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Article ; Online: Síndrome inflamatorio multisistémico asociado con SARS-CoV-2 en pediatría.

Bustos B, Raúl

2020 Volume 91, Issue 4, Page(s) 646–647

Title translation	Pediatric multisystem inflammatory syndrome associated with SARS-CoV-2.
MeSH term(s)	Adolescent ; COVID-19/diagnosis ; COVID-19/etiology ; COVID-19/therapy ; COVID-19 Testing ; Child ; Child, Preschool ; Humans ; Infant ; Infant, Newborn ; Risk Factors ; Severity of Illness Index ; Systemic Inflammatory Response Syndrome/diagnosis ; Systemic Inflammatory Response Syndrome/etiology ; Systemic Inflammatory Response Syndrome/therapy
Language	Spanish
Publishing date	2020-09-12
Publishing country	Chile
Document type	Letter
ZDB-ID	954077-5
ISSN	0717-6228 ; 0034-7396 ; 0370-4106
ISSN (online)	0717-6228
ISSN	0034-7396 ; 0370-4106
DOI	10.32641/rchped.v91i4.2616
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Article ; Online: Cánula nasal de alto flujo en la bronquiolitis aguda: La evidencia sigue pendiente.

Bustos B, Raúl

Revista chilena de pediatria

2019 Volume 90, Issue 2, Page(s) 137–138

Title translation	High-flow nasal cannula therapy in acute bronchiolitis: The evidence is still pending.
MeSH term(s)	Acute Disease ; Bronchiolitis/therapy ; Catheterization/methods ; Child ; Humans
Language	Spanish
Publishing date	2019-05-16
Publishing country	Chile
Document type	Editorial
ZDB-ID	954077-5
ISSN	0717-6228 ; 0034-7396 ; 0370-4106
ISSN (online)	0717-6228
ISSN	0034-7396 ; 0370-4106
DOI	10.32641/rchped.v90i2.1082
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Article ; Online: Mielitis flácida aguda e infección por enterovirus: una enfermedad grave emergente.

Bustos B, Raúl / Díaz, Franco / Cores, Camila / Castro Z, Francisca / Cruces, Pablo

Andes pediatrica : revista Chilena de pediatria

2023 Volume 93, Issue 4, Page(s) 552–560

Abstract: Acute flaccid myelitis (AFM) is a neuroinflammatory disease characterized by acute asymmetric weakness of the limbs associated with lesions of the gray matter of the spinal cord. It mainly affects children and has been increasingly identified since 2014.! ...

Title translation	Acute flaccid myelitis and enterovirus infection: a severe emerging disease.
Abstract	Acute flaccid myelitis (AFM) is a neuroinflammatory disease characterized by acute asymmetric weakness of the limbs associated with lesions of the gray matter of the spinal cord. It mainly affects children and has been increasingly identified since 2014. Objective: To describe a severe emerging neurological disease in Chile. Clinical case: Three children (2 females), previously healthy were in cluded. The age at the onset was between 4 and 6 years. All presented an acute febrile illness associated with upper respiratory symptoms, rapid onset of proximal asymmetric limb weakness, spinal fluid pleocytosis, and enterovirus isolated from nasopharyngeal swab; two patients developed tetraparesis. The MRI of the spinal cord showed T2 hyperintensity of the grey matter. The three patients were admitted to the Pediatric Intensive Care Unit (PICU), and two required mechanical ventilation. No significant improvements were observed after the use of immunomodulatory therapy and plasma ex change. At 12 months of follow-up, one case was quadriplegic and ventilator-dependent; the second died of ventricular arrhythmia in the PICU, and the third one is under rehabilitation with partial recovery. Conclusions: We report the first cases of this severe emerging neurological disease in our country. In a child with predominantly proximal and asymmetric acute limb paralysis, pediatricians must have a high index of suspicion for AFM. Since it can progress rapidly and lead to respiratory failure, suspected AFM should be considered a medical emergency.
MeSH term(s)	Child ; Female ; Humans ; Child, Preschool ; Neuromuscular Diseases/diagnosis ; Neuromuscular Diseases/therapy ; Myelitis/diagnosis ; Myelitis/therapy ; Central Nervous System Viral Diseases/complications ; Central Nervous System Viral Diseases/diagnosis ; Enterovirus Infections/complications ; Enterovirus Infections/diagnosis ; Enterovirus Infections/therapy
Language	Spanish
Publishing date	2023-10-25
Publishing country	Chile
Document type	English Abstract ; Journal Article
ISSN	2452-6053
ISSN (online)	2452-6053
DOI	10.32641/andespediatr.v93i4.4137
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Article ; Online: Shock séptico en pediatría: menos es más.

