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Article ; Online: Distribution of HLA-DQA1, -DQB1 and -DRB1 genes and haplotypes in Han, Uyghur, Kazakh and Hui populations inhabiting Xinjiang Uyghur Autonomous Region, China.

Zhou, Chunyan / Xu, Mengyu / Xiao, Zhiwen / Yuan, Juanli / Wu, Yong / Gao, Beiyao / Hui, Wenjia / Gao, Feng / Chen, Hongbing

International journal of immunogenetics

2021 Volume 48, Issue 3, Page(s) 229–238

Abstract: ... ethnic groups including Han (n = 70), Uyghur (n = 71), Kazakh (n = 52) and Hui (n = 40) subjects from Xinjiang ... respectively. In Hui, DRB1*07:01, DRB1*11:01 and DRB1*14:01 were the most dominant alleles with the same ... 15.38%) in Kazakh; and DQA1*03:01/02/03-DQB1*03:03 (11.25%) in Hui. The phylogenetic dendrograms ...

Abstract	Genetic polymorphisms of human leucocyte antigen (HLA)-DRB1, -DQA1 and -DQB1 among four main ethnic groups including Han (n = 70), Uyghur (n = 71), Kazakh (n = 52) and Hui (n = 40) subjects from Xinjiang Uyghur Autonomous Region were investigated using a polymerase chain reaction-sequence-based typing (PCR-SBT). In total, 32 HLA-DRB1 alleles, eight HLA-DQA1 alleles and 14 HLA-DQB1 alleles were identified. The most predominant HLA-DRB1, -DQA1 and -DQB1 alleles were DRB115:01 (12.50%), DQA101:02 (21.43%) and DQB103:01 (19.29%) in Han; DRB107:01 (18.48%), DQA105:01/03/05 (24.65%) and DQB102:01/02 (31.69%) in Uyghur; and DRB113:01 (13.64%), DQA105:01/03/05 (28.85%) and DQB102:01/02 (27.88%) in Kazakh, respectively. In Hui, DRB107:01, DRB111:01 and DRB114:01 were the most dominant alleles with the same frequency of 11.8%, while the predominant DQA1 and DQB1 alleles were DQA103:01/02/03 (23.75%) and DQB102:01/02 (16.25%), respectively. In addition, the most common two-locus haplotypes were DQA105:01/03/5-DQB103:01 (10.0%) in Han; DQA102:01-DQB102:01/02 (18.31%) in Uyghur; DQA105:01/03/05-DQB102:01/02 (15.38%) in Kazakh; and DQA103:01/02/03-DQB103:03 (11.25%) in Hui. The phylogenetic dendrograms constructed based on the allele frequencies of HLA-DRB1, -DQA1 and -DQB1 in 13 populations (e.g. Asian, Central Asian and European) revealed that the Han and Hui populations were clustered together and closest to Han population from China, while the Kazakh and Uyghur populations were closest to each other and two ethnic groups were clustered together with Central Asian and European populations.
MeSH term(s)	Alleles ; Asian Continental Ancestry Group/genetics ; China/epidemiology ; Ethnic Groups/genetics ; Female ; Gene Frequency ; Genetics, Population ; Genotype ; HLA-DQ alpha-Chains/genetics ; HLA-DQ alpha-Chains/immunology ; HLA-DQ beta-Chains/genetics ; HLA-DQ beta-Chains/immunology ; HLA-DRB1 Chains/genetics ; HLA-DRB1 Chains/immunology ; Haplotypes/genetics ; Haplotypes/immunology ; Histocompatibility Antigens Class I/genetics ; Histocompatibility Antigens Class I/immunology ; Humans ; Male ; Phylogeny ; Polymorphism, Genetic/genetics
Chemical Substances	HLA-DQ alpha-Chains ; HLA-DQ beta-Chains ; HLA-DQA1 antigen ; HLA-DQB1 antigen ; HLA-DRB1 Chains ; Histocompatibility Antigens Class I
Language	English
Publishing date	2021-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2177883-8
ISSN	1744-313X ; 1744-3121
ISSN (online)	1744-313X
ISSN	1744-3121
DOI	10.1111/iji.12529
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Article ; Online: Reply to Ugo Giovanni Falagario, Alberto Martini, Francesco Pellegrino, et al.'s Letter to the Editor re: Derya Tilki, Ming-Hui Chen, Jing Wu, et al. Prostate-specific Antigen Level at the Time of Salvage Therapy After Radical Prostatectomy for Prostate Cancer and the Risk of Death. J Clin Oncol 2023;41:2428-35.

