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  1. Article: [Therapeutic Strategy for Multiple Sclerosis Resistant to Standard Treatment: Refractory MS].

    Takeuchi, Hideyuki

    Brain and nerve = Shinkei kenkyu no shinpo

    2022  Volume 74, Issue 5, Page(s) 485–489

    Abstract: In Japan, disease-modifying drugs for multiple sclerosis have amounted to eight, to date, providing us with various therapeutic choices. However, we still encounter difficult cases resistant to these drugs. This review summarizes the diagnostic and ... ...

    Abstract In Japan, disease-modifying drugs for multiple sclerosis have amounted to eight, to date, providing us with various therapeutic choices. However, we still encounter difficult cases resistant to these drugs. This review summarizes the diagnostic and therapeutic strategies for refractory multiple sclerosis by presenting suggestive cases.
    MeSH term(s) Humans ; Japan ; Multiple Sclerosis/diagnosis
    Language Japanese
    Publishing date 2022-05-16
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416202069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 398: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: [Acute Neuro-Behçet's Disease].

    Takeuchi, Hideyuki

    Brain and nerve = Shinkei kenkyu no shinpo

    2021  Volume 73, Issue 5, Page(s) 560–567

    Abstract: Neuro-Behçet's disease accounts for 10-20% cases of Behçet's disease, and patients manifest neurological symptoms due to parenchymal inflammation in the central nervous system. Neuro-Behçet's disease is classified into two types (acute and chronic ... ...

    Abstract Neuro-Behçet's disease accounts for 10-20% cases of Behçet's disease, and patients manifest neurological symptoms due to parenchymal inflammation in the central nervous system. Neuro-Behçet's disease is classified into two types (acute and chronic progressive) based on clinical symptoms and therapeutic responsiveness. This review aimed to summarize the acute type of neuro-Behçet's disease according to the guidelines of the Japanese Behçet's Disease Research Committee.
    MeSH term(s) Acute Disease ; Behcet Syndrome/diagnosis ; Behcet Syndrome/drug therapy ; Central Nervous System ; Humans ; Magnetic Resonance Imaging
    Language Japanese
    Publishing date 2021-05-18
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 390389-8
    ISSN 1344-8129 ; 1881-6096 ; 0006-8969
    ISSN (online) 1344-8129
    ISSN 1881-6096 ; 0006-8969
    DOI 10.11477/mf.1416201799
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 398: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Special Issue: New Insights into Protein Glycosylation.

    Kurebayashi, Yuuki / Takeuchi, Hideyuki

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 7

    Abstract: Protein glycosylation is a general post-translational modification pathway that controls various biological functions including protein trafficking, cell adhesion, and protein-ligand interaction [ ... ]. ...

    Abstract Protein glycosylation is a general post-translational modification pathway that controls various biological functions including protein trafficking, cell adhesion, and protein-ligand interaction [...].
    MeSH term(s) Glycosylation ; Protein Processing, Post-Translational ; Protein Transport ; Cell Adhesion
    Language English
    Publishing date 2023-04-06
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28073263
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  4. Article ; Online: Special Issue

    Yuuki Kurebayashi / Hideyuki Takeuchi

    Molecules, Vol 28, Iss 3263, p

    New Insights into Protein Glycosylation

    2023  Volume 3263

    Abstract: Protein glycosylation is a general post-translational modification pathway that controls various biological functions including protein trafficking, cell adhesion, and protein-ligand interaction [.] ...

    Abstract Protein glycosylation is a general post-translational modification pathway that controls various biological functions including protein trafficking, cell adhesion, and protein-ligand interaction [.]
    Keywords n/a ; Organic chemistry ; QD241-441
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Significant Roles of Notch

    Wang, Weiwei / Okajima, Tetsuya / Takeuchi, Hideyuki

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 6

    Abstract: Notch signaling, which was initially identified ... ...

    Abstract Notch signaling, which was initially identified in
    MeSH term(s) Animals ; Fucose/chemistry ; Glycosylation ; N-Acetylglucosaminyltransferases/metabolism ; Neoplasms ; Receptors, Notch/metabolism
    Chemical Substances Receptors, Notch ; Fucose (28RYY2IV3F) ; N-Acetylglucosaminyltransferases (EC 2.4.1.-)
    Language English
    Publishing date 2022-03-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27061783
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  6. Article ; Online: Two-stage endoscopic resection of a huge duodenal tumor.

    Takeuchi, Nao / Ohata, Ken / Chiba, Hideyuki

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

    2022  Volume 35, Issue 3, Page(s) e39–e40

    MeSH term(s) Humans ; Duodenal Neoplasms/diagnostic imaging ; Duodenal Neoplasms/surgery ; Duodenal Neoplasms/pathology ; Endoscopy ; Duodenoscopy ; Treatment Outcome ; Endoscopic Mucosal Resection ; Retrospective Studies
    Language English
    Publishing date 2022-12-27
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1171589-3
    ISSN 1443-1661 ; 0915-5635
    ISSN (online) 1443-1661
    ISSN 0915-5635
    DOI 10.1111/den.14495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3854: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Other Types of Glycosylation.

