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  1. Article ; Online: On the mechanism of carboxylate elimination from carbohydrate monoester-derived radicals.

    Turner, Julia A / Zipse, Hendrik / Taylor, Mark S

    Organic & biomolecular chemistry

    2024  Volume 22, Issue 16, Page(s) 3225–3229

    Abstract: A computational study of the mechanism of hydrogen atom transfer-induced carboxylate elimination from monoacylated 1,2-diol groups in pyranosides is presented. A comprehensive analysis of the 1,2-migration, elimination and fragmentation pathways reveals ... ...

    Abstract A computational study of the mechanism of hydrogen atom transfer-induced carboxylate elimination from monoacylated 1,2-diol groups in pyranosides is presented. A comprehensive analysis of the 1,2-migration, elimination and fragmentation pathways reveals that concerted elimination
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d4ob00241e
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  2. Article ; Online: Boronic Acid-Catalyzed Regio- and Stereoselective

    Desai, Shrey P / Yatzoglou, Giorgos / Turner, Julia A / Taylor, Mark S

    Journal of the American Chemical Society

    2024  Volume 146, Issue 7, Page(s) 4973–4984

    Abstract: In the presence of an arylboronic acid catalyst, azole-type heterocycles, including purines, tetrazoles, triazoles, indazoles, and benzo-fused congeners, undergo regio- and ... ...

    Abstract In the presence of an arylboronic acid catalyst, azole-type heterocycles, including purines, tetrazoles, triazoles, indazoles, and benzo-fused congeners, undergo regio- and stereoselective
    Language English
    Publishing date 2024-02-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c14434
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  3. Article ; Online: Postpartum Remote Blood Pressure Monitoring Using a Mobile App in Women with a Hypertensive Disorder of Pregnancy.

    Burgess, Adriane / Deannuntis, Taylor / Wheeling, Julia

    MCN. The American journal of maternal child nursing

    2024  

    Abstract: Background: Hypertensive disorders of pregnancy affect approximately 15% of pregnancies in the United States and are a leading cause of postpartum readmissions. Morbidity due to hypertension may be higher in the first several weeks postpartum. The ... ...

    Abstract Background: Hypertensive disorders of pregnancy affect approximately 15% of pregnancies in the United States and are a leading cause of postpartum readmissions. Morbidity due to hypertension may be higher in the first several weeks postpartum. The ability to monitor blood pressure and intervene in the postpartum period is critical to reducing morbidity and mortality.
    Local problem: At WellSpan Health, hypertensive disorders were increasing and a leading cause of severe maternal morbidity and readmission.
    Interventions: A remote blood pressure monitoring app called BabyScripts™ myBloodPressure was implemented in September 2020. Prior to discharge postpartum, all patients with a diagnosis of a hypertensive disorder of pregnancy were given an automatic blood pressure cuff and instructions on how to monitor and track their blood pressure daily in the app.
    Results: A total of 1,260 patients were enrolled in the BabyScripts™ myBloodPressure module between September 2020 and July 2022 across five maternity hospitals. Of those enrolled 74% (n = 938) entered seven or more blood pressures, and of those who entered at least one blood pressure 9% (n = 107) entered at least one critical range blood pressure (≥150 mmHg systolic and or ≥100 mmHg diastolic).
    Conclusion: Most women enrolled in the app were highly engaged and entered seven or more readings. Patients with critical blood pressures were identified; thus, the program has the potential to identify those at risk of severe complications. Barriers should be removed, and remote patient monitoring considered as a solution to improve postpartum assessment in patients with hypertensive disorders of pregnancy.
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605601-5
    ISSN 1539-0683 ; 0361-929X
    ISSN (online) 1539-0683
    ISSN 0361-929X
    DOI 10.1097/NMC.0000000000001019
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1909: Show issues Location:
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  4. Article ; Online: Understanding the Origins of Site Selectivity in Hydrogen Atom Transfer Reactions from Carbohydrates to the Quinuclidinium Radical Cation: A Computational Study.

    Turner, Julia A / Adrianov, Timur / Taylor, Mark S

    The Journal of organic chemistry

    2023  Volume 88, Issue 9, Page(s) 5713–5730

    Abstract: The use of quinuclidine as a hydrogen atom transfer (HAT) mediator, along with a light-absorbing photoredox catalyst, has proved to be a powerful and general approach for achieving site-selective radical formation from carbohydrate substrates. Despite ... ...