Tilki, Derya / Chen, Ming-Hui / D'Amico, Anthony V

European urology oncology

2023 Volume 7, Issue 1, Page(s) 166

MeSH term(s)	Male ; Humans ; Prostate-Specific Antigen ; Salvage Therapy ; Prostate ; Prostatic Neoplasms/surgery ; Prostatectomy
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	English
Publishing date	2023-06-12
Publishing country	Netherlands
Document type	Letter
ISSN	2588-9311
ISSN (online)	2588-9311
DOI	10.1016/j.euo.2023.05.009
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Article: [Study on the relationship between transaminase activity and metabolic syndrome in Hui and Han nationality of Ningxia Province].

Qiu, Fangyuan / Liu, Herong / Chen, Lijun / Song, Lin / Ma, Wenqi / Song, Hui

Wei sheng yan jiu = Journal of hygiene research

2018 Volume 45, Issue 6, Page(s) 938–944

Abstract: ... syndrome( MS) and its related indicators in Hui and Han nationality of Ningxia Province.: Methods: Using ... of AST and ALT of Hui is higher than that of Han nationality, but there were no significant difference ...

Abstract	Objective: To analyze the relationship between the transaminase activity in serum and metabolic syndrome( MS) and its related indicators in Hui and Han nationality of Ningxia Province. Methods: Using the method of case-control study, people of regional organizations who received regular health checks in the General Hospital of Ningxia Medical University and Wuzhong City People's Hospital from the October 2011 to October 2012 were enrolled in the study. According to inclusion and exclusion criteria, we selected 877 unrelated cases with metabolic syndrome as the case group and 655 unrelated health cases as control group. Date were collected through questionnaire investigation, physical examination and laboratory tests. The association between the transaminase activity and MS was analyzed by Chi-square test, t test and analysis of variance. Results: The average levels and abnormality rate of AST and ALT in case group were significantly higher than that of control group, especially the average levels and abnormality rate of ALT, there were significant difference( t =-3. 971, t =-6. 048, χ2= 11. 556, χ2=33. 231, all P < 0. 01). To control the AST and ALT levels of seventy-five percent in control group and 40 U/L as the boundary and divided all the research object into low, medium and high groups. After adjustment for gender, age, nationality, culture degree, smoking and drinking, the odds ratios for MS were 1. 663( 95% CI 1. 263-2. 189) and2. 126( 95% CI 1. 586-2. 852) in the people with the medium AST, ALT levels people and low AST and ALT levels people, the odds ratios for MS were 2. 801( 95% CI 1. 696-4. 624) and 4. 918( 95% CI 2. 980-8. 116) in the people with the high AST, ALT levels people and low AST and ALT levels people, the odds ratios for MS were 2. 517( 95% CI1. 530-4. 142) and 4. 194( 95% CI 2. 554-6. 885) in the people with the high AST, ALT levels people and low and medium AST and ALT levels people. With the number of components of metabolic syndrome increases, the average levels of AST, ALT increased gradually, there were significant difference( F = 7. 742, F = 11. 753, all P < 0. 01). Comparing the average levels of AST and ALT of different age groups, except the control group, there were significant difference( all P < 0. 05). The average levels of AST and ALT of Hui is higher than that of Han nationality, but there were no significant difference( all P > 0. 05). The average levels of AST and ALT of male was significantly higher than that of female, there were significant difference in addition to the average levels of AST of case group( all P < 0. 01). There were significant difference in the average levels of AST, ALT in case, control and total survey population between different BMI levels( all P <0. 05). Conclusion: The average levels of AST and ALT are closely related with the incidence of MS, in normal range, the levels of AST and ALT on the high side can increase the risk of MS, and the risk of MS creased significantly in the abnormal increase ones. The levels of AST and ALT can become an important factor to predict the risk of MS, synthetically evaluate the risk factors of MS and predict the progress of the MS.
MeSH term(s)	Case-Control Studies ; Ethnic Groups ; Female ; Humans ; Male ; Metabolic Syndrome/blood ; Metabolic Syndrome/ethnology ; Risk Factors ; Transaminases/blood
Chemical Substances	Transaminases (EC 2.6.1.-)
Language	Chinese
Publishing date	2018-06-15
Publishing country	China
Document type	Journal Article
ZDB-ID	1050909-4
ISSN	1000-8020
ISSN	1000-8020
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Zs.A 4878: Show issues

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Article: Significant East Asian Affinity of the Sichuan Hui Genomic Structure Suggests the Predominance of the Cultural Diffusion Model in the Genetic Formation Process.

