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Article ; Online: Enhanced hypoglycemic effects of konjac glucomannan combined with Polygonatum cyrtonema Hua polysaccharide in complete nutritional liquid diet fed type 2 diabetes mice.

Chang, Le / Goff, H Douglas / Ding, Chao / Liu, Qiang / Zhao, Siqi / Tao, Tingting / Lu, Rongxin / Gao, Ying / Wu, Haijing / Guo, Liping

International journal of biological macromolecules

2024 Volume 266, Issue Pt 1, Page(s) 131121

Abstract: ... of supplementation of Polygonatum cyrtonema Hua polysaccharide (PCP), konjac glucomannan (KGM) and their combination ...

Abstract	In our aging society, dysphagia and malnutrition are growing concerns, necessitating intervention. Liquid nutrition support offers a practical solution for traditional dietary issues, but it raises a key issue: the potential for post-meal glucose spikes impacting efficacy. This study examined the effects of supplementation of Polygonatum cyrtonema Hua polysaccharide (PCP), konjac glucomannan (KGM) and their combination on acute phase postprandial glycemic response and long-term glucose metabolism in T2DM mice on a complete nutritional liquid diet. KGM was more effective in reducing postprandial glucose response, while PCP was more prominent in ameliorating long-term glucose metabolism. The KGM-PCP combination demonstrated superior outcomes in fasting blood glucose, insulin, and glucose homeostasis. PCP and KGM also influenced the composition and abundance of the gut microbiome, with the H-PCP group showing optimal performance. Moreover, the KGM-PCP combination improved body weight, lipid homeostasis, and liver health the most. PCP potentially regulates glycemia through metabolic pathways, while KGM improves glycemic metabolism by reducing postprandial glucose levels in response to viscous intestinal contents. This research identifies the structure, viscosity properties, and hypoglycemic effects of KGM and PCP in complete nutritional liquid diet fed T2DM mice, enabling their strategic utilization as hypoglycemic components in nutritional administration and glycemic regulation.
MeSH term(s)	Animals ; Mannans/pharmacology ; Mannans/chemistry ; Mice ; Polysaccharides/pharmacology ; Polysaccharides/chemistry ; Polysaccharides/administration & dosage ; Blood Glucose/metabolism ; Polygonatum/chemistry ; Diabetes Mellitus, Type 2/diet therapy ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/metabolism ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/chemistry ; Male ; Gastrointestinal Microbiome/drug effects ; Insulin/blood ; Insulin/metabolism ; Body Weight/drug effects ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/diet therapy
Chemical Substances	(1-6)-alpha-glucomannan (36W3E5TAMG) ; Mannans ; Polysaccharides ; Blood Glucose ; Hypoglycemic Agents ; Insulin
Language	English
Publishing date	2024-03-22
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.131121
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Zs.B 2374: Show issues

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Article ; Online: Oligosaccharides of Polygonatum Cyrtonema Hua ameliorates dextran sulfate sodium-induced colitis and regulates the gut microbiota.

Xu, Jin / Tang, Chuankang / Din, Ahmad Ud / Lu, Yu / Ma, Xiaoyu / Zhang, Tao / Wu, Jiaqi / Zuoqin, Du / Luo, Pei / Wu, Jianbo

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 161, Page(s) 114562

Abstract: ... isolated from Polygonatum Cyrtonema Hua (PFOS) and exhibits anti-inflammatory effects. Therefore, we are ...

Abstract	Ulcerative colitis (UC) is one common chronic inflammatory bowel disease that causes severe side effects, and expensive treatment limits effective and sustained treatment of UC. Fructooligosaccharide was isolated from Polygonatum Cyrtonema Hua (PFOS) and exhibits anti-inflammatory effects. Therefore, we are curious whether PFOS could be used for the treatment of UC. PFOS was introduced via intragastric gavage to C57BL/6 J mice exposed to acute colitis induced by DSS. The results showed that doses of PFOS at 2 and 5 mg/kg/day alleviated the DSS-induced histopathological damage and improved intestinal barrier function. qPCR analysis revealed that PFOS exerted a significant downregulation of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) and upregulation of antioxidant genes, including superoxide dismutase1 (SOD1), glutathion peroxidase2 (GPX2), and nuclear factor erythroid 2 related factor2 (Nrf2). Furthermore, PFOS suppressed the DSS-induced disruption of the mucosal barrier by downregulating MMP13. Moreover, using 16 S rRNA gene-based microbiota analysis, PFOS could selectively enhance the growth of probiotics, including Bifidobacterium, Alloprevofella, and Alistipes. Our findings indicated that PFOS attenuated DSS-induced colitis in mice, suggesting that PFOS might be used as an efficacious supplement for reducing inflammatory bowel disease.
MeSH term(s)	Animals ; Mice ; Dextran Sulfate/pharmacology ; Polygonatum ; Gastrointestinal Microbiome ; Mice, Inbred C57BL ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/microbiology ; Colitis, Ulcerative/drug therapy ; Inflammatory Bowel Diseases/chemically induced ; Oligosaccharides/pharmacology ; Disease Models, Animal ; Colon
Chemical Substances	Dextran Sulfate (9042-14-2) ; Oligosaccharides
Language	English
Publishing date	2023-03-17
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114562
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Article ; Online: Yi-Shen-Hua-Shi granule ameliorates diabetic kidney disease by the "gut-kidney axis".

