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Article ; Online: Impact of COVID-19 on American Family Physicians' Intent to Retreat from Clinical Care.

Brazeau, Chantal M L R / Chen, Ping-Hsin / Morley, Christopher P / Olson, Kristine

Journal of the American Board of Family Medicine : JABFM

2024 Volume 36, Issue 6, Page(s) 905–915

Abstract: Purpose: This survey evaluated whether the COVID-19 pandemic was a traumatic stress event for family physicians associated with burnout, changes in life priorities, and intentions to retreat from clinical practice.: Methods: We report on 683 ... ...

Abstract	Purpose: This survey evaluated whether the COVID-19 pandemic was a traumatic stress event for family physicians associated with burnout, changes in life priorities, and intentions to retreat from clinical practice. Methods: We report on 683 clinically active family physicians surveyed through the Council of Academic Family Medicine's Educational Research Alliance (CERA) in the fall of 2021. Results: Overall, 35.2% of family physicians experienced the pandemic as a traumatic stress like event. This was associated with changing life priorities (OR 2.6, CI 1.8-3.9), burnout (OR 1.6, CI 1.1 to 2.4), and withdrawal from clinical practice in various ways. Those who changed their priorities in life were more likely to restrict scope of practice (OR 3.9, CI 2.6-5.9), reduce clinical work effort (OR 3.4, 2.3 to 5.1), relocate (OR 3.1, CI 2.0 to 4.8), retire (OR 2.7, CI 1.4-4.9), reroute their career away from patient care (OR 2.1, CI 1.4-3.1) and less likely to avoid redesigning the practice to improve well-being (OR 0.3, CI 0.2-0.7). Those who experienced burnout were more likely to retire (OR 5.5, CI 2.8 to 10.5), reduce clinical work effort (OR 4.2, CI 2.9-6.1), reroute their career away from patient care (OR 3.9, CI 2.6-5.8), relocate (OR 3.8, CI 2.4 to 5.9), and restrict scope of practice (OR 3.3, CI 2.3 to 4.9). Overall, 48.5% of family physicians expressed some intention to retreat from clinical practice. Conclusion: The COVID-19 pandemic impacted family physician's career plans. Remedying burnout is a high-yield opportunity for retaining clinically active family physicians. Physicians retreating from clinical medicine related to changing life's priorities needs further exploration.
MeSH term(s)	Humans ; United States/epidemiology ; Physicians, Family ; Intention ; COVID-19/epidemiology ; Pandemics ; Burnout, Professional/epidemiology ; Surveys and Questionnaires
Language	English
Publishing date	2024-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2239939-2
ISSN	1558-7118 ; 1557-2625
ISSN (online)	1558-7118
ISSN	1557-2625
DOI	10.3122/jabfm.2023.230156R1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The vocal organ of hummingbirds shows convergence with songbirds.

Riede, Tobias / Olson, Christopher R

Scientific reports

2020 Volume 10, Issue 1, Page(s) 2007

Abstract: How sound is generated in the hummingbird syrinx is largely unknown despite their complex vocal behavior. To fill this gap, syrinx anatomy of four North American hummingbird species were investigated by histological dissection and contrast-enhanced ... ...

