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  1. Article ; Online: Global COVID-19 fatality analysis reveals Hubei-like countries potentially with severe outbreaks

    XINMIAO, FU

    Abstract: 1. CFR in Iran in the early stage of the outbreak is the highest among all the countries 2. CFRs in the USA and Italy are similar to that in Hubei Province in the early stage of the outbreak. 3. CFRs in South Korea are similar to that outside Hubei (in ... ...

    Abstract 1. CFR in Iran in the early stage of the outbreak is the highest among all the countries 2. CFRs in the USA and Italy are similar to that in Hubei Province in the early stage of the outbreak. 3. CFRs in South Korea are similar to that outside Hubei (in China), indicating less severe outbreaks therein. 4. Our findings highlight the potential severity of outbreaks globally, particular in the USA.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    Note WHO #Covidence: #20038075
    DOI 10.1101/2020.03.26.20038075
    Database COVID19

    Kategorien

  2. Article ; Online: Negligible Risk of the COVID-19 Resurgence Caused by Work Resuming in China (outside Hubei): a Statistical Probability Study

    XINMIAO, FU

    Abstract: The COVID-19 outbreak in China appears to reach the late stage since late February 2020, and a stepwise restoration of economic operations is implemented. Risk assessment for such economic restoration is of significance. Here we estimated the probability ...

    Abstract The COVID-19 outbreak in China appears to reach the late stage since late February 2020, and a stepwise restoration of economic operations is implemented. Risk assessment for such economic restoration is of significance. Here we estimated the probability of COVID-19 resurgence caused by work resuming in typical provinces/cities, and found that such probability is very limited (<5% for all the regions except Beijing). Our work may inform provincial governments to make risk level-based, differentiated control measures.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    Note WHO #Covidence: #20044271
    DOI 10.1101/2020.03.26.20044271
    Database COVID19

    Kategorien

  3. Article ; Online: Global analysis of daily new COVID-19 cases reveals many static-phase countries including US and UK potentially with unstoppable epidemics

    XINMIAO, FU

    Abstract: The COVID-19 epidemics are differentially progressing in different countries. Here, comparative analyses of daily new cases reveal that 61 most affected countries can be classified into four types: downward (22), upward (20), static-phase (12) and ... ...

    Abstract The COVID-19 epidemics are differentially progressing in different countries. Here, comparative analyses of daily new cases reveal that 61 most affected countries can be classified into four types: downward (22), upward (20), static-phase (12) and uncertain ones (7). In particular, the 12 static-phase countries including US and UK are characterized by largely constant numbers of daily new cases in the past over 14 days. Furthermore, these static-phase countries are overall significantly lower in testing density but higher in the level of positive COVID-19 tests than downward countries. These findings suggest that the testing capacity in static-phase countries is lagging behind the spread of the outbreak, i.e., daily new cases (confirmed) are likely less than daily new infections and the remaining undocumented infections are thus still expanding, resulting in unstoppable epidemics. As such, increasing the testing capacity and/or reducing the COVID-19 transmission are urgently needed to stop the severing crisis in static-phase countries.
    Keywords covid19
    Publisher MedRxiv; WHO
    Document type Article ; Online
    Note WHO #Covidence: #20095356
    DOI 10.1101/2020.05.08.20095356
    Database COVID19

    Kategorien

  4. Article ; Online: Global COVID-19 fatality analysis reveals Hubei-like countries potentially with severe outbreaks

    FU, XINMIAO

    Abstract: 1. CFR in Iran in the early stage of the outbreak is the highest among all the countries 2. CFRs in the USA and Italy are similar to that in Hubei Province in the early stage of the outbreak. 3. CFRs in South Korea are similar to that outside Hubei (in ... ...