Han, Cong / Shen, Zhen / Cui, Tao / Ai, Shan-Shan / Gao, Ran-Ran / Liu, Yao / Sui, Gui-Yuan / Hu, Hong-Zhen / Li, Wei

Journal of ethnopharmacology

2023 Volume 307, Page(s) 116257

Abstract: Ethnopharmacological relevance: Yi-Shen-Hua-Shi (YSHS) granule is an effective prescription widely ...

Abstract	Ethnopharmacological relevance: Yi-Shen-Hua-Shi (YSHS) granule is an effective prescription widely used in traditional Chinese medicine to treat diabetic kidney disease (DKD), its exact efficacy in treating DKD has been confirmed but the underlying regulatory mechanism has not been fully elucidated. Aim of the study: To explore the mechanism by which YSHS granule regulates intestinal flora and serum metabolites and then regulates renal mRNA expression through the "gut-kidney axis", so as to improve DKD. Materials and methods: 40 rats were divided into five groups: Normal group (N) (normal saline), model group (M) (STZ + normal saline), YSHS granule low-dose group (YL) (STZ + 2.27 g kg Results: In group M, blood glucose, blood lipid and proteinuria were increased, inflammation, oxidative stress and renal function were aggravated, with the proliferation of mesangial matrix, vacuolar degeneration of renal tubules, accumulation of collagen and lipid, and increased intestinal permeability, and YSHS granule and valsartan improved these disorders to varying degrees. High dose of YSHS granule improved the diversity and abundance of flora, decreased the F/B value, greatly increased the abundance of Lactobacillus and Lactobacillus_murinus, and decreased the abundance of Prevoella UCG_001. 14 target metabolites of YSHS granule were identified, which were mainly enriched in 20 KEGG pathways, such as Glycerophospholipid metabolism, Sphingolipid metabolism and Phenylalanine, tyrosine and tryptophan biosynthesis. 96 target mRNAs of YSHS granule were also identified. The enriched top 20 pathways were closely related to glucose and lipid metabolism, of which a total of 21 differential mRNAs were expressed. Further correlation analysis revealed that Lactobacillus, Lactobacillus_murinus and Prevotella UCG_001 were highly correlated with Glycerophospholipid metabolism, Sphingolipid metabolism and Phenylalanine, tyrosine and tryptophan biosynthesis pathways. At the same time, 6 pathways including Glycerophospholipid metabolism, Arachidonic acid metabolism, Purine metabolism, Primary bile acid biosynthesis, Ascorbate and aldarate metabolism and Galactose metabolism were co-enriched by the target metabolites and the target mRNAs of YSHS granule, including 7 differential metabolites such as phosphatidylethanolamine and 7 differential genes such as Adcy3. The 7 differential metabolites had high predictive value of AUC, and the validation of 7 differential genes were highly consistent with the sequencing results. Conclusion: YSHS granule could improve DKD through the "gut-kidney axis". Lactobacillus and Lactobacillus_murinus were the main driving forces. 6 pathways related to glucose and lipid metabolism, especially Glycerophospholipid metabolism, may be an important follow-up response and regulatory mechanism.
MeSH term(s)	Animals ; Rats ; Blood Glucose ; Chromatography, Liquid ; Diabetes Mellitus ; Diabetic Nephropathies ; Glucose ; Glycerophospholipids ; Kidney/physiology ; Saline Solution ; Sphingolipids ; Tandem Mass Spectrometry ; Tryptophan ; Valsartan ; Herbal Medicine
Chemical Substances	Blood Glucose ; Glucose (IY9XDZ35W2) ; Glycerophospholipids ; Saline Solution ; Sphingolipids ; Tryptophan (8DUH1N11BX) ; Valsartan (80M03YXJ7I)
Language	English
Publishing date	2023-02-12
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116257
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Article: [Effectiveness of knee dislocation and multiple ligament injury based on Hua Xi-knee dislocation and multiple ligament injury diagnosis and treatment system].

