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  1. Article ; Online: The clinical efficacy of Zuqing Xu "Wuduling" powder for snake injury on the swelling of the affected limb bitten by Agkistrodon

    Ye, Jingjing / Qian, Wei / Chen, Ninggang / Hu, Zhikai / Ye, Shu / Li, Mei / Zhang, Lian / Wang, Hui / Lu, Yanwu

    Biotechnology & genetic engineering reviews

    2023  , Page(s) 1–18

    Abstract: To determine the clinical efficacy of Zuqing Xu 'Wuduling' powder for snake injury on the swelling ...

    Abstract To determine the clinical efficacy of Zuqing Xu 'Wuduling' powder for snake injury on the swelling of the affected limb bitten by
    Language English
    Publishing date 2023-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 49457-4
    ISSN 2046-5556 ; 0264-8725
    ISSN (online) 2046-5556
    ISSN 0264-8725
    DOI 10.1080/02648725.2023.2191085
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Mechanistic study on the side arm effect in a palladium/Xu-Phos-catalyzed enantioselective alkoxyalkenylation of γ-hydroxyalkenes.

    Zhu, Shuai / Ye, Zihao / Chen, Ming-Jie / Wang, Lei / Wang, Yu-Zhuo / Zhang, Ke-Nan / Li, Wen-Bo / Ding, Han-Ming / Li, Zhiming / Zhang, Junliang

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 7611

    Abstract: ... identified Xu-Phos (Xu8 and Xu9) with a suitable side-arm adjacent to the PCy ...

    Abstract Recently, the asymmetric bifunctionalization of alkenes has received much attention. However, the development of enantioselective alkoxyalkenylation has posed a considerable challenge and has lagged largely behind. Herein, we report a new palladium-catalyzed enantioselective alkoxyalkenylation reaction, using a range of primary, secondary, and tertiary γ-hydroxy-alkenes with alkenyl halides. By employing newly identified Xu-Phos (Xu8 and Xu9) with a suitable side-arm adjacent to the PCy
    Language English
    Publishing date 2023-11-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-43202-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Corrigendum: Detecting key functional components group and speculating the potential mechanism of Xiao-Xu-Ming decoction in treating stroke.

    Chen, Yu-Peng / Wang, Ke-Xin / Cai, Jie-Qi / Li, Yi / Yu, Hai-Lang / Wu, Qi / Meng, Wei / Wang, Han-Duo / Yin, Chuan-Hui / Wu, Jie / Huang, Mian-Bo / Li, Rong / Guan, Dao-Gang

    Frontiers in cell and developmental biology

    2023  Volume 10, Page(s) 1107236

    Abstract: This corrects the article DOI: 10.3389/fcell.2022.753425.]. ...

    Abstract [This corrects the article DOI: 10.3389/fcell.2022.753425.].
    Language English
    Publishing date 2023-01-20
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.1107236
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Xu Su, China CDC's Chief Expert of Radiation Protection.

    Hao, Peter / Chen, Yu / Li, Zhenjun / Xi, Jingjing / Tan, Feng

    China CDC weekly

    2021  Volume 2, Issue 29, Page(s) 553–554

    Language English
    Publishing date 2021-08-29
    Publishing country China
    Document type Journal Article
    ISSN 2096-7071
    ISSN (online) 2096-7071
    DOI 10.46234/ccdcw2020.148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Palladium/Xu-Phos-catalyzed asymmetric carboamination towards isoxazolidines and pyrrolidines.

    Wang, Yuzhuo / Wang, Lei / Chen, Mingjie / Tu, Youshao / Liu, Yu / Zhang, Junliang

    Chemical science

    2021  Volume 12, Issue 23, Page(s) 8241–8245

    Abstract: An efficient palladium-catalyzed enantioselective carboamination reaction ... ...

    Abstract An efficient palladium-catalyzed enantioselective carboamination reaction of
    Language English
    Publishing date 2021-05-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d1sc01337h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: [Action mechanism of Professor Xu Fusong's Shuilu Erxian Dan in the treatment of premature ejaculation: An exploration based on network pharmacology and molecular docking technology].

