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Article ; Online: Circulating Tumor Cells and Circulating Tumor DNA in Urologic Cancers.

Madueke, Ikenna / Lee, Richard J / Miyamoto, David T

2022 Volume 50, Issue 1, Page(s) 109–114

Abstract: Liquid biopsies such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) have great potential to serve as prognostic and predictive biomarkers in urologic cancers. The possibility of using liquid biopsies for real-time noninvasive and ... ...

Abstract	Liquid biopsies such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) have great potential to serve as prognostic and predictive biomarkers in urologic cancers. The possibility of using liquid biopsies for real-time noninvasive and dynamic monitoring of response to therapy has been an active area of investigation. In this brief review, we outline the evidence for the potential clinical utility of CTC and ctDNA analyses in prostate, urothelial, and renal cancers.
MeSH term(s)	Male ; Humans ; Circulating Tumor DNA/genetics ; Neoplastic Cells, Circulating/pathology ; Biomarkers, Tumor/genetics ; Liquid Biopsy ; Urologic Neoplasms/genetics
Chemical Substances	Circulating Tumor DNA ; Biomarkers, Tumor
Language	English
Publishing date	2022-11-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	192293-2
ISSN	1558-318X ; 0094-0143
ISSN (online)	1558-318X
ISSN	0094-0143
DOI	10.1016/j.ucl.2022.09.010
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Article ; Online: PIK Carefully, AKT Accordingly: Towards Precision Medicine in Prostate Cancer.

Miyamoto, David T / Lee, Richard J

European urology

2020 Volume 78, Issue 6, Page(s) 845–846

MeSH term(s)	Class I Phosphatidylinositol 3-Kinases ; Humans ; Male ; Phosphoinositide-3 Kinase Inhibitors ; Precision Medicine ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/therapy ; Prostatic Neoplasms, Castration-Resistant ; Proto-Oncogene Proteins c-akt/genetics
Chemical Substances	Phosphoinositide-3 Kinase Inhibitors ; Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137) ; PIK3CA protein, human (EC 2.7.1.137) ; AKT1 protein, human (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2020-09-06
Publishing country	Switzerland
Document type	Editorial ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2020.08.034
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Immunotherapy Combined With Radiation Therapy for Genitourinary Malignancies.

Ukleja, Jacob / Kusaka, Erika / Miyamoto, David T

Frontiers in oncology

2021 Volume 11, Page(s) 663852

Abstract: Immunotherapy drugs have recently been approved by the Food and Drug Administration for the treatment of several genitourinary malignancies, including bladder cancer, renal cancer, and prostate cancer. Preclinical data and early clinical trial results ... ...

Abstract	Immunotherapy drugs have recently been approved by the Food and Drug Administration for the treatment of several genitourinary malignancies, including bladder cancer, renal cancer, and prostate cancer. Preclinical data and early clinical trial results suggest that immune checkpoint inhibitors can act synergistically with radiation therapy to enhance tumor cell killing at local irradiated sites and in some cases at distant sites through an abscopal effect. Because radiation therapy is commonly used in the treatment of genitourinary malignancies, there is great interest in testing the combination of immunotherapy with radiation therapy in these cancers to further improve treatment efficacy. In this review, we discuss the current evidence and biological rationale for combining immunotherapy with radiation therapy, as well as emerging data from ongoing and planned clinical trials testing the efficacy and tolerability of this combination in the treatment of genitourinary malignancies. We also outline outstanding questions regarding sequencing, dose fractionation, and biomarkers that remain to be addressed for the optimal delivery of this promising treatment approach.
Language	English
Publishing date	2021-05-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.663852
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Article ; Online: Reply from Authors re: Ananya Choudhury, Peter J. Hoskin. Predictive Biomarkers for Muscle-invasive Bladder Cancer: The Search for the Holy Grail Continues. Eur Urol 2019;76:69-70: Towards Biomarker-Informed Management of Muscle-Invasive Bladder Cancer.