Huang, Xihao / Li, Tao / Zhao, Tingwei / Li, Junqiao / Li, Jian

Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery

2022 Volume 36, Issue 1, Page(s) 1–9

Abstract: Objective: To investigate the effectiveness of personalized treatment based on Hua Xi ...

Abstract	Objective: To investigate the effectiveness of personalized treatment based on Hua Xi-knee dislocation and multiple ligament injury (HX-KDMLI) diagnosis and treatment system. Methods: A clinical data of 36 patients (36 knees) with KDMLI met the selective criteria between February 2019 and September 2020 was retrospectively analyzed. There were 24 males and 12 females with an average age of 45.7 years (range, 21-62 years). The KDMLI was caused by traffic accident in 15 cases, heavy pound in 8 cases, sports sprain in 7 cases, falling from height in 4 cases, and machine cutting in 2 cases. The interval between injury and operation was 1-9 weeks (mean, 3.6 weeks). All patients were categorized according to HX-KDMLI diagnosis and treatment system. Twenty patients were categorized as acute period and 16 patients as chronic period. Three patients were type HX-Ⅰ-A, 1 type HX-Ⅰ-P, 10 type HX-Ⅲ-L, 13 type HX-Ⅲ-M, 4 type HX-Ⅳ-S, 3 type HX-Ⅴ-F, and 2 type HX-Ⅴ-T. Thirty-five patients were positive in both the anterior drawer test and Lachman test, 31 were positive in the posterior drawer test; 19 patients were positive in varus stress test, 23 were positive in valgus stress test. According to the Internation Knee Documentation Committee (IKDC) grading, there was 1 case of grade A, 5 cases of grade B, 8 cases of grade C, and 2 cases of grade D. Surgical interventions included arthroscopic surgery, open surgery, or arthroscopy combined with open surgery, ligament suture or reconstruction, and internal fixation after anatomical reduction of the fracture. Different rehabilitation protocols were assigned to patients during different postoperative period, according to patient's individualized classification. Results: All incisions healed by first intention with no obvious complications. All patients were followed up 12-19 months (mean, 15 months). At 12 months after operation, all patients retained muscle strength of grade Ⅴ, and range of motion of the knee joint could reach 0° extension and over 120° flexion. Radiographic examination showed no sign of knee instability, healed fractures, ideal joint alignment, good continuity and tension, and clear image of repaired or reconstructed ligaments. The anterior and posterior drawer tests were all negative. Lachman test was degreeⅠpositive in 5 cases, valgus stress test was degreeⅠpositive in 2 cases, varus stress test was degreeⅠpositive in 2 cases; the other patients were all negative. At 12 months after operation, according to the IKDC grading, there were 9 cases of grade A, 19 cases of grade B, 5 cases of grade C, and 3 cases of grade D, showing significant differences when compared with the preoperative ones ( Conclusion: The promising effectiveness of KDMLI can obtain under the guidance of HX-KDMLI.
MeSH term(s)	Anterior Cruciate Ligament ; Anterior Cruciate Ligament Injuries/diagnosis ; Anterior Cruciate Ligament Injuries/surgery ; Arthroscopy ; Female ; Humans ; Knee Dislocation/diagnosis ; Knee Dislocation/surgery ; Knee Joint/surgery ; Male ; Middle Aged ; Retrospective Studies ; Treatment Outcome
Language	Chinese
Publishing date	2022-01-17
Publishing country	China
Document type	Journal Article
ZDB-ID	1420212-8
ISSN	1002-1892
ISSN	1002-1892
DOI	10.7507/1002-1892.202112064
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Zs.A 4866: Show issues

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Article: Duohua huangjing (Polygonatum cyrtonema Hua) seedling basal rot caused by Fusarium redolens in China.

