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  1. Article ; Online: Cardiopulmonary limitations in young Long Covid patients: A case control study.

    Halasz, Geza / Di Spigno, Francesco / Donelli, Davide / Giacani, Alessandro / Moderato, Luca / Lazzeroni, Davide / De Luca, Leonardo / Piepoli, Massimo

    European journal of preventive cardiology

    2024  

    Language English
    Publishing date 2024-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1093/eurjpc/zwae029
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4686: Show issues Location:
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  2. Article: Acute Stress Response Profiles in Health Workers Facing SARS-CoV-2.

    Moderato, Luca / Lazzeroni, Davide / Oppo, Annalisa / Dell'Orco, Francesco / Moderato, Paolo / Presti, Giovambattista

    Frontiers in psychology

    2021  Volume 12, Page(s) 660156

    Abstract: Objective: The study is an explorative investigation aimed to assess the differences in acute stress response patterns of health workers facing coronavirus disease 2019 (COVID-19) during Italy's first lockdown.: Methods: A cross-sectional ... ...

    Abstract Objective: The study is an explorative investigation aimed to assess the differences in acute stress response patterns of health workers facing coronavirus disease 2019 (COVID-19) during Italy's first lockdown.
    Methods: A cross-sectional investigation using convenience sampling method was conducted in Italy during April 2020. Eight hundred fifty-eight health workers participated in the research filling out self-report measures including Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder (GAD-7), Insomnia Severity Index (ISI), and Impact of Event Scale-Revised (IES-R).
    Results: Moderate/severe depression was found in 28.9% (95% CI, 25.8-32.04), moderate/severe anxiety in 55.4% (95% CI, 51.9-58.8), insomnia in 15% (95% CI, 12.5-17.5), and distress in 52.5% (95% CI, 48.5%-56.6) of participants. The 3% of health workers reported frequent suicidal thoughts. Female sex, working for >15 h/week in a COVID-19 unit, and living apart from family were associated with a significantly higher risk of distress, anxiety, insomnia, depression, and functional impairment. Four profiles were identified on the basis of psychopathological measures: Profile_0 included 44% (
    Conclusion: The identification of specific profiles could help psychiatrists and emergency psychologists to build specific interventions in terms of both primary and secondary prevention to face future waves of the COVID-19 outbreak.
    Language English
    Publishing date 2021-05-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2021.660156
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  3. Article ; Online: Simultaneous COVID-19 in Monozygotic Twins.

    Lazzeroni, Davide / Concari, Pietro / Moderato, Luca

    Annals of internal medicine

    2020  Volume 174, Issue 5, Page(s) 717–719

    MeSH term(s) COVID-19/diagnosis ; COVID-19/therapy ; Diseases in Twins/diagnosis ; Diseases in Twins/therapy ; Humans ; Male ; Middle Aged ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology ; SARS-CoV-2 ; Twins, Monozygotic
    Language English
    Publishing date 2020-12-08
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/L20-1207
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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.178/2: Show issues Location:
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  4. Article ; Online: Letter by Moderato et al Regarding Article, "Persistent Long-Term Structural, Functional, and Metabolic Changes After Stress-Induced (Takotsubo) Cardiomyopathy".

    Moderato, Luca / Lazzeroni, Davide / Coruzzi, Paolo

    Circulation

    2018  Volume 138, Issue 9, Page(s) 960–961

    MeSH term(s) Cardiomyopathies ; Electrocardiography ; Humans ; Takotsubo Cardiomyopathy
    Language English
    Publishing date 2018-10-23
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.117.033253
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    In stock of ZB MED Cologne/Königswinter

    Ui IV Zs.60: Show issues Location:
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  5. Article ; Online: Air pollution and out-of-hospital cardiac arrest risk: a 7-year study from a highly polluted area.