Mouw, Kent W / Miyamoto, David T / Efstathiou, Jason A

European urology

2019 Volume 76, Issue 1, Page(s) 71–72

MeSH term(s)	Biomarkers ; Cystectomy ; Humans ; Urinary Bladder Neoplasms/surgery
Chemical Substances	Biomarkers
Language	English
Publishing date	2019-03-23
Publishing country	Switzerland
Document type	Editorial ; Comment
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2019.03.009
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: A pair of deep learning auto-contouring models for prostate cancer patients injected with a radio-transparent versus radiopaque hydrogel spacer.

Wang, Yi / Boyd, Graham / Zieminski, Stephen / Kamran, Sophia C / Zietman, Anthony L / Miyamoto, David T / Kirk, Maxwell C / Efstathiou, Jason A

Medical physics

2023 Volume 50, Issue 6, Page(s) 3324–3337

Abstract: Background: Absorbable hydrogel spacer injected between prostate and rectum is gaining popularity for rectal sparing. The spacer alters patient anatomy and thus requires new auto-contouring models.: Purpose: To report the development and ... ...

Abstract	Background: Absorbable hydrogel spacer injected between prostate and rectum is gaining popularity for rectal sparing. The spacer alters patient anatomy and thus requires new auto-contouring models. Purpose: To report the development and comprehensive evaluation of two deep-learning models for patients injected with a radio-transparent (model I) versus radiopaque (model II) spacer. Methods and materials: Model I was trained and cross-validated by 135 cases with transparent spacer and tested on 24 cases. Using refined training methods, model II was trained and cross-validated by the same dataset, but with the Hounsfield Unit distribution in the spacer overridden by that obtained from ten cases with opaque spacer. Model II was tested on 64 cases. The models auto-contour eight regions of interest (ROIs): spacer, prostate, proximal seminal vesicles (SVs), left and right femurs, bladder, rectum, and penile bulb. Qualitatively, each auto contour (AC), as well as the composite set, was assessed against manual contour (MC), by a radiation oncologist using a 1 (accepted directly or after minor editing), 2 (accepted after moderate editing), 3 (accepted after major editing), and 4 (rejected) scoring scale. The efficiency gain was characterized by the mean score as nearly complete [1-1.75], substantial (1.75-2.5], meaningful (2.5-3.25], and no (3.25-4.00]. Quantitatively, the geometric similarity between AC and MC was evaluated by dice similarity coefficient (DSC) and mean distance to agreement (MDA), using tolerance recommended by AAPM TG-132 Report. The results by the two models were compared to examine the outcome of the refined training methods. The large number of testing cases for model II allowed further investigation of inter-observer variability in clinical dataset. The correlation between score and DSC/MDA was studied on the ROIs with 10 or more counts of each acceptable score (1, 2, 3). Results: For model I/model II: the mean score was 3.63/1.30 for transparent/opaque spacer, 2.71/2.16 for prostate, 3.25/2.44 for proximal SVs, 1.13/1.02 for both femurs, 2.25/1.25 for bladder, 3.00/2.06 for rectum, 3.38/2.42 for penile bulb, and 2.79/2.20 for the composite set; the mean DSC was 0.52/0.84 for spacer, 0.84/0.85 for prostate, 0.60/0.62 for proximal SVs, 0.94/0.96 for left femur, 0.95/0.96 for right femur, 0.91/0.95 for bladder, 0.81/0.84 for rectum, and 0.65/0.65 for penile bulb; and the mean MDA was 2.9/0.9 mm for spacer, 1.9/1.7 mm for prostate, 2.4/2.3 mm for proximal SVs, 0.8/0.5 mm for left femur, 0.7/0.5 mm for right femur, 1.5/0.9 mm for bladder, 2.3/1.9 mm for rectum, and 2.2/2.2 mm for penile bulb. Model II showed significantly improved scores for all ROIs, and metrics for spacer, femurs, bladder, and rectum. Significant inter-observer variability was only found for prostate. Highly linear correlation between the score and DSC was found for the two qualified ROIs (prostate and rectum). Conclusions: The overall efficiency gain was meaningful for model I and substantial for model II. The ROIs meeting the clinical deployment criteria (mean score below 3.25, DSC above 0.8, and MDA below 2.5 mm) included prostate, both femurs, bladder and rectum for both models, and spacer for model II.
MeSH term(s)	Male ; Humans ; Deep Learning ; Hydrogels ; Radiotherapy Planning, Computer-Assisted/methods ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/radiotherapy ; Prostate/diagnostic imaging ; Prostate/anatomy & histology
Chemical Substances	Hydrogels
Language	English
Publishing date	2023-03-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	188780-4
ISSN	2473-4209 ; 0094-2405
ISSN (online)	2473-4209
ISSN	0094-2405
DOI	10.1002/mp.16375
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Article ; Online: Pulsatile ECMO: The Future of Mechanical Circulatory Support for Severe Cardiogenic Shock.