    Abstract The use of quinuclidine as a hydrogen atom transfer (HAT) mediator, along with a light-absorbing photoredox catalyst, has proved to be a powerful and general approach for achieving site-selective radical formation from carbohydrate substrates. Despite numerous literature reports documenting the scope and limitations of such processes, a general rationale for the origins of site selectivity in the key HAT step has not been advanced. In this study, density functional theory calculations (M06-2X/def2-TZVP/PCM(acetonitrile)) were used to model transition states for HAT to the quinuclidinium radical cation from pyranosides and furanosides having various configurations and substitution patterns. The data set (>120 transition state geometries and energies) has allowed for a detailed examination of the factors that influence the relative rates, augmented by additional analysis using the atoms in molecules (AIM) and distortion/interaction-activation strain frameworks. The trends that have emerged regarding the effects of configuration, conformation, substitution, and noncovalent interactions are consistent with experimental observations and reveal a key role for C-H···O hydrogen bonds in stabilizing transition states for HAT to the quinuclidinium radical cation.
    Language English
    Publishing date 2023-04-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.3c00181
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4473: Show issues Location:
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  5. Article: Transformations of carbohydrate derivatives enabled by photocatalysis and visible light photochemistry.

    Gorelik, Daniel J / Desai, Shrey P / Jdanova, Sofia / Turner, Julia A / Taylor, Mark S

    Chemical science

    2024  Volume 15, Issue 4, Page(s) 1204–1236

    Abstract: This review article highlights the diverse ways in which recent developments in the areas of photocatalysis and visible light photochemistry are impacting synthetic carbohydrate chemistry. The major topics covered are photocatalytic glycosylations, ... ...

    Abstract This review article highlights the diverse ways in which recent developments in the areas of photocatalysis and visible light photochemistry are impacting synthetic carbohydrate chemistry. The major topics covered are photocatalytic glycosylations, generation of radicals at the anomeric position, transformations involving radical formation at non-anomeric positions, additions to glycals, processes initiated by photocatalytic hydrogen atom transfer from sugars, and functional group interconversions at OH and SH groups. Factors influencing stereo- and site-selectivity in these processes, along with mechanistic aspects, are discussed.
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc05400d
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  6. Article ; Online: Catalyst-Controlled, Site-Selective Sulfamoylation of Carbohydrate Derivatives.

    Gorelik, Daniel J / Turner, Julia A / Taylor, Mark S

    Organic letters

    2022  Volume 24, Issue 29, Page(s) 5249–5253

    Abstract: Methods for site-selective sulfamoylation of secondary hydroxyl groups in pyranosides are described. Using a boronic acid catalyst, selective installation of a Boc-protected sulfamoyl group at the equatorial position ... ...

    Abstract Methods for site-selective sulfamoylation of secondary hydroxyl groups in pyranosides are described. Using a boronic acid catalyst, selective installation of a Boc-protected sulfamoyl group at the equatorial position of
    MeSH term(s) Alcohols ; Boronic Acids ; Carbohydrates ; Catalysis
    Chemical Substances Alcohols ; Boronic Acids ; Carbohydrates
    Language English
    Publishing date 2022-06-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c01590
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  7. Article ; Online: Disparities in access but not outcomes: Medicaid versus non-Medicaid patients in multidisciplinary chronic pain rehabilitation.

    Crouch, Taylor B / Wedin, Sharlene / Kilpatrick, Rebecca / Smith, Allison / Flores, Brigette / Rodes, Julia / Borckardt, Jeffrey / Barth, Kelly

    Disability and rehabilitation

    2024  , Page(s) 1–8

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2024-02-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1104775-6
    ISSN 1464-5165 ; 0963-8288
    ISSN (online) 1464-5165
    ISSN 0963-8288
    DOI 10.1080/09638288.2024.2321326
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1569: Show issues Location:
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  8. Article ; Online: Older Adults' Perspectives of Independence Through Time: Results of a Longitudinal Interview Study.

    Taylor, Emily / Goodwin, Victoria A / Ball, Susan / Clegg, Andrew / Brown, Lesley / Frost, Julia

    The Gerontologist

    2023  Volume 64, Issue 2

    Abstract: Background and objectives: Understanding how older people experience independence has implications for person-centered care. Existing understanding of older people's experience of independence, generated through methods that provide a "snapshot" view of ...