    Abstract 1. CFR in Iran in the early stage of the outbreak is the highest among all the countries 2. CFRs in the USA and Italy are similar to that in Hubei Province in the early stage of the outbreak. 3. CFRs in South Korea are similar to that outside Hubei (in China), indicating less severe outbreaks therein. 4. Our findings highlight the potential severity of outbreaks globally, particular in the USA.
    Keywords covid19
    Publisher MedRxiv
    Document type Article ; Online
    DOI 10.1101/2020.03.26.20038075
    Database COVID19

    Kategorien

  5. Article ; Online: Global COVID-19 fatality analysis reveals Hubei-like countries potentially with severe outbreaks

    FU, XINMIAO

    medRxiv

    Abstract: 1. CFR in Iran in the early stage of the outbreak is the highest among all the countries 2. CFRs in the USA and Italy are similar to that in Hubei Province in the early stage of the outbreak. 3. CFRs in South Korea are similar to that outside Hubei (in ... ...

    Abstract 1. CFR in Iran in the early stage of the outbreak is the highest among all the countries 2. CFRs in the USA and Italy are similar to that in Hubei Province in the early stage of the outbreak. 3. CFRs in South Korea are similar to that outside Hubei (in China), indicating less severe outbreaks therein. 4. Our findings highlight the potential severity of outbreaks globally, particular in the USA.
    Keywords covid19
    Language English
    Publishing date 2020-03-29
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.03.26.20038075
    Database COVID19

    Kategorien

  6. Article ; Online: Negligible Risk of the COVID-19 Resurgence Caused by Work Resuming in China (outside Hubei): a Statistical Probability Study

    FU, XINMIAO

    Abstract: The COVID-19 outbreak in China appears to reach the late stage since late February 2020, and a stepwise restoration of economic operations is implemented. Risk assessment for such economic restoration is of significance. Here we estimated the probability ...

    Abstract The COVID-19 outbreak in China appears to reach the late stage since late February 2020, and a stepwise restoration of economic operations is implemented. Risk assessment for such economic restoration is of significance. Here we estimated the probability of COVID-19 resurgence caused by work resuming in typical provinces/cities, and found that such probability is very limited (<5% for all the regions except Beijing). Our work may inform provincial governments to make risk level-based, differentiated control measures.
    Keywords covid19
    Publisher MedRxiv
    Document type Article ; Online
    DOI 10.1101/2020.03.26.20044271
    Database COVID19

    Kategorien

  7. Article ; Online: Negligible Risk of the COVID-19 Resurgence Caused by Work Resuming in China (outside Hubei): a Statistical Probability Study

    FU, XINMIAO

    medRxiv

    Abstract: The COVID-19 outbreak in China appears to reach the late stage since late February 2020, and a stepwise restoration of economic operations is implemented. Risk assessment for such economic restoration is of significance. Here we estimated the probability ...

    Abstract The COVID-19 outbreak in China appears to reach the late stage since late February 2020, and a stepwise restoration of economic operations is implemented. Risk assessment for such economic restoration is of significance. Here we estimated the probability of COVID-19 resurgence caused by work resuming in typical provinces/cities, and found that such probability is very limited (<5% for all the regions except Beijing). Our work may inform provincial governments to make risk level-based, differentiated control measures.
    Keywords covid19
    Language English
    Publishing date 2020-03-30
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.03.26.20044271
    Database COVID19

    Kategorien

  8. Article ; Online: Forecasting COVID-19 cases and deaths in epidemic-mitigating European countries by Richards function-based regression analyses

    FU, XINMIAO

    medRxiv

    Abstract: The COVID-19 pandemic has hit many countries, and in some European countries it has been mitigated since April. Here we applied Richards function to simulate and forecast the course of COVID-19 epidemics in Italy, Spain, France, Germany, Turkey, Belgium, ...

