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Article: Identification and Characterization of Antigenic Properties of

Shen, Chunxiang / Zhu, Xinyi / Xu, Xuejun / Chang, Hao / Ni, Yangyue / Li, Chen / He, Kaiyue / Chen, Lin / Chen, Lu / Hou, Min / Ji, Minjun / Xu, Zhipeng

Pathogens (Basel, Switzerland)

2022 Volume 11, Issue 11

Abstract: It is known that schistosome-derived antigens induce innate and adaptive immune responses that are essential for the formation of hepatic immunopathology. Here, we screened and synthesized four peptides derived ... ...

Abstract	It is known that schistosome-derived antigens induce innate and adaptive immune responses that are essential for the formation of hepatic immunopathology. Here, we screened and synthesized four peptides derived from
Language	English
Publishing date	2022-10-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens11111238
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Article ; Online: Simultaneous detection and differentiation of SARS-CoV-2, influenza A virus and influenza B virus by one-step quadruplex real-time RT-PCR in patients with clinical manifestations.

Ni, Minjun / Xu, Hengyi / Luo, Jie / Liu, Wei / Zhou, Donggen

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2020 Volume 103, Page(s) 517–524

Abstract: Objective: To develop a novel quadruplex real-time reverse transcription polymerase chain reaction (rRT-PCR) assay for the diagnosis of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, differential diagnosis and detection of co- ... ...

Abstract	Objective: To develop a novel quadruplex real-time reverse transcription polymerase chain reaction (rRT-PCR) assay for the diagnosis of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, differential diagnosis and detection of co-infections. Methods: A one-step quadruplex rRT-PCR assay was developed for simultaneous detection and differentiation of SARS-CoV-2 ORF1ab and N genes, influenza A virus (hIAV) and influenza B virus (hIBV). Results: The quadruplex rRT-PCR assay had good sensitivity and specificity. Correlation coefficients and amplification efficiencies of all singleplex and quadruplex rRT-PCR reactions were within acceptable ranges. The 95% lower limits of detection for plasmid standards and positive nucleic acid extracts of the quadruplex rRT-PCR assay were 57.38-95.11 copies/μL and 114.65-154.25 copies/μL, respectively. Excellent results were attained for inter- and intra-assay reproducibility. Among these clinical samples, only four samples showed results inconsistent with the singleplex rRT-PCR assays. Conclusions: To the authors' knowledge, this is the first study to report a quadruplex rRT-PCR assay for the detection of two SARS-CoV-2 genes, hIAV and hIBV with perfect clinical performance.
Language	English
Publishing date	2020-12-14
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2020.12.027
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Article: Cepharanthine Ameliorates Chondrocytic Inflammation and Osteoarthritis

Yao, Minjun / Zhang, Caihua / Ni, Lingzhi / Ji, Xiaoxiao / Hong, Jianqiao / Chen, Yazhou / Wang, Jie / Li, Congsun / Lin, Jiyan / Lu, Tingting / Sheng, Yihao / Sun, Menghao / Shi, Mingmin / Zhou, Chenhe / Cai, Xunzi

Frontiers in pharmacology

2022 Volume 13, Page(s) 854239

Abstract: Osteoarthritis is a worldwide joint disease caused by abnormal chondrocytic metabolism. However, traditional therapeutic methods aimed at anti-inflammation for early-stage disease are palliative. In the present study, we demonstrated that cepharanthine ( ... ...

Abstract	Osteoarthritis is a worldwide joint disease caused by abnormal chondrocytic metabolism. However, traditional therapeutic methods aimed at anti-inflammation for early-stage disease are palliative. In the present study, we demonstrated that cepharanthine (CEP), extracted from the plant
Language	English
Publishing date	2022-06-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.854239
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Article: Helminth-induced CD9+ B-cell subset alleviates obesity-associated inflammation via IL-10 production

Li, Maining / Wang, Huiquan / Ni, Yangyue / Li, Chen / Xu, Xuejun / Chang, Hao / Xu, Zhipeng / Hou, Min / Ji, Minjun

Australian Society for Parasitology International journal for parasitology. 2022 Feb., v. 52, no. 2-3

2022

Abstract: It has been shown that helminth infection can protect against obesity and improve insulin sensitivity to a certain extent, based on epidemiological investigations and animal experiments. Meanwhile, helminths induce a network of regulatory immune cells, ... ...