Abstract	How sound is generated in the hummingbird syrinx is largely unknown despite their complex vocal behavior. To fill this gap, syrinx anatomy of four North American hummingbird species were investigated by histological dissection and contrast-enhanced microCT imaging, as well as measurement of vocalizations in a heliox atmosphere. The placement of the hummingbird syrinx is uniquely located in the neck rather than inside the thorax as in other birds, while the internal structure is bipartite with songbird-like anatomical features, including multiple pairs of intrinsic muscles, a robust tympanum and several accessory cartilages. Lateral labia and medial tympaniform membranes consist of an extracellular matrix containing hyaluronic acid, collagen fibers, but few elastic fibers. Their upper vocal tract, including the trachea, is shorter than predicted for their body size. There are between-species differences in syrinx measurements, despite similar overall morphology. In heliox, fundamental frequency is unchanged while upper-harmonic spectral content decrease in amplitude, indicating that syringeal sounds are produced by airflow-induced labia and membrane vibration. Our findings predict that hummingbirds have fine control of labia and membrane position in the syrinx; adaptations that set them apart from closely related swifts, yet shows convergence in their vocal organs with those of oscines.
MeSH term(s)	Animals ; Biological Evolution ; Elastic Tissue/anatomy & histology ; Elastic Tissue/diagnostic imaging ; Elastic Tissue/physiology ; Female ; Male ; Muscles/anatomy & histology ; Muscles/diagnostic imaging ; Muscles/physiology ; Songbirds/anatomy & histology ; Songbirds/physiology ; Trachea/anatomy & histology ; Trachea/diagnostic imaging ; Trachea/physiology ; Vocalization, Animal/physiology ; X-Ray Microtomography
Language	English
Publishing date	2020-02-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-58843-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Development and performance of a multiplex PCR assay for the detection of bacteria in sterile body fluids.

Johnson, Coreen / Marquez, Christopher / Olson, Damon / Ward, Tabitha / Cheney, Stephen / Hulten, Tina / Ton, Trang / Webb, C R / Dunn, James

Future microbiology

2023 Volume 18, Page(s) 187–195

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Child ; Humans ; Multiplex Polymerase Chain Reaction ; Methicillin-Resistant Staphylococcus aureus ; Body Fluids ; Streptococcus pyogenes/genetics ; Streptococcus pneumoniae
Language	English
Publishing date	2023-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2254620-0
ISSN	1746-0921 ; 1746-0913
ISSN (online)	1746-0921
ISSN	1746-0913
DOI	10.2217/fmb-2022-0226
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Shifting limitation of primary production: experimental support for a new model in lake ecosystems.

Olson, Carly R / Solomon, Christopher T / Jones, Stuart E

Ecology letters

2020 Volume 23, Issue 12, Page(s) 1800–1808

Abstract: The limits on primary production vary in complex ways across space and time. Strong tests of clear conceptual models have been instrumental in understanding these patterns in both terrestrial and aquatic ecosystems. Here we present the first experimental ...

Abstract	The limits on primary production vary in complex ways across space and time. Strong tests of clear conceptual models have been instrumental in understanding these patterns in both terrestrial and aquatic ecosystems. Here we present the first experimental test of a new model describing how shifts from nutrient to light limitation control primary productivity in lake ecosystems as hydrological inputs of nutrients and organic matter vary. We found support for two key predictions of the model: that gross primary production (GPP) follows a hump-shaped relationship with increasing dissolved organic carbon (DOC) concentrations; and that the maximum GPP, and the critical DOC concentration at which the hump occurs, are determined by the stoichiometry and chromophoricity of the hydrological inputs. Our results advance fundamental understanding of the limits on aquatic primary production, and have important applications given ongoing anthropogenic alterations of the nutrient and organic matter inputs to surface waters.
MeSH term(s)	Carbon ; Ecosystem ; Lakes ; Nutrients
Chemical Substances	Carbon (7440-44-0)
Language	English
Publishing date	2020-09-18
Publishing country	England
Document type	Letter
ZDB-ID	1441608-6
ISSN	1461-0248 ; 1461-023X
ISSN (online)	1461-0248
ISSN	1461-023X
DOI	10.1111/ele.13606
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Article ; Online: Implementation and prospective real-time evaluation of a generalized system for in-clinic deployment and validation of machine learning models in radiology.

Hawkins, James R / Olson, Marram P / Harouni, Ahmed / Qin, Ming Melvin / Hess, Christopher P / Majumdar, Sharmila / Crane, Jason C

PLOS digital health

2023 Volume 2, Issue 8, Page(s) e0000227

Abstract: The medical imaging community has embraced Machine Learning (ML) as evidenced by the rapid increase in the number of ML models being developed, but validating and deploying these models in the clinic remains a challenge. The engineering involved in ... ...