Bustos B, Raúl

Revista chilena de pediatria

2016 Volume 87, Issue 2, Page(s) 148–149

Title translation	Septic shock in paediatrics: Less is more.
MeSH term(s)	Child ; Humans ; Pediatrics ; Shock, Septic
Language	Spanish
Publishing date	2016-03
Publishing country	Chile
Document type	Letter ; Comment
ZDB-ID	954077-5
ISSN	0717-6228 ; 0034-7396 ; 0370-4106
ISSN (online)	0717-6228
ISSN	0034-7396 ; 0370-4106
DOI	10.1016/j.rchipe.2015.10.008
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Article ; Online: Retrospective study of poisoned patients admitted to a hospital's pediatric intensive care unit in Chile.

Hormazábal A, Nicolás / Yzoard A, Marcia / Bustos B, Raúl / Müller-Ramírez, Claudio

Archivos argentinos de pediatria

2022 Volume 120, Issue 4, Page(s) 257–263

Abstract: Introduction: Pediatric poisoning is a public health problem worldwide. The objective of this study was to establish the characteristics of pediatric cases of poisoning seen at the pediatric intensive care unit (PICU) of a hospital in Chile.: ... ...

Title translation	Estudio retrospectivo de pacientes intoxicados admitidos en la unidad de cuidados intensivos pediátricos de un hospital en Chile.
Abstract	Introduction: Pediatric poisoning is a public health problem worldwide. The objective of this study was to establish the characteristics of pediatric cases of poisoning seen at the pediatric intensive care unit (PICU) of a hospital in Chile. Population and methods: The medical records of patients diagnosed with poisoning and admitted to the PICU between 2013 and 2017 were reviewed. Results: A total of 105 cases were identified, who account for 3% of all admissions recorded in the study period. Patients' median age was 10 years. In total, 73.3% of cases were female patients; 51% of cases were associated with intentional poisoning; and 83% were caused by drug exposure. The most common drugs identified were antidepressants (11.2%) and non-steroidal anti-inflammatory drugs (10.7%). Intake was the most frequent route of exposure (93%). The average length of stay in the PICU was 1.3 days. One patient required intubation and another required hemodialysis in the PICU. Statistically significant relationships were established between patient sex and the circumstance of exposure and between the patient's psychiatric condition and the number of toxic substances ingested. Conclusions: Most poisoning cases seen at the PICU were intentional and occurred in female patients, who had a psychiatric condition. The most common drugs identified were antidepressants and non-steroidal anti-inflammatory drugs.
MeSH term(s)	Anti-Inflammatory Agents ; Antidepressive Agents ; Child ; Chile/epidemiology ; Female ; Hospitals ; Humans ; Infant ; Intensive Care Units, Pediatric ; Male ; Poisons ; Retrospective Studies
Chemical Substances	Anti-Inflammatory Agents ; Antidepressive Agents ; Poisons
Language	Spanish
Publishing date	2022-05-27
Publishing country	Argentina
Document type	Journal Article
ZDB-ID	424449-7
ISSN	1668-3501 ; 0325-0075 ; 0004-0487
ISSN (online)	1668-3501
ISSN	0325-0075 ; 0004-0487
DOI	10.5546/aap.2022.eng.257
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Article: Early damage enhances compensatory responses to herbivory in wild lima bean.

Bustos-Segura, Carlos / González-Salas, Raúl / Benrey, Betty

Frontiers in plant science

2022 Volume 13, Page(s) 1037047

Abstract: Damage by herbivores can induce various defensive responses. Induced resistance comprises traits that can reduced the damage, while compensatory responses reduce the negative effects of damage on plant fitness. Timing of damage may be essential in ... ...