Tang, Tao / Wang, Fanfan / Jie, Guo / Guo, Xiaoliang / Duan, Yuanyuan / You, Jingmao

Plant disease

2021

Abstract: Duohua huangjing (Polygonatum cyrtonema Hua) seedling basal stem rot caused by Fusarium redolens ... Polygonatum cyrtonema Hua), a herbal medicine, that is mostly planted in several provinces in China. In April ... in China Tao Tang1, Fanfan Wang1, Jie Guo1, Xiaoliang Guo1, Yuanyuan Duan1,Jingmao You1* 1 Institute ...

Abstract	Duohua huangjing (Polygonatum cyrtonema Hua) seedling basal stem rot caused by Fusarium redolens in China Tao Tang1, Fanfan Wang1, Jie Guo1, Xiaoliang Guo1, Yuanyuan Duan1,Jingmao You1* 1 Institute of Chinese Herbal Medicines, Hubei Academy of Agricultural Sciences, Enshi, 445000, China. Duohua huangjing (Polygonatum cyrtonema Hua), a herbal medicine, that is mostly planted in several provinces in China. In April 2020, severe diseases with about 40% seedling losse was found in the Huangjing seedling base in Shiyan city, Hubei province. The symptoms included softening and decay of the roots and stem bases, a progressive yellowing and wilting of leaves, and finally being completely rotted. Small pieces of symptomatic stems (0.5 cm in length) and leaves (0.5 × 0.5 cm in size) were surface sterilized with 75% ethanol for 30 s, followed by 0.1% HgCl2 for 1 min, rinsed three times with sterile water, and then dried with sterilized absorbent paper. The sections were placed on potato dextrose agar (PDA) medium containing 10 µg/ml of ampicillin and incubated at 25°C in the dark. After 3 days incubation, eight isolates with the same colony morphology were sub-cultured and purified by hyphal tip isolation. Macroconidia were sickle-shaped, 15.8 - 32.3 × 3.1 - 5.6 μm (n = 25), and three to five septate. Microconidia were oval or kidney-shaped, 5.2 - 11.4 × 2.0 - 3.2 μm (n = 25), and zero to one septate. To confirm the identity of the pathogen, molecular identification was performed with strain HJCD1. Following DNA extraction, PCR was performed using the TSINGKE 2×T5 Direct PCR Mix kit. Target areas of amplification were the internal transcribed spacer (ITS) and translation elongation factor 1α (TEF-1α) using ITS1/4 (White et al. 1990) , EF1/EF2 (Taylor et al. 2016), respectively. Following BLAST searches and phylogenetic reconstruction, the ITS region (GenBank MW485770.1) showed 99% identity with those of Fusarium redolens in GenBank (KU350713.1) and the TEF-1α (GenBank MW503930.1) showed 100% identity with F. redolens GenBank (MK922537.1). Pathogenicity tests were performed to fulfill Koch's postulates. Huangjing seedlings were rinsed with sterile water, wiped clean with sterile absorbent paper, and transferred to a tray covered with wet filter paper to maintain high humidity. The mycelial piugs of F. redolens HJCD1 were inoculated onto the surface of leaves and basal stems. Controls were inoculated with sterile PDA plugs. The inoculated seedlings were sealed with plastic wrap, and then cultivated in a 25 ℃ growth chamber with 16 h of light per day. The pathogen-inoculated plants exhibited etiolation and typical wilt symptoms after 4 days, whereas no symptoms were observed in the control plants. F. redolens was reisolated from the infected tissues, and colony morphology and ITS sequence of re-isolates were same as that of HJCD1. The pathogen has been reported previously in american ginseng in China (Fan et al. 2021), lentil in Pakistan (Rafique et al. 2020), and wild rocket in United Kingdom (Taylor et al. 2019). However, to the best of our knowledge, this is the first report of F. redolens causing seelding basal rot on Duohua huangjing in China. References: White, T. J., et al. 1990. Page 315 in: PCR Protocols: A Guide to Methods and Applications. Academic Press, San Diego, CA. Taylor, A., et al. 2016. Mol. Plant Pathol. 17:1032. https://doi.org/10.1111/mpp.12346 Fan, S. H., et al. 2021. Plant Dis. https://doi.org/10.1094/PDIS-11-19-2519-PDN Rafique, K., et al. 2020. Plant Dis. 9:104. https://doi.org/10.1094/PDIS-11-19-2519-PDN Taylor, A., et al. 2019. Plant Dis.6:103. https://doi.org/10.1094/PDIS-12-18-2143-PDN Funding: Science Funds for Young Scholar of Hubei Academy of Agricultural Science (grant no. 2020NKYJJ20), National Modern Agricultural Industrial Technology System (grant no. CARS-21), Technology R&D Program of Enshi (grant no. D20190015), Science Funds for Young Scholar of Institute of Chinese Herbal Medicines, Hubei Academy of Agricultural Sciences (grant no. 2019ZYCJJ03), Key Laboratory of Integrated Management of Crops of Central China, Ministry of Agriculture, P. R. China / Hubei Key Laboratory of Crop Disease, Insect Pests and Weeds Control (grant no.2020ZTSJJ6).
Language	English
Publishing date	2021-04-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-03-21-0597-PDN
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Z 2043: Show issues