JACC. Basic to translational science

2024 Volume 9, Issue 4, Page(s) 456–458

Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article
ISSN	2452-302X
ISSN (online)	2452-302X
DOI	10.1016/j.jacbts.2024.02.015
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Article ; Online: Prognostic Significance of Immune Cell Infiltration in Muscle-invasive Bladder Cancer Treated with Definitive Chemoradiation: A Secondary Analysis of RTOG 0524 and RTOG 0712.

Rana, Zaker / Kamran, Sophia C / Shetty, Amol C / Sutera, Philip / Song, Yang / Bazyar, Soha / Solanki, Abhishek A / Simko, Jeffry P / Pollack, Alan / McConkey, David / Kates, Max / Siddiqui, M Minhaj / Hiken, Jeffrey / Earls, Jon / Messina, David / Mouw, Kent W / Miyamoto, David / Shipley, William U / Michaelson, M Dror /

Zietman, Anthony / Coen, John J / Dahl, Douglas M / Jani, Ashesh B / Souhami, Luis / Chang, Brian K / Lee, R Jeffrey / Pham, Huong / Marshall, David T / Shen, Xinglei / Pugh, Stephanie L / Feng, Felix Y / Efstathiou, Jason A / Tran, Phuoc T / Deek, Matthew P

European urology oncology

2024

Abstract: ... 95% CI 0.24-0.97; p = 0.040) than the cluster with low immune cell content. Higher expression of T ...

Abstract	Chemoradiation therapy (CRT) is a treatment for muscle-invasive bladder cancer (MIBC). Using a novel transcriptomic profiling panel, we validated prognostic immune biomarkers to CRT using 70 pretreatment tumor samples from prospective trials of MIBC (NRG/RTOG 0524 and 0712). Disease-free survival (DFS) and overall survival (OS) were estimated via the Kaplan-Meier method and stratified by genes correlated with immune cell activation. Cox proportional-hazards models were used to assess group differences. Clustering of gene expression profiles revealed that the cluster with high immune cell content was associated with longer DFS (hazard ratio [HR] 0.53, 95% confidence interval [CI] 0.26-1.10; p = 0.071) and OS (HR 0.48, 95% CI 0.24-0.97; p = 0.040) than the cluster with low immune cell content. Higher expression of T-cell infiltration genes (CD8A and ICOS) was associated with longer DFS (HR 0.40, 95% CI 0.21-0.75; p = 0.005) and OS (HR 0.49, 95% CI 0.25-0.94; p = 0.033). Higher IDO1 expression (IFNγ signature) was also associated with longer DFS (HR 0.44, 95% CI 0.24-0.88; p = 0.021) and OS (HR 0.49, 95% CI 0.24-0.99; p = 0.048). These findings should be validated in prospective CRT trials that include biomarkers, particularly for trials incorporating immunotherapy for MIBC. PATIENT SUMMARY: We analyzed patient samples from two clinical trials (NRG/RTOG 0524 and 0712) of chemoradiation for muscle-invasive bladder cancer using a novel method to assess immune cells in the tumor microenvironment. Higher expression of genes associated with immune activation and high overall immune-cell content were associated with better disease-free survival and overall survival for patients treated with chemoradiation.
Language	English
Publishing date	2024-04-18
Publishing country	Netherlands
Document type	Journal Article
ISSN	2588-9311
ISSN (online)	2588-9311
DOI	10.1016/j.euo.2024.03.015
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Article ; Online: Cell-free and circulating tumor cell-based biomarkers in men with metastatic prostate cancer: Tools for real-time precision medicine?