    Moderato, Luca / Aschieri, Daniela / Lazzeroni, Davide / Rossi, Luca / Biagi, Andrea / Binno, Simone Maurizio / Monello, Alberto / Pelizzoni, Valentina / Sticozzi, Concetta / Zanni, Alessia / Capucci, Alessandro / Nani, Stefano / Ardissino, Diego / Nicolini, Francesco / Niccoli, Giampaolo

    European heart journal. Acute cardiovascular care

    2023  Volume 12, Issue 12, Page(s) 810–817

    Abstract: Aims: Globally, nearly 20% of cardiovascular disease deaths were attributable to air pollution. Out-of-hospital cardiac arrest (OHCA) represents a major public health problem; therefore, the identification of novel OHCA triggers is of crucial relevance. ...

    Abstract Aims: Globally, nearly 20% of cardiovascular disease deaths were attributable to air pollution. Out-of-hospital cardiac arrest (OHCA) represents a major public health problem; therefore, the identification of novel OHCA triggers is of crucial relevance. The aim of the study was to evaluate the association between air pollution (short-, mid-, and long-term exposures) and OHCA risk, during a 7-year period in a highly polluted urban area in northern Italy, with a high density of automated external defibrillators (AEDs).
    Methods and results: Out-of-hospital cardiac arrests were prospectively collected from the 'Progetto Vita Database' between 1 January 2010 and 31 December 2017; day-by-day air pollution levels were extracted from the Environmental Protection Agency stations. Electrocardiograms of OHCA interventions were collected from the AED data cards. Day-by-day particulate matter (PM) 2.5 and 10, ozone (O3), carbon monoxide (CO), and nitrogen dioxide (NO2) levels were measured. A total of 880 OHCAs occurred in 748 days. A significant increase in OHCA risk with a progressive increase in PM2.5, PM10, CO, and NO2 levels was found. After adjustment for temperature and seasons, a 9% and 12% increase in OHCA risk for each 10 μg/m3 increase in PM10 (P < 0.0001) and PM2.5 (P < 0.0001) levels was found. Air pollutant levels were associated with both asystole and shockable rhythm risk, while no correlation was found with pulseless electrical activity.
    Conclusion: Short- and mid-term exposures to PM2.5 and PM10 are independently associated with the risk of OHCA due to asystole or shockable rhythm.
    MeSH term(s) United States ; Humans ; Out-of-Hospital Cardiac Arrest/epidemiology ; Out-of-Hospital Cardiac Arrest/etiology ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Nitrogen Dioxide/analysis ; Air Pollution/adverse effects ; Air Pollution/analysis ; Air Pollutants/adverse effects ; Air Pollutants/analysis
    Chemical Substances Particulate Matter ; Nitrogen Dioxide (S7G510RUBH) ; Air Pollutants
    Language English
    Publishing date 2023-09-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2663340-1
    ISSN 2048-8734 ; 2048-8726
    ISSN (online) 2048-8734
    ISSN 2048-8726
    DOI 10.1093/ehjacc/zuad105
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  6. Article ; Online: Acute Stress Response Patterns and Factors Associated with Impaired Psychological Status in Health Workers Facing SARS-CoV-2

    Moderato, Luca / Lazzeroni, Davide / Oppo, Annalisa / Dell'Orco, Francesco / Moderato, Paolo / Presti, Giovambattista

    SSRN Electronic Journal ; ISSN 1556-5068

    Saving Private Ryan

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3608122
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Effects of Multidisciplinary Rehabilitation Enhanced with Neuropsychological Treatment on Post-Acute SARS-CoV-2 Cognitive Impairment (Brain Fog): An Observational Study.

    Rabaiotti, Paolo / Ciracì, Chiara / Donelli, Davide / Oggioni, Carlotta / Rizzi, Beatrice / Savi, Federica / Antonelli, Michele / Rizzato, Matteo / Moderato, Luca / Brambilla, Valerio / Ziveri, Valentina / Brambilla, Lorenzo / Bini, Matteo / Nouvenne, Antonio / Lazzeroni, Davide

    Brain sciences

    2023  Volume 13, Issue 5

    Abstract: Concentration and memory impairment (named "brain fog") represents a frequent and disabling neuropsychological sequela in post-acute COVID-19 syndrome (PACS) patients. The aim of this study was to assess whether neurocognitive function could improve ... ...

