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Article ; Online: High

Pilaquinga, Fernanda / Bosch, Rafael / Morey, Jeroni / Bastidas-Caldes, Carlos / Torres, Marbel / Toscano, Fernanda / Debut, Alexis / Pazmiño-Viteri, Katherine / Nieves Piña, María de Las

Nanotechnology

2023 Volume 34, Issue 17

Abstract: The search for new strategies to curb the spread of the SARS-CoV-2 coronavirus, which causes COVID-19, has become a global priority. Various nanomaterials have been proposed as ideal candidates to inactivate the virus; however, because of the high level ... ...

Abstract	The search for new strategies to curb the spread of the SARS-CoV-2 coronavirus, which causes COVID-19, has become a global priority. Various nanomaterials have been proposed as ideal candidates to inactivate the virus; however, because of the high level of biosecurity required for their use, alternative models should be determined. This study aimed to compare the effects of two types of nanomaterials gold (AuNPs) and silver nanoparticles (AgNPs), recognized for their antiviral activity and affinity with the coronavirus spike protein using PhiX174 and enveloped Phi6 bacteriophages as models. To reduce the toxicity of nanoparticles, a species known for its intermediate antiviral activity,
MeSH term(s)	Humans ; Metal Nanoparticles/chemistry ; Gold/pharmacology ; Gold/chemistry ; SARS-CoV-2 ; Spectroscopy, Fourier Transform Infrared ; Solanum ; COVID-19 ; Silver/pharmacology ; Plant Extracts/pharmacology ; Plant Extracts/chemistry
Chemical Substances	Gold (7440-57-5) ; Silver (3M4G523W1G) ; Plant Extracts
Language	English
Publishing date	2023-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/acb558
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Article ; Online: NANOTECNOLOGÍA APLICADA EN MATERIALES REFRACTARIOS

Marco Vinicio Carrión V. / Fernanda Pilaquinga F.

infoANALITÍCA, Vol 8, Iss

UNA REVISIÓN

2020 Volume 2

Abstract: Los materiales refractarios son de gran importancia para la humanidad, debido a su capacidad de resistir altas temperaturas. Son empleados en la industria del cemento, cerámica, vidrio, metalúrgica, siderúrgica y petroquímica. La mayor preocupación a ... ...

Abstract	Los materiales refractarios son de gran importancia para la humanidad, debido a su capacidad de resistir altas temperaturas. Son empleados en la industria del cemento, cerámica, vidrio, metalúrgica, siderúrgica y petroquímica. La mayor preocupación a nivel industrial, es que los materiales refractarios son sometidos a varios mecanismos de desgaste durante el proceso de producción, tales como: ataque químico, mecánico, termomecánico y carga térmica. Si el material no cuenta con las propiedades adecuadas, su durabilidad se verá afectada, y por ende los costos de producción. En este sentido la combinación de los nanomateriales, se convierte en una importante alternativa para mejorar las propiedades de los materiales refractarios, proporcionándoles mejor densidad, baja porosidad, resistencia a la erosión, baja conductividad térmica, entre otras. El presente artículo realiza una revisión de varios trabajos de investigación, acerca de la evolución de los nanomateriales aplicados a los materiales refractarios, entre los que se mencionan el uso de grafeno, dióxido de titanio, óxido férrico, magnesia, zirconia, alúmina y sílice, para mejorar las propiedades físicas de los materiales refractarios. De manera general, los estudios demuestran que el uso de los nanomateriales, provee a los materiales refractarios mejores propiedades, en rangos de concentración específicos. Sin embargo, todos los estudios han sido realizados a nivel de laboratorio, por lo que sería promisorio su uso a nivel industrial.
Keywords	materiales refractarios ; nanomateriales ; grafeno ; titanio ; óxido férrico ; magnesia ; zirconia ; sílice y alúmina ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Language	Spanish
Publishing date	2020-07-01T00:00:00Z
Publisher	Pontificia Universidad Católica del Ecuador
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Silver nanoparticles as a potential treatment against SARS-CoV-2: A review.

Pilaquinga, Fernanda / Morey, Jeroni / Torres, Marbel / Seqqat, Rachid / Piña, María de Las Nieves

Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

2021 Volume 13, Issue 5, Page(s) e1707

Abstract: Several human coronaviruses (HCoVs) are distinguished by the ability to generate epidemics or pandemics, with their corresponding diseases characterized by severe respiratory illness, such as that which occurs in severe acute respiratory syndrome (SARS- ... ...