    Abstract The COVID-19 pandemic has hit many countries, and in some European countries it has been mitigated since April. Here we applied Richards function to simulate and forecast the course of COVID-19 epidemics in Italy, Spain, France, Germany, Turkey, Belgium, Ireland, Netherlands, Portugal and Switzerland. Potential total COVID-19 confirmed cases in these countries were estimated to be 240400±1300, 294100±4000, 178500±800, 176900±700, 155400±1000, 57900±400, 24000±200, 46200±300, 30000±300 and 30700±100 respectively. Most of these countries are predicted to approach ending stage between late May and early June such that daily new cases will become minimal, which may guide societal and economic restorations. In addition, total COVID-19 deaths were estimated to be 33500±300, 28200±200, 27800±200, 8740±80, 4500±30, 9250±70, 1530±20, 6240±50, 1380±10 and 1960±8, respectively. To our best knowledge, this is the first study forecasting the COVID-19 epidemic by applying the Richard function-based regression analysis.
    Keywords covid19
    Language English
    Publishing date 2020-05-26
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.05.18.20106146
    Database COVID19

    Kategorien

  9. Article ; Online: Global analysis of daily new COVID-19 cases reveals many static-phase countries including US and UK potentially with unstoppable epidemics

    FU, XINMIAO

    medRxiv

    Abstract: The COVID-19 epidemics are differentially progressing in different countries. Here, comparative analyses of daily new cases reveal that 61 most affected countries can be classified into four types: downward (22), upward (20), static-phase (12) and ... ...

    Abstract The COVID-19 epidemics are differentially progressing in different countries. Here, comparative analyses of daily new cases reveal that 61 most affected countries can be classified into four types: downward (22), upward (20), static-phase (12) and uncertain ones (7). In particular, the 12 static-phase countries including US and UK are characterized by largely constant numbers of daily new cases in the past over 14 days. Furthermore, these static-phase countries are overall significantly lower in testing density but higher in the level of positive COVID-19 tests than downward countries. These findings suggest that the testing capacity in static-phase countries is lagging behind the spread of the outbreak, i.e., daily new cases (confirmed) are likely less than daily new infections and the remaining undocumented infections are thus still expanding, resulting in unstoppable epidemics. As such, increasing the testing capacity and/or reducing the COVID-19 transmission are urgently needed to stop the severing crisis in static-phase countries.
    Keywords covid19
    Language English
    Publishing date 2020-05-12
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2020.05.08.20095356
    Database COVID19

    Kategorien

  10. Article ; Online: Exploring the prebiotic potential of hydrolyzed fucoidan fermented in vitro with human fecal inocula: Impact on microbiota and metabolome.

    Huang, Xinru / Nie, Shaoping / Fu, Xiaodan / Nan, Shihao / Ren, Xinmiao / Li, Rong

    International journal of biological macromolecules

    2024  Volume 267, Issue Pt 1, Page(s) 131202

    Abstract: Fucoidan is widely applied in food and pharmaceutical industry for the promising bioactivities. Low-molecular weight hydrolyzed fucoidan has gained attention for its beneficial health effects. Here, the modulation on microbiome and metabolome features of ...

    Abstract Fucoidan is widely applied in food and pharmaceutical industry for the promising bioactivities. Low-molecular weight hydrolyzed fucoidan has gained attention for its beneficial health effects. Here, the modulation on microbiome and metabolome features of fucoidan and its acidolyzed derivatives (HMAF, 1.5-20 kDa; LMAF, <1.5 kDa) were investigated through human fecal cultures. Fucose is the main monosaccharide component in fucoidan and LMAF, while HMAF contains abundant glucuronic acid. LMAF fermentation resulted in the highest production of short-chain fatty acids, with acetate and propionate reaching maximum levels of 13.46 mmol/L and 11.57 mmol/L, respectively. Conversely, HMAF exhibited a maximum butyrate production of 9.28 mmol/L. Both fucoidan and acidolyzed derivatives decreased the abundance of Escherichia-Shigella and Klebsiella in human fecal cultures. Fucoidan and HMAF prefer to improve the abundance of Bacteroides. However, LMAF showed positive influence on Bifidobacterium, Lactobacillus, and Megamonas. Untargeted metabolome indicated that fucoidan and its derivatives mainly altered the metabolic level of lipids, indole, and their derivatives, with fucoidan and HMAF promoting higher level of indole-3-propionic acid and indole-3-carboxaldehyde compared to LMAF. Considering the chemical structural differences, this study suggested that hydrolyzed fucoidan can provide potential therapeutic applications for targeted regulation of microbial communities.
    Language English
    Publishing date 2024-03-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.131202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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