Liu, Yan / Yang, Junbao / Li, Yingxiang / Tang, Renkuan / Yuan, Didi / Wang, Yicheng / Wang, Peixin / Deng, Shudan / Zeng, Simei / Li, Hongliang / Chen, Gang / Zou, Xing / Wang, Mengge / He, Guanglin

Frontiers in genetics

2021 Volume 12, Page(s) 626710

Abstract: The ancestral origin and genomic history of Chinese Hui people remain to be explored due ... to modern Hui people, which is referred to as the ...

Abstract	The ancestral origin and genomic history of Chinese Hui people remain to be explored due to the paucity of genome-wide data. Some evidence argues that an eastward migration of Central Asians gave rise to modern Hui people, which is referred to as the
Language	English
Publishing date	2021-06-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2021.626710
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Article: Male-Dominated Migration and Massive Assimilation of Indigenous East Asians in the Formation of Muslim Hui People in Southwest China.

Wang, Qiyan / Zhao, Jing / Ren, Zheng / Sun, Jin / He, Guanglin / Guo, Jianxin / Zhang, Hongling / Ji, Jingyan / Liu, Yubo / Yang, Meiqing / Yang, Xiaomin / Chen, Jinwen / Zhu, Kongyang / Wang, Rui / Li, Yingxiang / Chen, Gang / Huang, Jiang / Wang, Chuan-Chao

Frontiers in genetics

2021 Volume 11, Page(s) 618614

Abstract: The origin and diversification of Muslim Hui people in China via demic or simple cultural diffusion ... single nucleotide polymorphisms (SNPs) from 45 Hui and 14 Han Chinese individuals collected from Guizhou province in southwest ...

Abstract	The origin and diversification of Muslim Hui people in China via demic or simple cultural diffusion is a long-going debate. We here generated genome-wide data at nearly 700,000 single nucleotide polymorphisms (SNPs) from 45 Hui and 14 Han Chinese individuals collected from Guizhou province in southwest China. We applied principal component analysis (PCA), ADMIXTURE,
Language	English
Publishing date	2021-01-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2020.618614
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Article: A Study on the Correlation Between MDR1 Polymorphism and Clopidogrel Resistance in Hui Patients Treated with Percutaneous Coronary Intervention.

Chen, Fang / Zhang, Jing / Bian, Cheng-Xue / Zhang, Jian / Xin, Xiang-Bin / Pan, Yang-Yang / Zhang, Xuan

International journal of general medicine

2021 Volume 14, Page(s) 665–671

Abstract: ... resistance (CR) in Hui patients with coronary heart disease (CHD) who were treated ... with percutaneous coronary intervention (PCI).: Methods: The study includes 204 Ningxia Hui patients with CHD who were treated with PCI ... For C1236T, no significant difference was found between the two groups.: Conclusion: Hui patients who had ...

Abstract	Objective: This study assesses the correlation between MDR1 gene polymorphism and clopidogrel resistance (CR) in Hui patients with coronary heart disease (CHD) who were treated with percutaneous coronary intervention (PCI). Methods: The study includes 204 Ningxia Hui patients with CHD who were treated with PCI. These patients were divided into two groups: those who with CR and others were non-clopidogrel resistant (NCR), according to the results of the patients' platelet aggregation rate, which was tested by adenosine diphosphate-induced turbidimetry on the second postoperative day. C3435T and C1236T genotypes and alleles were tested by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: The CR rate was 24.0%, and there were 3 genotypes of C3435T and C1236T. For C3435T, the distribution frequency of the 3435TT genotype and T allele was significantly higher in the CR group than in the NCR group. For C1236T, no significant difference was found between the two groups. Conclusion: Hui patients who had CHD were treated with PCI. CR was most likely to occur in those who had the T allele of MDR1 in gene C3435T.
Language	English
Publishing date	2021-02-25
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S293947
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Article: [Summary of Hui prescriptions for stroke].