Abstract	Damage by herbivores can induce various defensive responses. Induced resistance comprises traits that can reduced the damage, while compensatory responses reduce the negative effects of damage on plant fitness. Timing of damage may be essential in determining the patterns of induced defenses. Here, we tested how timing and frequency of leaf damage affect compensatory responses in wild lima bean plants in terms of growth and seed output, as well as their effects on induced resistance to seed beetles. To this end, we applied mechanical damage to plants at different ontogenetical stages, at one time point (juvenile stage only) or two time points (seedling and juvenile stage or juvenile and reproductive stage). We found that plants damaged at the seedling/juvenile stage showed higher compensatory growth, and seed output compared to plants damaged only at the juvenile stage or juvenile/reproductive stage. Seeds from plants damaged at the juvenile and juvenile/reproductive stages had fewer beetles than seeds from undamaged plants, however this was driven by a density dependent effect of seed abundance rather than a direct effect of damage treatments. We did not find differences in parasitism rate by parasitoid wasps on seed beetles among plant treatments. Our results show that damage at the seedling stage triggers compensatory responses which implies that tolerance to herbivory is enhanced or primed by early damage. Herbivory often occurs at several time points throughout plant development and this study illustrates that, for a full understanding of the factors associated with plant induced responses in a dynamic biotic environment, it is important to determine the multitrophic consequences of damage at more than one ontogenetical stage.
Language	English
Publishing date	2022-11-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2613694-6
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2022.1037047
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Article: Therapeutic plasma exchange in critically ill children: experience of the pediatric intensive care unit of two centers in Chile.

Bustos B, Raul / Hickmann O, Lilian / Cruces R, Pablo / Díaz, Franco

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

2021 Volume 60, Issue 5, Page(s) 103181

Abstract: Introduction: Therapeutic plasma exchange (TPE) is an extracorporeal blood purification technique used in a wide spectrum of diseases. We aim to review the indications, complications, and outcomes of critically ill children who received TPE and to ... ...

Abstract	Introduction: Therapeutic plasma exchange (TPE) is an extracorporeal blood purification technique used in a wide spectrum of diseases. We aim to review the indications, complications, and outcomes of critically ill children who received TPE and to compare a membrane versus centrifugal method in this cohort. Methods: A retrospective observational study in two pediatric intensive care units in Chile during eight years (2011-2019) Results: A total of 36 patients underwent 167 TPE sessions (20 centrifugation and 16 membrane-based). The more frequent indications for TPE were autoimmune neurological diseases in 14 cases, renal diseases (9), and rheumatological disorders (5). 58 % of children received other immunomodulatory therapy. According to ASFA, 45 % of cases were I-II category, 50 % to III, and 5% not classified. Response to treatment was complete in 64 % (23/36) and partial in 33 % (12/36). Complications occurred in 17.4 % of sessions, and the most frequent was transient hypotension during the procedure. Overall survival at discharge from the PICU was 92 %. Patients who received TPE as a single therapy (n = 26) survived 96 %. The clinical outcomes between the two apheresis methods were similar. Survivors had a significantly lower PELOD score on admission (14.5 vs. 6.5, p = 0.004). Conclusions: TPE is mainly indicated as a rescue treatment in neurological autoimmune diseases refractory to conventional immunomodulatory treatment. Complications in critically ill children are mild and low. The outcome in children requiring TPE as a single therapy is good, and no differences were observed with centrifugation or membrane method.
MeSH term(s)	Autoimmune Diseases/complications ; Autoimmune Diseases/therapy ; Blood Component Removal ; Centrifugation ; Child ; Child, Preschool ; Chile ; Critical Care/methods ; Critical Illness ; Female ; Humans ; Intensive Care Units, Pediatric ; Kidney Diseases/complications ; Kidney Diseases/therapy ; Male ; Nervous System Diseases/complications ; Nervous System Diseases/therapy ; Plasma Exchange/methods ; Plasmapheresis ; Retrospective Studies ; Rheumatic Diseases/complications ; Rheumatic Diseases/therapy
Language	English
Publishing date	2021-06-08
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Observational Study
ZDB-ID	2046795-3
ISSN	1878-1683 ; 1473-0502
ISSN (online)	1878-1683
ISSN	1473-0502
DOI	10.1016/j.transci.2021.103181
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Article ; Online: Pediatric Inflammatory Multisystem Syndrome Associated With SARS-CoV-2: A Case Series Quantitative Systematic Review.

