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  1. Article ; Online: Current State of Knowledge on the Definition, Pathophysiology, Etiology, Outcomes, and Management of Fever in the Intensive Care Unit.

    Cajanding, Ruff Joseph Macale

    AACN advanced critical care

    2023  Volume 34, Issue 4, Page(s) 297–310

    Abstract: Fever-an elevated body temperature-is a prominent feature of a wide range of disease conditions and is a common finding in intensive care, affecting up to 70% of patients in the intensive care unit (ICU). The causes of fever in the ICU are multifactorial, ...

    Abstract Fever-an elevated body temperature-is a prominent feature of a wide range of disease conditions and is a common finding in intensive care, affecting up to 70% of patients in the intensive care unit (ICU). The causes of fever in the ICU are multifactorial, and it can be due to a number of infective and noninfective etiologies. The production of fever represents a complex physiological, adaptive host response that is beneficial for host defense and survival but can be maladaptive and harmful if left unabated. Despite any cause, fever is associated with a wide range of cellular, local, and systemic effects, including multiorgan dysfunction, systemic inflammation, poor neurological recovery, and an increased risk of mortality. This narrative review presents the current state-of-the-art knowledge on the definition, pathophysiology, etiology, and outcomes of fever in the ICU and highlights evidence-based findings regarding the management of fever in the intensive care setting.
    MeSH term(s) Humans ; Fever ; Intensive Care Units ; Critical Care
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2239949-5
    ISSN 1559-7776 ; 1559-7768
    ISSN (online) 1559-7776
    ISSN 1559-7768
    DOI 10.4037/aacnacc2023314
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Silent Hypoxia in COVID-19 Pneumonia: State of Knowledge, Pathophysiology, Mechanisms, and Management.

    Cajanding, Ruff Joseph Macale

    AACN advanced critical care

    2022  Volume 33, Issue 2, Page(s) 143–153

    Abstract: Patients with COVID-19 often present with life-threatening hypoxemia without dyspnea or signs of respiratory distress. Termed silent or happy hypoxia, it has puzzled clinicians and challenged and defied our understanding of normal respiratory physiology. ...

    Abstract Patients with COVID-19 often present with life-threatening hypoxemia without dyspnea or signs of respiratory distress. Termed silent or happy hypoxia, it has puzzled clinicians and challenged and defied our understanding of normal respiratory physiology. A range of host- and pathogen-related factors appears to contribute to its development, including SARS-CoV-2's ability to produce different COVID-19 phenotypes; induce endothelial damage and elicit a vascular distress response; invade cells of the central nervous system and disrupt normal interoception and response; and modulate transcription factors involved in hypoxic responses. Because hypoxemia in COVID-19 is associated with increased mortality risk and poorer survival, early detection and prompt treatment is essential to prevent potential complications. Interventions to prevent hypoxemia and improve oxygen delivery to the blood and the tissues include home pulse-oximetry monitoring, optimization of patient positioning, judicious use of supplemental oxygen, breathing control exercises, and timely and appropriate use of ventilatory modalities and adjuncts.
    MeSH term(s) COVID-19 ; Dyspnea/complications ; Humans ; Hypoxia/diagnosis ; Hypoxia/therapy ; Oxygen ; SARS-CoV-2
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2022-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2239949-5
    ISSN 1559-7776 ; 1559-7768
    ISSN (online) 1559-7776
    ISSN 1559-7768
    DOI 10.4037/aacnacc2022448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Comprehensive Review of Cardiovascular Involvement in COVID-19.

    Cajanding, Ruff Joseph Macale

    AACN advanced critical care

    2021  Volume 32, Issue 2, Page(s) 169–187

    Abstract: COVID-19 has emerged as one of the most devastating and clinically significant infectious diseases of the last decade. It has reached global pandemic status at an unprecedented pace and has placed significant demands on health care systems worldwide. ... ...

    Abstract COVID-19 has emerged as one of the most devastating and clinically significant infectious diseases of the last decade. It has reached global pandemic status at an unprecedented pace and has placed significant demands on health care systems worldwide. Although COVID-19 primarily affects the lungs, epidemiologic reports have shown that the disease affects other vital organs of the body, including the heart, vasculature, kidneys, brain, and the hematopoietic system. Of importance is the emerging awareness of the effects of COVID-19 on the cardiovascular system. The current state of knowledge regarding cardiac involvement in COVID-19 is presented in this article, with particular focus on the cardiovascular manifestations and complications of COVID-19 infection. The mechanistic insights of disease causation and the relevant pathophysiology involved in COVID-19 as they affect the heart are explored and described. Relevant practice essentials and clinical management implications for patients with COVID-19 with a cardiac pathology are presented in light of recent evidence.
    MeSH term(s) Acute Coronary Syndrome/etiology ; Acute Coronary Syndrome/nursing ; Acute Coronary Syndrome/physiopathology ; Adult ; Aged ; Aged, 80 and over ; COVID-19/complications ; COVID-19/nursing ; COVID-19/physiopathology ; Critical Care Nursing/standards ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Practice Guidelines as Topic ; SARS-CoV-2
    Language English
    Publishing date 2021-03-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2239949-5
    ISSN 1559-7776 ; 1559-7768
    ISSN (online) 1559-7776
    ISSN 1559-7768
    DOI 10.4037/aacnacc2021302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: MDMA-Associated Liver Toxicity: Pathophysiology, Management, and Current State of Knowledge.