Li, Ting-Ting / Dong, Lin / Chen, Guo-Ting / Chen, Jing / Fu, Xue-Yan

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2013 Volume 38, Issue 14, Page(s) 2412–2415

Abstract: Current Hui prescriptions are mostly recorded in the Arabic language. Their fussy and inconsistent ... names (Arabic names) result in the restriction in the clinical application of Hui prescriptions. Having ... collected and screened out 101 Hui prescriptions for stroke, the author further studied some of their names ...

Abstract	Current Hui prescriptions are mostly recorded in the Arabic language. Their fussy and inconsistent names (Arabic names) result in the restriction in the clinical application of Hui prescriptions. Having collected and screened out 101 Hui prescriptions for stroke, the author further studied some of their names in literatures, in order to facilitate clinical application of these prescriptions (i. e. unification of their Arabic and Chinese names, and textual research of identical drugs with different Arabic names). This lays a foundation for the clinical application of Hui prescriptions and the analysis on compatibility regulatory, and provides scientific basis for studies on new Hui medicines.
MeSH term(s)	Asian Continental Ancestry Group ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Medicine, Arabic ; Medicine, Chinese Traditional/methods ; Plant Extracts/therapeutic use ; Stroke/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; Plant Extracts
Language	Chinese
Publishing date	2013-07
Publishing country	China
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
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Zs.A 3056: Show issues

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Article ; Online: Extending Hui-Walter framework to correlated outcomes with application to diagnosis tests of an eye disease among premature infants.

Liu, Yu-Lun / Ying, Gui-Shuang / Quinn, Graham E / Zhou, Xiao-Hua / Chen, Yong

Statistics in medicine

2021 Volume 41, Issue 3, Page(s) 433–448

Abstract: Diagnostic accuracy, a measure of diagnostic tests for correctly identifying patients with or without a target disease, plays an important role in evidence-based medicine. Diagnostic accuracy of a new test ideally should be evaluated by comparing to a ... ...

Abstract	Diagnostic accuracy, a measure of diagnostic tests for correctly identifying patients with or without a target disease, plays an important role in evidence-based medicine. Diagnostic accuracy of a new test ideally should be evaluated by comparing to a gold standard; however, in many medical applications it may be invasive, costly, or even unethical to obtain a gold standard for particular diseases. When the accuracy of a new candidate test under evaluation is assessed by comparison to an imperfect reference test, bias is expected to occur and result in either overestimates or underestimates of its true accuracy. In addition, diagnostic test studies often involve repeated measurements of the same patient, such as the paired eyes or multiple teeth, and generally lead to correlated and clustered data. Using the conventional statistical methods to estimate diagnostic accuracy can be biased by ignoring the within-cluster correlations. Despite numerous statistical approaches have been proposed to tackle this problem, the methodology to deal with correlated and clustered data in the absence of a gold standard is limited. In this article, we propose a method based on the composite likelihood function to derive simple and intuitive closed-form solutions for estimates of diagnostic accuracy, in terms of sensitivity and specificity. Through simulation studies, we illustrate the relative advantages of the proposed method over the existing methods that simply treat an imperfect reference test as a gold standard in correlated and clustered data. Compared with the existing methods, the proposed method can reduce not only substantial bias, but also the computational burden. Moreover, to demonstrate the utility of this approach, we apply the proposed method to the study of National-Eye-Institute-funded Telemedicine Approaches to Evaluating of Acute-Phase Retinopathy of Prematurity (e-ROP), for estimating accuracies of both the ophthalmologist examination and the image evaluation.
MeSH term(s)	Bias ; Eye Diseases ; Humans ; Infant, Newborn ; Infant, Premature ; Likelihood Functions ; Sensitivity and Specificity
Language	English
Publishing date	2021-12-03
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	843037-8
ISSN	1097-0258 ; 0277-6715
ISSN (online)	1097-0258
ISSN	0277-6715
DOI	10.1002/sim.9269
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Zs.A 1756: Show issues

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Article: Interleukin-6 genotypes and serum levels in Chinese Hui population.