Bustos B, Raúl / Jaramillo-Bustamante, Juan Camilo / Vasquez-Hoyos, Pablo / Cruces, Pablo / Díaz, Franco

Pediatric emergency care

2020 Volume 37, Issue 1, Page(s) 44–47

Abstract: Abstract: Pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (PIMS-TS) is infrequent, but children might present as a life-threatening disease. In a systematic quantitative review, we ... ...

Abstract	Abstract: Pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (PIMS-TS) is infrequent, but children might present as a life-threatening disease. In a systematic quantitative review, we analyzed 11 studies of PIMS-TS, including 468 children reported before July 1, 2020. We found a myriad of clinical features, but we were able to describe common characteristics: previously healthy school-aged children, persistent fever and gastrointestinal symptoms, lymphopenia, and high inflammatory markers. Clinical syndromes such as myocarditis and Kawasaki disease were present in only one third of cases each one. Pediatric intensive care unit admission was frequent, although length of stay was less than 1 week, and mortality was low. Most patients received immunoglobulin or steroids, although the level of evidence for that treatment is low. The PIMS-ST was recently described, and the detailed quantitative pooled data will increase clinicians' awareness, improve diagnosis, and promptly start treatment. This analysis also highlights the necessity of future collaborative studies, given the heterogeneous nature of the PIMS-TS.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Anti-Bacterial Agents/therapeutic use ; Anticoagulants/therapeutic use ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/etiology ; COVID-19/therapy ; Child ; Combined Modality Therapy ; Female ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Immunosuppressive Agents/therapeutic use ; Intensive Care Units, Pediatric/statistics & numerical data ; Length of Stay/statistics & numerical data ; Male ; Mucocutaneous Lymph Node Syndrome/epidemiology ; Mucocutaneous Lymph Node Syndrome/etiology ; Myocarditis/epidemiology ; Myocarditis/etiology ; SARS-CoV-2 ; Systemic Inflammatory Response Syndrome/drug therapy ; Systemic Inflammatory Response Syndrome/epidemiology ; Systemic Inflammatory Response Syndrome/etiology ; COVID-19 Drug Treatment
Chemical Substances	Adrenal Cortex Hormones ; Anti-Bacterial Agents ; Anticoagulants ; Immunoglobulins, Intravenous ; Immunosuppressive Agents
Keywords	covid19
Language	English
Publishing date	2020-11-09
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	632588-9
ISSN	1535-1815 ; 0749-5161
ISSN (online)	1535-1815
ISSN	0749-5161
DOI	10.1097/PEC.0000000000002306
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Article ; Online: Vitamina D y enfermedades respiratorias pediátricas.

Cepeda S, Javier / Zenteno A, Daniel / Fuentes S, Claudia / Bustos B, Raúl

Revista chilena de pediatria

2019 Volume 90, Issue 1, Page(s) 94–101

Abstract: The better understanding of the global activity of vitamin D has led to an intense search for its involvement in non-skeletal diseases. This article presents an updated review of the relationship between vitamin D and pediatric respiratory pathology. A ... ...