Abstract	The medical imaging community has embraced Machine Learning (ML) as evidenced by the rapid increase in the number of ML models being developed, but validating and deploying these models in the clinic remains a challenge. The engineering involved in integrating and assessing the efficacy of ML models within the clinical workflow is complex. This paper presents a general-purpose, end-to-end, clinically integrated ML model deployment and validation system implemented at UCSF. Engineering and usability challenges and results from 3 use cases are presented. A generalized validation system based on free, open-source software (OSS) was implemented, connecting clinical imaging modalities, the Picture Archiving and Communication System (PACS), and an ML inference server. ML pipelines were implemented in NVIDIA's Clara Deploy framework with results and clinician feedback stored in a customized XNAT instance, separate from the clinical record but linked from within PACS. Prospective clinical validation studies of 3 ML models were conducted, with data routed from multiple clinical imaging modalities and PACS. Completed validation studies provided expert clinical feedback on model performance and usability, plus system reliability and performance metrics. Clinical validation of ML models entails assessing model performance, impact on clinical infrastructure, robustness, and usability. Study results must be easily accessible to participating clinicians but remain outside the clinical record. Building a system that generalizes and scales across multiple ML models takes the concerted effort of software engineers, clinicians, data scientists, and system administrators, and benefits from the use of modular OSS. The present work provides a template for institutions looking to translate and clinically validate ML models in the clinic, together with required resources and expected challenges.
Language	English
Publishing date	2023-08-21
Publishing country	United States
Document type	Journal Article
ISSN	2767-3170
ISSN (online)	2767-3170
DOI	10.1371/journal.pdig.0000227
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Involvement in Alcoholics Anonymous Scale - Short Form: Factor Structure & Validation.

Beasley, Christopher R / LaBelle, Onawa / Vest, Noel / Olson, Bradley / Skinner, Michael D / Ferrari, Joseph R / Jason, Leonard A

Substance use & misuse

2022 Volume 58, Issue 1, Page(s) 119–128

Abstract: ... ...

Abstract	Background
MeSH term(s)	Adult ; Humans ; United States ; Alcoholics Anonymous ; Alcoholism/diagnosis ; Cross-Sectional Studies ; Psychometrics ; Reproducibility of Results
Language	English
Publishing date	2022-12-06
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1310358-1
ISSN	1532-2491 ; 1082-6084
ISSN (online)	1532-2491
ISSN	1082-6084
DOI	10.1080/10826084.2022.2149245
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Article: Nitro-benzylideneoxymorphone, a bifunctional mu and delta opioid receptor ligand with high mu opioid receptor efficacy.

Olson, Keith M / Devereaux, Andrea L / Chatterjee, Payal / Saldaña-Shumaker, Savanah L / Shafer, Amanda / Plotkin, Adam / Kandasamy, Ram / MacKerell, Alexander D / Traynor, John R / Cunningham, Christopher W

Frontiers in pharmacology

2023 Volume 14, Page(s) 1230053

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-07-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1230053
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Recent Development of the Molecular and Cellular Mechanisms of Hydrogen Sulfide Gasotransmitter.

Liu, Jianyun / Mesfin, Fikir M / Hunter, Chelsea E / Olson, Kenneth R / Shelley, W Christopher / Brokaw, John P / Manohar, Krishna / Markel, Troy A

Antioxidants (Basel, Switzerland)

2022 Volume 11, Issue 9

Abstract: Hydrogen sulfide has been recently identified as the third biological gasotransmitter, along with the more well studied nitric oxide (NO) and carbon monoxide (CO). Intensive studies on its potential as a therapeutic agent for cardiovascular, inflammatory, ...

Abstract	Hydrogen sulfide has been recently identified as the third biological gasotransmitter, along with the more well studied nitric oxide (NO) and carbon monoxide (CO). Intensive studies on its potential as a therapeutic agent for cardiovascular, inflammatory, infectious and neuropathological diseases have been undertaken. Here we review the possible direct targets of H
Language	English
Publishing date	2022-09-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2704216-9
ISSN	2076-3921
ISSN	2076-3921
DOI	10.3390/antiox11091788
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Wildfires Increase Concentrations of Hazardous Air Pollutants in Downwind Communities.