    Zhang, Xing / Han, Zi-Yang / Nie, Pan / Wang, Heng / Chen, Jian-Huai / Chen, Yun

    Zhonghua nan ke xue = National journal of andrology

    2023  Volume 28, Issue 2, Page(s) 149–156

    Abstract: Objective: To analyze the potential action mechanism of Shuilu Erxian Dan in the treatment of premature ejaculation based on network pharmacology.: Methods: The TCMSP database was searched for the main chemical constituents of Euryale and golden ... ...

    Abstract Objective: To analyze the potential action mechanism of Shuilu Erxian Dan in the treatment of premature ejaculation based on network pharmacology.
    Methods: The TCMSP database was searched for the main chemical constituents of Euryale and golden cherry, the core components of Shuilu Erxian Dan. Oral bioavailability and medicinal properties were set as the parameters for screening active components, premature ejaculation-related disease targets retrieved from the DisGeNET, GeneCards, OMIM and TTD databases, the common targets of drug pairs and diseases identified with the Wayne diagram, and a drug-active ingredient-target-disease network map constructed with the software Cytoscape. A PPI network map designed through the STRING platform, the website Metascape used for GO and KEGG analyses of the common targets, and the protein receptors and small molecular ligands of the core genes employed for molecular docking and PyMOL visualization.
    Results: A total of 7 chemical constituents and 171 predictive targets, 1 918 premature ejaculation targets and 113 common targets were identified. GO analysis showed significant enrichment of BP in response to toxic substances and inorganic substances, CC in membrane raft and plasma membrane protein complex, and MF in transcription factor binding and kinase binding. KEGG analysis manifested markedly enriched TNF signaling pathway, JAK-STAT signaling pathway and Cocaine addiction. The results of molecular docking exhibited a good binding energy between the core gene and the component.
    Conclusion: Network pharmacology has revealed the potential action mechanism of Shuilu Erxian Dan in the treatment of premature ejaculation, which has paved the theoretical ground for verification of the effectiveness of Shuilu Erxian Dan in the treatment of premature ejaculation via animals and cells.
    MeSH term(s) Animals ; Male ; Humans ; Network Pharmacology ; Molecular Docking Simulation ; Premature Ejaculation/drug therapy ; Signal Transduction ; Drugs, Chinese Herbal/pharmacology
    Chemical Substances Drugs, Chinese Herbal
    Language Chinese
    Publishing date 2023-07-18
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 2267480-9
    ISSN 1009-3591
    ISSN 1009-3591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6577: Show issues Location:
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  7. Article ; Online: Metabolomics-based study of the potential interventional effects of Xiao-Xu-Ming Decoction on cerebral ischemia/reperfusion rats.

    Wu, Ziqian / Qian, Shiyan / Zhao, Liangcai / Zhang, Zaiheng / Song, Chengcheng / Chen, Ling / Gao, Hongchang / Zhu, Wenzong

    Journal of ethnopharmacology

    2022  Volume 295, Page(s) 115379

    Abstract: Ethnopharmacological relevance: Xiao-Xu-Ming Decoction (XXMD) is a classical Chinese medicinal ...

    Abstract Ethnopharmacological relevance: Xiao-Xu-Ming Decoction (XXMD) is a classical Chinese medicinal compound for the treatment of ischemic stroke, which has good efficacy in clinical studies and also plays a neuroprotective role in pharmacological studies.
    Aim of the study: The purpose of this study is to investigate the potential and integral interventional effects of XXMD on cerebral ischemia/reperfusion rat model.
    Materials and methods: In this study,
    Results: It's observed that XXMD treatment could improve the neurological deficit scores and reduce the cerebral infarct areas on cerebral ischemia/reperfusion rat model. The pathological staining results performed that XXMD treatment could improve the decrease of Nissl bodies and the expression of NeuN and MCT2, reduce the high expression of TUNEL. In
    Conclusion: Our findings indicated that XXMD has positive effect on neuroprotection and improvement of metabolism targeting cerebral ischemic injury in rats, which showed great potential for ischemic stroke.
    MeSH term(s) Animals ; Brain Ischemia/drug therapy ; Brain Ischemia/metabolism ; Cerebral Infarction/drug therapy ; Drugs, Chinese Herbal ; Ischemia/drug therapy ; Ischemic Stroke ; Metabolomics ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Rats ; Reperfusion ; Reperfusion Injury/metabolism
    Chemical Substances Drugs, Chinese Herbal ; Neuroprotective Agents ; xiao-xu-ming
    Language English
    Publishing date 2022-05-18
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.115379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1494: Show issues Location:
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  8. Article: Detecting Key Functional Components Group and Speculating the Potential Mechanism of Xiao-Xu-Ming Decoction in Treating Stroke.