Title translation	Vitamin D and pediatrics respiratory diseases.
Abstract	The better understanding of the global activity of vitamin D has led to an intense search for its involvement in non-skeletal diseases. This article presents an updated review of the relationship between vitamin D and pediatric respiratory pathology. A literature search was performed in PUBMED using free terms and MESH terms: vitamin D, asthma, respiratory system diseases, and bronchiolitis. Stu dies in human patients younger than 18 years and animals, published in English and Spanish until 2017 were included. 507 articles were found, of which 43 were included. Indirect evidence suggests a role of vitamin D and fetal lung maturation. In relation to pediatric pulmonary pathology, studies are scarce and inconclusive. Recent meta-analyses performed with individualized evaluation of the participants shows an important protective role of vitamin D supplementation in the prevention of severe asthma exacerbations and acute viral infections. In bronchiolitis, the results are contradictory, with no clear relationship between plasma levels and severity. There is not enough evidence to assess the benefits of vitamin D supplementation in cystic fibrosis and tuberculosis. A direct relationship between the severity of sleep-related breathing disorders and vitamin D plasma levels has recently been proposed, although the exact mechanisms involved in this association are unknown. Current information suggests that vitamin D supplementation may represent a cost-effective strategy in redu cing important causes of infant morbidity and mortality.
MeSH term(s)	Biomarkers/blood ; Child ; Dietary Supplements ; Humans ; Lung/embryology ; Pediatrics ; Respiratory Tract Diseases/drug therapy ; Respiratory Tract Diseases/etiology ; Respiratory Tract Diseases/prevention & control ; Risk Factors ; Vitamin D/blood ; Vitamin D/physiology ; Vitamin D/therapeutic use ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/diagnosis ; Vitamin D Deficiency/drug therapy ; Vitamins/blood ; Vitamins/physiology ; Vitamins/therapeutic use
Chemical Substances	Biomarkers ; Vitamins ; Vitamin D (1406-16-2)
Language	Spanish
Publishing date	2019-01-21
Publishing country	Chile
Document type	Journal Article ; Review
ZDB-ID	954077-5
ISSN	0717-6228 ; 0034-7396 ; 0370-4106
ISSN (online)	0717-6228
ISSN	0034-7396 ; 0370-4106
DOI	10.32641/rchped.v90i1.747
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Article ; Online: Valor predictivo de la procalcitonina en niños con sospecha de sepsis.

Bustos B, Raúl / Padilla P, Oslando

Revista chilena de pediatria

2015 Volume 86, Issue 5, Page(s) 331–336

Abstract: Introduction: The use of biomarkers could be a tool for diagnosis, prognosis and stratifying children with sepsis. Our main goal was to analyze the value of procalcitonin (PCT), C reactive protein (CRP) and lactate in predicting mortality, septic shock ... ...

Title translation	Predictive value of procalcitonin in children with suspected sepsis.
Abstract	Introduction: The use of biomarkers could be a tool for diagnosis, prognosis and stratifying children with sepsis. Our main goal was to analyze the value of procalcitonin (PCT), C reactive protein (CRP) and lactate in predicting mortality, septic shock and the stratification in children with suspected sepsis Patients and method: Prospective study in 81 patients. Plasma levels of PCT, CRP and lactate were measured at admission in the pediatric intensive care unit. Patients were categorized into systemic inflammatory response syndrome, sepsis, severe sepsis and septic shock. Results: Concentrations of PCT (ng/mL) increased significantly according to the severity of sepsis: 0.36 (0-1.2) for systemic inflammatory response syndrome; 1.96 (0.4-3.5) for sepsis; 7.5 (3.9-11.1) for severe sepsis; and 58.9 (35.1-82.7) for septic shock (P<.001). Compared to CRP and lactate, the area under the ROC curve revealed a good discriminative power of PCT to predict septic shock and mortality, 0.91 (95% CI: 0.83-0.97) and 0.80 (95% CI: 0.69-0.88), respectively. Conclusions: In contrast to CRP and lactate, the determination of PCT in pediatric intensive care unit admission is a good predictor of mortality and septic shock and can stratify patients according to severity of sepsis.
MeSH term(s)	Biomarkers ; C-Reactive Protein/metabolism ; Calcitonin/blood ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Intensive Care Units, Pediatric ; Lactic Acid/blood ; Male ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Sepsis/blood ; Sepsis/mortality ; Sepsis/physiopathology ; Severity of Illness Index ; Shock, Septic/blood ; Shock, Septic/diagnosis ; Systemic Inflammatory Response Syndrome/blood ; Systemic Inflammatory Response Syndrome/physiopathology
Chemical Substances	Biomarkers ; Lactic Acid (33X04XA5AT) ; Calcitonin (9007-12-9) ; C-Reactive Protein (9007-41-4)
Language	Spanish
Publishing date	2015-09
Publishing country	Chile
Document type	Journal Article
ZDB-ID	954077-5
ISSN	0717-6228 ; 0034-7396 ; 0370-4106
ISSN (online)	0717-6228
ISSN	0034-7396 ; 0370-4106
DOI	10.1016/j.rchipe.2015.07.006
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