    Cajanding, Ruff Joseph Macale

    AACN advanced critical care

    2019  Volume 30, Issue 3, Page(s) 232–248

    Abstract: 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) has become a popular recreational drug of abuse among young adults, partly because of the belief that it is relatively safe compared with other drugs with the same stimulant and hallucinogenic effects. ... ...

    Abstract 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) has become a popular recreational drug of abuse among young adults, partly because of the belief that it is relatively safe compared with other drugs with the same stimulant and hallucinogenic effects. However, MDMA use has been associated with a wide spectrum of organ toxicities, with the liver being severely affected by its deleterious effects. This article discusses the essential pharmacology of MDMA and describes the effects MDMA has on various organ systems of the body, with particular focus on the liver. The putative mechanisms by which MDMA can cause liver damage are explored, with emphasis on patient-related factors that explain why some individuals are more susceptible than others to damage from MDMA. The incidence of hepatotoxicity related to MDMA use is presented, and the nursing management of patients who develop acute liver failure due to MDMA overuse is explored in light of current evidence.
    MeSH term(s) Adolescent ; Adult ; Chemical and Drug Induced Liver Injury/diagnosis ; Chemical and Drug Induced Liver Injury/nursing ; Chemical and Drug Induced Liver Injury/physiopathology ; Critical Care Nursing/education ; Critical Care Nursing/standards ; Education, Nursing, Continuing ; Female ; Hallucinogens/adverse effects ; Humans ; Male ; N-Methyl-3,4-methylenedioxyamphetamine/adverse effects ; Practice Guidelines as Topic ; United States ; Young Adult
    Chemical Substances Hallucinogens ; N-Methyl-3,4-methylenedioxyamphetamine (KE1SEN21RM)
    Language English
    Publishing date 2019-08-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2239949-5
    ISSN 1559-7776 ; 1559-7768
    ISSN (online) 1559-7776
    ISSN 1559-7768
    DOI 10.4037/aacnacc2019852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Administering and monitoring high-alert medications in acute care.

    Cajanding, Joseph Macale Ruff

    Nursing standard (Royal College of Nursing (Great Britain) : 1987)

    2017  Volume 31, Issue 47, Page(s) 42–52

    Abstract: The nurse's primary role in the medication process is to ensure that drugs are administered safely to patients, thus reducing the risk of unnecessary harm or injury. High-alert medications are a particular concern for healthcare professionals, since they ...

    Abstract The nurse's primary role in the medication process is to ensure that drugs are administered safely to patients, thus reducing the risk of unnecessary harm or injury. High-alert medications are a particular concern for healthcare professionals, since they are associated with an increased risk of causing patient harm. This article identifies high-risk medications and outlines measures that can be used to prevent potential harm to patients as a result of these medications, including computerised provider order entry, Tall Man lettering, order sets, independent double-checks and proactive patient monitoring.
    Language English
    Publishing date 2017-07-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 645016-7
    ISSN 2047-9018 ; 0029-6570
    ISSN (online) 2047-9018
    ISSN 0029-6570
    DOI 10.7748/ns.2017.e10849
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2410: Show issues Location:
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    Zs.MO 273: Show issues

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  6. Article ; Online: The Effectiveness of a Nurse-Led Cognitive-Behavioral Therapy on the Quality of Life, Self-Esteem and Mood Among Filipino Patients Living With Heart Failure: a Randomized Controlled Trial.

    Cajanding, Ruff Joseph Macale

    Applied nursing research : ANR

    2016  Volume 31, Page(s) 86–93

    Abstract: Aims/objectives: The diagnosis and complications associated with heart failure (HF) have been very well established to adversely impact an individual's physical and psychosocial well-being, and interventions such as cognitive-behavioral techniques have ... ...

    Abstract Aims/objectives: The diagnosis and complications associated with heart failure (HF) have been very well established to adversely impact an individual's physical and psychosocial well-being, and interventions such as cognitive-behavioral techniques have demonstrated potential positive benefits among patients with HF. However, the effects of such interventions among Filipino HF patients have not been studied. This study aimed to determine the effectiveness of a nurse-led cognitive-behavioral intervention program on the quality of life, self-esteem and mood among Filipino patients with HF.
    Methods: A randomized control two-group design with repeated measures and collected data before and after the intervention was used in this study. Participants were assigned to either the control (n=48) or the intervention group (n=52). Control group participants received traditional care. Intervention participants underwent a 12-week nurse-led cognitive-behavioral intervention program focusing on patient education, self-monitoring, skills training, cognitive restructuring and spiritual development. Measures of quality of life, self-esteem and mood were obtained at baseline and after the intervention.
    Results: At baseline, participants in both groups have poor quality of life, low self-esteem, and moderate depressive symptom scores. After the 12-week intervention period, participants in the intervention group had significant improvement in their quality of life, self-esteem and mood scores compared with those who received only standard care.
    Conclusion: Nurse-led cognitive-behavioral intervention is an effective strategy in improving the quality of life, self-esteem and mood among Filipino patients living with HF. It is recommended that this intervention be incorporated in the optimal care of patients with this cardiac condition.
    Language English
    Publishing date 2016-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1027369-4
    ISSN 1532-8201 ; 0897-1897
    ISSN (online) 1532-8201
    ISSN 0897-1897
    DOI 10.1016/j.apnr.2016.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2884: Show issues Location:
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