    Abstract Concentration and memory impairment (named "brain fog") represents a frequent and disabling neuropsychological sequela in post-acute COVID-19 syndrome (PACS) patients. The aim of this study was to assess whether neurocognitive function could improve after a multidisciplinary rehabilitation program enhanced with individualized neuropsychological treatment. A prospective monocentric registry of PACS patients consecutively admitted to our Rehabilitation Unit was created. The Montreal Cognitive Assessment (MoCA) was used to assess cognitive impairment at admission and discharge. A total of sixty-four (64) PACS patients, fifty-six (56) of them with brain fog, were treated with a day-by-day individualized psychological intervention of cognitive stimulation (45 min) on top of a standard in-hospital rehabilitation program. The mean duration of the acute-phase hospitalization was 55.8 ± 25.8 days and the mean in-hospital rehabilitation duration was 30 ± 10 days. The mean age of the patients was 67.3 ± 10.4 years, 66% of them were male, none had a previous diagnosis of dementia, and 66% of the entire sample had experienced severe COVID-19. At admission, only 12% of the patients had normal cognitive function, while 57% showed mild, 28% moderate, and 3% severe cognitive impairment. After psychological treatment, a significant improvement in the MoCA score was found (20.4 ± 5 vs. 24.7 ± 3.7;
    Language English
    Publishing date 2023-05-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2651993-8
    ISSN 2076-3425
    ISSN 2076-3425
    DOI 10.3390/brainsci13050791
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  8. Article ; Online: Relationship between aortic stiffness and cardiorespiratory fitness in primary and secondary cardiovascular prevention patients.

    Lazzeroni, Davide / Moderato, Luca / Breviario, Federico / De Finis, Alessandra / Catellani, Giorgia / Marazzi, Pier Luca / Castiglioni, Paolo / Camaiora, Umberto / Bini, Matteo / Geroldi, Simone / Brambilla, Lorenzo / Brambilla, Valerio / Coruzzi, Paolo

    European journal of preventive cardiology

    2021  Volume 28, Issue 18, Page(s) e45–e48

    MeSH term(s) Cardiorespiratory Fitness ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Exercise Test ; Humans ; Physical Fitness ; Pulse Wave Analysis ; Vascular Stiffness
    Language English
    Publishing date 2021-02-23
    Publishing country England
    Document type Letter
    ZDB-ID 2626011-6
    ISSN 2047-4881 ; 2047-4873
    ISSN (online) 2047-4881
    ISSN 2047-4873
    DOI 10.1093/eurjpc/zwaa090
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4686: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article: Perceived Anxiety, Coping, and Autonomic Function in Takotsubo Syndrome Long after the Acute Event.

    Lazzeroni, Davide / Ciraci, Chiara / Sommaruga, Marinella / Oggioni, Carlotta / Saccò, Melissa / Ziveri, Valentina / Paglialonga, Letizia / Bini, Matteo / Moderato, Luca / Brambilla, Lorenzo / Coruzzi, Paolo / Cruciani, Gianluca / Lingiardi, Vittorio / Tanzilli, Annalisa / Galli, Federica

    Life (Basel, Switzerland)

    2022  Volume 12, Issue 9

    Abstract: Background: Anxiety and depressive disorders represent predisposing factors for the autonomic dysfunctions that characterize the acute phase of Takotsubo syndrome (TS). However, there is insufficient data on this relationship after the acute event. The ... ...