Abstract	Several human coronaviruses (HCoVs) are distinguished by the ability to generate epidemics or pandemics, with their corresponding diseases characterized by severe respiratory illness, such as that which occurs in severe acute respiratory syndrome (SARS-CoV), Middle East respiratory syndrome (MERS-CoV), and, today, in SARS-CoV-2, an outbreak that has struck explosively and uncontrollably beginning in December 2019 and has claimed the lives of more than 1.9 M people worldwide as of January 2021. The development of vaccines has taken one year, which is why it is necessary to investigate whether some already-existing alternatives that have been successfully developed in recent years can mitigate the pandemic's advance. Silver nanoparticles (AgNPs) have proved effective in antiviral action. Thus, in this review, several in vitro and in vivo studies of the effect of AgNPs on viruses that cause respiratory diseases are analyzed and discussed to promote an understanding of the possible interaction of AgNPs with SARS-CoV-2. The study focuses on several in vivo toxicological studies of AgNPs and a dose extrapolation to humans to determine the chief avenue of exposure. It can be concluded that the use of AgNPs as a possible treatment for SARS-CoV-2 could be viable, based on comparing the virus' behavior to that of similar viruses in in vivo studies, and that the suggested route of administration in terms of least degree of adverse effects is inhalation. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Respiratory Disease Toxicology and Regulatory Issues in Nanomedicine > Toxicology of Nanomaterials.
MeSH term(s)	COVID-19/therapy ; Humans ; Metal Nanoparticles/therapeutic use ; Pandemics ; SARS-CoV-2/drug effects ; Silver
Chemical Substances	Silver (3M4G523W1G)
Language	English
Publishing date	2021-02-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2502698-7
ISSN	1939-0041 ; 1939-5116
ISSN (online)	1939-0041
ISSN	1939-5116
DOI	10.1002/wnan.1707
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Article ; Online: Computational Modeling of the Interaction of Silver Clusters with Carbohydrates.

Gallegos, Felipe E / Meneses, Lorena M / Cuesta, Sebastián A / Santos, Juan C / Arias, Josefa / Carrillo, Pamela / Pilaquinga, Fernanda

ACS omega

2022 Volume 7, Issue 6, Page(s) 4750–4756

Abstract: Silver nanoparticles are recognized for their numerous physical, biological, and pharmaceutical applications. In the present study, the interaction of silver clusters with monosaccharide molecules is examined to identify which molecule works better as a ... ...

Abstract	Silver nanoparticles are recognized for their numerous physical, biological, and pharmaceutical applications. In the present study, the interaction of silver clusters with monosaccharide molecules is examined to identify which molecule works better as a reducing agent in the application of a green synthesis approach. Geometry optimization of clusters containing one, three, and five silver atoms is performed along with the optimization of α-d-glucose, α-d-ribose, d-erythrose, and glyceraldehyde using density functional theory. Optimized geometries allow identifying the interaction formed in the silver cluster and monosaccharide complexes. An electron localization function analysis is performed to further analyze the interaction found and explain the reduction process in the formation of silver nanoparticles. The overall results indicate that glyceraldehyde presents the best characteristics to serve as the most efficient reducing agent.
Language	English
Publishing date	2022-02-04
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.1c04149
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Article ; Online: Comparative statistical analysis of the release kinetics models for nanoprecipitated drug delivery systems based on poly(lactic-co-glycolic acid).

Heredia, Nathaly S / Vizuete, Karla / Flores-Calero, Marco / Pazmiño V, Katherine / Pilaquinga, Fernanda / Kumar, Brajesh / Debut, Alexis

PloS one

2022 Volume 17, Issue 3, Page(s) e0264825

Abstract: Poly(lactic-co-glycolic acid) is one of the most used polymers for drug delivery systems (DDSs). It shows excellent biocompatibility, biodegradability, and allows spatio-temporal control of the release of a drug by altering its chemistry. In spite of ... ...

Abstract	Poly(lactic-co-glycolic acid) is one of the most used polymers for drug delivery systems (DDSs). It shows excellent biocompatibility, biodegradability, and allows spatio-temporal control of the release of a drug by altering its chemistry. In spite of this, few formulations have reached the market. To characterize and optimize the drug release process, mathematical models offer a good alternative as they allow interpreting and predicting experimental findings, saving time and money. However, there is no general model that describes all types of drug release of polymeric DDSs. This study aims to perform a statistical comparison of several mathematical models commonly used in order to find which of them best describes the drug release profile from PLGA particles synthesized by nanoprecipitation method. For this purpose, 40 datasets extracted from scientific articles published since 2016 were collected. Each set was fitted by the models: order zero to fifth order polynomials, Korsmeyer-Peppas, Weibull and Hyperbolic Tangent Function. Some data sets had few observations that do not allow to apply statistic test, thus bootstrap resampling technique was performed. Statistic evidence showed that Hyperbolic Tangent Function model is the one that best fit most of the data.
MeSH term(s)	Drug Delivery Systems ; Glycols ; Kinetics ; Lactic Acid/chemistry ; Polyglycolic Acid/chemistry ; Polylactic Acid-Polyglycolic Acid Copolymer/chemistry
Chemical Substances	Glycols ; Polylactic Acid-Polyglycolic Acid Copolymer (1SIA8062RS) ; Polyglycolic Acid (26009-03-0) ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2022-03-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0264825
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Article ; Online: Síntesis y caracterización de nanopartículas de plata preparadas con extracto acuoso de cilantro (Coriandrum sativum) y recubiertas con látex de Sangre de Drago (Croton lechleri)