Abstract	It has been shown that helminth infection can protect against obesity and improve insulin sensitivity to a certain extent, based on epidemiological investigations and animal experiments. Meanwhile, helminths induce a network of regulatory immune cells, including regulatory B cells (Bregs). However, the molecule characteristics and function of these Bregs in improving whole-body metabolic homeostasis remains largely unclear. We established a mouse model with chronic Schistosoma japonicum infection, and compared the differences in B10 cells (CD19⁺CD5⁺CD1dʰⁱ) and B10⁻ cells (CD19⁺CD5⁻CD1d⁻) from splenic B cells of infected mice using RNA-seq. A unique Breg population was identified. Furthermore, these Bregs were evaluated for their ability to produce inhibitory cytokines in vitro and suppress obesity when adoptively transferred into mice on a high-fat diet. We found that schistosome infection could expand Breg cell populations in mice. CD9 was demonstrated to be a key surface marker for most murine IL-10⁺ B cells in spleen. CD19⁺CD9⁺ B cells produced more IL-10 than conventional B10 cells. Adoptive transfer of CD9⁺ B cells had the capacity to alleviate obesity-associated inflammation via promoting Tregs, Th2 cells and decreasing Th1, Th17 cells in high-fat diet mice. In conclusion, schistosome infection can induce regulatory CD9⁺ B cell production, which plays a critical role in the regulation of metabolic disorders through IL-10 production.
Keywords	B-lymphocytes ; Schistosoma japonicum ; helminthiasis ; helminths ; high fat diet ; homeostasis ; inflammation ; insulin resistance ; interleukin-10 ; mice ; obesity ; parasitology ; sequence analysis ; spleen
Language	English
Dates of publication	2022-02
Size	p. 111-123.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	120518-3
ISSN	1879-0135 ; 0020-7519
ISSN (online)	1879-0135
ISSN	0020-7519
DOI	10.1016/j.ijpara.2021.08.009
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Oral berberine ameliorates high-fat diet-induced obesity by activating TAS2Rs in tuft and endocrine cells in the gut.

Sun, Siyu / Yang, Yuxuan / Xiong, Ruiyan / Ni, Yangyue / Ma, Xiaojie / Hou, Min / Chen, Lin / Xu, Zhipeng / Chen, Lu / Ji, Minjun

Life sciences

2022 Volume 311, Issue Pt A, Page(s) 121141

Abstract: Background and aims: Although oral berberine, a natural compound extracted from the Chinese herbal medicine curcumin, has low bioavailability, it is still effective in suppressing obesity; however, the underlying mechanism is unclear. Berberine can bind ...

Abstract	Background and aims: Although oral berberine, a natural compound extracted from the Chinese herbal medicine curcumin, has low bioavailability, it is still effective in suppressing obesity; however, the underlying mechanism is unclear. Berberine can bind to bitter-taste receptors (TAS2Rs) in intestinal endocrine secretin tumor (STC-1) cells to promote glucagon-like peptide-1 (GLP-1) secretion. Notably, TAS2Rs also exist in the tuft cells of the gut. Therefore, this study aimed to explore whether the beneficial effect of oral berberine on obesity is dependent on bitter-taste signaling in the tuft cells of the gut. Methods and results: Standard chow diet (SCD) or high-fat diet (HFD) was administered to C57BL/6 mice, with or without berberine (100 mg/kg, 200 mg/kg, p. o.). The PLCβ2 inhibitor U73122 was used to verify whether the anti-obesity effect of berberine was dependent on the bitter-taste signaling pathway. In this study, we observed that the oral administration of berberine alleviated HFD-induced obesity in mice that U73122 partially inhibited. Both in vivo and ex vivo, berberine upregulated the release of GLP-1, promoted the proliferation of tuft cells and secretion of IL-25 in obesity via the TAS2R signaling pathway. Conclusions: Oral berberine ameliorated HFD-induced obesity through the TAS2R-IL-25 signaling pathway in tuft cells in the gut. Significance: We identified and functionally characterized the TAS2Rs and Gα-gustducin/Gβ1γ13 signaling pathway utilized by tuft cells in response to oral berberine in obese mice and proposed a new mechanism underlying the anti-obesity effect of berberine.
MeSH term(s)	Animals ; Mice ; Berberine/pharmacology ; Diet, High-Fat ; Endocrine Cells/metabolism ; Glucagon-Like Peptide 1/metabolism ; Mice, Inbred C57BL ; Mice, Obese ; Obesity/drug therapy ; Obesity/metabolism ; Receptors, G-Protein-Coupled/metabolism
Chemical Substances	Berberine (0I8Y3P32UF) ; Glucagon-Like Peptide 1 (89750-14-1) ; Receptors, G-Protein-Coupled ; taste receptors, type 2
Language	English
Publishing date	2022-10-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	3378-9
ISSN	1879-0631 ; 0024-3205
ISSN (online)	1879-0631
ISSN	0024-3205
DOI	10.1016/j.lfs.2022.121141
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Article ; Online: Peritoneal GATA6

Chang, Hao / Ni, Yangyue / Shen, Chunxiang / Li, Chen / He, Kaiyue / Zhu, Xinyi / Chen, Lin / Chen, Lu / Qiu, Jingfan / Ji, Yong / Hou, Min / Ji, Minjun / Xu, Zhipeng

Immunology

2022 Volume 167, Issue 1, Page(s) 77–93

Abstract: The source of macrophages that contribute to human liver disease remains poorly understood. The purpose of this study is to investigate the functional mechanism of peritoneal macrophages in the development of hepatic immunopathology. By performing the ... ...