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Article ; Online: Qing-Hua Granule induces GLP-1 secretion via bitter taste receptor in db/db mice.

Li, Junyan / Xu, Jie / Hou, Ruifang / Jin, Xin / Wang, Jingyi / Yang, Na / Yang, Li / Liu, Li / Tao, Feng / Lu, Hao

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2017 Volume 89, Page(s) 10–17

Abstract: Qing-Hua Granule (QHG), the modified formulation of a classical Chinese prescription named Gegen ...

Abstract	Qing-Hua Granule (QHG), the modified formulation of a classical Chinese prescription named Gegen Qinlian Decoction, was clinically employed to treat type 2 diabetes mellitus (T2DM) through regulation of glucagon-like peptide-1 (GLP-1). However, the potential mechanism is unknown. We investigate whether QHG induces GLP-1 secretion via activation of bitter taste receptor (TAS2R) pathway in the gastrointestinal tract of db/db mice. The db/db mice were intragastrically (i.g.) administered QHG (low/medium/high dose) once daily for 8 weeks. GLP-1 secretion was evaluated. The bitter receptor signaling pathway, which regulates GLP-1 secretion, including TAS2R5 (a subtype of TAS2R), α-gustducin (Gαgust), 1-phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta-2 (PLCβ2), transient receptor potential cation channel subfamily M member 5 (TRPM5), was assessed by quantitative real-time polymerase chain reaction (qRT-PCR), Western blot and immunohistochemistry (IHC). The biochemical observations of ileum and pancreas tissue were detected histopathologically. Acquity Ultra Performance LCTM - Micromass ZQ 2000 (UPLC-MS) was used for the phytochemical analysis. QHG exhibited significant and dose-dependent effect on GLP-1 secretion in db/db mice, along with significant up-regulation of TAS2R5 mRNA level and activation of TAS2R pathway (p<0.05). In addition, QHG improved the histopathological structure of ileum and pancreatic tissue. Seventeen compounds were identified in QHG. In conclusion, QHG induces GLP-1 secretion in db/db mice, most likely through the bitter taste receptor pathway.
Language	English
Publishing date	2017-05
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2017.01.168
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Article: Rapid Screening and Quantitative Determination of Active Components in Qing-Hua-Yu-Re-Formula Using UHPLC-Q-TOF/MS and HPLC-UV.

Shao, Xin / Zhao, Jie / Wang, Xu / Tao, Yi

Journal of analytical methods in chemistry

2018 Volume 2018, Page(s) 8535127

Abstract: Qing-Hua-Yu-Re-Formula (QHYRF), a new herbal preparation, has been extensively used for treating ...

Abstract	Qing-Hua-Yu-Re-Formula (QHYRF), a new herbal preparation, has been extensively used for treating diabetic cardiomyopathy. However, the chemical constituents of QHYRF remain uninvestigated. In the present study, rapid ultrahigh-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) was used to qualitatively analyze the components of QHYRF. Qualitative detection was performed on a Kromasil C
Language	English
Publishing date	2018-03-11
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2654178-6
ISSN	2090-8873 ; 2090-8865
ISSN (online)	2090-8873
ISSN	2090-8865
DOI	10.1155/2018/8535127
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Article: [Prevalence and risk factors for hepatitis B in Hua County, Henan Province].

Deng, Qiu-ju / Pan, Ya-qi / Wang, Chao-yi / Li, Feng-lei / Lv, Shao-jiang / Hu, Shao-yong / Ning, Tao / Guo, Chuan-hai / He, Zhong-hu / Ke, Yang

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

2013 Volume 45, Issue 6, Page(s) 965–970

Abstract: ... of hepatitis B surface antigens (HBsAg) prevalence in rural areas of Hua County, Henan Province, and to provide ... clustered and selected from 5 targeted villages for this study in rural areas of Hua County, Henan Province ... B virus (HBV) infection.: Conclusion: The prevalence of HBsAg in rural Hua County, Henan Province ...