Rice, R Byron / Boaggio, Katie / Olson, Nicole E / Foley, Kristen M / Weaver, Christopher P / Sacks, Jason D / McDow, Stephen R / Holder, Amara L / LeDuc, Stephen D

Environmental science & technology

2023 Volume 57, Issue 50, Page(s) 21235–21248

Abstract: Due in part to climate change, wildfire activity is increasing, with the potential for greater public health impact from smoke in downwind communities. Studies examining the health effects of wildfire smoke have focused primarily on fine particulate ... ...

Abstract	Due in part to climate change, wildfire activity is increasing, with the potential for greater public health impact from smoke in downwind communities. Studies examining the health effects of wildfire smoke have focused primarily on fine particulate matter (PM
MeSH term(s)	Acetaldehyde ; Acrolein ; Air Pollutants/adverse effects ; Air Pollutants/analysis ; Environmental Exposure ; Formaldehyde ; Particulate Matter/analysis ; Smoke/adverse effects ; United States ; Wildfires
Chemical Substances	Acetaldehyde (GO1N1ZPR3B) ; Acrolein (7864XYD3JJ) ; Air Pollutants ; Formaldehyde (1HG84L3525) ; Particulate Matter ; Smoke
Language	English
Publishing date	2023-12-05
Publishing country	United States
Document type	Journal Article
ISSN	1520-5851
ISSN (online)	1520-5851
DOI	10.1021/acs.est.3c04153
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Benthos of Green Bay, Lake Michigan revisited after 40 years: A temporal update and assessment of environmental associations

Olson, Cadie R. / Schmude, Kurt L. / Dimick, Jeffrey J. / Stahlheber, Karen A. / Forsythe, Patrick S. / Houghton, Christopher J.

International Association for Great Lakes Research Journal of Great Lakes research. 2022 Jan. 01,

2022

Abstract: Benthos of southern Green Bay, Lake Michigan have not been comprehensively examined since 1978. Since then, invasive species appeared, urbanization intensified, and restoration efforts were implemented, which likely altered the benthic macroinvertebrate ... ...

Abstract	Benthos of southern Green Bay, Lake Michigan have not been comprehensively examined since 1978. Since then, invasive species appeared, urbanization intensified, and restoration efforts were implemented, which likely altered the benthic macroinvertebrate community. Further, current benthos are subjected to dynamic factors including eutrophication, sedimentation, and periodic hypoxia. Understanding community responses to these anthropogenic stressors and natural habitat gradients is imperative to preserving biological integrity within Green Bay. Therefore, the objectives of this project were to describe the current macroinvertebrate community, examine changes since 1978, and assess the roles of productivity, substrate type, water depth, and hypoxia in structuring macroinvertebrate communities. Benthos were sampled at 197 stations, including 97 also sampled in 1978 by Markert (1982) and 100 that were added to increase spatial resolution. We collected 93 macroinvertebrate taxa in southern Green Bay with the community dominated by Chironomus and immature tubificid worms. Nonmetric multidimensional scaling (NMDS) ordination distinguished present and historical communities. Although oligochaete worms and chironomids remained dominant over time, Chironomus abundance increased and characterized the present community, whereas benthos were historically more diverse. The magnitude of temporal change varied spatially among zones of Green Bay, with larger differences concentrated in the Middle Bay and the Inner Bay remaining comparable to 1978. Present-day assemblages were most associated with the trophic gradient driven by Green Bay’s southernmost tributary, the Fox River, but also differed with substrate type and had similar structures in areas subjected to frequent hypoxia. Routine monitoring should continue to track changes while accounting for spatial effects.
Keywords	Chironomus ; Oligochaeta ; anthropogenic stressors ; benthic organisms ; eutrophication ; habitats ; hypoxia ; invasive species ; macroinvertebrates ; research ; rivers ; temporal variation ; urbanization ; Lake Michigan
Language	English
Dates of publication	2022-0101
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	2163239-X
ISSN	0380-1330 ; 0380-1330
ISSN (online)	0380-1330
ISSN	0380-1330
DOI	10.1016/j.jglr.2022.01.001
Database	NAL-Catalogue (AGRICOLA)

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