    Tsukamoto, Yohei / Takeuchi, Hideyuki

    Advances in experimental medicine and biology

    2021  Volume 1325, Page(s) 117–135

    Abstract: O-Linked glycosylation such as O-fucose, O-glucose, and O-N-acetylglucosamine are considered to be unusual. As suggested by the high levels of evolutional conservation, these O-glycans are fundamentally important for life. In the last two decades, our ... ...

    Abstract O-Linked glycosylation such as O-fucose, O-glucose, and O-N-acetylglucosamine are considered to be unusual. As suggested by the high levels of evolutional conservation, these O-glycans are fundamentally important for life. In the last two decades, our understanding of the importance of these glycans has greatly advanced. In particular, identification of the glycosyltransferases responsible for the biosynthesis of these glycans has accelerated basic research on the functional significance and molecular mechanisms by which these O-glycans regulate protein functions as well as clinical research on human diseases due to changes in these types of O-glycosylation. Notably, Notch receptor signaling is modified with and regulated by these types of O-glycans. Here, we summarize the current view of the structures and the significance of these O-glycans mainly in the context of Notch signaling regulation and human diseases.
    MeSH term(s) Fucose ; Glucose ; Glycosylation ; Humans ; Polysaccharides ; Receptors, Notch/metabolism ; Signal Transduction
    Chemical Substances Polysaccharides ; Receptors, Notch ; Fucose (28RYY2IV3F) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2021-09-08
    Publishing country United States
    Document type Journal Article
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-030-70115-4_5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Transcriptome analysis reveals limited toxic effects of the UV-filter benzophenone-3 (BP-3) on the hermatypic coral Acropora tenuis and its symbiotic dinoflagellates.

    Ishibashi, Hiroshi / Nishimura, Saori / Tanaka, Kokoro / Haruta, Shinsuke / Takayama, Kotaro / Yamashiro, Hideyuki / Takeuchi, Ichiro

    Marine pollution bulletin

    2024  Volume 201, Page(s) 116260

    Abstract: This study aimed to investigate the toxic and transcriptomic effects of the ultraviolet filter benzophenone-3 (BP-3) on Acropora tenuis and its symbiotic dinoflagellates while using acetone as a solvent. Seven-day exposure to 50 and 500 μg/L, which is ... ...

    Abstract This study aimed to investigate the toxic and transcriptomic effects of the ultraviolet filter benzophenone-3 (BP-3) on Acropora tenuis and its symbiotic dinoflagellates while using acetone as a solvent. Seven-day exposure to 50 and 500 μg/L, which is higher than most BP-3 records from coastal waters, did not affect coral colour or dinoflagellate photosynthesis. Differentially expressed genes (DEGs) between seawater and solvent controls were <20 in both corals and dinoflagellates. Eleven coral DEGs were detected after treatment with 50 μg/L BP-3. Fourteen coral DEGs, including several fluorescent protein genes, were detected after treatment with 500 μg/L BP-3. In contrast, no dinoflagellate DEGs were detected in the BP-3 treatment group. These results suggest that the effects of 50-500 μg/L BP-3 on adult A. tenuis and its dinoflagellates are limited. Our experimental methods with lower acetone toxicity provide a basis for establishing standard ecotoxicity tests for corals.
    MeSH term(s) Animals ; Anthozoa ; Dinoflagellida/genetics ; Acetone/metabolism ; Acetone/pharmacology ; Gene Expression Profiling ; Transcriptome ; Symbiosis ; Solvents ; Coral Reefs ; Benzophenones
    Chemical Substances oxybenzone (95OOS7VE0Y) ; Acetone (1364PS73AF) ; Solvents ; Benzophenones
    Language English
    Publishing date 2024-03-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001296-2
    ISSN 1879-3363 ; 0025-326X
    ISSN (online) 1879-3363
    ISSN 0025-326X
    DOI 10.1016/j.marpolbul.2024.116260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: [Significance of O-glycosylation in Notch signaling].

    Takeuchi, Hideyuki

    Seikagaku. The Journal of Japanese Biochemical Society

    2015  Volume 87, Issue 4, Page(s) 459–462

    MeSH term(s) Animals ; Cell Membrane/metabolism ; Epidermal Growth Factor/metabolism ; Glycosylation ; Humans ; Receptors, Notch/metabolism ; Signal Transduction/physiology
    Chemical Substances Receptors, Notch ; Epidermal Growth Factor (62229-50-9)
    Language Japanese
    Publishing date 2015-08
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 282319-6
    ISSN 0037-1017
    ISSN 0037-1017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 592: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  10. Article ; Online: Current Views on the Roles of

    Saiki, Wataru / Ma, Chenyu / Okajima, Tetsuya / Takeuchi, Hideyuki

    Biomolecules

    2021  Volume 11, Issue 2

    Abstract: The 100th anniversary of Notch discovery ... ...

    Abstract The 100th anniversary of Notch discovery in
    MeSH term(s) Animals ; Glycosylation ; Humans ; Mass Spectrometry ; Protein Binding ; Receptors, Notch/genetics ; Receptors, Notch/metabolism
    Chemical Substances Receptors, Notch
    Language English
    Publishing date 2021-02-18
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom11020309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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