasms/diagnosis ; Colonic Neoplasms/pathology ; Humans ; Lymph Nodes/pathology ; Lymphatic Metastasis ; Neoplasm Staging/methods ; Neoplasm Staging/trends ; Prognosis ; Rectal Neoplasms/diagnosis ; Rectal Neoplasms/pathology ; Registries ; Research Design
Language	English
Publishing date	2011-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	189220-4
ISSN	1532-8708 ; 0093-7754
ISSN (online)	1532-8708
ISSN	0093-7754
DOI	10.1053/j.seminoncol.2011.05.004
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