    Abstract Background and objectives: Understanding how older people experience independence has implications for person-centered care. Existing understanding of older people's experience of independence, generated through methods that provide a "snapshot" view of a person's independence at a given time point, provides little insight into the process of maintaining independence through time. The aim of this study was to explore older participants' perceptions to understand the processes and resources that were most important for maintaining independence.
    Research design and methods: Two semistructured interviews were conducted longitudinally to explore the perspectives of 12 community-dwelling, older people, aged 76-85 years. A social constructivist approach, using dramaturgical and descriptive codes, facilitated the interpretation of the data. Sixteen analytical questions guided the exploration of participants' perceptions of independence through time.
    Results: Older people suggested that objective representations underestimated, and omitted, important aspects of their independence through time. Some participants perceived "snapshot" judgments of their independence as insensitive to their individual values and context. Change over time required some participants to adapt their methods for maintaining independence. The stability of participants' sense of independence was value dependent and informed by the purpose a participant ascribed to maintaining independence.
    Discussion and implications: This study augments the understanding of independence as a complex and multifaceted construct. The findings challenge the congruence of common interpretations of independence with older people's views, showing areas of commonality, and discrepancy. Exploration of independence in terms of form and function provides an important understanding of how function takes precedence to form in determining the maintenance of independence through time.
    MeSH term(s) Humans ; Aged ; Qualitative Research ; Independent Living ; Longitudinal Studies
    Language English
    Publishing date 2023-06-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 216760-8
    ISSN 1758-5341 ; 0016-9013
    ISSN (online) 1758-5341
    ISSN 0016-9013
    DOI 10.1093/geront/gnad073
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    Zs.B 112: Show issues Location:
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  9. Article ; Online: Endorsing a Biopsychosocial Perspective of Pain in Individuals With Chronic Pain: Development and Validation of a Scale.

    Kleinstäuber, Maria / Garland, Eric L / Sisco-Taylor, Brittany L / Sanyer, Mathias / Corfe-Tan, Julia / Barke, Antonia

    The Clinical journal of pain

    2024  Volume 40, Issue 1, Page(s) 35–45

    Abstract: Objectives: Patients' beliefs about pain play an important role in their readiness to engage with chronic pain self-management. The central aim of this study was to validate a self-report instrument to assess a specific set of pain beliefs, patients' ... ...

    Abstract Objectives: Patients' beliefs about pain play an important role in their readiness to engage with chronic pain self-management. The central aim of this study was to validate a self-report instrument to assess a specific set of pain beliefs, patients' endorsement of a biopsychosocial model of chronic pain Patients' Endorsement of a Biopsychosocial Model of Chronic Pain Scale (PEB).
    Methods: Interdisciplinary experts in the field of pain were involved in creating an instrument, the PEB Scale, to operationalize patients' endorsement of a biopsychosocial pain model. A sample of 199 patients with chronic pain was recruited to evaluate the factorial structure (principal axis factoring), the internal consistency (Cronbach alpha), the convergent and discriminant validity (correlational analyses), incremental validity (multiple, hierarchical regression analyses), and construct validity (differential population analysis) of the instrument.
    Results: The factor analysis resulted in a unidimensional, 11-item instrument that explained 51.2% of the total variance. Cronbach alpha (=0.92) indicated high internal consistency of the created set of pain-related beliefs. Regression analyses demonstrated that PEB is a strong predictor of patients' engagement with pain self-management ( P < 0.001) after controlling for demographic variables, anxiety, depression, and other pain-related beliefs.
    Discussion: Our results show that the PEB Scale is a highly reliable self-report instrument that has the potential to predict patients' readiness to adopt pain self-management. Future research should focus on revalidating the scale to operationalize PEB. Moreover, the PEB Scale should be implemented in longitudinal study designs to investigate its ability to predict the transition from acute to chronic pain and patients' long-term pain management.
    MeSH term(s) Humans ; Chronic Pain/therapy ; Longitudinal Studies ; Surveys and Questionnaires ; Pain Management ; Self Report ; Reproducibility of Results ; Psychometrics
    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 632582-8
    ISSN 1536-5409 ; 0749-8047
    ISSN (online) 1536-5409
    ISSN 0749-8047
    DOI 10.1097/AJP.0000000000001163
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    Zs.A 2078: Show issues Location:
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  10. Article ; Online: Performance of the Southend pre-test probability score (PTPS) for giant cell arteritis in a fast-track clinic in Western Australia.

    Mathake, Mmoloki / Murdoch, Julia / DeSousa, Jean-Louis / Taylor, Andrew / Keen, Helen

    Rheumatology advances in practice

    2022  Volume 6, Issue 2, Page(s) rkac055

    Language English
    Publishing date 2022-07-26
    Publishing country England
    Document type Journal Article
    ISSN 2514-1775
    ISSN (online) 2514-1775
    DOI 10.1093/rap/rkac055
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