Marcelo Salguero / Fernanda Pilaquinga

infoANALITÍCA, Vol 5, Iss

2017 Volume 1

Abstract: El objetivo de este estudio fue sintetizar nanopartículas de plata con métodos de química verde, combinando extractos de plantas. En la primera etapa se sintetizaron nanopartículas de plata a partir de AgNO3 10 mM con un extracto acuoso de cilantro al 5 % ...

Abstract	El objetivo de este estudio fue sintetizar nanopartículas de plata con métodos de química verde, combinando extractos de plantas. En la primera etapa se sintetizaron nanopartículas de plata a partir de AgNO3 10 mM con un extracto acuoso de cilantro al 5 %. En la segunda etapa se colocó el látex de sangre de drago al 10 % en etanol-agua (1:1 v/v), como aditivo a la disolución acuosa de nanopartículas. Por espectrofotometría UV-Visible se comprobó la formación de nanopartículas de plata a 422 nm y 439 nm respectivamente. Para la caracterización se realizaron análisis por Espectrofotometría de Infrarrojos con transformadas de Fourier acoplada a un accesorio horizontal de reflectancia total atenuada (FTIR-HATR), Microscopía Electrónica de Barrido con detector de rayos X (SEM-EDX), Espectrofotometría de Absorción Atómica de Llama (FAAS) y Dispersión de Luz Dinámica (DLS). En los resultados obtenidos, se observaron cambios evidentes en las bandas de los espectros FTIR, al comparar las nanopartículas sintetizadas con el extracto de cilantro y mezcladas con el látex de sangre de drago. Se determinó el tamaño de nanopartícula a través de SEM, obteniendo un tamaño de nanopartícula de 50 y 72 nm en cada etapa. El análisis EDX mostró la presencia de plata en un 14,9 % durante la síntesis y únicamente un 0,6 % del elemento al adicionar el látex, lo cual sugiere un adecuado recubrimiento alrededor de las nanopartículas. Para contrastar este resultado, se determinó contenido de plata por FAAS antes y después de la adición del látex, el mismo que no evidenció cambios. Además, mediante DLS se encontraron los tamaños hidrodinámicos de las nanopartículas obtenidas con y sin látex, cuyos valores fueron 259,0 y 294,3 nm respectivamente. Finalmente, se concluye que la metodología empleada para la síntesis fue exitosa y permite obtener nanopartículas de plata susceptibles de recubrirse con varios extractos vegetales, mejorando así su aplicabilidad en investigaciones biomédicas y microbiológicas.
Keywords	SEM-EDX ; sangre de drago ; nanopartículas de plata ; FT-IR ; DLS ; cilantro ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Language	Spanish
Publishing date	2017-07-01T00:00:00Z
Publisher	Pontificia Universidad Católica del Ecuador
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Synthesis and Characterization of Silver Nanoparticles Prepared With Aqueous Extract of Coriander (coriandrum Sativum) and Coated With Dragon’s Blood Latex (croton Lechleri)

Marcelo Salguero / Fernanda Pilaquinga

infoANALITÍCA, Vol 5, Iss 1, Pp 9-

2017 Volume 23

Abstract: The aim of this study was to synthesize and characterize silver nanoparticles by means of Green Chemistry methods; plant extracts were used in the procedure. First, silver nanoparticles were synthesized with 10 mM AgNO3 and a coriander aqueous extract 5 % ...