    Chen, Yu-Peng / Wang, Ke-Xin / Cai, Jie-Qi / Li, Yi / Yu, Hai-Lang / Wu, Qi / Meng, Wei / Wang, Han-Duo / Yin, Chuan-Hui / Wu, Jie / Huang, Mian-Bo / Li, Rong / Guan, Dao-Gang

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 753425

    Abstract: ... traditional Chinese medicine (TCM) has widely been used at clinical level in China and some countries in Asia. Xiao-Xu-Ming ...

    Abstract Stroke is a cerebrovascular event with cerebral blood flow interruption which is caused by occlusion or bursting of cerebral vessels. At present, the main methods in treating stroke are surgical treatment, statins, and recombinant tissue-type plasminogen activator (rt-PA). Relatively, traditional Chinese medicine (TCM) has widely been used at clinical level in China and some countries in Asia. Xiao-Xu-Ming decoction (XXMD) is a classical and widely used prescription in treating stroke in China. However, the material basis of effect and the action principle of XXMD are still not clear. To solve this issue, we designed a new system pharmacology strategy that combined targets of XXMD and the pathogenetic genes of stroke to construct a functional response space (FRS). The effective proteins from this space were determined by using a novel node importance calculation method, and then the key functional components group (KFCG) that could mediate the effective proteins was selected based on the dynamic programming strategy. The results showed that enriched pathways of effective proteins selected from FRS could cover 99.10% of enriched pathways of reference targets, which were defined by overlapping of component targets and pathogenetic genes. Targets of optimized KFCG with 56 components can be enriched into 166 pathways that covered 80.43% of 138 pathways of 1,012 pathogenetic genes. A component potential effect score (PES) calculation model was constructed to calculate the comprehensive effective score of components in the components-targets-pathways (C-T-P) network of KFCGs, and showed that ferulic acid, zingerone, and vanillic acid had the highest PESs. Prediction and docking simulations show that these components can affect stroke synergistically through genes such as MEK, NFκB, and PI3K in PI3K-Akt, cAMP, and MAPK cascade signals. Finally, ferulic acid, zingerone, and vanillic acid were tested to be protective for PC12 cells and HT22 cells in increasing cell viabilities after oxygen and glucose deprivation (OGD). Our proposed strategy could improve the accuracy on decoding KFCGs of XXMD and provide a methodologic reference for the optimization, mechanism analysis, and secondary development of the formula in TCM.
    Language English
    Publishing date 2022-05-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.753425
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Letter by Xu et al Regarding Article, "Cilostazol for Secondary Prevention of Stroke and Cognitive Decline: Systematic Review and Meta-Analysis".

    Xu, Tao / Wang, You / Chen, Yangmei

    Stroke

    2020  Volume 51, Issue 12, Page(s) e375–e376

    MeSH term(s) Cilostazol ; Cognitive Dysfunction/drug therapy ; Cognitive Dysfunction/prevention & control ; Humans ; Platelet Aggregation Inhibitors ; Secondary Prevention ; Stroke/drug therapy ; Stroke/prevention & control
    Chemical Substances Platelet Aggregation Inhibitors ; Cilostazol (N7Z035406B)
    Language English
    Publishing date 2020-11-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.120.031872
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Erratum for Xu et al., "A Single Amino Acid at Position 431 of the PB2 Protein Determines the Virulence of H1N1 Swine Influenza Viruses in Mice".

    Xu, Chengzhi / Xu, Bangfeng / Wu, Yunpu / Yang, Shiman / Jia, Yunhui / Liang, Wenhua / Yang, Dawei / He, Likun / Zhu, Wenfei / Chen, Yan / Yang, Huanliang / Yu, Benliang / Wang, Dayan / Qiao, Chuanling

    Journal of virology

    2020  Volume 94, Issue 13

    Language English
    Publishing date 2020-06-16
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.00653-20
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