Miyamoto, David T / Lee, Richard J

Urologic oncology

2016 Volume 34, Issue 11, Page(s) 490–501

Abstract: The recent expansion of therapeutic options for the treatment of metastatic prostate cancer highlights the need for precision medicine approaches to enable the rational selection of appropriate therapies for individual patients. In this context, ... ...

Abstract	The recent expansion of therapeutic options for the treatment of metastatic prostate cancer highlights the need for precision medicine approaches to enable the rational selection of appropriate therapies for individual patients. In this context, circulating biomarkers in the peripheral blood are attractive as readily accessible tools for predicting and monitoring therapeutic response. In the case of circulating tumor cells and circulating tumor DNA, they may also serve as a noninvasive means of assessing molecular aberrations in tumors at multiple time points before and during therapy. These so-called "liquid biopsies" can provide a snapshot view of tumor molecular architecture and may enable clinicians to monitor the molecular status of tumors as they evolve during treatment, thus allowing for individualized precision therapeutic decisions for patients over time. In this review, we outline recent progress in the field of circulating biomarkers in metastatic prostate cancer and evaluate their potential for enabling this vision of real-time precision medicine.
Language	English
Publishing date	2016-11
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1336505-8
ISSN	1873-2496 ; 1078-1439
ISSN (online)	1873-2496
ISSN	1078-1439
DOI	10.1016/j.urolonc.2016.09.001
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Article ; Online: Noncanonical Wnt as a prognostic marker in prostate cancer: "you can't always get what you Wnt".

Fisher, Rebecca R / Pleskow, Haley M / Bedingfield, Kathleen / Miyamoto, David T

Expert review of molecular diagnostics

2019 Volume 20, Issue 2, Page(s) 245–254

Abstract: ... ...

Abstract	Introduction
MeSH term(s)	Biomarkers, Tumor ; Clinical Decision-Making ; Disease Management ; Disease Progression ; Disease Susceptibility ; Drug Resistance, Neoplasm ; Humans ; Male ; Prognosis ; Prostatic Neoplasms/diagnosis ; Prostatic Neoplasms/etiology ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/therapy ; Wnt Proteins/metabolism ; Wnt Signaling Pathway
Chemical Substances	Biomarkers, Tumor ; Wnt Proteins
Language	English
Publishing date	2019-12-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2112530-2
ISSN	1744-8352 ; 1473-7159
ISSN (online)	1744-8352
ISSN	1473-7159
DOI	10.1080/14737159.2020.1702522
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Zs.A 6073: Show issues

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Article ; Online: Molecular analysis of circulating tumors cells: Biomarkers beyond enumeration.

Hwang, William L / Pleskow, Haley M / Miyamoto, David T

Advanced drug delivery reviews

2018 Volume 125, Page(s) 122–131

Abstract: Advances in our molecular understanding of cancer biology have paved the way to an expanding compendium of molecularly-targeted therapies, accompanied by the urgent need for biomarkers that enable the precise selection of the most appropriate therapies ... ...

Abstract	Advances in our molecular understanding of cancer biology have paved the way to an expanding compendium of molecularly-targeted therapies, accompanied by the urgent need for biomarkers that enable the precise selection of the most appropriate therapies for individual cancer patients. Circulating biomarkers such as circulating tumor cells (CTCs) are poised to fill this need, since they are "liquid biopsies" that can be performed non-invasively and serially, and may capture the spectrum of spatial and temporal tumor heterogeneity better than conventional tissue biopsies. Increasing evidence suggests that moving beyond the enumeration of CTCs towards more sophisticated molecular analyses can provide actionable data that may predict and potentially improve clinical outcomes. In this review, we discuss the potential of molecular CTC analyses to serve as prognostic and predictive biomarkers to guide cancer therapy and early cancer detection. As technologies to capture and analyze CTCs continue to increase in sophistication, we anticipate that the potential clinical applications of CTCs will grow exponentially in the coming years.
MeSH term(s)	Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Humans ; Neoplasms/pathology ; Neoplasms/therapy ; Neoplastic Cells, Circulating/metabolism ; Neoplastic Cells, Circulating/pathology
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2018-01-08
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	639113-8
ISSN	1872-8294 ; 0169-409X
ISSN (online)	1872-8294
ISSN	0169-409X
DOI	10.1016/j.addr.2018.01.003
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