    Abstract Background: Anxiety and depressive disorders represent predisposing factors for the autonomic dysfunctions that characterize the acute phase of Takotsubo syndrome (TS). However, there is insufficient data on this relationship after the acute event. The present study aimed at evaluating the psychological and autonomic status of patients with a history of TS.
    Methods: Ten TS patients whose acute event occurred at least 1 year prior to the evaluation and nine healthy age- and sex-matched subjects were evaluated. The cardiovascular assessment included a clinical examination, beat-to-beat heart rate monitoring to assess heart rate variability, and a psychological examination using the 16 Personality Factors-C Form (16PF), the Acceptance and Action Questionnaire-II, the Coping Orientations to Problems Experienced (COPE), the Beck Depression Inventory-II, and the State-Trait Anxiety Inventory (STAI).
    Results: TS patients scored significantly higher on the STAI (i.e., Anxiety Trait), 16PF (i.e., Tension), and COPE (i.e., Transcendental Orientation). TS patients also showed lower heart rate variability. Moreover, a significant inverse correlation was found between sympathetic tone (LF/HF ratio) and coping orientation.
    Conclusions: Long after the acute event, TS patients are characterized by elevated anxiety, high tension, and a specific religious coping strategy.
    Language English
    Publishing date 2022-09-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life12091376
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  10. Article: An Impairment in Resting and Exertional Breathing Pattern May Occur in Long-COVID Patients with Normal Spirometry and Unexplained Dyspnoea.

    Frizzelli, Annalisa / Di Spigno, Francesco / Moderato, Luca / Halasz, Geza / Aiello, Marina / Tzani, Panagiota / Manari, Gaia / Calzetta, Luigino / Pisi, Roberta / Pelà, Giovanna / Piepoli, Massimo / Chetta, Alfredo

    Journal of clinical medicine

    2022  Volume 11, Issue 24

    Abstract: Background: Long-term sequelae, called Long-COVID (LC), may occur after SARS-CoV-2 infection, with unexplained dyspnoea as the most common symptom. The breathing pattern (BP) analysis, by means of the ratio of the inspiratory time (TI) during the tidal ... ...

    Abstract Background: Long-term sequelae, called Long-COVID (LC), may occur after SARS-CoV-2 infection, with unexplained dyspnoea as the most common symptom. The breathing pattern (BP) analysis, by means of the ratio of the inspiratory time (TI) during the tidal volume (VT) to the total breath duration (TI/TTOT) and by the VT/TI ratio, could further elucidate the underlying mechanisms of the unexplained dyspnoea in LC patients. Therefore, we analysed TI/TTOT and VT/TI at rest and during maximal exercise in LC patients with unexplained dyspnoea, compared to a control group. Methods: In this cross-sectional study, we enrolled LC patients with normal spirometry, who were required to perform a cardio-pulmonary exercise test (CPET) for unexplained dyspnoea, lasting at least 3 months after SARS-CoV-2 infection. As a control group, we recruited healthy age and sex-matched subjects (HS). All subjects performed spirometry and CPET, according to standardized procedures. Results: We found that 42 LC patients (23 females) had lower maximal exercise capacity, both in terms of maximal O2 uptake (VO2peak) and workload, compared to 40 HS (22 females) (p < 0.05). LC patients also showed significantly higher values of TI/TTOT at rest and at peak, and lower values in VT/TI at peak (p < 0.05). In LC patients, values of TI/TTOT at peak were significantly related to ∆PETCO2, i.e., the end-tidal pressure of CO2 at peak minus the one at rest (p < 0.05). When LC patients were categorized by the TI/TTOT 0.38 cut-off value, patients with TI/TTOT > 0.38 showed lower values in VO2peak and maximal workload, and greater values in the ventilation/CO2 linear relationship slope than patients with TI/TTOT ≤ 0.38 (p < 0.05). Conclusions: Our findings show that LC patients with unexplained dyspnoea have resting and exertional BP more prone to diaphragmatic fatigue, and less effective than controls. Pulmonary rehabilitation might be useful to revert this unpleasant condition.
    Language English
    Publishing date 2022-12-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11247388
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