Abstract	The source of macrophages that contribute to human liver disease remains poorly understood. The purpose of this study is to investigate the functional mechanism of peritoneal macrophages in the development of hepatic immunopathology. By performing the natural infection with the blood fluke Schistosoma japonicum (S. japonicum) and the chemically carbon tetrachloride (CCl
MeSH term(s)	Animals ; GATA6 Transcription Factor/genetics ; GATA6 Transcription Factor/metabolism ; Humans ; Liver/metabolism ; Macrophages/metabolism ; Mice ; Mice, Inbred C57BL ; Schistosoma japonicum ; Schistosomiasis japonica/metabolism ; T-Lymphocytes, Regulatory/metabolism
Chemical Substances	GATA6 Transcription Factor ; GATA6 protein, human
Language	English
Publishing date	2022-06-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80124-0
ISSN	1365-2567 ; 0019-2805 ; 0953-4954
ISSN (online)	1365-2567
ISSN	0019-2805 ; 0953-4954
DOI	10.1111/imm.13519
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Article ; Online: Helminth-induced CD9

Li, Maining / Wang, Huiquan / Ni, Yangyue / Li, Chen / Xu, Xuejun / Chang, Hao / Xu, Zhipeng / Hou, Min / Ji, Minjun

International journal for parasitology

2021 Volume 52, Issue 2-3, Page(s) 111–123

Abstract	It has been shown that helminth infection can protect against obesity and improve insulin sensitivity to a certain extent, based on epidemiological investigations and animal experiments. Meanwhile, helminths induce a network of regulatory immune cells, including regulatory B cells (Bregs). However, the molecule characteristics and function of these Bregs in improving whole-body metabolic homeostasis remains largely unclear. We established a mouse model with chronic Schistosoma japonicum infection, and compared the differences in B10 cells (CD19
MeSH term(s)	Animals ; Antigens, CD19/metabolism ; B-Lymphocytes, Regulatory ; Helminths/metabolism ; Inflammation ; Interleukin-10/genetics ; Interleukin-10/metabolism ; Mice ; Mice, Inbred C57BL ; Obesity/complications ; Obesity/metabolism
Chemical Substances	Antigens, CD19 ; Interleukin-10 (130068-27-8)
Language	English
Publishing date	2021-12-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120518-3
ISSN	1879-0135 ; 0020-7519
ISSN (online)	1879-0135
ISSN	0020-7519
DOI	10.1016/j.ijpara.2021.08.009
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Article ; Online: A target-based discovery from a parasitic helminth as a novel therapeutic approach for autoimmune diseases.

Ni, Yangyue / Xiong, Ruiyan / Zhu, Yuxiao / Luan, Ning / Yu, Chuanxin / Yang, Kun / Wang, Huiquan / Xu, Xuejun / Yang, Yuxuan / Sun, Siyu / Shi, Liyun / Padde, Jon Rob / Chen, Lin / Chen, Lu / Hou, Min / Xu, Zhipeng / Lai, Ren / Ji, Minjun

EBioMedicine

2023 Volume 95, Page(s) 104751

Abstract: Background: Regulatory T cells (Tregs) can alleviate the development of autoimmune and inflammatory diseases, thereby proposing their role as a new therapeutic strategy. Parasitic helminths have co-evolved with hosts to generate immunological privilege ... ...