Abstract	The aim of this study was to synthesize and characterize silver nanoparticles by means of Green Chemistry methods; plant extracts were used in the procedure. First, silver nanoparticles were synthesized with 10 mM AgNO3 and a coriander aqueous extract 5 %. Later, latex obtained from dragon’s blood 10 % in ethanol-water (1:1), was spiked to the preparation mixture. Silver nanoparticle formation was established with UV-visible spectroscopy by means of measurements at 422 and 439 nm, before and after latex addition, respectively. Characterization was performed by Fourier transform Infrared Spectrophotometry with Horizontal Attenuated Total Reflectance accessory (FTIR-HATR), Scanning Electron Microscopy coupled to X-ray (SEM-EDX), Flame Atomic Absorption Spectrophotometry (FAAS) and, Dynamic Light Scattering (DLS). Changes in FTIR spectra bands were evident when comparing nanoparticles obtained with the initial extract and with the colloidal dissolution (latex). Nanoparticle size was determined using SEM; an average value of 50 nm and 72 nm was obtained at each stage. EDX analysis showed the presence of silver: 14.9 % in the product of the synthesis and 0.6 % after adding latex, suggesting the formation of an organic coating around the nanoparticles. However, silver concentration, estimated with FAAS, did not show differences between nanoparticles with and without dragon’s blood. Besides, nanoparticle hydrodynamic size was found by means of DLS, being the ones without cover, those with a higher value (294.3 vs. 259.0 nm). Finally, it was concluded that the methodology used for this synthesis was successful, and it allows silver nanoparticles coating with other plant extracts, thus improving its applicability in biomedical and microbiological investigations.
Keywords	Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	620
Language	Spanish
Publishing date	2017-07-01T00:00:00Z
Publisher	Pontificia Universidad Católica del Ecuador
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Computational Modeling of the Interaction of Silver Clusters with Carbohydrates

Felipe E. Gallegos / Lorena M. Meneses / Sebastián A. Cuesta / Juan C. Santos / Josefa Arias / Pamela Carrillo / Fernanda Pilaquinga

ACS Omega, Vol 7, Iss 6, Pp 4750-

2022 Volume 4756

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Fertility and Iron Bioaccumulation in

Pilaquinga, Fernanda / Cárdenas, Sofía / Vela, Doris / Jara, Eliza / Morey, Jeroni / Gutiérrez-Coronado, José Luis / Debut, Alexis / Piña, María de Las Nieves

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 9

Abstract: Research on nanomaterial exposure-related health risks is still quite limited; this includes standardizing methods for measuring metals in living organisms. Thus, this study validated an atomic absorption spectrophotometry method to determine fertility ... ...

Abstract	Research on nanomaterial exposure-related health risks is still quite limited; this includes standardizing methods for measuring metals in living organisms. Thus, this study validated an atomic absorption spectrophotometry method to determine fertility and bioaccumulated iron content in
MeSH term(s)	Animals ; Bioaccumulation ; Chitosan/chemistry ; Drosophila melanogaster/physiology ; Feeding Behavior ; Fertility ; Iron/metabolism ; Limit of Detection ; Magnetite Nanoparticles/chemistry ; Magnetite Nanoparticles/ultrastructure ; Static Electricity ; X-Ray Diffraction
Chemical Substances	Magnetite Nanoparticles ; Chitosan (9012-76-4) ; Iron (E1UOL152H7)
Language	English
Publishing date	2021-05-10
Publishing country	Switzerland
Document type	Journal Article ; Validation Study
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26092808
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Article ; Online: Comparative statistical analysis of the release kinetics models for nanoprecipitated drug delivery systems based on poly(lactic-co-glycolic acid).

Nathaly S Heredia / Karla Vizuete / Marco Flores-Calero / Katherine Pazmiño V / Fernanda Pilaquinga / Brajesh Kumar / Alexis Debut

PLoS ONE, Vol 17, Iss 3, p e

2022 Volume 0264825

Abstract	Poly(lactic-co-glycolic acid) is one of the most used polymers for drug delivery systems (DDSs). It shows excellent biocompatibility, biodegradability, and allows spatio-temporal control of the release of a drug by altering its chemistry. In spite of this, few formulations have reached the market. To characterize and optimize the drug release process, mathematical models offer a good alternative as they allow interpreting and predicting experimental findings, saving time and money. However, there is no general model that describes all types of drug release of polymeric DDSs. This study aims to perform a statistical comparison of several mathematical models commonly used in order to find which of them best describes the drug release profile from PLGA particles synthesized by nanoprecipitation method. For this purpose, 40 datasets extracted from scientific articles published since 2016 were collected. Each set was fitted by the models: order zero to fifth order polynomials, Korsmeyer-Peppas, Weibull and Hyperbolic Tangent Function. Some data sets had few observations that do not allow to apply statistic test, thus bootstrap resampling technique was performed. Statistic evidence showed that Hyperbolic Tangent Function model is the one that best fit most of the data.
Keywords	Medicine ; R ; Science ; Q
Subject code	660
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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