Gao, Shu-Ping / Liang, Shu / Pan, Min / Sun, Rong-Liang / Chen, Chu / Luan, Hong / Jiang, Min-Hui

International journal of clinical and experimental medicine

2014 Volume 7, Issue 9, Page(s) 2851–2857

Abstract: ... pathophysiologic processes, and circulating levels of IL-6 differ greatly between individuals. The Chinese Hui is one ... their effects on serum levels in Hui population. The aim of the present study is to determine the prevalence ... promoter region and their association with IL-6 serum levels in the Ningxia Hui population. A total of 96 Hui ...

Abstract	Interleukin-6 (IL-6) is a key pro-inflammatory cytokine involved in different physiologic and pathophysiologic processes, and circulating levels of IL-6 differ greatly between individuals. The Chinese Hui is one of the largest ethnic minorities, little is known about the distribution of IL-6 genetic variations and their effects on serum levels in Hui population. The aim of the present study is to determine the prevalence of -174G/C (rs1800795), -597G/A (rs1800797), and -634C/G (rs1800796) polymorphisms in the IL-6 gene promoter region and their association with IL-6 serum levels in the Ningxia Hui population. A total of 96 Hui subjects, (57 men and 39 women; mean age 49.65 ± 19.73 years) unrelated nationality residents in Ningxia Hui Autonomous Region were enrolled. Genotyping of the three polymorphisms were performed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) combined with gel electrophoresis and then confirmed by direct sequencing. The -174G/C (97.92% GG, 2.08% GC, and 0% CC) and -597G/A (98.96% GG, 1.04% GA, and 0% AA) polymorphisms were rare. The frequencies of -634C/G genotypes CC, CG, and GG were found to be 54.17%, 40.62%, and 5.21%, respectively in total studied subjects, the derived allele frequencies for the C and G alleles were 74.48% and 25.52%. Increased IL-6 levels were correlated with the IL-6 -634G allele carriers (CG+GG genotypes). The results suggest that IL-6 -174G/C and -597G/A are rare but -634C/G is common in the Ningxia Hui population, and the -634G allele is associated with circulating levels of IL-6.
Language	English
Publishing date	2014-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2418305-2
ISSN	1940-5901
ISSN	1940-5901
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Article ; Online: The Genetic Structure of Chinese Hui Ethnic Group Revealed by Complete Mitochondrial Genome Analyses Using Massively Parallel Sequencing.

Chen, Chong / Li, Yuchun / Tao, Ruiyang / Jin, Xiaoye / Guo, Yuxin / Cui, Wei / Chen, Anqi / Yang, Yue / Zhang, Xingru / Zhang, Jingyi / Li, Chengtao / Zhu, Bofeng

Genes

2020 Volume 11, Issue 11

Abstract: ... provides a pivotal way for us to investigate the formation histories of populations. The Hui minority ... the world as reference data, to comprehensively dissect the matrilineal landscape of Hui group. Our results ... demonstrated that Hui group exhibited closer genetic relationships with Chinese Han populations from different ...

Abstract	Mitochondrial DNA (mtDNA), coupled with maternal inheritance and relatively high mutation rates, provides a pivotal way for us to investigate the formation histories of populations. The Hui minority with Islamic faith is one of the most widely distributed ethnic groups in China. However, the exploration of Hui's genetic architecture from the complete mitochondrial genome perspective has not been detected yet. Therefore, in this study, we employed the complete mitochondrial genomes of 98 healthy and unrelated individuals from Northwest China, as well as 99 previously published populations containing 7274 individuals from all over the world as reference data, to comprehensively dissect the matrilineal landscape of Hui group. Our results demonstrated that Hui group exhibited closer genetic relationships with Chinese Han populations from different regions, which was largely attributable to the widespread of haplogroups D4, D5, M7, B4, and F1 in these populations. The demographic expansion of Hui group might occur during the Late Pleistocene. Finally, we also found that Hui group might have gene exchanges with Uygur, Tibetan, and Tajik groups in different degrees and retained minor genetic imprint of European-specific lineages, therefore, hinting the existence of multi-ethnic integration events in shaping the genetic landscape of Chinese Hui group.
MeSH term(s)	Asian People/genetics ; China/ethnology ; DNA, Mitochondrial/genetics ; Ethnicity/genetics ; Genetic Variation ; Genetics, Population ; Genome, Mitochondrial ; Haplotypes ; High-Throughput Nucleotide Sequencing/methods ; Humans ; Population Dynamics ; Principal Component Analysis
Chemical Substances	DNA, Mitochondrial
Language	English
Publishing date	2020-11-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes11111352
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