Abstract	Background: Regulatory T cells (Tregs) can alleviate the development of autoimmune and inflammatory diseases, thereby proposing their role as a new therapeutic strategy. Parasitic helminths have co-evolved with hosts to generate immunological privilege and immune tolerance through inducing Tregs. Thus, constructing a "Tregs-induction"-based discovery pipeline from parasitic helminth is a promising strategy to control autoimmune and inflammatory diseases. Methods: The gel filtration chromatography and reverse-phase high-performance liquid chromatography (RP-HPLC) were used to isolate immunomodulatory components from the egg extracts of Schistosoma japonicum. The extracted peptides were evaluated for their effects on Tregs suppressive functions using flow cytometry, ELISA and T cell suppression assay. Finally, we carried out colitis and psoriasis models to evaluate the function of Tregs induced by helminth-derived peptide in vivo. Findings: Here, based on target-driven discovery strategy, we successfully identified a small 3 kDa peptide (SjDX5-53) from egg extracts of schistosome, which promoted both human and murine Tregs production. SjDX5-53 presented immunosuppressive function by arresting dendritic cells (DCs) at an immature state and augmenting the proportion and suppressive capacity of Tregs. In mouse models, SjDX5-53 protected mice against autoimmune-related colitis and psoriasis through inducing Tregs and inhibiting inflammatory T-helper (Th) 1 and Th17 responses. Interpretation: SjDX5-53 exhibited the promising therapeutic effects in alleviating the phenotype of immune-related colitis and psoriasis. This study displayed a screening and validation pipeline of the inducer of Tregs from helminth eggs, highlighting the discovery of new biologics inspired by co-evolution of hosts and their parasites. Funding: This study was supported by the Natural Science Foundation of China (82272368) and Natural Science Foundation of Jiangsu Province (BK20211586).
MeSH term(s)	Mice ; Humans ; Animals ; Schistosoma japonicum ; T-Lymphocytes, Regulatory ; Autoimmune Diseases/therapy ; Colitis ; Psoriasis
Language	English
Publishing date	2023-08-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2023.104751
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Article ; Online: Systemic metastasis-targeted nanotherapeutic reinforces tumor surgical resection and chemotherapy

Minjun Xu / Kaili Hu / Yipu Liu / Yukun Huang / Shanshan Liu / Yu Chen / Dayuan Wang / Songlei Zhou / Qian Zhang / Ni Mei / Huiping Lu / Fengan Li / Xiaoling Gao / Jun Chen

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 17

Abstract: Failure of conventional clinical therapies such as tumor resection and chemotherapy are mainly due to the ineffective control of tumor metastasis. Here, the authors show that a systemic metastasis-targeted nanotherapeutic may offer a powerful adjunct ... ...

Abstract	Failure of conventional clinical therapies such as tumor resection and chemotherapy are mainly due to the ineffective control of tumor metastasis. Here, the authors show that a systemic metastasis-targeted nanotherapeutic may offer a powerful adjunct therapy for suppressing tumor metastasis.
Keywords	Science ; Q
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Correlation between nutritional status and oral health quality of life, self-efficacy of older inpatients and the influencing factors.

Zhu, Zhu / Xu, Jiayun / Lin, Ying / Chai, Kai / Zhou, Yiyun / Jia, Runyu / Ni, Huijue / Wu, Minjun / Wen, Cuihong / Qiao, Yuehua / Wang, Haixia / Luan, Wei

BMC geriatrics

2022 Volume 22, Issue 1, Page(s) 280

Abstract: Objective: This study explores the relationship between nutritional status and oral health quality of life, the self-efficacy of older inpatients and the correlative factors.: Methods: In this study, the convenience sampling method was used to select ...

Abstract	Objective: This study explores the relationship between nutritional status and oral health quality of life, the self-efficacy of older inpatients and the correlative factors. Methods: In this study, the convenience sampling method was used to select 307 older inpatients in the southern section of the Renji Hospital affiliated to Shanghai Jiao Tong University School of Medicine from October to December 2020 as the main research participants. A mini nutritional assessment questionnaire was used to assess nutritional status, and the Chinese version of a geriatric oral health assessment index questionnaire was used to determine the oral health quality of life. Self-efficacy was assessed by a general self-efficacy scale questionnaire. Descriptive statistics were used to analyse data using the SPSS 22.0 software. Pearson correlation and multiple linear regression analysis were applied to explore the correlation between variables and factors concerned with nutritional status, respectively. Results: The results of this study showed that the self-efficacy and oral health quality of life of older inpatients were at a moderate level. Among the patients, 263 had one or more tooth defects, and only 128 had oral restorations or wore dentures. The risk of malnutrition in hospitalised older patients was 37.1%, and the incidence of malnutrition was 13.4%. The risk factors of nutritional status of older patients were age, oral-related quality of life, prealbumin index, self-efficacy, chronic disease, monthly income and tooth defect (P < 0.05). Conclusion: The incidence of malnutrition and malnutrition risk in hospitalised older patients is relatively high. The main associated factors include age, tooth defect, oral health quality of life, self-efficacy, chronic disease status and monthly income. Therefore, older inpatients, especially those with prosthodontic problems, should carry out nutritional assessments, intervention and graded management as soon as possible to improve their self-efficacy, improve their nutrition and health status and reduce the incidence of a poor prognosis.
MeSH term(s)	Aged ; China ; Cross-Sectional Studies ; Geriatric Assessment/methods ; Humans ; Inpatients ; Malnutrition/epidemiology ; Nutrition Assessment ; Nutritional Status ; Oral Health ; Quality of Life ; Self Efficacy
Language	English
Publishing date	2022-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2059865-8
ISSN	1471-2318 ; 1471-2318
ISSN (online)	1471-2318
ISSN	1471-2318
DOI	10.1186/s12877-022-02830-0
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