Abstract	Objective: To determine the epidemiological characteristics and associated risk factors of hepatitis B surface antigens (HBsAg) prevalence in rural areas of Hua County, Henan Province, and to provide scientific evidence for Hepatitis B prevention and control in local areas. Methods: On the basis of an ongoing esophageal cancer cohort study in rural Anyang, a total of 5 104 subjects aged 25-65 years were clustered and selected from 5 targeted villages for this study in rural areas of Hua County, Henan Province. HBsAg was detected in their blood samples and a questionnaire was completed by all the subjects in a manner of one-on-one interview. All statistical analyses were conducted using SPSS for Windows version 13.0. Results: Of the 5 104 studied subjects (overall participation rate: 92.05%), 5.17% were positive for HBsAg. The detection rate was significantly higher in males than in females (6.54% vs. 3.87%, P<0.001) and the highest detection rates were observed in the 25-29 and 55-59 years groups in both males and females. Multiple Logistic analyses showed unmarried status (OR=1.80, 95% CI: 1.00-3.25) and high frequency of sexual intercourse (Ptrend=0.049) were associated with higher the risk for hepatitis B virus (HBV) infection. Conclusion: The prevalence of HBsAg in rural Hua County, Henan Province, was slightly lower than the national average of the same time period. More attention should be attached to high risk groups of HBV infection in this population, i.e. males aged 25-29 years and 55-59 years and sexually active population. Immunization and health education projects against hepatitis B should be carried out in this population to further reduce the overall prevalence of hepatitis B.
MeSH term(s)	Adult ; Age Factors ; China/epidemiology ; Cohort Studies ; Coitus ; Female ; Hepatitis B/blood ; Hepatitis B/epidemiology ; Hepatitis B Surface Antigens/blood ; Humans ; Male ; Marital Status ; Middle Aged ; Prevalence ; Risk Factors ; Rural Population ; Sex Factors ; Smoking ; Surveys and Questionnaires
Chemical Substances	Hepatitis B Surface Antigens
Language	Chinese
Publishing date	2013-12-18
Publishing country	China
Document type	English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1671-167X
ISSN	1671-167X
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Book: Zhong hua Min guo shi

Zhu, Zongzhen / Li, Xin / Tao, Wenzhao

2011

Institution	Zhong guo she hui ke xue yuan jin dai shi yan jiu suo Zhong hua Min guo shi yan jiu shi 中国社会科学院近代史研究所中华民国史研究室
Author's details	Zhong guo she hui ke xue yuan jin dai shi yan jiu suo Zhonghua Minguo shi yan jiu shi, Zong bian Li Xin
Language	Chinese
Size	4, 4, 660 S., ill. (some col.) map, portraits, 22 cm
Edition	Di 1 ban
Publisher	Zhong hua shu ju
Publishing place	Bei jing
Document type	Book
Note	Includes bibliographical references
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Towards the identification of alkaline phosphatase binding ligands in Li-Dan-Hua-Shi pills: A Box-Behnken design optimized affinity selection approach tandem with UHPLC-Q-TOF/MS analysis.

Tao, Yi / Huang, Surun / Gu, Xianghui / Li, Weidong / Cai, Baochang

Journal of pharmaceutical and biomedical analysis

2018 Volume 154, Page(s) 486–491

Abstract: Alkaline phosphatase conjugated magnetic microspheres were synthesized via amide reaction, and employed as an effective adsorbent in affinity selection of binding ligands followed by UHPLC-Q-TOF/MS analysis. The analytical validity of the developed ... ...

Abstract	Alkaline phosphatase conjugated magnetic microspheres were synthesized via amide reaction, and employed as an effective adsorbent in affinity selection of binding ligands followed by UHPLC-Q-TOF/MS analysis. The analytical validity of the developed approach was evaluated under optimized conditions and the following figures of merit were obtained: linearity, 0.01-0.5 g L
MeSH term(s)	Alkaline Phosphatase/chemistry ; Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/chemistry ; Ligands ; Limit of Detection ; Magnetics ; Reproducibility of Results ; Tandem Mass Spectrometry/methods
Chemical Substances	Drugs, Chinese Herbal ; Ligands ; Alkaline Phosphatase (EC 3.1.3.1)
Language	English
Publishing date	2018-03-21
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2018.03.041
Database	MEDical Literature Analysis and Retrieval System OnLINE

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